2584 Crotoxin Crotoxin is a peptide toxin produced by the South American rattlesnake (Crotalus durissus terrificus). (T170) 9007-40-3 15272.965000000011 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Crotoxin inhibits neuromuscular transmission by presynaptically blocking acetylcholine release from the nerve termini. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.262 mg/kg (Intravenous, Mouse) (L1830) LD50: 0.216 mg/kg (Intraperitoneal, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Crotoxin is a peptide toxin produced by the South American rattlesnake (Crotalus durissus terrificus). (T170) Crotoxin is neurotoxic. (T170) Bites from snakes in the Viperidae family cause local pain, swelling, edema, skin discoloration, and ecchymosis. (T156) An antivenom exists for South American rattlesnake venom. (L1044) 2009-07-03T22:19:18Z 2014-12-24T20:25:40Z P08878 3R0L true Exogenous Liquid 3r0l_bio_r_500.jpg image/jpeg 45825 2014-10-14T18:13:14Z BSEQ0008462