Showing toxin card for Acetic acid (T3D3268)
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| Version | 1.0 |
| Creation Date | 2009-07-30 17:56:54 |
| Update Date | 2010-03-18 22:00:18 |
| Accession Number | T3D3268 |
| Name | Acetic acid |
| Compound Type |
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| Description | Acetic acid is an organic acid which gives vinegar its sour taste and pungent smell. It is an important chemical reagent and industrial chemical, used in the plastic, pharmaceutical, dye, insecticide, textile, rubber, and photographic industries. Water-free acetic acid (glacial acetic acid) is used in the production of certain fragrances. Acetic acid can be very corrosive, depending on the concentration. (W618) |
| Synonyms |
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| Chemical IUPAC Name | acetic acid |
| Chemical Formula | C2H4O2 |
| Chemical Structure | |
| CAS Registry Number | 64-19-7 |
| InChI Identifier | InChI=1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4) |
| InChI Key | InChIKey=QTBSBXVTEAMEQO-UHFFFAOYSA-N |
| PubChem Compound ID | 176  |
| KEGG ID | C00033 |
| UniProt ID | Not Available |
| OMIM ID | 276100
601705 |
| ChEBI ID | 15366 |
| BioCyc ID | ACET |
| SuperToxic ID | Not Available |
| CTD ID | Not Available |
| Stitch ID | Acetic acid |
| DrugBank ID | Not Available |
| PDB ID | Not Available |
| ACToR ID | 3254 |
| Wikipedia Link | http://en.wikipedia.org/wiki/Acetic_acid |
| Monoisotopic Mass | 60.021129 |
| MOL File | Show |
| PDB File | Show |
| SDF File | Show |
| SMILES | CC(O)=O |
| Appearance | Colorless liquid. |
| Melting Point | 16.6 oC |
| Solubility | 1000 mg/mL at 25 oC [MERCK INDEX (1996)] |
| Predicted LogP | -0.2233 |
| Route of Exposure | Oral (W619) ; ihalation (W619) ; ingestion (W619) |
| Mechanism of Action | Acetic acid is toxic due to its corrosive nature. In addition to causing skin burns and irritation to the mucous membranes, ingestion can result in severe damage to the digestive system and a potentially lethal change in the acidity of the blood. (W618) |
| Metabolism | Acetic acid is is absorbed from the gastrointestinal tract and through the lungs. It is completely oxidized by the tissues, with metabolism involving the formation of ketone bodies. The products of acetic acid are used in the formation of glycogen, as intermediates of carbohydrates and fatty acid synthesis, and in cholesterol synthesis. In addition, acetic acid participates in the acetylation of amines and formation of proteins of plasma, liver, kidney, gut mucosa, muscle, and brain. (W619) |
| Toxicity Values | LD50: 3.53 g/kg (Oral, Rat) (R700) LD50: 525 mg/kg (Intravenous, Mouse) (R263) LD50: 1060 mg/kg (Dermal, Rabbit) (R263) LC50: 5620 ppm over 1 hour (Inhalation, Mouse) (W620) |
| Lethal Dose | Not Available |
| Carcinogenicity (IARC Classification) | Not Available |
| Uses/Sources | Acetic acid gives vinegar its sour taste and pungent smell. It is an important chemical reagent and industrial chemical, used in the plastic, pharmaceutical, dye, insecticide, textile, rubber, and photographic industries. Water-free acetic acid (glacial acetic acid) is used in the production of certain fragrances. (W618) |
| Minimum Risk Level | Not Available |
| Health Effects | Concentrated acetic acid is corrosive and can cause skin burns, permanent eye damage, and irritation to the mucous membranes. Ingestion can cause severe damage to the digestive system and a potentially lethal change in the acidity of the blood. (W618) |
| Symptoms | Acetic acid is corrosive and can cause skin burns and irritation to the mucous membranes. These burns or blisters may not appear until hours after exposure. (W618) |
| Treatment | In cases of skin or eye exposure, the area should be flushed with water and burns covered with dry, sterile dressings after decontamination. If ingested, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution. Watch for signs of respiratory insufficiency and assist respiration if necessary. (S212) |
| General References |
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