137 Neptunium-237 Neptunium is a chemical element with the symbol Np and atomic number 93. A radioactive metallic element, neptunium is the first transuranic element and belongs to the actinide series. Its most stable isotope, 237Np, is a by-product of nuclear reactors and plutonium production and it can be used as a component in neutron detection equipment. Neptunium is also found in trace amounts in uranium ores due to transmutation reactions. (L1849) 13994-20-2 104783 Np 0.000000 Silver metal. Oral (L1837) ; Inhalation (L1837) The ionizing radiation produced by neptunium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal change, and genetic instability. This leads to loss of normal cell and tissue homeostasis, and development of malignancy. Ionizing radiation that does not directly damage DNA can produce reactive oxygen intermediates that directly affect the stability of p53, an important enzyme in cell-cycle regulation, and produce oxidative damage to individual bases in DNA and point mutations by mispairing during DNA replication. (L1837) 1, carcinogenic to humans. (L135) 237Np is a by-product of nuclear reactors and plutonium production and it can be used as a component in neutron detection equipment. (L1849) 237-Neptunium's radioactivity can cause cancer. (L1837) Exposure to high doses of ionizing radiation results in acute radiation syndrome, which can cause skin burns, hair loss, nausea, vomiting, dizziness, disorientation, low blood pressure, headache, fatigue, weakness, fever, birth defects, illness, infection, and death. (L1837, L1852) Treatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (L1852) 2009-03-06T18:58:09Z 2014-12-24T20:21:11Z Neptunium-237 true [237Np] Np InChI=1S/Np/i1+0 InChIKey=LFNLGNPSGWYGGD-IGMARMGPSA-N 237.0482 237.048167253 Exogenous Solid 94588