| Version |
1.0 |
| Creation Date |
2009-07-21 20:27:51 |
| Update Date |
2010-05-18 21:00:53 |
| Accession Number |
T3D2918 |
| Name |
Diflunisal |
| Compound Type |
- Anti-Inflammatory Agent, Non-Steroidal
- Cyclooxygenase Inhibitor
- Drug
|
| Description |
A salicylate derivative and anti-inflammatory analgesic with actions and side effects similar to those of aspirin. [PubChem] |
| Synonyms |
- 2',4'-Difluoro-4-hydroxy-(1',1-diphenyl)-3-carboxylic Acid
- 2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic Acid
- 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic Acid
- 2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxylic Acid
- 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic Acid
- 2-(Hydroxy)-5-(2,4-difluorophenyl)benzoic Acid
- 5-(2,4-Difluorophenyl)salicylic Acid
- 5-(2,4-difluorophenyl)-2-hydroxybenzoic Acid
- 5-[2,4-Difluorophenyl]salicylic Acid
- Adomal
- Algobid
- Apo-Diflunisal Tab
- Apo-diflunisal
- Apotex brand of diflunisal
- Cahill may roberts brand of diflunisal
- Citidol
- Difludol
- Diflunisal (jan/usp/inn)
- Diflunisal [usan:inn:ban:jan]
- Diflunisal novopharm brand
- Diflunisalum
- Diflunisalum [inn-latin]
- Diflusinal
- Dolisal
- Dolobid
- Dolobid (TN)
- Dolobil
- Dolobis
- Dolocid
- Flovacil
- Fluniget
- Fluodonil
- Flustar
- Frosst sa brand of diflunisal
- Merck brand of diflunisal
- Merck sharp & dohme brand of diflunisal
- Noaldol
- Novo-Diflunisal Tab
- Novo-diflunisal
- Novopharm brand of diflunisal
- Nu pharm brand of diflunisal
- Nu-Diflunisal Tab
- Nu-diflunisal
- Nu-pharm brand of diflunisal
- Reuflos
- Unisal
|
| Chemical IUPAC Name |
5-(2,4-difluorophenyl)-2-hydroxybenzoic acid |
| Chemical Formula |
C13H8F2O3 |
| Chemical Structure |
 |
| CAS Registry Number |
22494-42-4 |
| InChI Identifier |
InChI=1S/C13H8F2O3/c14-8-2-3-9(11(15)6-8)7-1-4-12(16)10(5-7)13(17)18/h1-6,16H,(H,17,18) |
| InChI Key |
InChIKey=HUPFGZXOMWLGNK-UHFFFAOYSA-N |
| PubChem Compound ID |
3059  |
| KEGG ID |
C01691 |
| UniProt ID |
Not Available |
| OMIM ID |
Not Available |
| ChEBI ID |
4538 |
| BioCyc ID |
Not Available |
| SuperToxic ID |
Not Available |
| CTD ID |
Not Available |
| Stitch ID |
Diflunisal |
| DrugBank ID |
DB00861 |
| PDB ID |
Not Available |
| ACToR ID |
Not Available |
| Wikipedia Link |
http://en.wikipedia.org/wiki/Diflunisal |
| Monoisotopic Mass |
250.044151 |
| MOL File |
Show |
| PDB File |
Show |
| SDF File |
Show |
| SMILES |
OC(=O)C1=CC(=CC=C1O)C1=CC=C(F)C=C1F |
| Appearance |
Not Available |
| Melting Point |
210-221 oC |
| Solubility |
Practically insoluble (14.5 mg/L) at neutral or acidic pH. |
| Predicted LogP |
3.9099 |
| Route of Exposure |
