2515 Naftidrofuryl Naftidrofuryl (INN, also known as nafronyl or as the oxalate salt nafronyl oxalate) is a drug used in the management of peripheral and cerebral vascular disorders. It is claimed to enhance cellular oxidative capacity and to be a spasmolytic. It may also be a 5-HT2 receptor antagonist (L999). 31329-57-4 4417 C24H33NO3 383.246040 White powder. 190°C at 5.00E-01 mm Hg Oral (A302). Naftidrofuryl blocks the type 2 serotonin (5-HT2) receptors and thereby inhibits the effects of serotonin-induced vasoconstriction or platelet aggregation. It is also a stimulator of metabolism by improving aerobic glucose metabolism and by these means preserving cell function in ischemic conditions. Overdosage may result in disturbance of the atrioventricular conduction time, ventricular arrhythmia, convulsions, acute renal failure or acute hepatic necrosis (A302). LD50: 1890 mg/kg (Oral, Rat) (L1001) No indication of carcinogenicity to humans (not listed by IARC). Naftidrofuryl is a drug used in the management of peripheral and cerebral vascular disorders (L999). Naftidrofuryl increases the peripheric circulation of blood, e.g. in peripheral vascular disease (PAOD), Raynaud's phenomenon, cerebrovascular diseases, diffuse circulatory insufficiency in the elderly going along with confusion or behavioral disturbances. Overdosage may result in disturbance of the atrioventricular conduction time, ventricular arrhythmia, convulsions, acute renal failure or acute hepatic necrosis (A302). Convulsions, Nausea and epigastric pain, rash, hepatitis or hepatic failure, calcium oxalate stones (A302, L1000). 2009-07-03T21:54:23Z 2014-12-24T20:25:33Z TETRA-H-BIOPTERIN D009257 Naftidrofuryl true CCN(CC)CCOC(=O)C(CC1CCCO1)CC1=C2C=CC=CC2=CC=C1 C24H33NO3 InChI=1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3 InChIKey=KBAFPSLPKGSANY-UHFFFAOYSA-N 383.5237 383.246043927 Exogenous Solid CHEMBL1620794 4264