2563 Noxiustoxin Noxiustoxin is a peptide toxin produced by the Mexican scorpion (Centruroides noxius). It affects potassium channels. (T170) 85205-49-8 4201.92 Clear solution. >10 mg/mL Injection (sting/bite) (L1813) Noxiustoxin blocks voltage-gated non-inactivating potassium channels and unblocks inactivating potassium channels blocked by alpha-dendrotoxin in synaptosomes. It also displaces the alpha-dendrotoxin homolog dendrotoxin I from its receptor on brain synaptic membranes. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.31 mg/kg (Intravenous, Mouse) (T256) No indication of carcinogenicity to humans (not listed by IARC). Noxiustoxin is a peptide toxin produced by the Mexican scorpion (Centruroides noxius). (T170) Noxiustoxin is neurotoxic. (T170) Scorpion stings cause tingling or burning at the site of the sting. In more severe cases, symptoms may include spasm in the throat, feeling of thick tongue, restlessness, muscular fibrillation, abdominal cramps, convulsions, incontinence, hypertension, hypotension, oliguria, cardiac arrhythmias, pulmonary edema, and respiratory failure. (T156) An antivenom exists for Mexican scorpion stings. (L1044) 2009-07-03T22:19:09Z 2014-12-24T20:25:39Z P08815 1SXM true Exogenous Liquid 1sxm_asym_r_500.jpg image/jpeg 20616 2014-10-14T18:13:04Z BSEQ0008451