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Browsing toxins
| T3DB ID | Name CAS Number |
Formula Weight |
Structure | Type | Mechanism of Action |
|---|---|---|---|---|---|
| T3D0055 | Endosulfan sulfate 1031-07-8 |
C9H6Cl6O4S 422.925 |
|
|
Endosulfan sulfate antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced ... more |
| T3D0056 | Diazinon 333-41-5 |
C12H21N2O3PS 304.346 |
|
|
Diazoxon the main toxic intermediate of diazinon, inhibits acetylcholinesterase in the central and peripheral nervous system. This results in the accumulation of acety... more |
| T3D0057 | alpha-Endosulfan 959-98-8 |
|
|
Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake o... more | |
| T3D0058 | 3-Xylene 1330-20-7 |
|
|
In the blood, xylene is bound to serum proteins and accumulates primarily in the adipose tissue. The lipophilic effects of xylene, which dissolve lipid membranes, is r... more | |
| T3D0059 | cis-Chlordane 5103-71-9 |
|
|
Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related r... more | |
| T3D0060 | Dibromochloropropane 67708-83-2 |
C3H5Br2Cl 236.333 |
|
|
The initial metabolism of dibromochloropropane to reactive epoxide metabolites that bind to DNA and other macromolecules may be responsible for its hepatotoxicity and ... more |
| T3D0061 | Methoxychlor 72-43-5 |
C16H15Cl3O2 345.648 |
|
|
Certain mono- and bis-hydroxy metabolites of methoxychlor, especially 2,2-bis(p-hydroxyphenyl)-1,1, 1-trichloroethane (HPTE), act as estrogen analogues. HPTE is an est... more |
| T3D0062 | Benzo[k]fluoranthene 207-08-9 |
C20H12 252.3093 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0063 | Endrin ketone 53494-70-5 |
C12H8Cl6O 380.909 |
|
|
Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch... more |
| T3D0064 | trans-Chlordane 5103-74-2 |
|
|
Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related r... more | |
| T3D0065 | Chromium(VI) oxide 1333-82-0 |
CrO3 99.9943 |
|
|
Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce... more |
| T3D0066 | Methane 74-82-8 |
CH4 16.0425 |
|
|
Methane is an asphyxiant and displaces oxygen in enclosed spaces. At high enough concentrations, oxygen depletion may cause asphyxiation. Low concentrations of surroun... more |
| T3D0067 | beta Endosulfan 33213-65-9 |
C9H6Cl6O3S 406.925 |
|
|
Endosulfan antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake o... more |
| T3D0068 | Aroclor 1232 11141-16-5 |
|
|
The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio... more | |
| T3D0069 | Endrin aldehyde 7421-93-4 |
C12H8Cl6O 380.909 |
|
|
Endrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch... more |
| T3D0070 | Benzofluoranthene 56832-73-6 |
C20H12 252.3093 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0071 | Toluene 108-88-3 |
C7H8 92.1384 |
|
|
Neurological effects such as central nervous system depression and narcosis is generally thought to involve reversible interactions between toluene and components of n... more |
| T3D0072 | 2-Hexanone 591-78-6 |
C6H12O 100.1589 |
|
|
2-Hexanone's toxicity is believed to be caused by covalent binding of its metabolites, especially 2,5-hexanedione, with axonal components of nerve tissue and inhibitio... more |
| T3D0073 | 2,3,7,8-Tetrachlorodibenzo-p-dioxin 1746-01-6 |
|
|
CDDs bind to the aryl hydrocarbon (Ah) receptor and subsequently alter the transcription of several genes (oncogenes, growth factors, receptors, hormones, and drug-met... more | |
| T3D0074 | Zinc 7440-66-6 |
Zn 65.409 |
|
|
Excessive zinc intake alters copper and iron absorption, most likely through competitive binding in intestinal mucosal cells. Stomach acid dissolves metallic zinc, pro... more |
| T3D0075 | Dimethylarsinic acid 75-60-5 |
C2H7AsO2 137.9974 |
|
|
Arsenic and its metabolites disrupt ATP production through different mechanisms. At the level of the citric acid cycle, arsenic inhibits the pyruvate dehydrogenase and... more |
| T3D0076 | Di(2-ethylhexyl)phthalate 117-81-7 |
C24H38O4 390.5561 |
|
|
Monoethylhexylphthalate (MEHP), one of the major metabolites of DEHP, induces peroxisome proliferation by activating peroxisome proliferator activated receptors. This ... more |
| T3D0077 | Chromium 7440-47-3 |
Cr 51.9961 |
|
|
Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce... more |
| T3D0078 | Naphthalene 91-20-3 |
C10H8 128.1705 |
|
|
PAH's are transported throughout the body after binding blood proteins such as albumin. Binding to the aryl hydrocarbon receptor or glycine N-methyltransferase induces... more |
| T3D0079 | 1,1-Dichloroethene 75-35-4 |
C2H2Cl2 96.943 |
|
|
1,1-Dichloroethene toxicity is caused by its reactive metabolites, which include epoxides, acyl chlorides, and halogenated aldehydes generated via oxidation by cytochr... more |