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Showing toxin card for Antimony acetate (T3D1905)

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Version 1.0
Creation Date 2009-06-23 21:03:15
Update Date 2010-03-18 21:55:09
Accession Number T3D1905
Name Antimony acetate
Compound Type
  • Antimony Compound
  • Organic Compound
  • Organometallic
Description Antimony acetate is a chemical compound of antimony. It is a moderately water soluble crystalline antimony source that decomposes to antimony oxide on heating. It is generally immediately available in most volumes. Antimony is a metallic element with the chemical symbol Sb and atomic number 51. Small amounts of antimony are found in the earth's crust. (R1131, S074)
Synonyms
  1. Acetic Acid, antimony salt
  2. Acetic Acid, antimony(3+) salt
  3. Acetic Acid, trianhydride with antimonic Acid (H3SbO3)
  4. Antimony(III) acetate
  5. Octan antimonity [czech]
  6. antimony(3+) triacetate
Chemical IUPAC Name antimony(3+) ion tris(acetate)
Chemical Formula C6H9O6Sb
Chemical Structure Structure
CAS Registry Number 3643-76-3
InChI Identifier InChI=1S/3C2H4O2.Sb/c3*1-2(3)4;/h3*1H3,(H,3,4);/q;;;+3/p-3
InChI Key InChIKey=JVLRYPRBKSMEBF-UHFFFAOYSA-K
PubChem Compound ID 23354 Link Image
KEGG ID Not Available
UniProt ID Not Available
OMIM ID Not Available
ChEBI ID Not Available
BioCyc ID Not Available
SuperToxic ID Not Available
CTD ID Not Available
Stitch ID Antimony acetate Link Image
DrugBank ID Not Available
PDB ID Not Available
ACToR ID Not Available
Wikipedia Link Not Available
Monoisotopic Mass 297.943731
MOL File Show
PDB File Show
SDF File Show
SMILES [Sb+3].CC([O-])=O.CC([O-])=O.CC([O-])=O
Appearance Not Available
Melting Point 127 °C (400 K)
Solubility Not Available
Predicted LogP -0.2233
Route of Exposure Inhalation (R1131) ; oral (R1131) ; dermal (R1131)
Mechanism of Action The inhalation data suggests that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes of the glycogenolysis and gluconeogenesis pathways. The mechanism of action of antimony remains unclear. However, some studies suggest that antimony combines with sulfhydryl groups including those in several enzymes important for tissue respiration. The antidotal action of BAL depends on its ability to prevent or break the union between antimony and vital enzymes. Moreover, the The cause of death is believed to be essentially the same as that in acute arsenic poisoning. (R276, R1131, S004)
Metabolism Antimony is widely distributed throughout the body. The hair and skin contain the highest levels of antimony. The adrenal glands, lung, large intestine, trachea, cerebellum, and kidneys also contain relatively high levels of antimony. Blood is the main vehicle for the transport of absorbed antimony to various tissue compartments of the body. Antimony is a metal and, therefore, does not undergo catabolism. Antimony can covalently interact with sulfhydryl groups and phosphate, as well as numerous reversible binding interactions with endogenous ligands (e.g., proteins). It is not known if these interactions are toxicologically significant. Antimony is excreted via the urine and feces. Some of the fecal antimony may represent unabsorbed antimony that is cleared from the lung via mucociliary action into the esophagus to the gastrointestinal tract. (R1131)
Toxicity Values Not Available
Lethal Dose Not Available
Carcinogenicity (IARC Classification) 2B, possibly carcinogenic to humans. (R264)
Uses/Sources Breathing air, drinking water, and eating foods that contain antimony. Exposure can also occur through dermal or skin contact (R1131).