Oral |
| Mechanism of Action |
The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues. |
| Metabolism |
Hepatic, primarily via glucuronide conjugation (90% of administered dose). |
| Toxicity Values |
LD50: 392 mg/kg (Oral, Rat) (S405)
LD50: 439 mg/kg (Oral, Mouse) (S405)
LD50: 603 mg/kg (Oral, Rabbit) (S405) |
| Lethal Dose |
The lowest dose without the presence of other medicines which caused death was 15 grams. |
| Carcinogenicity (IARC Classification) |
Not Available |
| Uses/Sources |
Used to relieve pain, tenderness, swelling and stiffness caused by osteoarthritis (arthritis caused by a breakdown of the lining of the joints) and rheumatoid arthritis (arthritis caused by swelling of the lining of the joints). [W564] |
| Minimum Risk Level |
Not Available |
| Health Effects |
Not Available |
| Symptoms |
Symptoms of overdose include coma, tachycardia, stupor, and vomiting. |
| Treatment |
In the event of overdosage, the stomach should be emptied by inducing vomiting or by gastric lavage, and the patient carefully observed and given symptomatic and supportive treatment. Because of the high degree of protein binding, hemodialysis may not be effective. (V650) |
| General References |
- S405 - DrugBank: a knowledgebase for drugs, drug actions and drug targets. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. [PubMed ]
- W564 - Medline Plus. Diflunisal []
|
| Targets |
- Prostaglandin G/H synthase 1
- Prostaglandin G/H synthase 2
- Transthyretin
- Serum albumin
|
|
Target 1
[top]
|
| Target 1 ID |
694 |
| Target 1 Name |
Prostaglandin G/H synthase 1 |
| Target 1 Mechanism of Action |
The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues. |
| Target 1 Description |
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells |
| Target 1 Synonyms |
- Cyclooxygenase-1; COX-1; Prostaglandin-endoperoxide synthase 1; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1
|
| Target 1 Gene Name |
PTGS1 |
| Target 1 Protein Sequence |
>Prostaglandin G/H synthase 1
MSRSLLLRFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTR
TGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRS
NLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRF
LLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQ
YQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLY
ATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKF
DPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEA
LVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQEL
VGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICS
PEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
|
| Target 1 Number of Residues |
599 |
