2587 Dendrotoxin (Dendroaspis angusticeps) Dendrotoxin A is a peptide toxin produced by the Eastern green mamba (Dendroaspis angusticeps). Dendrotoxins block particular subtypes of voltage-gated potassium channels in neurons, thereby enhancing the release of acetylcholine at neuromuscular junctions. (L1096) 74504-53-3 3417.8250000000007 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Dendrotoxins block particular subtypes of voltage-gated potassium channels in neurons, thereby prolonging the duration of action potentials and enhancing the release of acetylcholine at neuromuscular junctions, which may result in muscle hyperexcitability and convulsive symptoms. This is believed to be done by binding to anionic sites near the extracellular surface of the channel and physically occluding the pore, thereby preventing ion conductance. (L1096) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 3.05 mg/kg (Subcutaneous, Mouse) (L1830) LD50: 1.3 mg/kg (Intravenous, Mouse) (L1830) LD50: 0.117 mg/kg (Intraperitoneal, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Dendrotoxin A is a peptide toxin produced by the Eastern green mamba (Dendroaspis angusticeps). (L1096) Dendrotoxins and neurotoxic. (L1096) Dendrotoxins cause muscle hyperexcitability and convulsive symptoms. (L1096) An antivenom exists for Eastern green mamba venom. (L1044) 2009-07-03T22:19:19Z 2014-12-24T20:25:41Z Q9PS08 true Exogenous Liquid 1dtx_bio_r_500.jpg image/jpeg 24875 2014-10-14T18:13:17Z BSEQ0008465