2555 Imperatoxin-1 Imperatoxin is a peptide toxin produced by the Emperor scorpion (Pandinus imperator). Imperatoxin-I is an inhibitor which decreases the influx of Ca2+ from the sarcoplasmatic reticulum into the cell. (L1051) 18663.670000000002 Clear solution. >10 mg/mL Injection (sting/bite) (L1813) Imperatoxin-I is an inhibitor which decreases the influx of Ca2+ from the sarcoplasmatic reticulum into the cell. Imperatoxin-I acts on the Ryanodine receptors (RyR), which are intracellular calcium release channels mainly known for their role in regulating calcium release from the sarcoplasmatic reticulum of striated muscles. It hydrolyzes fatty acids from the membrane of the sarcoplasmatic reticulum, which then bind to the RyR, inducing a block of the channel. (L1051) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Imperatoxin is a peptide toxin produced by the Emperor scorpion (Pandinus imperator). (L1051) Imperatoxin-I is neurotoxic. (L1077) Scorpion stings cause tingling or burning at the site of the sting. In more severe cases, symptoms may include spasm in the throat, feeling of thick tongue, restlessness, muscular fibrillation, abdominal cramps, convulsions, incontinence, hypertension, hypotension, oliguria, cardiac arrhythmias, pulmonary edema, and respiratory failure. (T156) 2009-07-03T22:19:06Z 2014-12-24T20:25:38Z P59888 true Exogenous Liquid BSEQ0008443