<?xml version="1.0" encoding="UTF-8"?>
<compound>
  <id type="integer">2562</id>
  <title>T3D2521</title>
  <common-name>Maurotoxin</common-name>
  <description>Maurotoxin is a peptide toxin produced by the Chactoid scorpion (Scorpio maurus palmatus). It acts by blocking several types of voltage-gated potassium channel. (L1059)</description>
  <cas>188240-41-7</cas>
  <pubchem-id></pubchem-id>
  <chemical-formula nil="true"/>
  <weight>3621.2050000000017</weight>
  <appearance>Clear solution.</appearance>
  <melting-point></melting-point>
  <boiling-point></boiling-point>
  <density nil="true"/>
  <solubility>&gt;10 mg/mL</solubility>
  <specific-gravity nil="true"/>
  <flash-point nil="true"/>
  <vapour-pressure nil="true"/>
  <route-of-exposure>Injection (sting/bite) (L1813)</route-of-exposure>
  <target nil="true"/>
  <mechanism-of-toxicity>Maurotoxin acts by blocking several types of voltage-gated potassium channel. (L1059)</mechanism-of-toxicity>
  <metabolism>Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases.</metabolism>
  <toxicity>LD50: 9.37 mg/kg (Intravenous, Mouse) (T256)</toxicity>
  <lethaldose></lethaldose>
  <carcinogenicity>No indication of carcinogenicity to humans (not listed by IARC).</carcinogenicity>
  <use-source>Maurotoxin is a peptide toxin produced by the Chactoid scorpion (Scorpio maurus palmatus). (L1059)</use-source>
  <min-risk-level></min-risk-level>
  <health-effects>Maurotoxin is neurotoxic. (L1059)</health-effects>
  <symptoms>Scorpion stings cause tingling or burning at the site of the sting. In more severe cases, symptoms may include spasm in the throat, feeling of thick tongue, restlessness, muscular fibrillation, abdominal cramps, convulsions, incontinence, hypertension, hypotension, oliguria, cardiac arrhythmias, pulmonary edema, and respiratory failure. (T156)</symptoms>
  <treatment></treatment>
  <created-at type="dateTime">2009-07-03T22:19:09Z</created-at>
  <updated-at type="dateTime">2014-12-24T20:25:39Z</updated-at>
  <interacting-proteins nil="true"/>
  <wikipedia></wikipedia>
  <uniprot-id>P80719</uniprot-id>
  <kegg-compound-id></kegg-compound-id>
  <omim-id></omim-id>
  <chebi-id></chebi-id>
  <biocyc-id></biocyc-id>
  <ctd-id></ctd-id>
  <stitch-id>Maurotoxin</stitch-id>
  <drugbank-id></drugbank-id>
  <pdb-id>1TXM</pdb-id>
  <actor-id></actor-id>
  <organism nil="true"/>
  <export type="boolean">true</export>
  <metabolizing-proteins nil="true"/>
  <transporting-proteins nil="true"/>
  <moldb-smiles nil="true"/>
  <moldb-formula nil="true"/>
  <moldb-inchi nil="true"/>
  <moldb-inchikey nil="true"/>
  <moldb-average-mass type="decimal" nil="true"/>
  <moldb-mono-mass type="decimal" nil="true"/>
  <origin>Exogenous</origin>
  <state>Liquid</state>
  <logp></logp>
  <hmdb-id></hmdb-id>
  <chembl-id></chembl-id>
  <chemspider-id></chemspider-id>
  <structure-image-file-name>1txm_asym_r_500.jpg</structure-image-file-name>
  <structure-image-content-type>image/jpeg</structure-image-content-type>
  <structure-image-file-size type="integer">26768</structure-image-file-size>
  <structure-image-updated-at type="dateTime">2014-10-14T18:13:03Z</structure-image-updated-at>
  <biodb-id>BSEQ0008450</biodb-id>
  <synthesis-reference></synthesis-reference>
  <structure-image-caption nil="true"/>
</compound>