| Target 1 Molecular Weight |
68655.8 |
| Target 1 Theoretical pI |
7.39 |
| Target 1 GO Classification |
|
Function
|
antioxidant activity
peroxidase activity |
|
Process
|
| Not Available |
|
Component
|
| Not Available |
|
| Target 1 General Function |
Involved in heme binding |
| Target 1 Pathways |
Lipid metabolism; prostaglandin biosynthesis |
| Target 1 Reactions |
Not Available |
| Target 1 Signals |
|
| Target 1 Transmembrane Regions |
|
| Target 1 Essentiality |
Non Essential |
| Target 1 Domain Function |
PF03098:An_peroxidase
PF00008:EGF |
| Target 1 GenBank ID Protein |
Not Available |
| Target 1 UniProtKB ID |
P23219 |
| Target 1 Cellular Location |
Microsome membrane |
| Target 1 Gene Sequence |
>1800 bp
ATGAGCCGGAGTCTCTTGCTCCGGTTCTTGCTGTTCCTGCTCCTGCTCCCGCCGCTCCCC
GTCCTGCTCGCGGACCCAGGGGCGCCCACGCCAGTGAATCCCTGTTGTTACTATCCATGC
CAGCACCAGGGCATCTGTGTCCGCTTCGGCCTTGACCGCTACCAGTGTGACTGCACCCGC
ACGGGCTATTCCGGCCCCAACTGCACCATCCCTGGCCTGTGGACCTGGCTCCGGAATTCA
CTGCGGCCCAGCCCCTCTTTCACCCACTTCCTGCTCACTCACGGGCGCTGGTTCTGGGAG
TTTGTCAATGCCACCTTCATCCGAGAGATGCTCATGCGCCTGGTACTCACAGTGCGCTCC
AACCTTATCCCCAGTCCCCCCACCTACAACTCAGCACATGACTACATCAGCTGGGAGTCT
TTCTCCAACGTGAGCTATTACACTCGTATTCTGCCCTCTGTGCCTAAAGATTGCCCCACA
CCCATGGGAACCAAAGGGAAGAAGCAGTTGCCAGATGCCCAGCTCCTGGCCCGCCGCTTC
CTGCTCAGGAGGAAGTTCATACCTGACCCCCAAGGCACCAACCTCATGTTTGCCTTCTTT
GCACAACACTTCACCCACCAGTTCTTCAAAACTTCTGGCAAGATGGGTCCTGGCTTCACC
AAGGCCTTGGGCCATGGGGTAGACCTCGGCCACATTTATGGAGACAATCTGGAGCGTCAG
TATCAACTGCGGCTCTTTAAGGATGGGAAACTCAAGTACCAGGTGCTGGATGGAGAAATG
TACCCGCCCTCGGTAGAAGAGGCGCCTGTGTTGATGCACTACCCCCGAGGCATCCCGCCC
CAGAGCCAGATGGCTGTGGGCCAGGAGGTGTTTGGGCTGCTTCCTGGGCTCATGCTGTAT
GCCACGCTCTGGCTACGTGAGCACAACCGTGTGTGTGACCTGCTGAAGGCTGAGCACCCC
ACCTGGGGCGATGAGCAGCTTTTCCAGACGACCCGCCTCATCCTCATAGGGGAGACCATC
AAGATTGTCATCGAGGAGTACGTGCAGCAGCTGAGTGGCTATTTCCTGCAGCTGAAATTT
GACCCAGAGCTGCTGTTCGGTGTCCAGTTCCAATACCGCAACCGCATTGCCATGGAGTTC
AACCATCTCTACCACTGGCACCCCCTCATGCCTGACTCCTTCAAGGTGGGCTCCCAGGAG
TACAGCTACGAGCAGTTCTTGTTCAACACCTCCATGTTGGTGGACTATGGGGTTGAGGCC
CTGGTGGATGCCTTCTCTCGCCAGATTGCTGGCCGGATCGGTGGGGGCAGGAACATGGAC
CACCACATCCTGCATGTGGCTGTGGATGTCATCAGGGAGTCTCGGGAGATGCGGCTGCAG
CCCTTCAATGAGTACCGCAAGAGGTTTGGCATGAAACCCTACACCTCCTTCCAGGAGCTC
GTAGGAGAGAAGGAGATGGCAGCAGAGTTGGAGGAATTGTATGGAGACATTGATGCGTTG
GAGTTCTACCCTGGACTGCTTCTTGAAAAGTGCCATCCAAACTCTATCTTTGGGGAGAGT
ATGATAGAGATTGGGGCTCCCTTTTCCCTCAAGGGTCTCCTAGGGAATCCCATCTGTTCT
CCGGAGTACTGGAAGCCGAGCACATTTGGCGGCGAGGTGGGCTTTAACATTGTCAAGACG
GCCACACTGAAGAAGCTGGTCTGCCTCAACACCAAGACCTGTCCCTACGTTTCCTTCCGT
GTGCCGGATGCCAGTCAGGATGATGGGCCTGCTGTGGAGCGACCATCCACAGAGCTCTGA
|
| Target 1 GenBank Gene ID |
Not Available |
| Target 1 GeneCard ID |
PTGS1 |
