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Browsing toxins
| T3DB ID | Name CAS Number |
Formula Weight |
Structure | Type | Mechanism of Action |
|---|---|---|---|---|---|
| T3D0001 | Arsenic 7440-38-2 |
As 74.9216 |
|
|
Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by co... more |
| T3D0002 | Lead 7439-92-1 |
Pb 207.2 |
|
|
Lead mimics other biologically important metals, such as zinc, calcium, and iron, competing as cofactors for many of their respective enzymatic reactions. For example,... more |
| T3D0003 | Mercury 7439-97-6 |
Hg 200.59 |
|
|
High-affinity binding of the divalent mercuric ion to thiol or sulfhydryl groups of proteins is believed to be the major mechanism for the activity of mercury. Through... more |
| T3D0004 | Vinyl chloride 75-01-4 |
C2H3Cl 62.498 |
|
|
Vinyl chloride poisoning exhibits many of the characteristics of autoimmune diseases. This is believed to be the result of a reactive vinyl chloride intermediate metab... more |
| T3D0006 | Benzene 71-43-2 |
C6H6 78.1118 |
|
|
The toxic agents of benzene are its metabolites. Benzene is able increase its toxicity by inducing cytochrome P450 2E1, its main metabolic enzyme. Benzene's primary to... more |
| T3D0007 | Cadmium 7440-43-9 |
Cd 112.411 |
|
|
Cadmium initially binds to metallothionein and is transported to the kidney. Toxic effects are observed once the concentration of cadmium exceeds that of available met... more |
| T3D0009 | Benzo[a]pyrene 50-32-8 |
C20H12 252.3093 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0010 | Benzo[b]fluoranthene 205-99-2 |
C20H12 252.3093 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0011 | Chloroform 67-66-3 |
CHCl3 119.378 |
|
|
Chloroform and the reactive intermediates of chloroform metabolism, especially phosgene, bind covalently and irreversibly to cellular macromolecules and cause cellular... more |
| T3D0012 | P,P'-DDT 50-29-3 |
C14H9Cl5 354.486 |
|
|
DDT toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDT reduces potassium transport across the membrane. DDT inhibits the inacti... more |
| T3D0013 | Aroclor 1254 11097-69-1 |
|
|
The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio... more | |
| T3D0014 | Aroclor 1260 11096-82-5 |
|
|
The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio... more | |
| T3D0015 | Dibenzo[a,h]anthracene 53-70-3 |
C22H14 278.3466 |
|
|
The ability of PAH's to bind to blood proteins such as albumin allows them to be transported throughout the body. Many PAH's induce the expression of cytochrome P450 e... more |
| T3D0016 | Trichloroethylene 79-01-6 |
C2HCl3 131.388 |
|
|
The toxic and carcinogenic effects of trichloroethylene are believed to be caused mainly by its metabolites, including trichloroacetic acid, dichloroacetic acid, and c... more |
| T3D0017 | Dieldrin 60-57-1 |
|
|
Dieldrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ... more | |
| T3D0018 | Hexavalent chromium 18540-29-9 |
Cr 51.9961 |
|
|
Hexavalent chromium's carcinogenic effects are caused by its metabolites, pentavalent and trivalent chromium. The DNA damage may be caused by hydroxyl radicals produce... more |
| T3D0019 | Phosphorus 7723-14-0 |
P 30.973762 |
|
|
Exposure to white phosphorus has been shown to damage the rough endoplasmic reticulum and cause a disaggregation of polyribosomes. This damage results in impairment of... more |
| T3D0020 | Chlordane 57-74-9 |
|
|
Chlordane is believed to bind irreversibly to DNA, leading to cell death or altered cellular function. It also affects transcription by antagonizing estrogen-related r... more | |
| T3D0021 | P,P'-DDE 72-55-9 |
C14H8Cl4 318.025 |
|
|
DDE toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDE reduces potassium transport across the membrane. DDE inhibits the inacti... more |
| T3D0022 | Hexachlorobutadiene 87-68-3 |
C4Cl6 260.761 |
|
|
It is believed that intermediates produced by modification of the S- 1,1,2,3,4-pentachlorodienyl cysteine derivative metabolite by gamma-glutamyltransferase are respon... more |
| T3D0024 | Aldrin 309-00-2 |
|
|
Aldrin antagonizes the action of the neurotransmitter gamma-aminobutyric acid (GABA) acting at the GABA-A receptors, effectively blocking the GABA-induced uptake of ch... more | |
| T3D0025 | P,P'-DDD 72-54-8 |
C14H10Cl4 320.041 |
|
|
DDD toxicity occurs via at least four mechanisms, possibly all functioning simultaneously. DDD reduces potassium transport across the membrane. DDD inhibits the inacti... more |
| T3D0026 | Benzidine 92-87-5 |
C12H12N2 184.2371 |
|
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N-acetylated benzidine metabolites are believed to form adducts with nucleic acids. Carcinogenesis is initiated when they are activated by peroxidation by prostaglandi... more |
| T3D0027 | Aroclor 1248 12672-29-6 |
|
|
The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcriptio... more | |
| T3D0028 | Cyanide 57-12-5 |
CN 26.0174 |
|
|
Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). ... more |