235 Arsine Arsine is a highly toxic gas formed when arsenic-containing materials react with hydrogen in water or acids. It is nonirritating and colorless, with a slight garlic odor. (L11) 7784-42-1 5359596 AsH3 74.921600 Colorless gas. > 615°C −62.5 °C 4.93 g/l, gas; 1.640 g/mL Inhalation Hemoglobin subunit alpha (P69905) Hemoglobin subunit beta (P68871) Hemoglobin subunit gamma-1 (P69891) Hemoglobin subunit gamma-2 (P69892) Hemoglobin subunit delta (P02042) Hemoglobin subunit epsilon (P02100) Hemoglobin subunit mu (Q6B0K9) Hemoglobin subunit theta-1 (P09105) Hemoglobin subunit zeta (P02008) Catalase (P04040) (L11) Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic dihydride intermediate and elemental arsenic, both of which are hemolytic agents. Arsine also depletes the reduced glutathione content of the red blood cells, resulting in the oxidation of sulfhydryl groups in hemoglobin and red cell membranes. These effects produce membrane instability, resulting in hemolysis. Arsine may also inhibit catalase, which leads to the accumulation of hydrogen peroxide. This destroys red cell membranes and may contribute to arsine-induced conversion of Fe+2 to Fe+3, which also impairs oxygen transport. (L11) Arsine is gradually converted to arsenite (As3+), then methylated into monomethylarsonic and dimethylarsinic acids. It is primarily excreted in the urine. (T21) LD50: 2.5 mg/kg (Intraperitoneal, Mouse) (T35) LC50: 20 ppm over 1 hour (Inhalation, Rat) (L1853) 3 ppm for an adult human. 1, carcinogenic to humans. (L135) Exposure to arsine usually occurs in an industrial setting, as it is often produced as a byproduct during the smelting and refining of metals. It is also used in the manufacture of semiconductors and crystals for fiberoptics and computer chips. Chronic Inhalation: 0.016 mg/m3 (L134) Arsine exposure causes haemolytic anaemia, polyneuropathy, hypotension, and damage to the lungs, kidneys, liver, nervous system, heart, and blood-forming organs. (L11) The first signs of arsine exposure are difficultly breathing, headaches, vertigo, nausea, vomiting, abdominal pain, skin discoloration, and haemoglobinuria. (L11) There is no antidote for arsine. Treatment is symptomatic and consists of measures to support respiratory, vascular, and renal function. Whole blood transfusions may be effective if significant haemolysis has occurred. (L11) 2009-03-06T18:58:20Z 2014-12-24T20:21:23Z http://en.wikipedia.org/wiki/Arsenic C06269 47217 CPD-763 C006633 Arsine 6368 true [AsH3] AsH3 InChI=1S/AsH3/h1H3 InChIKey=RBFQJDQYXXHULB-UHFFFAOYSA-N 77.9454 77.945071513 Exogenous Gas