2581 Calcicludine Calcicludine is a peptide toxin produced by the Eastern green mamba (Dendroaspis angusticeps). It inhibits high-voltage-activated calcium channels, especially of the L-type. (L1092) 178037-96-2 6986.2049999999945 Clear solution. >10 mg/mL Injection (sting/bite) (L1814) Calcicludine inhibits high-voltage-activated calcium channels, especially of the L-type. (L1092) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 3.05 mg/kg (Subcutaneous, Mouse) (L1830) LD50: 1.3 mg/kg (Intravenous, Mouse) (L1830) LD50: 0.117 (Intraperitoneal, Mouse) (L1830) No indication of carcinogenicity to humans (not listed by IARC). Calcicludine is a peptide toxin produced by the Eastern green mamba (Dendroaspis angusticeps). (L1092) Calcicludine is neurotoxic and cardiotoxic. (L1092) Bites from snakes in the Elapidae family produce pain at the site of the bite, followed by drowsiness, weakness, excessive salivation, decreased blood pressure, difficulty breathing, and paralysis of the facial muscles, lips, tongue, and larynx. In addition, ptosis, blurring of vision, convulsions, and headache may occur. (T156) An antivenom exists for Eastern green mamba venom. (L1044) 2009-07-03T22:19:17Z 2014-12-24T20:25:40Z P81658 1BF0 true Exogenous Liquid 1bf0_asym_r_500.jpg image/jpeg 33948 2014-10-14T18:13:12Z BSEQ0008459