117 1,2,3-Trichlorobenzene 1,2,3-Trichlorobenzene is an organochloride aromatic compound and one of the three isomeric forms of trichlorobenzene. Trichlorobenzene is used as a solvent. (L223) 87-61-6 6895 C6H3Cl3 179.930030 White crystals. 53.5°C 0.018 mg/mL at 25 °C [CHIOU,CT et al. (1986)] Oral (T38) ; inhalation (T38) ; dermal (T38) Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalently bind to cellular proteins and alkylate DNA. (A154, A155) Trichlorobenzene is absorbed via oral, inhalation, and dermal routes. It is believed to be metabolized via cytochrome p-450 enzymes into metabolites that include phenols, mercapturic acid, and catechols.(T38) LD50: 756 mg/kg (Oral, Rat) (T20) No indication of carcinogenicity to humans (not listed by IARC). Trichlorobenzene is used as a solvent in chemical manufacturing, as well as in dyes, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium, and insecticides. (T39) High levels of trichlorobenzene may damage the liver, kidney, and thyroid. (A153) Trichlorobenzene irritates the eyes and respiratory tract. (T20) 2009-03-06T18:58:06Z 2014-12-24T20:21:08Z C14408 35289 CPD-1125 1,2,3-Trichlorobenzene 3345 true ClC1=CC=CC(Cl)=C1Cl C6H3Cl3 InChI=1S/C6H3Cl3/c7-4-2-1-3-5(8)6(4)9/h1-3H InChIKey=RELMFMZEBKVZJC-UHFFFAOYSA-N 181.447 179.930033217 Exogenous Solid CHEMBL46557 13864445