2565 Slotoxin Slotoxin is a peptide from Centruroides noxius Hoffmann scorpion venom. It belongs to the short scorpion toxin superfamily. Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only ‘±-subunits (Kd = 1.5 nM). Unreversibly blocks the high conductance calcium-activated potassium channels composed of ‘±- and beta1-subunits. Unreversibly and weakly blocks the high conductance calcium-activated potassium channels composed of ‘±- and beta4-subunits. It shows no activity on other potassium channels. 144026-79-9 2734571 4091.8499999999995 Clear solution. >10 mg/mL Injection (sting/bite) (L1813) Slotoxin reversibly blocks the high conductance calcium-activated potassium channels composed of only alpha-subunits and irreversibly blocks the high conductance calcium-activated potassium channels composed of alpha- and beta1- or beta4- subunits. (L1063) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.31 mg/kg (Intravenous, Mouse) (A688) No indication of carcinogenicity to humans (not listed by IARC). Slotoxin is a peptide toxin produced by the Mexican scorpion (Centruroides noxius). (L1063) Slotoxin is neurotoxic. (L1063) Scorpion stings cause tingling or burning at the site of the sting. In more severe cases, symptoms may include spasm in the throat, feeling of thick tongue, restlessness, muscular fibrillation, abdominal cramps, convulsions, incontinence, hypertension, hypotension, oliguria, cardiac arrhythmias, pulmonary edema, and respiratory failure. (A594) An antivenom exists for Mexican scorpion stings. (L1044) 2009-07-03T22:19:10Z 2014-12-24T20:25:39Z http://en.wikipedia.org/wiki/Slotoxin P0C182 Slotoxin true [Sc+3].[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F.[O-]S(=O)(=O)C(F)(F)F C3F9O9S3Sc InChI=1S/3CHF3O3S.Sc/c3*2-1(3,4)8(5,6)7;/h3*(H,5,6,7);/q;;;+3/p-3 InChIKey=HZXJVDYQRYYYOR-UHFFFAOYSA-K 492.163 491.811982756 Exogenous Liquid 2016319 Slotoxin.jpg image/jpeg 102358 2014-10-14T18:13:06Z BSEQ0008453