2567 Tityustoxin (Tityus serrulatus ) Tityustoxin is a peptide toxin produced by the Brazilian scorpion (Tityus serrulatus). It binds to voltage-dependent sodium and potassium channels. (L1066) 39465-37-7 6997.934999999996 Clear solution. >10 mg/mL Injection (sting/bite) (L1813) Tityustoxin binds to voltage-dependent sodium and potassium channels. alpha-Type tityustoxin inhibits the inactivation of the activated sodium channels by binding to site 3, causing cell depolarization, which increases calcium uptake and triggers acetylcholine release. beta-Type tityustoxin binds voltage-independently at site-4 of sodium channels and shift the voltage of activation toward more negative potentials, thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. (L1066) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 6 ug/kg (Intracerebroventricular, Mouse) (T170) LD50: 0.43 mg/kg (Subcutaneous, Mouse) (T255) No indication of carcinogenicity to humans (not listed by IARC). Tityustoxin is a peptide toxin produced by the Brazilian scorpion (Tityus serrulatus). (L1066) Tityustoxin is a potent neurotoxin. It also affects the circulatory and respiratory systems. (L1066) Tityustoxin causes sialorrhea, lacrimation and rhinorrhea. Animal studies have also demonstrated dramatic effects on the circulatory and respiratory systems, consisting of hypotension, tachypnea, hyperpnea, ataxic and gasping breathing. (L1066) An antivenom exists for Brazilian scorpion stings. Phenobarbital may be administered to treat lung oedema. (L1044, L1066) 2009-07-03T22:19:11Z 2014-12-24T20:25:39Z P68410 true Exogenous Liquid 1hp2_asym_r_500.jpg image/jpeg 34266 2014-10-14T18:13:08Z BSEQ0008455