196 Benzyl butyl phthalate Benzyl butyl phthalate (BBzP) is a phthalate ester mostly used as a plasticizer for PVC. Phthalate esters can cause reproductive and developmental toxicity. (A2883, L1902) 85-68-7 2347 C19H20O4 312.136160 Colourless oily liquid. (L1208) < -35°C 370 °C 1.1 g/cm³ (at 25 °C, 100 kPa) 0.00269 mg/mL at 25 °C [HOWARD,PH et al. (1985)] 99 °C (open cup) 113 °C (closed cup) Oral (L1208) ; inhalation (L1208) ; dermal (L1208) Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883) Phthalate esters are first hydrolyzed to their monoester derivative. Once formed, the monoester derivative can be further hydrolyzed in vivo to phthalic acid or conjugated to glucuronide, both of which can then be excreted. The terminal or next-to-last carbon atom in the monoester can also be oxidized to an alcohol, which can be excreted as is or first oxidized to an aldehyde, ketone, or carboxylic acid. The monoester and oxidative metabolites are excreted in the urine and faeces. (A2884) LD50: 3160 mg/kg (Intraperitoneal, Mouse) (L1208) LD50: 2330 mg/kg (Oral, Rat) (L1208) LD50: 4170 mg/kg (Oral, Mouse) (L1208) 3, not classifiable as to its carcinogenicity to humans. (L135) Benzyl butyl phthalate (BBzP) is mostly used as a plasticizer for PVC. (L1902) Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883) Phthalate esters are endocrine disruptors and can cause a number of developmental malformations termed 'phthalate syndrome'. (A2883) 2009-03-06T18:58:15Z 2014-12-24T20:21:18Z http://en.wikipedia.org/wiki/Benzyl_butyl_phthalate C14211 CPD0-1263 C027561 Benzyl butyl phthalate 207 true CCCCOC(=O)C1=CC=CC=C1C(=O)OCC1=CC=CC=C1 C19H20O4 InChI=1S/C19H20O4/c1-2-3-13-22-18(20)16-11-7-8-12-17(16)19(21)23-14-15-9-5-4-6-10-15/h4-12H,2-3,13-14H2,1H3 InChIKey=IRIAEXORFWYRCZ-UHFFFAOYSA-N 312.3597 312.136159128 Exogenous Liquid CHEMBL1450327 2257