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Browsing toxins
| T3DB ID | Name CAS Number |
Formula Weight |
Structure | Type | Mechanism of Action |
|---|---|---|---|---|---|
| T3D0163 | 1,1,2-Trichloroethane 79-00-5 |
C2H3Cl3 133.404 |
|
|
Acyl chlorides and free radicals formed during the metabolism of 1,1,2-trichloroethane are reactive metabolites that can bind to proteins and nucleic acids (DNA, RNA),... more |
| T3D0165 | Hexachlorocyclopentadiene 77-47-4 |
C5Cl6 272.772 |
|
|
HCCPD may interact with the microsomes that binds to secretory molecules and changes their ability to be transported from the cell. It can be postulated, that some of ... more |
| T3D0166 | Heptachlorodibenzofuran 38998-75-3 |
|
|
Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso... more | |
| T3D0167 | 1,2-Diphenylhydrazine 122-66-7 |
C12H12N2 184.2371 |
|
|
Two of the known metabolites, aniline and benzidine, may contribute to the toxicity and/or carcinogenicity of 1,2-diphenylhydrazine. Nonneoplastic liver lesions, hepat... more |
| T3D0168 | 2,3,4,7,8-Pentachlorodibenzofuran 57117-31-4 |
C12H3Cl5O 340.417 |
|
|
Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso... more |
| T3D0170 | para-Cresol 106-44-5 |
|
|
p-Cresol is the most toxic of the three cresol isomers. Target organs of ingested cresols in humans are the blood, kidneys, lungs, liver, heart, and central nervous sy... more | |
| T3D0172 | 1,2-Dichlorobenzene 95-50-1 |
C6H4Cl2 147.002 |
|
|
1,2-DCB was found to covalently bind to DNA, RNA, and proteins of liver, kidney, lung, and stomach. (R677) |
| T3D0173 | trans-1,2-Dichloroethene 156-60-5 |
C2H2Cl2 96.943 |
|
|
Trans-1,2-dichloroethene is a volatile, lipophilic molecule that easily moves through the respiratory and gastrointestinal systems. It has a high affinity for lipids a... more |
| T3D0174 | Indeno(1,2,3-cd)pyrene 0193-39-5 |
C22H12 276.3307 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0176 | Carbon disulfide 075-15-0 |
CS2 76.141 |
|
|
Carbon disulfide is a potent nerve toxin and also affect liver enzymes, particularly those related to lipid metabolism. The increases in serum cholesterol that are som... more |
| T3D0177 | 2,3,4,5-Tetrachlorophenol 25167-83-3 |
C6H2Cl4O 231.891 |
|
|
Tetrachlorophenols decrease or block ATP production without blocking the electron transport chain. Thus the poisons uncouple phosphorylation from oxidation. Free energ... more |
| T3D0178 | Americium 7440-35-9 |
Am 243 |
|
|
Americium toxicity results primarily from the damage done by the alpha particle emitted during radioactive decay. This alpha particle has very limited penetration in t... more |
| T3D0179 | Uranium-233 13968-55-3 |
U 233.039628196 |
|
|
Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot... more |
| T3D0180 | Palladium 7440-05-3 |
Pd 106.42 |
|
|
Palladium ions are able to inhibit most major cellular fuctions. They form strong complexes with both inorganic and organic ligands, substitute essential ions, bind to... more |
| T3D0181 | Hexachlorodibenzofuran 55684-94-1 |
|
|
Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso... more | |
| T3D0182 | Phenol 108-95-2 |
C6H6O 94.1112 |
|
|
Phenol is irritating and corrosive at high concentrations. Phenol impairs the stratum corneum and produces coagulation necrosis by denaturing and precipitating protein... more |
| T3D0183 | Chloroethane 75-00-3 |
C2H5Cl 64.514 |
|
|
Chloroethane targets the central nervous system and the heart. The lipophilicity of chloroethane suggests it acts upon the lipid layer of cellular membrane or the hydr... more |
| T3D0184 | Acetone 67-64-1 |
C3H6O 58.0791 |
|
|
Since acetone is highly water soluble, it is readily taken up by the blood and widely distributed to body tissues. Acetone may interfere with the composition of the me... more |
| T3D0185 | para-Xylene 106-42-3 |
C8H10 106.165 |
|
|
Xylene binds to serum proteins and accumulates primarily in the adipose tissue. Xylene dissolves lipid membranes and is responsible for irritant effects on eyes, mucou... more |
| T3D0187 | Aluminum 7429-90-5 |
Al 26.9815386 |
|
|
The main targets of aluminum are the central nervous system and bones. Aluminum binds to dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The ... more |
| T3D0189 | Carbon monoxide 630-08-0 |
CO 28.0101 |
|
|
Carbon monoxide possesses a higher affinity than oxygen for hemoglobin, leading to the formation of carboxyhemoglobin, this provoking anoxemia. Carbon monoxide also bi... more |
| T3D0191 | Hydrogen sulfide 7783-06-4 |
H2S 34.081 |
|
|
Although very pungent at first, hydrogen sulfide quickly deadens the sense of smell, so potential victims may be unaware of its presence until it is too late. Hydrogen... more |
| T3D0192 | Pentachlorodibenzofuran 30402-15-4 |
|
|
Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso... more | |
| T3D0194 | Bis(2-methoxyethyl) phthalate 34006-76-3 |
C13H16O4 236.2637 |
|
|
Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr... more |
| T3D0195 | Benzyl butyl phthalate 85-68-7 |
C19H20O4 312.3597 |
|
|
Phthalate esters are endocrine disruptors. They decrease foetal testis testosterone production and reduce the expression of steroidogenic genes by decreasing mRNA expr... more |