2535 omega-Agatoxin Agatoxins are a class of chemically diverse polyamine and peptide toxins which are isolated from the venom of various spiders, in particular the North American funnel-web spider (Agelenopsis aperta), after which agatoxins are named. omega-Agatoxins are subdivided in four classes based on their primary structures, biochemical properties and calcium channels specificity. They block the calcium channels in the presynaptic terminals of the neuromuscular junction in insects and vertebrates. (L1024) 145017-83-0 12807.574999999993 Clear solution. >10 mg/mL Injection (sting/bite) (L1812) omega-Agatoxins block the calcium channels in the presynaptic terminals of the neuromuscular junction in insects and vertebrates. This reduces calcium influx, resulting in a decreased release of neurotransmitters in the synaptic cleft. (L1024) Free toxin may be removed by opsonization via the reticuloendothelial system (primarily the liver and kidneys) or it may be degraded through cellular internalization via the lysosomes. Lysosomes are membrane-enclosed organelles that contain an array of digestive enzymes, including several proteases. No indication of carcinogenicity to humans (not listed by IARC). Agatoxins are a class of chemically diverse polyamine and peptide toxins which are isolated from the venom of various spiders, in particular the North American funnel-web spider (Agelenopsis aperta). (L1024) omega-Agatoxin causes spasms leading to a progressive paralysis which will eventually lead to death in insects. (L1024) The bites of funnel-web spiders may cause tingling around the mouth and tongue, facial muscle twitching, nausea, vomiting, profuse sweating, salivation, and shortness of breath. Patients may also rapidly develop agitation, confusion and coma associated with hypertension, metabolic acidosis, dilation of the pupils, generalised muscle twitching and pulmonary oedema. (L1036) First aid for funnel-web bites consists of applying a pressure immobilization bandage to slow venom movement. Further supportive care may be necessary, but the mainstay of treatment is antivenom. (L1036) 2009-07-03T22:18:58Z 2014-12-24T20:25:37Z P15969 omega-Agatoxin true Exogenous Liquid 1agg_asym_r_500.jpg image/jpeg 22426 2014-10-14T18:12:41Z BSEQ0008424