2553 Iberiotoxin Iberiotoxin is a peptide toxin produced by the Eastern Indian red scorpion (Buthus tamulus). It selectively inhibits the current through large-conductance calcium-activated potassium channels. (L1050) 129203-60-7 71433880 4253.919999999999 Clear solution. >10 mg/mL Injection (sting/bite) (L1813) Iberiotoxin binds to the outer face of the large-conductance calcium-activated potassium channels with high affinity. It selectively inhibits the current by decreasing both the probability of opening and the open time of the channel. (L1050) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Iberiotoxin is a peptide toxin produced by the Eastern Indian red scorpion (Buthus tamulus). (L1050) Iberiotoxin produces mainly cardiopulmonary abnormalities like circulatory derangements, myocarditis and changes in cardiac sarcolemmal ATPase. These abnormalities can potentially cause death. (L1050) Iberiotoxin initially causes transient cholinergic stimulation (vomiting, profuse sweating, bradycardia, priapism, hypersalivation, and hypotension) which is followed by sustained adrenergic hyperactivity (hypertension, tachycardia, and myocardial failure). (A161) Treatment is mainly symptomatic. Local pain is treated by injecting dehydroemetine at the site of the sting. Hypovolaemia is corrected by oral rehydration solution. Agitated, confused and non-cooperative patients are given a 5% dextrose saline drip. Patients with hypertension on admission are given a single dose of 5 mg sublingual nifedipine and oral prazosin. The blood pressure in patients with hypertension is controlled with sublingual nifedipine alone. Patients with pulmonary oedema are propped up and given intravenous aminophylline, sodium bicarbonate, oral prazosin, and oxygen by mask. (L1050) 2009-07-03T22:19:05Z 2014-12-24T20:25:38Z P24663 Iberiotoxin true C83H133N29O27S4 InChI=1/C83H133N29O27S4/c1-42(2)28-50-76(133)107-51(29-44-14-6-5-7-15-44)70(127)98-38-65(121)112-68(43(3)4)80(137)109-53(31-67(124)125)77(134)104-45(18-12-25-91-82(87)88)69(126)97-36-63(119)101-47(17-9-11-24-85)74(131)110-54(39-141-140-27-22-58(114)100-46(16-8-10-23-84)73(130)108-52(30-66(122)123)78(135)106-50)71(128)96-34-61(117)94-32-59(115)93-33-60(116)95-35-62(118)103-56-41-143-142-40-55(111-75(132)48(105-79(56)136)19-13-26-92-83(89)90)72(129)99-37-64(120)102-49(81(138)139)20-21-57(86)113/h5-7,14-15,42-43,45-56,68H,8-13,16-41,84-85H2,1-4H3,(H2,86,113)(H,93,115)(H,94,117)(H,95,116)(H,96,128)(H,97,126)(H,98,127)(H,99,129)(H,100,114)(H,101,119)(H,102,120)(H,103,118)(H,104,134)(H,105,136)(H,106,135)(H,107,133)(H,108,130)(H,109,137)(H,110,131)(H,111,132)(H,112,121)(H,122,123)(H,124,125)(H,138,139)(H4,87,88,91)(H4,89,90,92) InChIKey=PVLXIJSXQQLSEN-UHFFFAOYNA-N 2097.382 2095.880852955 Exogenous Liquid 31149632 Iberiotoxin.jpg image/jpeg 220400 2014-10-14T18:12:56Z BSEQ0008441