T3D0737

738 T3D0737

Zinc peroxide

Zinc peroxide (ZnO2) appears as a bright yellow powder at room temperature. It was historically used as a surgical antiseptic. More recently zinc peroxide has also been used as an oxidant in explosives and pyrotechnic mixtures. Its properties have been described as a transition between ionic and covalent peroxides. Zinc peroxide is very hazardous in case of skin contact, of eye contact, ingestion, or inhalation. It has been shown to be corrosive to skin. Prolonged exposure may result in skin burns and ulcerations. Over-exposure by inhalation may cause respiratory irritation. Skin inflammation is characterized by itching, scaling, reddening, or, occasionally, blistering. Zinc Peroxide is toxic to lungs and mucous membranes. Repeated or prolonged exposure can produce organ damage. Repeated or prolonged inhalation of vapors may lead to chronic respiratory irritation. 1314-22-3

14809

H2O2Zn

97.934630 White-yellow crystals.

Inhalation (L49) ; oral (L49) ; dermal (L49)

Anaemia results from the excessive absorption of zinc suppressing copper and iron absorption, most likely through competitive binding of intestinal mucosal cells. Unbalanced levels of copper and zinc binding to Cu,Zn-superoxide dismutase has been linked to amyotrophic lateral sclerosis (ALS). Stomach acid dissolves metallic zinc to give corrosive zinc chloride, which can cause damage to the stomach lining. Metal fume fever is thought to be an immune response to inhaled zinc. (L48, L49, A49)

Zinc can enter the body through the lungs, skin, and gastrointestinal tract. Intestinal absorption of zinc is controlled by zinc carrier protein CRIP. Zinc also binds to metallothioneins, which help prevent absorption of excess zinc. Zinc is widely distributed and found in all tissues and tissues fluids, concentrating in the liver, gastrointestinal tract, kidney, skin, lung, brain, heart, and pancreas. In the bloodstream zinc is found bound to carbonic anhydrase in erythrocytes, as well as bound to albumin, _2-macroglobulin, and amino acids in the the plasma. Albumin and amino acid bound zinc can diffuse across tissue membranes. Zinc is excreted in the urine and faeces. (L49) No indication of carcinogenicity to humans (not listed by IARC).

Zinc peroxide is used as a bleaching and curing agent, and as an additive in antiseptic ointments. (L73)

Intermediate Oral: 0.3 mg/kg/day (L134) Chronic Oral: 0.3 mg/kg/day (L134)

Chronic exposure to zinc causes anemia, atazia, lethargy, and decreases the level of good cholesterol in the body. It is also believed to cause pancreatic and reproductive damage. (L49)

Ingestion of large doses of zinc causes stomach cramps, nausea, and vomiting. Acute inhalation of large amounts of zinc causes metal fume fever, which is characterized by chills, fever, headache, weakness, dryness of the nose and throat, chest pain, and coughing. Dermal contact with zinc results in skin irritation. (L49) Zinc poisoning is treated symptomatically, often by administering fluids such as water or milk, or with gastric lavage. (L49)

2009-03-27T01:18:55Z

2014-12-24T20:22:43Z

Metallothionein-2 (P02795) Metallothionein-1G (P13640) Metallothionein-1H (P80294) Metallothionein-3 (P25713) Metallothionein-1F (P04733) Metallothionein-1E (P04732) Metallothionein-1X (P80297) Metallothionein-1A (P04731) Metallothionein-1B (P07438) Metallothionein-1M (Q8N339) Metallothionein-4 (P47944) Metallothionein-1L (Q93083) Cysteine-rich protein 1 (P50238) Cysteine-rich protein 2 (P52943) Cysteine-rich protein 3 (Q6Q6R5) Serum albumin (P02768) (L49, A49, L92)

Zinc peroxide

true

[Zn].OO

H2O2Zn

InChI=1S/H2O2.Zn/c1-2;/h1-2H;

InChIKey=DLINORNFHVEIFE-UHFFFAOYSA-N

99.424

97.934625886

Exogenous Solid

14125