| Target 1 GenAtlas ID |
PTGS1 |
| Target 1 HGNC ID |
HGNC:9604 |
| Target 1 Chromosome Location |
Not Available |
| Target 1 Locus |
9q32-q33.3 |
| Target 1 SNPs |
SNPJam Report |
| Target 1 Toxin References |
- S405 - DrugBank: a knowledgebase for drugs, drug actions and drug targets. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. [PubMed ]
|
| Target 1 General References |
2512924; 1907252; 1734857; 1587858; 12192304; 15164053; 15489334; 15308583 |
|
Target 2
[top]
|
| Target 2 ID |
695 |
| Target 2 Name |
Prostaglandin G/H synthase 2 |
| Target 2 Mechanism of Action |
The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues. |
| Target 2 Description |
May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity |
| Target 2 Synonyms |
- Cyclooxygenase-2; COX-2; Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PGH synthase 2; PGHS-2; PHS II
|
| Target 2 Gene Name |
PTGS2 |
| Target 2 Protein Sequence |
>Prostaglandin G/H synthase 2
MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
|
| Target 2 Number of Residues |
604 |
| Target 2 Molecular Weight |
68995.6 |
| Target 2 Theoretical pI |
7.41 |
| Target 2 GO Classification |
|
Function
|
antioxidant activity
peroxidase activity |
|
Process
|
| Not Available |
|
Component
|
| Not Available |
|
| Target 2 General Function |
Involved in heme binding |
| Target 2 Pathways |
Lipid metabolism; prostaglandin biosynthesis |
| Target 2 Reactions |
Not Available |
| Target 2 Signals |
|
| Target 2 Transmembrane Regions |
|
| Target 2 Essentiality |
Non Essential |
| Target 2 Domain Function |
PF03098:An_peroxidase
PF00008:EGF |
| Target 2 GenBank ID Protein |
Not Available |
| Target 2 UniProtKB ID |
P35354 |
| Target 2 Cellular Location |
Microsome membrane |
| Target 2 Gene Sequence |
>1815 bp
ATGCTCGCCCGCGCCCTGCTGCTGTGCGCGGTCCTGGCGCTCAGCCATACAGCAAATCCT
TGCTGTTCCCACCCATGTCAAAACCGAGGTGTATGTATGAGTGTGGGATTTGACCAGTAT
AAGTGCGATTGTACCCGGACAGGATTCTATGGAGAAAACTGCTCAACACCGGAATTTTTG
ACAAGAATAAAATTATTTCTGAAACCCACTCCAAACACAGTGCACTACATACTTACCCAC
TTCAAGGGATTTTGGAACGTTGTGAATAACATTCCCTTCCTTCGAAATGCAATTATGAGT
TATGTGTTGACATCCAGATCACATTTGATTGACAGTCCACCAACTTACAATGCTGACTAT
GGCTACAAAAGCTGGGAAGCCTTCTCTAACCTCTCCTATTATACTAGAGCCCTTCCTCCT
GTGCCTGATGATTGCCCGACTCCCTTGGGTGTCAAAGGTAAAAAGCAGCTTCCTGATTCA
AATGAGATTGTGGAAAAATTGCTTCTAAGAAGAAAGTTCATCCCTGATCCCCAGGGCTCA
AACATGATGTTTGCATTCTTTGCCCAGCACTTCACGCATCAGTTTTTCAAGACAGATCAT
AAGCGAGGGCCAGCTTTCACCAACGGGCTGGGCCATGGGGTGGACTTAAATCATATTTAC
GGTGAAACTCTGGCTAGACAGCGTAAACTGCGCCTTTTCAAGGATGGAAAAATGAAATAT
CAGATAATTGATGGAGAGATGTATCCTCCCACAGTCAAAGATACTCAGGCAGAGATGATC
TACCCTCCTCAAGTCCCTGAGCATCTACGGTTTGCTGTGGGGCAGGAGGTCTTTGGTCTG
