47 Heptachlor epoxide Heptachlor epoxide is a chemical produced when heptachlor is broken down by bacteria and animals. Heptachlor is a manufactured cyclodiene organochlorine insecticide. As it is a persistant organic pollutant, heptachlor use is banned or limited in most areas. The epoxide is more likely to be found in the environment than heptachlor. (L118, L119) 1024-57-3 13930 C10H5Cl7O 385.816010 White powder. 160°C 0.0002 mg/mL at 25 °C [BIGGAR,JW & RIGGS,RI (1974)] Oral (L118) ; inhalation (L118) ; dermal (L118) Heptachlor epoxide is a central nervous system stimulant. It non-competitively blocks neurotransmitter action at gamma-amino butyric acid receptors, resulting in overstimulation of the nervous system. Heptachlor epoxide is also believed to exert carcinogenic effects by activating key kinases in signalling pathways and inhibiting apoptosis. (L118, A81, A82) Heptachlor epoxide is readily absorbed by the skin, lungs and gastrointestinal tract and excreted in the urine and faeces. (L118) No indication of carcinogenicity (not listed by IARC). (L135) Heptachlor epoxide is a chemical produced when heptachlor is broken down by bacteria and animals. Heptachlor was originally widely produced as an insecticide, but is now used only in fire and control in underground transformers. (L118) Exposure to heptachlor epoxide may cause damage to liver, nervous system, and immune system. (L118) Heptachlor epoxide poisoning may cause convulsions, vomiting, seizures, confusion, incoordination, excitability, coma, hypotension, and respiratory failure. (L118) Treatment is symptomatic and is aimed at controlling convulsions, coma, and respiratory depression. (L118) 2009-03-06T18:57:59Z 2014-12-24T20:20:58Z C14327 25520 D006534 Heptachlor epoxide 6458 true ClC1C2OC2C2C1C1(Cl)C(Cl)=C(Cl)C2(Cl)C1(Cl)Cl C10H5Cl7O InChI=1S/C10H5Cl7O/c11-3-1-2(4-5(3)18-4)9(15)7(13)6(12)8(1,14)10(9,16)17/h1-5H InChIKey=ZXFXBSWRVIQKOD-UHFFFAOYSA-N 389.317 385.816008731 Exogenous Solid CHEMBL1903207 13328