2582 Cardiotoxin (Naja atra) Cardiotoxin is a peptide toxin produced by the Chinese cobra (Naja atra). It is cytotoxic. (T170) 155808-00-7 8991.970000000001 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Cardiotoxin binds to the cell membrane and depolarizes cardiomyocytes. It also shows lytic activities on many other cells, including red blood cells. It also targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation, binds to the integrin alpha-V/beta-3 with a moderate affinity, and inhibits protein kinases C. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.29 mg/kg (Subcutaneous, Mouse) (L1830) LD50: 0.345 mg/kg (Intravenous, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Cardiotoxin is a peptide toxin produced by the Chinese cobra (Naja atra). (T170) Cardiotoxin is cardiotoxic. (T170) Bites from snakes in the Elapidae family produce pain at the site of the bite, followed by drowsiness, weakness, excessive salivation, decreased blood pressure, difficulty breathing, and paralysis of the facial muscles, lips, tongue, and larynx. In addition, ptosis, blurring of vision, convulsions, and headache may occur. (T156) An antivenom exists for Chinese cobra venom. (L1044) 2009-07-03T22:19:17Z 2014-12-24T20:25:40Z P60304 2CDX true Exogenous Liquid 1h0j_bio_r_500.jpg image/jpeg 29955 2014-10-14T18:13:13Z BSEQ0008460