Minimum Risk Level Not Available
Health Effects Dermal exposure to antimony can cause antimony spots (papules and pustules around sweat and sebaceous glands). Antimony poisoning can also lead to pneumoconiosis. Alterations in pulmonary function and other effects including chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural adhesions, and irritation can result from inhalation of antimony. Increased blood pressure can also result from antimony poisoning. Myocardial depression, vasodilation and fluid loss may cause shock with hypotension, electrolyte disturbances and acute renal failure. Cerebral oedema, coma, convulsions, and death are possible. (R1131)
Symptoms Abdominal pain, vomiting, diarrhea can result from inhalation of antimony. Dyspnea, headache, vomiting,cough, conjunctivitis, and bloody purulent discharge from nose can result from inhalation exposure. Skin or eye contact can cause pain and redness of the exposed surface. (R692, R1131)
Treatment Following oral exposure to antimony, administer charcoal as a slurry (240 mL water/30 g charcoal). Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Following dermal exposure, Remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. (R383)
General References
  • R1131 - ATSDR - Agency for Toxic Substances and Disease Registry (1992). Toxicological profile for antimony. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
  • S004 - Poon R, Chu I, Lecavalier P, Valli VE, Foster W, Gupta S, Thomas B: Effects of antimony on rats following 90-day exposure via drinking water. Food Chem Toxicol. 1998 Jan;36(1):21-35. [PubMed Link Image]
  • R383 - Rumack BH (2009). POISINDEX(R) Information System. Englewood, CO: Micromedex, Inc. CCIS Volume 141, edition expires Aug, 2009.
  • R692 - Hamilton A and Hardy HL (1974). Industrial Toxicology. 3rd ed. Acton, MA: Publishing Sciences Group, Inc.
  • R276 - Hayes WJ Jr. and Laws ER Jr. (eds) (1991). Handbook of Pesticide Toxicology. Volume 3. Classes of Pesticides. New York, NY: Academic Press, Inc.
  • S074 - ATSDR - Agency for Toxic Substances and Disease Registry (1990). Toxicological profile for silver. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Targets
  1. Glutathione S-transferase A1
  2. Glutathione S-transferase A2
  3. Glutathione S-transferase A3
  4. Glutathione S-transferase Mu 4
  5. Glutathione S-transferase A5
  6. Glutathione S-transferase kappa 1
  7. Glutathione S-transferase Mu 1
  8. Glutathione S-transferase Mu 2
  9. Glutathione S-transferase Mu 3
  10. Glutathione S-transferase Mu 5
  11. Glutathione S-transferase omega-1
  12. Glutathione S-transferase omega-2
  13. Glutathione S-transferase P
  14. Glutathione S-transferase theta-1
  15. Glutathione S-transferase theta-2
  16. Glutathione S-transferase theta-4
  17. Microsomal glutathione S-transferase 1
  18. Microsomal glutathione S-transferase 2
  19. Microsomal glutathione S-transferase 3
  20. Maleylacetoacetate isomerase
Target 1 [top]
Target 1 ID 750
Target 1 Name Glutathione S-transferase A1
Target 1 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 1 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 1 Synonyms
  1. GTH1; HA subunit 1; GST-epsilon; GSTA1-1; GST class-alpha member 1
