T3DB Logo

Showing toxin card for Vinyl acetate (T3D3470)

Legend: toxin field target field

Version 1.0
Creation Date 2009-07-30 17:58:33
Update Date 2010-03-18 22:00:34
Accession Number T3D3470
Name Vinyl acetate
Compound Type
  • Industrial Precursor/Intermediate
  • Organic Compound
Description Vinyl acetate is an organic compound and industrial chemical. It is used mainly for the production of other industrial chemicals, such as polyvinyl acetate, an important polymer for which it is the precursor. These chemicals are used mainly to make glues for the packaging and building industries. They are also used to make paints, textiles, and paper. Vinyl acetate is also used as a coating in plastic films for food packaging and as a modifier of food starch. (S883, S885)
Synonyms
  1. 1-Acetoxyethylene
  2. Acetate de vinyle
  3. Acetate de vinyle(french)
  4. Acetic Acid ethylene ether
  5. Acetic Acid vinyl ester
  6. Acetoxyethene
  7. Acetoxyethylene
  8. Essigsaeurevinylester
  9. Ethenyl acetate
  10. Ethenyl ethanoate
  11. Everflex 81L
  12. Octan winylu
  13. Octan winylu(polish)
  14. VAC
  15. VYAC
  16. Vinile
  17. Vinile (acetato di)
  18. Vinile(acetato di)
  19. Vinile(acetato di)(italian)
  20. Vinnapas A 50
  21. Vinyl a monomer
  22. Vinyl acetate
  23. Vinyl acetate h.q
  24. Vinyl acetate monomer
  25. Vinyl acetate, inhibited [UN1301] [Flammable liquid]
  26. Vinyl ester of acetic Acid
  27. Vinyl ethanoate
  28. Vinylacetaat
  29. Vinylacetaat [dutch]
  30. Vinylacetaat(dutch)
  31. Vinylacetat
  32. Vinylacetat [german]
  33. Vinylacetat(german)
  34. Vinylacetate
  35. Vinylazetat
  36. Vinyle
  37. Vinyle (acetate de)
  38. Vinyle (acetate de) [french]
  39. Vinylester kyseliny octove
  40. Vinylester kyseliny octove [czech]
  41. Zeset t
  42. vinyl acetate
Chemical IUPAC Name ethenyl acetate
Chemical Formula C4H6O2
Chemical Structure Structure
CAS Registry Number 108-05-4
InChI Identifier InChI=1S/C4H6O2/c1-3-6-4(2)5/h3H,1H2,2H3
InChI Key InChIKey=XTXRWKRVRITETP-UHFFFAOYSA-N
PubChem Compound ID 7904 Link Image
KEGG ID Not Available
UniProt ID Not Available
OMIM ID Not Available
ChEBI ID 46916 Link Image
BioCyc ID Not Available
SuperToxic ID Not Available
CTD ID Not Available
Stitch ID Vinyl acetate Link Image
DrugBank ID Not Available
PDB ID Not Available
ACToR ID 1463
Wikipedia Link Not Available
Monoisotopic Mass 86.036779
MOL File Show
PDB File Show
SDF File Show
SMILES CC(=O)OC=C
Appearance Not Available
Melting Point -93.2 oC
Solubility 20 mg/mL at 20 oC [RIDDICK,JA et al. (1986)]
Predicted LogP 0.4272
Route of Exposure Oral (R885) ; inhalation (R885) ; dermal (R885)
Mechanism of Action One of the metabolites of vinyl acetate, acetaldehyde, is a known animal carcinogen. Acetaldehyde can form adducts with DNA, causing damage such as cross-links. (S885, S891)
Metabolism Vinyl acetate may be absorbed following ingestion, inhalation, or dermal exposure, and distributes throughout the body. It is rapidly hydrolyzed by esterases in the blood to acetate and the unstable intermediate, vinyl alcohol. Vinyl alcohol is then rapidly converted to acetaldehyde, which in turn is metabolized to acetate in the liver. This in turn is incorporated into the "2 carbon pool" of normal body metabolism and eventually forms carbon dioxide as the major breakdown product, which is expired. (S885)
Toxicity Values LD50: 2.92 g/kg (Oral, Rat) (R603) LC50: 2511 ppm over 4 hours (Inhalation, Rabbit) (R285)
Lethal Dose Not Available
Carcinogenicity (IARC Classification) 2B (R264)
Uses/Sources Vinyl acetate is used mainly for the production of other industrial chemicals, such as polyvinyl acetate, an important polymer for which it is the precursor. These chemicals are used mainly to make glues for the packaging and building industries. They are also used to make paints, textiles, and paper. Vinyl acetate is also used as a coating in plastic films for food packaging and as a modifier of food starch. (S883, S885)
Minimum Risk Level Intermediate Inhalation: 0.01 ppm (R260)
Health Effects Vinyl acetate may affect the immune system. It may also be a carcinogen. (S885)
Symptoms Inhalation of vinyl acetate irritates the eyes, nose, and throat. Skin contact causes irritation and blisters. (S885)
Treatment Not Available
General References
  • R285 - American Conference of Governmental Industrial Hygienists, Inc. (1991). Documentation of the Threshold Limit Values and Biological Exposure Indices. 6th ed. Volumes I, II, III. Cincinnati, OH: American Conference of Governmental Industrial Hygienists.
  • S883 - Wikipedia. Vinyl acetate. Last Updated 26 July 2009.
  • R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
  • S891 - Brooks PJ, Theruvathu JA. DNA adducts from acetaldehyde: implications for alcohol-related carcinogenesis. Alcohol. 2005 Apr;35(3):187-93. Review. [PubMed Link Image]
  • R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • S885 - ATSDR - Agency for Toxic Substances and Disease Registry (1999). Toxicological profile for vinyl acetate. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R603 - Budavari, S (ed) (1989). The Merck Index - Encyclopedia of Chemicals, Drugs and Biologicals. Rahway, NJ: Merck and Co., Inc.

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.