670 Cobalt sulfate Cobalt sulfate is found in alcoholic beverages. Once used in fermented malt beverages as a foam stabiliser; now prohibited from use in food<br /> Cobalt sulfate belongs to the family of Transition Metal Sulfates. These are inorganic compounds in which the largest oxoanion is sulfate, and in which the heaviest atom not in an oxoanion is a transition metal. 10124-43-3 24965 CoO4S 154.884930 Dark blue or red solid. 735°C (anhydrous) 74°C (heptahydrate) 420°C Inhalation (L29) ; oral (L29) ; dermal (L29) Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (L29) Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29) LD50: 424 mg/kg (Oral, Rat) (A195) LD50: 143 mg/kg (Intraperitoneal, Mouse) (T74) LD50: 18 200 ug/kg (Intravenous, Rat) (T74) 2B, possibly carcinogenic to humans. (L135) Cobalt(II) sulfate is used in pigments for glass and porcelain, as well as in storage batteries and electroplating baths, sympathetic inks, and as an additive to soils and animal feeds. (L36) Chronic Inhalation: 0.0001 mg/m3 (L134) Intermediate Oral: 0.01 mg/kg/day (L134) Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitis. Cobalt may also have mutagenic and carcinogenic effects. (L29, L30) Cobalt inhalation can cause asthma-like breathing problems. Skin contact is known to result in contact dermatitis, which is characterized by irritation and rashes. Ingesting large amounts of cobalt may cause nausea and vomiting. (L2090) Treatment of cobalt poisoning is symptomatic. (L29) 2009-03-22T21:12:56Z 2014-12-24T20:22:31Z Serum albumin (P02768) (A39) C17383 53470 C026305 Cobalt(II) sulfate 8039 true Serum albumin (P02768) (A39) [Co++].[O-]S([O-])(=O)=O CoO4S InChI=1S/Co.H2O4S/c;1-5(2,3)4/h;(H2,1,2,3,4)/q+2;/p-2 InChIKey=KTVIXTQDYHMGHF-UHFFFAOYSA-L 154.996 154.884929372 Exogenous Solid HMDB35000 23338