256 Ethyl ether Diethyl ether, also known as ether and ethoxyethane, is a clear, colorless, and highly flammable liquid with a low boiling point and a characteristic odor. It is the most common member of a class of chemical compounds known generically as ethers. Diethyl ether is used as a common solvent and has been used as a general anesthetic. It can also be found in recreational drug use. (L1660) 60-29-7 3283 C4H10O 74.073170 -116.3°C 34.6°C 60.4 mg/mL at 25°C [RIDDICK,JA et al. (1986)] Oral (T36) ; inhalation (T36) Diethyl ether inhibits alcohol dehydrogenase. This slows down the metabolism of ethanol and also inhibits the metabolism of other drugs requiring oxidative metabolism. (L1660, A2461) Diethyl ether can be absorbed following ingestion and inhalation, and is then rapidly distributed to the brain and fatty tissues. Diethyl ether is not metabolized in humans and is excreted mainly in expired air. (T36) LD50: 996 mg/kg (Intravenous, Mouse) (L1327) LD50: 2420 mg/kg (Intraperitoneal, Mouse) (L1327) LD50: 1213 mg/kg (Oral, Rat) (A681) LC50: 186 mg/L (Inhalation, Mouse) (A680) 30 mL for an adult human. (T36) No indication of carcinogenicity to humans (not listed by IARC). Diethyl ether is used as a common solvent and has been used as a general anesthetic. It can also be found in recreational drug use. (L1660) Diethyl ether causes CNS depression. Death due to respiratory depression may result from severe and prolonged exposure. (T36) Inhalation may result in dizziness, giddiness, euphoria, drowsiness, salivation, and CNS depression. Diethyl ether is also a skin and eye irritant. (T36) There is no antidote for diethyl ether poisoning, thus treatment is symptomatic and supportive. (T36) 2009-03-06T18:58:22Z 2014-12-24T20:21:25Z C13240 35702 CPD-5702 Ethyl ether 1704 true CCOCC C4H10O InChI=1S/C4H10O/c1-3-5-4-2/h3-4H2,1-2H3 InChIKey=RTZKZFJDLAIYFH-UHFFFAOYSA-N 74.1216 74.073164942 Exogenous Liquid CHEMBL16264 3168