174 trans-1,2-Dichloroethene Trans-1,2-dichloroethene (1,2-DCE) is one of two isomers of 1,2-dichloroethene. It is a highly flammable, colorless liquid with a sharp, harsh odor. 1,2-DCE is used as a solvent for waxes, resins, acetylcellulose, perfumes, dyes, lacquers, thermoplastics, fats, and phenols. It is also used as an intermediate in the preparation of other chlorinated solvents. (L585, L586) 156-60-5 638186 C2H2Cl2 95.953360 Colorless liquid. -49.8°C 47.2 °C at 745 mm Hg 48.0 - 48.5 °C at 760 mm Hg 1.2565 6.41 mg/mL at 25 °C [HORVATH,AL et al. (1999)] 2-4 °C Inhalation (L585) ; oral (L585) ; dermal (L585) ; eye contact (L585) Trans-1,2-dichloroethene is a volatile, lipophilic molecule that easily moves through the respiratory and gastrointestinal systems. It has a high affinity for lipids and blood, but little accumulation in tissues. 1,2-Dichloroethene isomers inhibit liver enzymes involved in metabolism and may increase the “toxic” response to other chemicals. Reactive metabolites of trans-1,2-dichloroethene modify the heme moiety of hepatic microsomal cytochrome P-450, resulting in a loss of both cytochrome P-450 and heme. Trans-1,2-dichloroethene can also mixed-function oxidase activities. Metabolism of trans-1,2-dichloroethene can lead to dose-related decrease in the levels of serum glutamicoxaloacetic transaminase (SGOT) and serum glutamic-pyruvic transaminase (SGPT). (L585) Metabolism of trans-1,2-dichloroethene is initially catalyzed by hepatic microsomal cytochrome P-450. This metabolism is believed to involve epoxidation of the ethylene double bond, forming dichlorinated epoxides. Dichlorinated epoxides, in turn, can undergo a non-enzymatic rearrangement. Studies on the metabolism of 1,2-dichloroethene by hepatic microsomes and hepatocytes provide evidence to suggest that dichloroacetaldehyde is the predominant metabolite of microsomal cytochrome P-450 and that it, in turn, is extensively converted to dichloroethanol and dichloroacetate by cytosolic and/or mitochondrial aldehyde and alcohol dehydrogenases present in hepatocytes. (L585) LD50: 1 300-10 000 mg/kg/day (Inhalation, Rat) (L585) No indication of carcinogenicity (not listed by IARC). (L135) Trans-1,2-DCE is used as a solvent for waxes, resins, acetylcellulose, perfumes, dyes, lacquers, thermoplastics, fats, and phenols. It is also used as an intermediate in the preparation of other chlorinated solvents. One may be exposed by breathing contaminated air, eating, or drinking the substance, or by skin contact (L585, L586). Acute Inhalation: 0.2 ppm (Rat) (L585) Acute Oral: 1 mg/kg/day (Rat) (L585) Intermediate Oral: 0.3 mg/kg/day (L585) Breathing trans-1,2-DCE can cause sever liver and kidney damages, pulmonary capillary hyperemia, as well as alveolar septal distention; depression of the central nervous sustem can occur; moderate iritis and conjunctivitis can follow eye exposure; dermatitis and irritation of mucous membranes can follow dermal exposure. Symptoms associated with lethal oral doses included decreased activity, ataxia, suppressed or total loss of righting reflex, and depressed respiration. (L585) Symptoms of trans-1,2-DCE exposure include nausea, dowiness, and tiredness. Mild or moderate erythema may follow dermal exposure, and skin or eye irritation can follow dermal/eye contact. (L585) Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of seizures, administer a benzodiazepine IV. Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes in case of eye exposure. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. Treat dermal irritation or burns with standard topical therapy. Patients developing dermal hypersensitivity reactions may require treatment with systemic or topical corticosteroids or antihistamines. (T36) 2009-03-06T18:58:13Z 2014-12-24T20:21:16Z C06791 29027 11-DCE 1,2-Dichloroethene, trans- 3719 true Cl\C=C\Cl C2H2Cl2 InChI=1S/C2H2Cl2/c3-1-2-4/h1-2H/b2-1+ InChIKey=KFUSEUYYWQURPO-OWOJBTEDSA-N 96.943 95.953355478 Exogenous Liquid