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Browsing toxins
| T3DB ID | Name CAS Number |
Formula Weight |
Structure | Type | Mechanism of Action |
|---|---|---|---|---|---|
| T3D0109 | Barium 7440-39-3 |
Ba 137.327 |
|
|
Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to... more |
| T3D0110 | Fluoranthene 206-44-0 |
C16H10 202.2506 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0111 | Uranium-234 13966-29-5 |
U 234.040945606 |
|
|
Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot... more |
| T3D0112 | n-Nitrosodi-n-propylamine 621-64-7 |
C6H14N2O 130.1882 |
|
|
Reactive metabolites of n-nitrosodi-n-propylamine are believed to form adducts with DNA, resulting in carcinogenic effects. (R420) |
| T3D0113 | Thorium-228 14274-82-9 |
Th 228.028731348 |
|
|
The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal cha... more |
| T3D0114 | Radon-222 14859-67-7 |
Rn 222.017570472 |
|
|
The ionizing radiation produced by radon causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal chang... more |
| T3D0115 | alpha-Hexachlorocyclohexane 319-84-6 |
|
|
Hexachlorocyclohexane is a neurotoxin that interferes with GABA neurotransmitter function by interacting with the GABA-A receptor-chloride channel complex at the picro... more | |
| T3D0116 | 1,2,3-Trichlorobenzene 87-61-6 |
|
|
Trichlorobenzene may uncouple mitochondrial oxidative phosphorylation, inducing potassium ion release and inhibiting respiratory control. It's metabolites may covalent... more | |
| T3D0117 | Manganese 7439-96-5 |
Mn 54.938045 |
|
|
Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particu... more |
| T3D0119 | Chrysotile asbestos 12001-29-5 |
|
|
When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long pe... more | |
| T3D0120 | Strontium-90 10098-97-2 |
Sr 89.907737596 |
|
|
The fact that strontium is chemically similar to calcium allows it to exchange for calcium in bone. It affects bone development and strength by binding directly to hyd... more |
| T3D0121 | Plutonium-239 15117-48-3 |
Pu 239.052156519 |
|
|
The alpha radiation plutonium emits does not penetrate the skin but can irradiate internal organs when plutonium is inhaled or ingested. Particularly at risk are the s... more |
| T3D0122 | Polonium-210 13981-52-7 |
Po 209.982857396 |
|
|
The alpha radiation polonium emits does not penetrate the skin but can irradiate internal organs when polonium is inhaled or ingested. The ionizing radiation produced ... more |
| T3D0123 | Methylmercury 22967-92-6 |
CH3Hg 215.62 |
|
|
High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through... more |
| T3D0124 | Plutonium-238 13981-16-3 |
Pu 238.0495534 |
|
|
The alpha radiation plutonium emits does not penetrate the skin but can irradiate internal organs when plutonium is inhaled or ingested. Particularly at risk are the s... more |
| T3D0125 | Lead-210 14255-04-0 |
Pb 209.984173129 |
|
|
Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,... more |
| T3D0126 | Plutonium 7440-07-5 |
Pu 244 |
|
|
The alpha radiation plutonium emits does not penetrate the skin but can irradiate internal organs when plutonium is inhaled or ingested. Particularly at risk are the s... more |
| T3D0127 | Chlorpyrifos 2921-88-2 |
C9H11Cl3NO3PS 350.586 |
|
|
Chlorpyrifos and its bioactivation product, chlorpyrifos oxon, inhibit neural acetylcholinesterase by forming a stable covalent bond at the active site. The result of ... more |
| T3D0128 | Copper 7440-50-8 |
Cu 63.546 |
|
|
Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes bec... more |
| T3D0129 | Americium-241 86954-36-1 |
Am 241.056822944 |
|
|
Americium toxicity results primarily from the damage done by the alpha particle emitted during radioactive decay. This alpha particle has very limited penetration in t... more |
| T3D0130 | Radon-220 22481-48-7 |
Rn 220.011384149 |
|
|
The ionizing radiation produced by radon causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal chang... more |
| T3D0131 | Amosite asbestos 12172-73-5 |
C14H15NO7 309.2714 |
|
|
When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long pe... more |
| T3D0132 | Iodine-131 10043-66-0 |
I 130.906124168 |
|
|
Iodide inhibits adenylate cyclase in thyroid gland follicle cells and decreases the TSH-induced rise in intracellular cAMP. This results in decreased iodination of thy... more |
| T3D0133 | Hydrogen cyanide 74-90-8 |
CHN 27.0253 |
|
|
Cyanide complexes with ferric iron of cytochrome c oxidase in the fourth complex of the electron transport chain, leading to the inhibition of the electron transport f... more |
| T3D0134 | Tributyltin 0688-73-3 |
|
|
Organotin compounds produce neurotoxic and immunotoxic effects. Organotins may directly activate glial cells contributing to neuronal cell degeneration by local releas... more |