Target 1 Gene Name GSTA1
Target 1 Protein Sequence >Glutathione S-transferase A1 
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAK
LALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
Target 1 Number of Residues 222
Target 1 Molecular Weight 25630.8
Target 1 Theoretical pI 9.34
Target 1 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 1 General Function Involved in glutathione transferase activity
Target 1 Pathways Not Available
Target 1 Reactions Not Available
Target 1 Signals
  • None
Target 1 Transmembrane Regions
  • None
Target 1 Essentiality Non Essential
Target 1 Domain Function PF00043:GST_C PF02798:GST_N
Target 1 GenBank ID Protein Not Available
Target 1 UniProtKB ID P08263 Link Image
Target 1 Cellular Location Cytoplasm
Target 1 Gene Sequence >669 bp 
TAACAAAGCTTAGAGAAACCTCCAGGAGACTGCTATCATGGCAGAGAAGCCCAAGCTCCA
CTACTTCAATGCACGGGGCAGAATGGAGTCCACCCGGTGGCTCCTGGCTGCAGCTGGAGT
AGAGTTTGAAGAGAAATTTATAAAATCTGCAGAAGATTTGGACAAGTTAAGAAATGATGG
ATATTTGATGTTCCAGCAAGTGCCAATGGTTGAGATTGATGGGATGAAGCTGGTGCAGAC
CAGAGCCATTCTCAACTACATTGCCAGCAAATACAACCTCTATGGGAAAGACATAAAGGA
GAGAGCCCTGATTGATATGTATATAGAAGGTATAGCAGATTTGGGTGAAATGATCCTCCT
TCTGCCCGTATGTCCACCTGAGGAAAAAGATGCCAAGCTTGCCTTGATCAAGGAGAAAAT
AAAAAATCGCTACTTCCCTGCCTTTGAAAAAGTCTTAAAGAGCCATGGACAAGACTACCT
TGTTGGCAACAAGCTGAGCCGGGCTGACATTCATCTGGTGGAACTTCTCTACTACGTCGA
GGAGCTTGACTCCAGTCTTATCTCCAGCTTCCCTCTGCTGAAGGCCCTGAAAACCAGAAT
CAGCAACCTGCCCACAGTGAAGAAGTTTCTACAGCCTGGCAGCCCAAGGAAGCCTCCCAT
GGATGAGAA
Target 1 GenBank Gene ID Not Available
Target 1 GeneCard ID GSTA1 Link Image
Target 1 GenAtlas ID GSTA1 Link Image
Target 1 HGNC ID HGNC:4626 Link Image
Target 1 Chromosome Location Not Available
Target 1 Locus 6p12.1
Target 1 SNPs SNPJam Report Link Image
Target 1 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 1 General References 3800996; 3036131; 3678589; 3031680; 1731620; 1330133; 15489334; 3138230; 8431482; 2604726
Target 2 [top]
Target 2 ID 752
Target 2 Name Glutathione S-transferase A2
Target 2 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 2 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 2 Synonyms
  1. GTH2; HA subunit 2; GST-gamma; GSTA2-2; GST class-alpha member 2
Target 2 Gene Name GSTA2
Target 2 Protein Sequence >Glutathione S-transferase A2 
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF
Target 2 Number of Residues 222
Target 2 Molecular Weight 25663.7
Target 2 Theoretical pI 9.07
Target 2 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 2 General Function Involved in glutathione transferase activity
Target 2 Pathways Not Available
Target 2 Reactions Not Available
Target 2 Signals
  • None
Target 2 Transmembrane Regions
  • None
Target 2 Essentiality Non Essential
Target 2 Domain Function PF00043:GST_C PF02798:GST_N
Target 2 GenBank ID Protein Not Available
Target 2 UniProtKB ID P09210 Link Image
Target 2 Cellular Location Cytoplasm
Target 2 Gene Sequence >669 bp 
AGAAACCTCCAGGAGACTGCTACCATGGCAGAGAAGCCCAAGCTCCACTACTCCAATATA
CGGGGCAGAATGGAGTCCATCCGGTGGCTCCTGGCTGCAGCTGGAGTAGAGTTTGAAGAG
AAATTTATAAAATCTGCAGAAGATTTGGACAAGTTAAGAAATGATGGATATTTGATGTTC
CAGCAAGTGCCAATGGTTGAGATTGATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTC
AACTACATTGCCAGCAAATACAACCTCTATGGGAAAGACATAAAGGAGAAAGCCCTGATT