GTGCCTGGTCTGATGATGTATGCCACAATCTGGCTGCGGGAACACAACAGAGTATGCGAT
GTGCTTAAACAGGAGCATCCTGAATGGGGTGATGAGCAGTTGTTCCAGACAAGCAGGCTA
ATACTGATAGGAGAGACTATTAAGATTGTGATTGAAGATTATGTGCAACACTTGAGTGGC
TATCACTTCAAACTGAAATTTGACCCAGAACTACTTTTCAACAAACAATTCCAGTACCAA
AATCGTATTGCTGCTGAATTTAACACCCTCTATCACTGGCATCCCCTTCTGCCTGACACC
TTTCAAATTCATGACCAGAAATACAACTATCAACAGTTTATCTACAACAACTCTATATTG
CTGGAACATGGAATTACCCAGTTTGTTGAATCATTCACCAGGCAAATTGCTGGCAGGGTT
GCTGGTGGTAGGAATGTTCCACCCGCAGTACAGAAAGTATCACAGGCTTCCACTGACCAG
AGCAGGCAGATGAAATACCAGTCTTTTAATGAGTACCGCAAACGCTTTATGCTGAAGCCC
TATGAATCATTTGAAGAACTTACAGGAGAAAAGGAAATGTCTGCAGAGTTGGAAGCACTC
TATGGTGACATCGATGCTGTGGAGCTGTATCCTGCCCTTCTGGTAGAAAAGCCTCGGCCA
GATGCCATCTTTGGTGAAACCATGGTAGAAGTTGGAGCACCATTCTCCTTGAAAGGACTT
ATGGGTAATGTTATATGTTCTCCTGCCTACTGGAAGCCAAGCACTTTTGGTGGAGAAGTG
GGTTTTCAAATCATCAACACTGCCTCAATTCAGTCTCTCATCTGCAATAACGTGAAGGGC
TGTCCCTTTACTTCATTCAGTGTTCCAGATCCAGAGCTCATTAAAACAGTCACCATCAAT
GCAAGTTCTTCCCGCTCCGGACTAGATGATATCAATCCCACAGTACTACTAAAAGAACGT
TCGACTGAACTGTAG
|
| Target 2 GenBank Gene ID |
Not Available |
| Target 2 GeneCard ID |
PTGS2 |
| Target 2 GenAtlas ID |
PTGS2 |
| Target 2 HGNC ID |
HGNC:9605 |
| Target 2 Chromosome Location |
Not Available |
| Target 2 Locus |
1q25.2-q25.3 |
| Target 2 SNPs |
SNPJam Report |
| Target 2 Toxin References |
- S405 - DrugBank: a knowledgebase for drugs, drug actions and drug targets. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. [PubMed ]
|
| Target 2 General References |
8473346; 1380156; 8181472; 7945196; 16710414; 15489334; 7947975 |
|
Target 3
[top]
|
| Target 3 ID |
365 |
| Target 3 Name |
Transthyretin |
| Target 3 Mechanism of Action |
The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues. |
| Target 3 Description |
Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain |
| Target 3 Synonyms |
- Prealbumin; TBPA; TTR; ATTR
|
| Target 3 Gene Name |
TTR |
| Target 3 Protein Sequence |
>Transthyretin
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
|
| Target 3 Number of Residues |
147 |
| Target 3 Molecular Weight |
15886.9 |
| Target 3 Theoretical pI |
5.58 |
| Target 3 GO Classification |
|
Function
|
binding
steroid binding
transporter activity
carrier activity |
|
Process
|
physiological process
cellular physiological process
transport |
|
Component
|
| Not Available |
|
| Target 3 General Function |
Involved in hormone activity |
| Target 3 Pathways |
Not Available |
| Target 3 Reactions |
Not Available |
| Target 3 Signals |
|
| Target 3 Transmembrane Regions |
|
| Target 3 Essentiality |
Non Essential |
| Target 3 Domain Function |
PF00576:Transthyretin |
| Target 3 GenBank ID Protein |
Not Available |
| Target 3 UniProtKB ID |
