Showing toxin card for Mitomycin (T3D2743)
Legend:
toxin field
target field
| Version |
1.0 |
| Creation Date |
2009-07-21 20:26:32 |
| Update Date |
2010-03-18 21:58:00 |
| Accession Number |
T3D2743 |
| Name |
Mitomycin |
| Compound Type |
- Alkylating Agent
- Antibiotic, Antineoplastic
- Cross-Linking Reagent
- Drug
- Nucleic Acid Synthesis Inhibitor
|
| Description |
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional alkylating agents causing cross-linking of DNA and inhibition of DNA synthesis. [PubChem] |
| Synonyms |
- 7-Amino-9&alpha
- -methoxymitosane
- Mitamycin
- MMC
|
| Chemical IUPAC Name |
{11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.0^{2,7}.0^{4,6}]trideca-1(9),11-dien-8-yl}methyl carbamate |
| Chemical Formula |
C15H18N4O5 |
| Chemical Structure |
 |
| CAS Registry Number |
50-07-7 |
| InChI Identifier |
InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22) |
| InChI Key |
InChIKey=NWIBSHFKIJFRCO-UHFFFAOYSA-N |
| PubChem Compound ID |
5746  |
| KEGG ID |
C06681 |
| UniProt ID |
Not Available |
| OMIM ID |
Not Available |
| ChEBI ID |
27504 |
| BioCyc ID |
Not Available |
| SuperToxic ID |
Not Available |
| CTD ID |
Not Available |
| Stitch ID |
Mitomycin |
| DrugBank ID |
DB00305 |
| PDB ID |
Not Available |
| ACToR ID |
Not Available |
| Wikipedia Link |
http://en.wikipedia.org/wiki/Mitomycin |
| Monoisotopic Mass |
334.12772 |
| MOL File |
Show |
| PDB File |
Show |
| SDF File |
Show |
| SMILES |
COC12C3NC3CN1C1=C(C2COC(N)=O)C(=O)C(N)=C(C)C1=O |
| Appearance |
Not Available |
| Melting Point |
> 360 oC |
| Solubility |
Soluble (8430 mg/L) |
| Predicted LogP |
-1.0465 |
| Route of Exposure |
Intravesical |
| Mechanism of Action |
Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. |
| Metabolism |
Primarily hepatic, some in various other tissues. |
| Toxicity Values |
LD50: 23 mg/kg (Oral, Mouse) (S405)
LD50: 30 mg/kg (Oral, Rat) (S405) |
| Lethal Dose |
Not Available |
| Carcinogenicity (IARC Classification) |
Not Available |
| Uses/Sources |
Not Available |
| Minimum Risk Level |
Not Available |
| Health Effects |
Not Available |
| Symptoms |
Not Available |
| Treatment |
Not Available |
| General References |
|
| Targets |
- DNA
|
|
Target 1
[top]
|
| Target 1 ID |
632 |
| Target 1 Name |
DNA |
| Target 1 Mechanism of Action |
Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. |
| Target 1 Description |
Not Available |
| Target 1 Synonyms |
Not Available |
| Target 1 Gene Name |
Not Available |
| Target 1 Protein Sequence |
Not Available |
| Target 1 Number of Residues |
Not Available |
| Target 1 Molecular Weight |
Not Available |
| Target 1 Theoretical pI |
Not Available |
| Target 1 GO Classification |
|
Function
|
| Not Available |
|
Process
|
| Not Available |
|
Component
|
| Not Available |
|
| Target 1 General Function |
Not Available |
| Target 1 Pathways |
Not Available |
| Target 1 Reactions |
Not Available |
| Target 1 Signals |
Not Available |
| Target 1 Transmembrane Regions |
Not Available |
| Target 1 Essentiality |
Not Available |
| Target 1 Domain Function |
Not Available |
| Target 1 GenBank ID Protein |
Not Available |
| Target 1 UniProtKB ID |
DNA |
| Target 1 Cellular Location |
Not Available |
| Target 1 Gene Sequence |
Not Available |
| Target 1 GenBank Gene ID |
Not Available |
| Target 1 GeneCard ID |
Not Available |
| Target 1 GenAtlas ID |
Not Available |
| Target 1 HGNC ID |
Not Available |
| Target 1 Chromosome Location |
Not Available |
| Target 1 Locus |
Not Available |
| Target 1 SNPs |
Not Available |
| Target 1 Toxin References |
- S912 - Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed ]
- S911 - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed ]
|
| Target 1 General References |
Not Available |
