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Browsing toxins
| T3DB ID | Name CAS Number |
Formula Weight |
Structure | Type | Mechanism of Action |
|---|---|---|---|---|---|
| T3D0228 | Chlordane, technical 12789-03-6 |
C10H6Cl8 409.779 |
|
|
Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related r... more |
| T3D0229 | Dimethoate 60-51-5 |
C5H12NO3PS2 229.257 |
|
|
Dimethoate is a cholinesterase inhibitor. (S683) |
| T3D0230 | Actinium-227 14952-40-0 |
Ac 227.027746979 |
|
|
The ionizing radiation produced by actinium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal ch... more |
| T3D0232 | 4-Aminobiphenyl 92-67-1 |
C12H11N 169.2224 |
|
|
4-Aminobiphenyl requires metabolic activation in order to exert its toxicity. This is catalyzed by N-hydroxylation via cytochrome P450 1A2, then followed by O-sulfatio... more |
| T3D0233 | Pyrethrum 8003-34-7 |
C22H28O5 372.4547 |
|
|
Both type I and type II pyrethroids exert their effect by prolonging the open phase of the sodium channel gates when a nerve cell is excited. They appear to bind to th... more |
| T3D0234 | Arsine 7784-42-1 |
AsH3 77.9454 |
|
|
Arsine enters the bloodstream and crosses the alveolo-capillary membrane into red blood cells. Here it preferentially binds to hemoglobin and is oxidized to an arsenic... more |
| T3D0235 | Naled 300-76-5 |
C4H7Br2Cl2O4P 380.784 |
|
|
Naled is a cholinesterase inhibitor. (S689) |
| T3D0236 | Chlorinated dibenzofurans 42934-53-2 |
|
|
Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso... more | |
| T3D0237 | Ethoprop 13194-48-4 |
C8H19O2PS2 242.339 |
|
|
Ethoprop inhibits acetylcholinesterase. This results in the accumulation of acetylcholine in the nerve synapses, causing overstimulation of the nervous system. (V362) |
| T3D0240 | Dichlorvos 62-73-7 |
C4H7Cl2O4P 220.976 |
|
|
Organophosphates apparently share a common mechanism of cholinesterase inhibition and cause similar symptoms. Organophosphates poison insects and mammals primarily by ... more |
| T3D0241 | Calcium arsenate 7778-44-1 |
As2Ca3O8 398.072 |
|
|
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co... more |
| T3D0242 | Mercuric chloride 7487-94-7 |
Cl2Hg 271.5 |
|
|
High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through... more |
| T3D0243 | Sodium arsenite 7784-46-5 |
AsNaO2 129.9102 |
|
|
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co... more |
| T3D0244 | Formaldehyde 50-00-0 |
CH2O 30.026 |
|
|
It is likely that formaldehyde toxicity occurs when intracellular levels saturate formaldehyde dehydrogenase activity, allowing the unmetabolized intact molecule to ex... more |
| T3D0245 | 2-Chlorophenol 95-57-8 |
C6H5ClO 128.556 |
|
|
2-chlorophenol works as a weak uncoupler of oxidative phosphorylation and inhibitors of cellular respiration. The ability of chlorophenols to uncouple oxidative phosph... more |
| T3D0246 | Phenanthrene 85-01-8 |
C14H10 178.2292 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0247 | Hydrogen fluoride 7664-39-3 |
FH 20.00634 |
|
|
Fluoride ions are incorporated into bone by substituting for hydroxyl groups in the carbonate-apatite structure to produce hydroxyfluorapatite, thus altering the miner... more |
| T3D0248 | 2,4-Dichlorophenoxyacetic acid 94-75-7 |
C8H6Cl2O3 221.037 |
|
|
2,4-Dichlorophenoxyacetic acid induces free radical reactions that cause DNA damage and cell death in apoptotic process. Its mutagenicity concerns homologous recombina... more |
| T3D0249 | Dibromochloromethane 124-48-1 |
CHBr2Cl 208.28 |
|
|
Dibromochloromethane is oxidized into trihalomethanol by the cytochrome P-450 mixed function oxidase system of liver. Trihalomethanol then decomposes by loss of hydrog... more |
| T3D0252 | Dimethyl formamide 68-12-2 |
C3H7NO 73.0938 |
|
|
While the mechanism of action of dimethyl formamide has not bee fully elucidated, thiocarbamate pesticides have been shown to inhibit aldehyde dehydrogenases. (V369) |
| T3D0253 | Pyrene 000129-00-0 |
C16H10 202.2506 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0255 | Ethyl ether 60-29-7 |
C4H10O 74.1216 |
|
|
Diethyl ether inhibits alcohol dehydrogenase. This slows down the metabolism of ethanol and also inhibits the metabolism of other drugs requiring oxidative metabolism.... more |
| T3D0257 | 4-Nitrophenol 100-02-7 |
C6H5NO3 139.1088 |
|
|
The nitrite in nitrophenols causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a con... more |
| T3D0259 | Phosphine 007803-51-2 |
H3P 33.99758 |
|
|
Phosphine inhibits cytochrome c oxidase, preventing mitochondrial oxidative phosphorylation. This non-competitive inhibition prevents cellular respiration and leads to... more |
| T3D0260 | Trichlorobenzene 012002-48-1 |
C6H3Cl3 181.447 |
|
|
Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalent... more |