P02766 |
| Target 3 Cellular Location |
Secreted. Cytoplasm |
| Target 3 Gene Sequence |
>444 bp
OSOMEQ.-Q..ACAGAAGTCCACTCATTCTTGGCAGGATGGCTTCTCATCGTCTGCTCCT
CCTCTGCCTTGCTGGACTGGTATTTGTGTCTGAGGCTGGCCCTACGGGCACCGGTGAATC
CAAGTGTCCTCTGATGGTCAAAGTTCTAGATGCTGTCCGAGGCAGTCCTGCCATCAATGT
GGCCGTGCATGTGTTCAGAAAGGCTGCTGATGACACCTGGGAGCCATTTGCCTCTGGGAA
AACCAGTGAGTCTGGAGAGCTGCATGGGCTCACAACTGAGGAGGAATTTGTAGAAGGGAT
ATACAAAGTGGAAATAGACACCAAATCTTACTGGAAGGCACTTGGCATCTCCCCATTCCA
TGAGCATGCAGAGGTGGTATTCACAGCCAACGACTCCGGCCCCCGCCGCTACACCATTGC
CGCCCTGCTGAGCCCCTACTCCTA
|
| Target 3 GenBank Gene ID |
Not Available |
| Target 3 GeneCard ID |
TTR |
| Target 3 GenAtlas ID |
TTR |
| Target 3 HGNC ID |
HGNC:12405 |
| Target 3 Chromosome Location |
Chromosome:18 |
| Target 3 Locus |
18q12.1 |
| Target 3 SNPs |
SNPJam Report |
| Target 3 Toxin References |
- S405 - DrugBank: a knowledgebase for drugs, drug actions and drug targets. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. [PubMed ]
|
| Target 3 General References |
6093805; 2990465; 4054629; 2995367; 3818577; 3022108; 2015890; 1666289; 10328977; 14702039 |
|
Target 4
[top]
|
| Target 4 ID |
250 |
| Target 4 Name |
Serum albumin |
| Target 4 Mechanism of Action |
The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues. |
| Target 4 Description |
Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood |
| Target 4 Synonyms |
Not Available |
| Target 4 Gene Name |
ALB |
| Target 4 Protein Sequence |
>Serum albumin
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPF
EDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEP
ERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLF
FAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAV
ARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLK
ECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYAR
RHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFE
QLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVV
LNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTL
SEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLV
AASQAALGL
|
| Target 4 Number of Residues |
609 |
| Target 4 Molecular Weight |
69365.9 |
| Target 4 Theoretical pI |
6.21 |
| Target 4 GO Classification |
|
Function
|
transporter activity
carrier activity |
|
Process
|
physiological process
cellular physiological process
transport |
|
Component
|
extracellular region
extracellular space |
|
| Target 4 General Function |
Involved in antioxidant activity |
| Target 4 Pathways |
REACT_604-Hemostasis; |
| Target 4 Reactions |
Not Available |
| Target 4 Signals |
|
| Target 4 Transmembrane Regions |
|
| Target 4 Essentiality |
