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Browsing toxins
| T3DB ID | Name CAS Number |
Formula Weight |
Structure | Type | Mechanism of Action |
|---|---|---|---|---|---|
| T3D0135 | Guthion 86-50-0 |
C10H12N3O3PS2 317.324 |
|
|
Guthion and its reactive metabolite, gutoxon, directly affect the nervous system by inhibiting acetylcholinesterase (AChE) in the central and peripheral nervous system... more |
| T3D0136 | Neptunium-237 13994-20-2 |
Np 237.048167253 |
|
|
The ionizing radiation produced by neptunium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal c... more |
| T3D0137 | Chrysene 218-01-9 |
C18H12 228.2879 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0138 | Chlordecone 143-50-0 |
C10Cl10O 490.636 |
|
|
It is believed that the α-noradrenergic and serotonergic transmitter systems in the central nervous system are the primary neurotransmitter systems affected by chlorde... more |
| T3D0139 | Iodine-129 15046-84-1 |
I 128.904987487 |
|
|
Iodide inhibits adenylate cyclase in thyroid gland follicle cells and decreases the TSH-induced rise in intracellular cAMP. This results in decreased iodination of thy... more |
| T3D0140 | Plutonium-240 14119-33-6 |
Pu 240.05380746 |
|
|
The alpha radiation plutonium emits does not penetrate the skin but can irradiate internal organs when plutonium is inhaled or ingested. Particularly at risk are the s... more |
| T3D0141 | S,S,S-Tributyl phosphorotrithioate 78-48-8 |
C12H27OPS3 314.511 |
|
|
Like other organophosphate compounds, S,S,S-tributyl phosphorotrithioate causes neurotoxic effects by inhibiting acetylcholinesterase. This results in overstimulation ... more |
| T3D0142 | Bromine 7726-95-6 |
Br 79.904 |
|
|
Bromine is a powerful oxidizing agent and is able to release oxygen free radicals from the water in mucous membranes. These free radicals are also potent oxidizers and... more |
| T3D0143 | Polybrominated biphenyls 67774-32-7 |
|
|
The exact mechanism of toxicty of PBBs varies depending on the specific congener. The predominant interaction is believed to involve the aryl hydrocarbon receptor (AhR... more | |
| T3D0144 | Dicofol 115-32-2 |
C14H9Cl5O 370.486 |
|
|
Like other organochloride pesticides, dicofol is believed to act by at least four mechanisms, possibly all functioning simultaneously. It may reduce potassium transpor... more |
| T3D0145 | Parathion 56-38-2 |
C10H14NO5PS 291.261 |
|
|
The active metabolite of parathion, paraoxon, inactivates acetylcholinesterase by phosphorylating the active site of the enzyme, thus inhibiting its activity in the ne... more |
| T3D0146 | 1,1,2,2-Tetrachloroethane 79-34-5 |
C2H2Cl4 167.849 |
|
|
The presence of the functional group consisting of a terminal dichloromethyl moiety in a molecule is known to confer toxicity. Moreover, the metabolism of 1,1,2,2-tetr... more |
| T3D0147 | Selenium 7782-49-2 |
Se 78.96 |
|
|
Selenium readily substitutes for sulfur in biomolecules and in many biochemical reactions, especially when the concentration of selenium is high and the concentration ... more |
| T3D0148 | Hexachlorocyclohexane, technical Grade 608-73-1 |
C6H6Cl6 290.83 |
|
|
Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picro... more |
| T3D0151 | O,P'-DDD 53-19-0 |
C14H10Cl4 320.041 |
|
|
DDD toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDD reduces potassium transport across the membrane. DDD inhibits the inacti... more |
| T3D0152 | 4,4'-Methylenebis(2-chloroaniline) 101-14-4 |
C13H12Cl2N2 267.154 |
|
|
MBOCA's carcinogenicity is thought to be a result of its ability to bind to DNA, hemoglobin, and serum albumin. One metabolite in particular, N-hydroxy-N,N’-diacetyl M... more |
| T3D0153 | Hexachlorodibenzo-p-dioxin 34465-46-8 |
C34H50O12 650.7536 |
|
|
CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the transcription of certain genes. The affinity for the Ah recept... more |
| T3D0154 | Heptachlorodibenzo-p-dioxin 37871-00-4 |
C13H24O 196.3291 |
|
|
CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the trascription of certain genes. The affinity for the Ah recepto... more |
| T3D0156 | 1,3-Butadiene 106-99-0 |
C4H6 54.0904 |
|
|
Certain metabolites of 1,3-butadiene have been shown to bind to DNA and nucleoproteins, forming protein-DNA and DNA-DNA crosslinks. Specifically, 1,2-epoxybutene-3 and... more |
| T3D0157 | Ammonia 7664-41-7 |
H3N 17.0305 |
|
|
The topical damage caused by ammonia is probably due mainly to its alkaline properties. Its high water solubility allows it to dissolve in moisture on the mucous membr... more |
| T3D0158 | 2-Methylnaphthalene 91-57-6 |
C11H10 142.1971 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0159 | 1,4-Dichlorobenzene 106-46-7 |
C6H4Cl2 147.002 |
|
|
The hepatotoxicity and nephrotoxicity observed in laboratory animals are likely due to the formation of toxic intermediates formed while converting 1,4-DCB to 2,5-dich... more |
| T3D0160 | 1,1-Dichloroethane 75-34-3 |
C2H4Cl2 98.959 |
|
|
The limited information available about 1,1-dichloroethane suggests that it may be nephrotoxic, fetotoxic, and possibly carcinogenic. 1,1-Dichloroethane has been obser... more |
| T3D0161 | Acenaphthene 83-32-9 |
C12H10 154.2078 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0162 | 1,2,3,4,6,7,8,9-Octachlorodibenzofuran 39001-02-0 |
C12Cl8O 443.752 |
|
|
Halogenated dibenzofurans (PCDFs and PBDFs) bind the aryl hydrocarbon receptor (AhR), which increases its ability to activate transcription in the XRE (xenobiotic reso... more |