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Browsing toxins
| T3DB ID | Name CAS Number |
Formula Weight |
Structure | Type | Mechanism of Action |
|---|---|---|---|---|---|
| T3D0080 | Methylene chloride 75-09-2 |
CH2Cl2 84.933 |
|
|
Methylene chloride targets the lungs, blood system, and nervous system. In the lungs its metabolites damage Clara cells. It is also metabolized into carbon monoxide, w... more |
| T3D0082 | 2,4,6-Trinitrotoluene 118-96-7 |
C7H5N3O6 227.1311 |
|
|
2,4,6-Trinitrotoluene is a competitive inhibitor with respect to NADPH and a noncompetitive inhibitor with respect to L-arginine. It binds to the P450 reductase domain... more |
| T3D0084 | Hydrazine 302-01-2 |
H4N2 32.0452 |
|
|
At least two mechanisms of action have been observed. One involves the direct binding of those hydrazines with a free amino group (hydrazine and 1,1-dimethylhydrazine)... more |
| T3D0085 | 1,2-Dichloroethane 107-06-2 |
C2H4Cl2 98.959 |
|
|
1,2-Dichloroethane is metabolized to 2-chloroacetaldehyde, S-(2-chloroethyl)glutathione by conjugation with glutathione, and to other putative reactive intermediates c... more |
| T3D0086 | 2,4,6-Trichlorophenol 88-06-2 |
C6H3Cl3O 197.446 |
|
|
It has been suggested that 2,4,6-TCP would interfer with mitochondrial oxidative phosphorylation and inhibit cytochrome P-450-dependent mixes-function oxidases. 2,4,6-... more |
| T3D0087 | 2,4-Dinitrophenol 51-28-5 |
C6H4N2O5 184.1064 |
|
|
Acute 2,4-dinitrophenol poisoning (from ingestion) involves uncoupling of oxidative phosphorylation, which presumably reduces body's reservoirs of high-energy phosphat... more |
| T3D0088 | Bis(2-chloroethyl) ether 111-44-4 |
C4H8Cl2O 143.012 |
|
|
BCEE is extremely meabolized, with thiodiglycolic acid (TDGA) being the principal endproduct. The pathway leading to TDGA formation is uncertain, but probably involves... more |
| T3D0089 | Thiocyanate 01762-95-4 |
CNS 58.082 |
|
|
Thiocyanate (sulphocyanate or SCN) is believed to be a goitrogenic compound. It is a competitive inhibitor of the human thyroid sodium/iodide symporter NIS. Thus, the ... more |
| T3D0090 | Asbestos 1332-21-4 |
|
|
When asbestos fibers are inhaled, many are deposited on the epithelial surface of the respiratory tree. Fibers that are retained in the lung or mesothelium for long pe... more | |
| T3D0091 | Chlorine 7782-50-5 |
Cl 35.453 |
|
|
Chlorine is a strong oxidizer that hydrolyzes in water forming hydrochloric and hypochlorous acids. In this form, it apparently can penetrate the cell and form N-chlor... more |
| T3D0092 | Cyclotrimethylenetrinitramine 121-82-4 |
C3H6N6O6 222.1163 |
|
|
RDX can get into the lungs after breathing in the fumes of burning RDX or breathing in the dust from powdered RDX. It can also enter the body after ingestion of contam... more |
| T3D0093 | Hexachlorobenzene 118-74-1 |
C6Cl6 284.782 |
|
|
Hexachlorobenzene causes porphyria by modifying sulfhydryl groups in the catalytic or substrate-binding sites of uroporphyrinogen decarboxylase. This inhibits uroporph... more |
| T3D0094 | 2,4-Dinitrotoluene 121-14-2 |
|
|
2,4-DNT may cause conversion of oxyhemoglobin to methemoglobin via oxidation of iron(II) to iron(III) by its metabolites. High levels of methemoglobin are removed by c... more | |
| T3D0096 | Ethion 563-12-2 |
C9H22O4P2S4 384.476 |
|
|
Ethion is converted, in the liver, into its active form ethion monoxon. Ethion monoxon is a potent inhibitor of cholinesterases and exerts toxicity by reacting with an... more |
| T3D0097 | 1,1,1-Trichloroethane 71-55-6 |
C2H3Cl3 133.404 |
|
|
An involvement of cytochrome P-450-mediated dechlorination in the production of liver injury has been demonstrated. 1,1,1-Trichloroethane is converted by the cytochrom... more |
| T3D0099 | Ethylbenzene 100-41-4 |
C8H10 106.165 |
|
|
Changes in the integrity of the cell membrane after partitioning of ethylbenzene into the lipid bilayer may subsequently affect the function of membrane, particularly ... more |
| T3D0100 | Radium-226 13982-63-3 |
Ra 226.025402555 |
|
|
Ionizing radiation produced by radium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both initiate and promote carcinogenesis, and ... more |
| T3D0101 | Thorium 7440-29-1 |
Th 232.03806 |
|
|
The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal cha... more |
| T3D0102 | 4,6-Dinitro-o-cresol 534-52-1 |
C7H6N2O5 198.1329 |
|
|
4,6-Dinitro-o-cresol is an uncoupler of oxidative phosphorylation. It is believed to cause an acceleration of metabolic processes that are part of the tricarboxylic ac... more |
| T3D0103 | 1,3,5-Trinitrobenzene 99-35-4 |
C6H3N3O6 213.1045 |
|
|
In the red blood cell, 1,3,5-TNB induces formation of methemoglobin, leading to cyanosis. Reduction of the nitrogroup(s) of 1,3,5-TNB produces reactive nitroaromatic r... more |
| T3D0104 | Chlorobenzene 108-90-7 |
C6H5Cl 112.557 |
|
|
The reactive metabolites of chlorobenzene are believed to bind both liver and kidney proteins, causing direct damage. Chlorobenzene also activates nuclear factor-kappa... more |
| T3D0105 | Radon 10043-92-2 |
Rn 222 |
|
|
The ionizing radiation produced by radon causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal chang... more |
| T3D0106 | Radium-228 15262-20-1 |
Ra 228.031064101 |
|
|
Ionizing radiation produced by radium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both initiate and promote carcinogenesis, and ... more |
| T3D0107 | Thorium-230 14269-63-7 |
Th 230.033126574 |
|
|
The ionizing radiation produced by thorium causes cellular damage that includes DNA breakage, accurate or inaccurate repair, apoptosis, gene mutations, chromosomal cha... more |
| T3D0108 | Uranium-235 15117-96-1 |
U 235.043923062 |
|
|
Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and prot... more |