857 Mirex Mirex is a a chlorinated hydrocarbon , a manufactured insecticide. It was used to control fire ants, and as a flame retardant in plastics, rubber, paint, paper, and electrical goods. However, its used was banned in 1976 due to its toxicity and nature as a persistent organic pollutant. (L601, L617). Mirex is only moderately toxic in single-dose animal studies (oral LD50 values range from 365Р3000 mg/kg body weight).[6] It can enter the body via inhalation, ingestion, and via the skin. The most sensitive effects of repeated exposure in animals are principally associated with the liver, and these effects have been observed with doses as low as 1.0 mg/kg diet (0.05 mg/kg body weight per day), the lowest dose tested. At higher dose levels, it is fetotoxic (25 mg/kg in diet) and teratogenic (6.0 mg/kg per day). Mirex was not generally active in short-term tests for genetic activity. There is sufficient evidence of its carcinogenicity in mice and rats. Delayed onset of toxic effects and mortality is typical of mirex poisoning. Mirex is toxic for a range of aquatic organisms, with crustacea being particularly sensitive. 2385-85-5 16945 C10Cl12 539.626230 White crystals. 485°C 8.5e-05 mg/mL at 25°C [YALKOWSKY,SH & HE,Y (2003)] Oral (L601) ; inhalation (L601) ; dermal (L601) Mirex inhibits sodium/potassium-transporting ATPases, producing neurotoxic effects and impairing energy-dependent cellular processes. (A216) Mirex is mainly absorbed through the gastrointestional tract, but may also be absorbed through the lungs and skin. Once absorbed, mirex is widely distributed throughout the body but is sequestered in the adipose tissue. It has a long retention time in the body. Mirex is not metabolized by humans and is excreted unchanged in the feces. (L601) LD50: 306 mg/kg (Oral, Rat) (T98) LD50: 800 mg/kg (Subcutaneous, Rabbit) (T98) LD50: 2000 mg/kg (Dermal, Rabbit) (T99) LD50: 365 mg/kg (Intraperitoneal, Rat) (T99) 2B, possibly carcinogenic to humans. (L135) Mirex is an insecticide used to control fire ants. It was also used as a flame retardant in plastics, rubber, paint, paper, and electrical goods. (L601) Chronic Oral: 0.0008 mg/kg/day (L134) Animal studies have shown that ingesting high levels of mirex can harm the stomach, intestine, liver, kidneys, eyes, thyroid, and nervous and reproductive systems. (L601) 2009-06-09T17:20:39Z 2014-12-24T20:22:53Z C14184 34852 DIHYDRO-DIOH-BENZOATE D008917 Mirex 915 true ClC12C3(Cl)C4(Cl)C5(Cl)C(Cl)(C1(Cl)C4(Cl)Cl)C2(Cl)C(Cl)(Cl)C35Cl C10Cl12 InChI=1S/C10Cl12/c11-1-2(12)7(17)4(14)3(13,5(1,15)9(7,19)20)6(1,16)10(21,22)8(2,4)18 InChIKey=GVYLCNUFSHDAAW-UHFFFAOYSA-N 545.543 539.626232484 Exogenous Solid HMDB59573 CHEMBL442231 16054