2560 Kurtoxin Kurtoxin is a peptide toxin produced by the South African fat tail scorpion (Parabuthus transvaalicus). It affects the gating of voltage-gated sodium channels and calcium channels. (L1054) 820959-57-7 7394.399999999996 Clear solution. >10 mg/mL Injection (sting/bite) (L1813) Kurtoxin affects the gating of voltage-gated sodium channels and calcium channels. In calcium channels Kurtoxin binds close to the channel voltage sensor and thereby produces complex gating modifications, inhibiting T-type, L-type, and N-type calcium channels and facilitating P-type channels. Kurtoxin also slows down both activation and inactivation of sodium channels. (L1054) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 4.25 mg/kg (Subcutaneous, Mouse) (T255) No indication of carcinogenicity to humans (not listed by IARC). Kurtoxin is a peptide toxin produced by the South African fat tail scorpion (Parabuthus transvaalicus). (L1054) Kurtoxin is neurotoxic. (L1054) Scorpion stings cause tingling or burning at the site of the sting. In more severe cases, symptoms may include spasm in the throat, feeling of thick tongue, restlessness, muscular fibrillation, abdominal cramps, convulsions, incontinence, hypertension, hypotension, oliguria, cardiac arrhythmias, pulmonary edema, and respiratory failure. (T156) 2009-07-03T22:19:08Z 2014-12-24T20:25:39Z P58910 1T1T true Exogenous Liquid 1t1t_asym_r_500.jpg image/jpeg 34682 2014-10-14T18:13:01Z BSEQ0008448