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Browsing toxins
| T3DB ID | Name CAS Number |
Formula Weight |
Structure | Type | Mechanism of Action |
|---|---|---|---|---|---|
| T3D0196 | ortho-Cresol 95-48-7 |
C7H8O 108.1378 |
|
|
Target organs of ingested cresols in humans are the blood, kidneys, lungs, liver, heart, and central nervous system. Cresols impair the stratum corneum and produce coa... more |
| T3D0198 | Vanadium 7440-62-2 |
V 50.9415 |
|
|
Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cell's phagocytotic ability and viability. The pentavalent fo... more |
| T3D0199 | n-Nitrosodimethylamine 62-75-9 |
C2H6N2O 74.0818 |
|
|
The mechanism of NDMAinduced liver toxicity is not clearly understood but may be related to alkylation of cellular protein. (S725) |
| T3D0200 | 1,2,4-Trichlorobenzene 120-82-1 |
C6H3Cl3 181.447 |
|
|
Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalent... more |
| T3D0202 | Tetrachlorodibenzo-p-dioxin 41903-57-5 |
C12H4Cl4O2 321.971 |
|
|
CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the transcription of certain genes. The affinity for the Ah recept... more |
| T3D0204 | Pentachlorodibenzo-p-dioxin 36088-22-9 |
C42H64O19 872.9462 |
|
|
CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the transcription of certain genes. The affinity for the Ah recept... more |
| T3D0207 | 2,3,7,8-Tetrachlorodibenzofuran 51207-31-9 |
C12H4Cl4O 305.972 |
|
|
Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso... more |
| T3D0209 | 2,4-Dichlorophenol 120-83-2 |
C6H4Cl2O 163.001 |
|
|
Chlorophenols have moderately high lipophilicity. Absorption through the gastrointestinal tract is by simple diffusion and is expected to be both rapid and virtually c... more |
| T3D0210 | 1,4-Dioxane 123-91-1 |
C4H8O2 88.1051 |
|
|
Though the mechanism of toxicity of 1,4-dioxane has not yet been elucidated, it is known that its carcinogenic effects are caused by a non-genotoxic mechanism that is ... more |
| T3D0211 | Fluorine 7782-41-4 |
|
|
Fluoride ions are incorporated into bone by substituting for hydroxyl groups in the carbonate-apatite structure to produce hydroxyfluorapatite, thus altering the miner... more | |
| T3D0212 | Nitrite 14797-65-0 |
NO2 46.0055 |
|
|
Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and methemoglobin. This elevation of methemoglobin levels is a condition known as meth... more |
| T3D0213 | Cesium-137 10045-97-3 |
Cs 136.907083505 |
|
|
Highly penetrating gamma rays are the major cause of damage to tissues and internal organs following external overexposure to radioactive cesium. Once radioactive cesi... more |
| T3D0214 | Silver 7440-22-4 |
Ag 107.8682 |
|
|
Metallic silver is oxidized and may deposit in the tissues, causing arygria. The silver ion is known to inhibit glutathione peroxidase and NA+,K+-ATPase activity, resp... more |
| T3D0215 | Chromic acid 7738-94-5 |
CrH2O4 118.0096 |
|
|
Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce... more |
| T3D0216 | Nitrate 14797-55-8 |
NO3 62.0049 |
|
|
Nitrate's toxicity is a result of it's conversion to nitrite once in the body. Nitrite causes the autocatalytic oxidation of oxyhemoglobin to hydrogen peroxide and met... more |
| T3D0217 | Potassium-40 13966-00-2 |
K 39.963998672 |
|
|
The ionizing radiation produced by potassium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal c... more |
| T3D0218 | Dinitrotoluene 25321-14-6 |
C7H6N2O4 182.1335 |
|
|
Dinitrotoluene may cause conversion of oxyhemoglobin to methemoglobin via oxidation of iron(II) to iron(III) by its metabolites. High levels of methemoglobin are remov... more |
| T3D0219 | Antimony 7440-36-0 |
Sb 121.76 |
|
|
The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes... more |
| T3D0221 | Thorium-227 15623-47-9 |
Th 227.027698859 |
|
|
The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal cha... more |
| T3D0222 | 2,4,5-Trichlorophenol 95-95-4 |
C6H3Cl3O 197.446 |
|
|
2,4,5-TCP acts as an uncoupler of oxidative phosphorylation. (R307) |
| T3D0223 | Arsenic acid 7778-39-4 |
|
|
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase. By compe... more | |
| T3D0224 | Arsenic trioxide 1327-53-3 |
As2O3 197.8414 |
|
|
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co... more |
| T3D0225 | Phorate 298-02-2 |
C7H17O2PS3 260.377 |
|
|
Phorate and its metabolites are cholinesterase inhibitors; they affect the normal functioning of the nervous system. Phorate metabolites are even more toxic and have g... more |
| T3D0226 | Benzo[e]pyrene 192-97-2 |
C20H12 252.3093 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0227 | Cresols 1319-77-3 |
C7H8O 108.1378 |
|
|
Target organs of ingested cresols in humans are the blood, kidneys, lungs, liver, heart, and central nervous system. Cresols impair the stratum corneum and produce coa... more |