390 Biphenyl Biphenyl is found in alcoholic beverages. Fungistat, especially for citrus fruits. Biphenyl is used as food preservative and flavouring agent. Biphenyl is detected in bilberry, wine grape, carrot, peas, rum, potato, bell pepper, tomato, butter, milk, smoked fatty fish, cocoa, coffee, roast peanuts, olive, buckwheat and tamarind. Generally, the fruit packaging is impregnated with biphenyl, which evaporates into the air space surrounding the fruit. Some biphenyl is absorbed by the fruit skins Biphenyl has been shown to exhibit anti-coagulant and catabolic functions (A7741, A7742). Biphenyl belongs to the family of Biphenyls and Derivatives. These are organic compounds containing to benzene rings linked together by a C-C bond. 92-52-4 7095 C12H10 154.078250 White scales (A567). 71°C 254.5°C (490.1°F) 0.00748 mg/mL at 25°C Inhalation (A587) ; dermal (A587) ; eye contact (A587) Biphenyl alters the permeability properties of mitochondrial membranes (A279). Diphenyl is well absorbed through the gastrointestinal tract. It is rapidly metabolized to 4-hydroxybiphenyl, 4-phenyl-catechol and 4,4'-dihydroxyphenyl, which are excreted in urine and bile as glucuronide and mercapturic conjugates. The metabolites of diphenyl, mainly 4-hydroxybiphenyl, are excreted rapidly and almost exclusively in the urine. Acute oral toxicity is moderate. (T48, A588). LD50: 3280 mg/kg (Oral, Rat) (T66) LD50: 2400 mg/kg (Oral, Rabbit) (T23) LD50: 2500 mg/kg (Dermal, Rabbit) (T59) No indication of carcinogenicity (not listed by IARC). (L135) Organic synthesis; heat transfer agent; fungistat in packaging of citrus fruit; plant disease control; manufacture of benzidine; dyeing assistant for polyesters (A567). Exposure to diphenyl can cause necrosis in the liver and kidney, with regions of cirrhosis in liver; also, degenerative changes in heart muscle, damage to the central and peripheral nervous systems, as well as death can result from diphenyl poisoning (T48). Symptoms of diphenyl poisoning include headache, fatigue, abdominal pain with nausea or diarrhea and various symptoms, vomiting and bronchitis (T48). Consider gastric lavage, after ingestion of a potentially life-threatening amount of poison if it can be performed soon after ingestion. In case of inhalation exposure, move patient to fresh air and monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. I f the exposure occurred through dermal contact, remove contaminated clothing and wash exposed area thoroughly with soap and water. (T36) 2009-03-06T18:58:41Z 2014-12-24T20:21:46Z C06588 17097 CPD-945 C010574 Diphenyl BNL 162 true C1=CC=C(C=C1)C1=CC=CC=C1 C12H10 InChI=1S/C12H10/c1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H InChIKey=ZUOUZKKEUPVFJK-UHFFFAOYSA-N 154.2078 154.07825032 Exogenous Solid 4.01 HMDB34437 CHEMBL14092 6828