201 1,2,4-Trichlorobenzene 1,2,4-Trichlorobenzene is an organochloride aromatic compound and one of the three isomeric forms of trichlorobenzene. Trichlorobenzene is used as a solvent. (L223) 120-82-1 13 C6H3Cl3 179.930030 White crystals. 17°C 0.049 mg/mL at 25 °C [SOUTHWORTH,GR & KELLER,JL (1986)] Oral (T38) ; inhalation (T38) ; dermal (T38) Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalently bind to cellular proteins and alkylate DNA. (A154, A155) Trichlorobenzene is absorbed via oral, inhalation, and dermal routes. It is believed to be metabolized via cytochrom p-450 enzymes into metabolites that include phenols, mercapturic acid, and catechols.(T38) LD50: 756 mg/kg (Oral, Rat) (T22) No indication of carcinogenicity to humans (not listed by IARC). Trichlorobenzene is used as a solvent in chemical manufacturing, as well as in dyes, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium, and insecticides. (T39) High levels of trichlorobenzene may damage the liver, kidney, and thyroid. (A153) Trichlorobenzene irritates the eyes and respiratory tract. (T20) 2009-03-06T18:58:16Z 2014-12-24T20:21:19Z C06594 28222 CPD-1125 C009947 1,2,4-Trichlorobenzene 1878 true ClC1=CC=C(Cl)C(Cl)=C1 C6H3Cl3 InChI=1S/C6H3Cl3/c7-4-1-2-5(8)6(9)3-4/h1-3H InChIKey=PBKONEOXTCPAFI-UHFFFAOYSA-N 181.447 179.930033217 Exogenous Solid CHEMBL296348 13862559