2539 Grammotoxin Grammotoxin is a peptide toxin produced by the Chilean rose tarantula (Grammostola rosea). It inhibits voltage-gated calcium channels in neurons. (L1026) 152617-90-8 9600.979999999996 Clear solution. >10 mg/mL Injection (sting/bite) (L1812) Grammotoxin inhibits P-, Q- and N-type voltage-gated calcium channels in neurons. Binding to the calcium channels modifies their voltage-dependent gating. This makes it more difficult for channels to be opened by depolarization, so much larger depolarisations are required for channel activation. Grammotoxin also binds to potassium channels, but with lower affinity than to the calcium channels. (L1026) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Grammotoxin is a peptide toxin produced by the Chilean rose tarantula (Grammostola rosea). (L1026) Grammotoxin is neurotoxic. (L1026) Tarantula bites can be very painful. In some individuals they may cause an allergic reaction, which is usually anaphylactic and will have symptoms such as breathing difficulties or chest pain. (L1823) 2009-07-03T22:19:00Z 2014-12-24T20:25:37Z P60590 1KOZ true Exogenous Liquid 1koz_asym_r_500.jpg image/jpeg 25653 2014-10-14T18:12:45Z BSEQ0008428