2540 Huwentoxin Huwentoxin is a peptide toxin produced by the Chinese bird spider (Haplopelma schmidti). It blocks neuromuscular transmission by binding to the nicotinic acetylcholine receptor and also selectively inhibits N-type calcium channels. (T170) 526224-73-7 9318.829999999996 Clear solution. >10 mg/mL Injection (sting/bite) (L1812) Huwentoxin blocks neuromuscular transmission by binding to the nicotinic acetylcholine receptor, which affects the release of neurotransmitters from autonomic nerve endings of both cholinergic and adrenergic neuroeffector junctions. It also selectively inhibits N-type calcium channels. (T170) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Huwentoxin is a peptide toxin produced by the Chinese bird spider (Haplopelma schmidti). (T170) Huwentoxin is neurotoxic. (T170) Huwentoxin is a peptide toxin produced by the Chinese bird spider (Haplopelma schmidti). (T170) 2009-07-03T22:19:00Z 2014-12-24T20:25:37Z P56676 1QK6 true Exogenous Liquid 1mb6_asym_r_500.jpg image/jpeg 38706 2014-10-14T18:12:46Z BSEQ0008429