2549 Chlorotoxin Chlorotoxin is a peptide toxin produced by the Egyptian scorpion (Leiurus quinquestriatus quinquestriatus). It blocks small-conductance chloride channels. The fact that Chlorotoxin binds preferentially to glioma cells compared with non-neoplastic cells or normal brain cells has allowed the development of new methods for the treatment and diagnosis of several types of cancer. (L1043) 163515-35-3 4004.725000000001 Clear solution. >10 mg/mL Injection (sting/bite) (L1813) Chlorotoxin blocks small conductance chloride channels. (L1043) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. LD50: 0.25 mg/kg (Subcutaneous, Mouse) (T255) No indication of carcinogenicity to humans (not listed by IARC). Chlorotoxin is a peptide toxin produced by the Egyptian scorpion (Leiurus quinquestriatus quinquestriatus). The fact that Chlorotoxin binds preferentially to glioma cells compared with non-neoplastic cells or normal brain cells has allowed the development of new methods for the treatment and diagnosis of several types of cancer. (L1043) Chlorotoxin has been shown to cause paralysis in prey animals of the Egyptian scorpion. (L1043) Scorpion stings cause tingling or burning at the site of the sting. In more severe cases, symptoms may include spasm in the throat, feeling of thick tongue, restlessness, muscular fibrillation, abdominal cramps, convulsions, incontinence, hypertension, hypotension, oliguria, cardiac arrhythmias, pulmonary edema, and respiratory failure. (T156) An antivenom exists for Leiurus quinquestriatus stings. (L1044) 2009-07-03T22:19:04Z 2014-12-24T20:25:38Z P45639 1CHL true Exogenous Liquid 1chl_asym_r_500.jpg image/jpeg 33840 2014-10-14T18:12:53Z BSEQ0008437