946 Carbendazim Carbendazim is a widely used, broad-spectrum benzimidazole fungicide. It is also a metabolite of benomyl (another widely used fungicide). It is also employed as a casting worm control agent in amenity turf situations such as golf greens and tennis courts. Carbendazim is used to control plant diseases in cereals and fruits, including citrus, bananas, strawberries, pineapples, and pomes. It is also used in Queensland, Australia on macadamia plantations. Carbendazim is absorbed through the roots and green tissues. It acts by inhibiting beta-tubulin synthesis, inhibiting development of germ tubes and the growth of mycelia. It is compatible with most of the insecticides. It is used for the control of blast, sheath blight, brown spot, powdery mildew, scab, anthracnose and leaf spot diseases in various crops. The primary source of carbendazim exposure for the public at large is dietary intake. 10605-21-7 25429 C9H9N3O2 191.069480 White powder. 302 - 307°C 0.029 mg/mL at 24°C [TOMLIN,C (1994); pH4] Inhalation (L793) ; oral (L793); dermal (L793) Carbendazim targets beta tubulin in actively dividing cells. It binds to microtubules, interfering with cell functions, such as meiosis and intracellular transportation (A15332). The carbamates are hydrolyzed enzymatically by the liver; degradation products are excreted by the kidneys and the liver. (L793) Acute oral LD50 for rats is >15000 mg/kg and >2500 mg/kg for dogs No indication of carcinogenicity to humans (not listed by IARC). It is a systemic fungicide that is selectively toxic to microorganisms and invertebrates. It is also employed as a casting worm control agent in amenity turf situations such as golf greens and tennis courts. It is also used to control plant diseases in cereals and fruits, including citrus, bananas, strawberries, pineapples, and pomes. The MRLs for fresh produce in the European Union are now between 0.1 and 0.7 mg/kg Carbendazim is a suspected endocrine disruptor. It is also a developmental toxin. Animals exposed to carbendazim in the womb to have serious deformities such as lack of eyes and hydrocephalus (water on the brain). Carbendazim can disrupt the development of sperm and damage testicular development in adult rats. Skin redness and skin irritation. Fetuses exposed to high levels may exhibit microphthalmia (small eyes) or anaphthalmia (no eyes). For acute exposures and first aid: EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. 2009-06-17T23:53:01Z 2014-12-24T20:22:58Z C10897 3392 C006698 Carbendazim 5785 true COC(O)=NC1=NC2=CC=CC=C2N1 C9H9N3O2 InChI=1S/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13) InChIKey=TWFZGCMQGLPBSX-UHFFFAOYSA-N 191.1867 191.069476547 Exogenous Solid 1.52 HMDB31769 CHEMBL70971 23741