GATATGTATATAGAAGGTATAGCAGATTTGGGTGAAATGATCCTTCTTCTGCCCTTTACT
CAACCTGAGGAACAAGATGCCAAGCTTGCCTTGATCCAAGAGAAAACAAAAAATCGCTAC
TTCCCTGCCTTTGAAAAAGTCTTAAAGAGCCACGGACAAGACTACCTTGTTGGCAACAAG
CTGAGCCGGGCTGACATTCACCTGGTGGAACTTCTCTACTACGTGGAAGAGCTTGACTCT
AGCCTTATTTCCAGCTTCCCTCTGCTGAAGGCCCTGAAAACCAGAATCAGTAACCTGCCC
ACAGTGAAGAAGTTTCTACAGCCTGGCAGCCCAAGGAAGCCTCCCATGGATGAGAAATCT
TTAGAAGAA
Target 2 GenBank Gene ID Not Available
Target 2 GeneCard ID GSTA2 Link Image
Target 2 GenAtlas ID GSTA2 Link Image
Target 2 HGNC ID HGNC:4627 Link Image
Target 2 Chromosome Location Not Available
Target 2 Locus 6p12.1
Target 2 SNPs SNPJam Report Link Image
Target 2 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 2 General References 3036131; 1329668; 1497629; 14574404; 15489334; 8431482; 2604726; 7892174; 11668220
Target 3 [top]
Target 3 ID 751
Target 3 Name Glutathione S-transferase A3
Target 3 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 3 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively
Target 3 Synonyms
  1. Glutathione S-transferase A3-3; GST class-alpha member 3
Target 3 Gene Name GSTA3
Target 3 Protein Sequence >Glutathione S-transferase A3 
MAGKPKLHYFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGKLRNDGSLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAK
IALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPL
LKALKTRISNLPTVKKFLQPGSPRKPPADAKALEEARKIFRF
Target 3 Number of Residues 222
Target 3 Molecular Weight 25301.4
Target 3 Theoretical pI 9.69
Target 3 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 3 General Function Involved in glutathione transferase activity
Target 3 Pathways Not Available
Target 3 Reactions Not Available
Target 3 Signals
  • None
Target 3 Transmembrane Regions
  • None
Target 3 Essentiality Non Essential
Target 3 Domain Function PF00043:GST_C PF02798:GST_N
Target 3 GenBank ID Protein Not Available
Target 3 UniProtKB ID Q16772 Link Image
Target 3 Cellular Location Cytoplasm
Target 3 Gene Sequence >669 bp 
ATGGCAGGGAAGCCCAAGCTTCACTACTTCAATGGACGGGGCAGAATGGAGCCCATCCGG
TGGCTCTTGGCTGCAGCTGGAGTGGAGTTTGAAGAGAAATTTATAGGATCTGCAGAAGAT
TTGGGAAAGTTAAGAAATGATGGGAGTTTGATGTTCCAGCAAGTACCAATGGTTGAGATT
GATGGGATGAAGTTGGTACAGACCAGAGCCATTCTCAACTACATTGCCAGCAAATACAAC
CTCTACGGGAAAGACATAAAGGAGAGAGCCCTAATTGATATGTATACAGAAGGTATGGCA
GATTTGAATGAAATGATCCTTCTTCTGCCCTTATGTCGACCTGAGGAAAAAGATGCCAAG
ATTGCCTTGATCAAAGAGAAAACAAAAAGTCGCTATTTCCCTGCCTTCGAAAAAGTGTTA
CAGAGCCATGGACAAGACTACCTTGTTGGCAACAAGCTGAGCCGGGCTGACATTAGCCTG
GTGGAACTTCTCTACTATGTGGAAGAGCTTGACTCCAGCCTTATCTCCAACTTCCCTCTG
CTGAAGGCCCTGAAAACCAGAATCAGCAACCTGCCCACGGTGAAGAAGTTTCTACAGCCT
GGCAGCCCAAGGAAGCCTCCCGCAGATGCAAAAGCTTTAGAAGAAGCCAGAAAGATTTTC
AGGTTTTAA
Target 3 GenBank Gene ID Not Available
Target 3 GeneCard ID GSTA3 Link Image
Target 3 GenAtlas ID GSTA3 Link Image
Target 3 HGNC ID HGNC:4628 Link Image
Target 3 Chromosome Location Not Available
Target 3 Locus 6p12.1
Target 3 SNPs SNPJam Report Link Image
Target 3 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 3 General References 8307579; 11418619; 14574404; 15489334; 9480897
Target 4 [top]
Target 4 ID 749
Target 4 Name Glutathione S-transferase Mu 4
Target 4 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 4 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1- chloro-2,4-dinitrobenzene
