2585 Convulxin Convulxin is a peptide toxin produced by the South American rattlesnake (Crotalus durissus terrificus). (L1095) 37206-04-5 18140.724999999995 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Convulxin binds to the platelet and collagen receptor, glycoprotein VI (GPVI). This causes platelet activation in the blood forming clots and a build up of pressure, which can cause the bloodstream to burst, or the heart or brain to lose blood and result in death. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.262 mg/kg (Intravenous, Mouse) (L1830) LD50: 0.216 mg/kg (Intraperitoneal, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Convulxin is a peptide toxin produced by the South American rattlesnake (Crotalus durissus terrificus). (L1095) Convulxin causes platelet activation in the blood forming clots and a build up of pressure. This can cause the bloodstream to burst, or the heart or brain to lose blood and result in death. (T170) Bites from snakes in the Viperidae family cause local pain, swelling, edema, skin discoloration, and ecchymosis. (T156) An antivenom exists for South American rattlesnake venom. (L1044) 2009-07-03T22:19:18Z 2014-12-24T20:25:40Z O93426 1UMR true Exogenous Liquid 1umr_bio_r_500.jpg image/jpeg 54823 2014-10-14T18:13:15Z BSEQ0008463