195 Bis(2-methoxyethyl) phthalate Bis(2-methoxyethyl) phthalate (DMEP) is a specialty plasticiser, used in cellulose ester plastics, and can also be used as a solvent. This compound can form peroxides. (L1210) 34006-76-3 36655 C13H16O4 236.104860 Light coloured, clear liquid, with a mild aromatic odour. (L1210) -40°C 340 °C 1170 kg/m3 (at 15°C) 0.9 g/L (20°C) 194°C (open cup) <0.013 kPa (20°C) Oral (L1903) ; inhalation (L1903) ; dermal (L1903) Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expression. Some phthalates have also been shown to reduce the expression of insulin-like peptide 3 (insl3), an important hormone secreted by the Leydig cell necessary for development of the gubernacular ligament. Animal studies have shown that these effects disrupt reproductive development and can cause a number of malformations in affected young. (A2883) In pregnant rat, DMEP rapidly undergoes hydrolysis to 2-methoxyethanol (2-ME) and mono-2-methoxyethyl phthalate (MMEP). 2-ME is then oxidised to methoxyacetic acid (MAA). The rat foetus has little or no ability to hydrolyse DMEP to the monoester and intact DMEP is rapidly transferred across the placenta into the foetus. (L1210) No indication of carcinogenicity to humans (not listed by IARC). Bis(2-methoxyethyl) phthalate (DMEP) is a specialty plasticizer, used in cellulose ester plastics, and can also be used as a solvent. (L1210) Phthalate esters are endocrine disruptors. Animal studies have shown that they disrupt reproductive development and can cause a number of malformations in affected young, such as reduced anogenital distance (AGD), cryptorchidism, hypospadias, and reduced fertility. The combination of effects associated with phthalates is called 'phthalate syndrome’. (A2883) Phthalate esters are endocrine disruptors and can cause a number of developmental malformations termed 'phthalate syndrome'. (A2883) 2009-03-06T18:58:15Z 2014-12-24T20:21:18Z Bis(2-methoxyethyl) phthalate true CCCCOC(=O)C1=CC=CC=C1C(=O)OC C13H16O4 InChI=1S/C13H16O4/c1-3-4-9-17-13(15)11-8-6-5-7-10(11)12(14)16-2/h5-8H,3-4,9H2,1-2H3 InChIKey=XXFSYINDUHLBIL-UHFFFAOYSA-N 236.2637 236.104859 Exogenous Liquid 33674