Non Essential |
| Target 4 Domain Function |
PF00273:Serum_albumin |
| Target 4 GenBank ID Protein |
Not Available |
| Target 4 UniProtKB ID |
P02768 |
| Target 4 Cellular Location |
Secreted |
| Target 4 Gene Sequence |
>1830 bp
ATGAAGTGGGTAACCTTTATTTCCCTTCTTTTTCTCTTTAGCTCGGCTTATTCCAGGGGT
GTGTTTCGTCGAGATGCACACAAGAGTGAGGTTGCTCATCGGTTTAAAGATTTGGGAGAA
GAAAATTTCAAAGCCTTGGTGTTGATTGCCTTTGCTCAGTATCTTCAGCAGTGTCCATTT
GAAGATCATGTAAAATTAGTGAATGAAGTAACTGAATTTGCAAAAACATGTGTTGCTGAT
GAGTCAGCTGAAAATTGTGACAAATCACTTCATACCCTTTTTGGAGACAAATTATGCACA
GTTGCAACTCTTCGTGAAACCTATGGTGAAATGGCTGACTGCTGTGCAAAACAAGAACCT
GGGAGAAATGAATGCTTCTTGCAACACAAAGATGACAACCCAAACCTCCCCCGATTGGTG
AGACCAGAGGTTGATGTGATGTGCACTGCTTTTCATGACAATGAAGAGACATTTTTGAAA
AAATACTTATATGAAATTGCCAGAAGACATCCTTACTTTTATGCCCCGGAACTCCTTTTC
TTTGCTAAAAGGTATAAAGCTGCTTTTACAGAATGTTGCCAAGCTGCTGATAAAGCTGCC
TGCCTGTTGCCAAAGCTCGATGAACTTCGGGATGAAGGGAAGGCTTCGTCTGCCAAACAG
AGACTCAAGTGTGCCAGTCTCCAAAAATTTGGAGAAAGAGCTTTCAAAGCATGGGCAGTA
GCTCGCCTGAGCCAGAGATTTCCCAAAGCTGAGTTTGCAGAAGTTTCCAAGTTAGTGACA
GATCTTACCAAAGTCCACACGGAATGCTGCCATGGAGATCTGCTTGAATGTGCTGATGAC
AGGGCGGACCTTGCCAAGTATATCTGTGAAAATCAAGATTCGATCTCCAGTAAACTGAAG
GAATGCTGTGAAAAACCTCTGTTGGAAAAATCCCACTGCATTGCCGAAGTGGAAAATGAT
GAGATGCCTGCTGACTTGCCTTCATTAGCTGCTGATTTTGTTGAAAGTAAGGATGTTTGC
AAAAACTATGCTGAGGCAAAGGATGTCTTCTTGGGCATGTTTTTGTATGAATATGCAAGA
AGGCATCCTGATTACTCTGTCGTGCTGCTGCTGAGACTTGCCAAGACATATGAAACCACT
CTAGAGAAGTGCTGTGCCGCTGCAGATCCTCATGAATGCTATGCCAAAGTGTTCGATGAA
TTTAAACCTCTTGTGGAAGAGCCTCAGAATTTAATCAAACAAAATTGTGAGCTTTTTGAG
CAGCTTGGAGAGTACAAATTCCAGAATGCGCTGTTAGTTCGTTACACCAAGAAAGTACCC
GAAGTGTCAACTCCAACTCTTGTAGAGGTCTCAAGAAACCTAGGAAAAGTGGGCAGCAAA
TGTTGTAAACATCCTGAAGCAAAAAGAATGCCCTGTGCAGAAGACTATCTATCCGTGGTC
CTGAACCAGTTATGTGTGTTGCATGAGAAAACGCCAGTAAGTGACAGAGTCACCAAATGC
TGCACAGAATCCTTGGTGAACAGGCGACCATGCTTTTCAGCTCTGGAAGTCGATGAAACA
TACGTTCCCAAAGAGTTTAATGCTGAAACATTCACCTTCCATGCAGATATATGCACACTT
TCTGAGAAGGAGAGACAAATCAAGAAACAAACTGCACTTGTTGAGCTCGTGAAACACAAG
CCCAAGGCAACAAAAGAGCAACTGAAAGCTGTTATGGATGATTTCGCTGCTTTTGTAGAG
AAGTGCTGCAAGGCTGACGATAAGGAGACCTGCTTTGCCGAGGAGGGTAAAAAACTTGTT
GCTGCAAGTCAAGCTGCCTTAGGCTTATAA
|
| Target 4 GenBank Gene ID |
Not Available |
| Target 4 GeneCard ID |
ALB |
| Target 4 GenAtlas ID |
ALB |
| Target 4 HGNC ID |
HGNC:399 |
| Target 4 Chromosome Location |
Not Available |
| Target 4 Locus |
4q11-q13 |
| Target 4 SNPs |
SNPJam Report |
| Target 4 Toxin References |
- S405 - DrugBank: a knowledgebase for drugs, drug actions and drug targets. Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M. Nucleic Acids Res. 2008 Jan;36(Database issue):D901-6. [PubMed ]
|
| Target 4 General References |
6171778; 6275391; 3009475; 11483580 |