Target 4 Synonyms
  1. GSTM4-4; GST class-mu 4; GTS-Mu2
Target 4 Gene Name GSTM4
Target 4 Protein Sequence >Glutathione S-transferase Mu 4 
MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDF
EKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK
Target 4 Number of Residues 218
Target 4 Molecular Weight 25561.1
Target 4 Theoretical pI 5.69
Target 4 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 4 General Function Involved in glutathione transferase activity
Target 4 Pathways Not Available
Target 4 Reactions Not Available
Target 4 Signals
  • None
Target 4 Transmembrane Regions
  • None
Target 4 Essentiality Non Essential
Target 4 Domain Function PF00043:GST_C PF02798:GST_N
Target 4 GenBank ID Protein Not Available
Target 4 UniProtKB ID Q03013 Link Image
Target 4 Cellular Location Cytoplasm
Target 4 Gene Sequence >657 bp 
ATGTCCATGACACTGGGGTACTGGGACATCCGCGGGCTGGCCCACGCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTACGAGGAAAAGAAGTATACGATGGGGGACGCTCCTGAC
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTAGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAACGCCATCCTGTGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGGCTATGGACGTCTCCAATCAGCTGGCCAGAGTCTGCTACAGCCCTGACTTT
GAGAAACTGAAGCCAGAATACTTGGAGGAACTTCCTACAATGATGCAGCACTTCTCACAG
TTCCTGGGGAAGAGGCCATGGTTTGTTGGAGACAAGATCACCTTTGTAGATTTCCTCGCC
TATGATGTCCTTGACCTCCACCGTATATTTGAGCCCAACTGCTTGGACGCCTTTCCAAAT
CTGAAGGACTTCATCTCCCGCTTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAAACCTCTGTACACAAGGGTGGCTGTCTGGGGCAACAAGTAA
Target 4 GenBank Gene ID Not Available
Target 4 GeneCard ID GSTM4 Link Image
Target 4 GenAtlas ID GSTM4 Link Image
Target 4 HGNC ID HGNC:4636 Link Image
Target 4 Chromosome Location Not Available
Target 4 Locus 1p13.3
Target 4 SNPs SNPJam Report Link Image
Target 4 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 4 General References 8349586; 8471052; 8373352; 15489334; 2006920; 8203914; 10587441
Target 5 [top]
Target 5 ID 759
Target 5 Name Glutathione S-transferase A5
Target 5 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 5 Description RX + glutathione = HX + R-S-glutathione
Target 5 Synonyms
  1. Glutathione S-transferase A5-5; GST class-alpha member 5
Target 5 Gene Name GSTA5
Target 5 Protein Sequence >Glutathione S-transferase A5 
MAEKPKLHYSNARGSMESIRWLLAAAGVELEEKFLESAEDLDKLRNDGSLLFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDMKERALIDMYTEGIVDLTEMILLLLICQPEERDAK
TALVKEKIKNRYFPAFEKVLKSHRQDYLVGNKLSWADIHLVELFYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSQRKPPMDEKSLEEARKIFRF
Target 5 Number of Residues 222
Target 5 Molecular Weight 25721.7
Target 5 Theoretical pI 8.37
Target 5 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 5 General Function Involved in glutathione transferase activity
Target 5 Pathways Not Available
Target 5 Reactions Not Available
Target 5 Signals
  • None
Target 5 Transmembrane Regions
  • None
Target 5 Essentiality Non Essential
Target 5 Domain Function PF00043:GST_C PF02798:GST_N
Target 5 GenBank ID Protein Not Available
Target 5 UniProtKB ID Q7RTV2 Link Image
Target 5 Cellular Location Cytoplasm (By similarity)
Target 5 Gene Sequence Not Available
Target 5 GenBank Gene ID Not Available
Target 5 GeneCard ID GSTA5 Link Image
Target 5 GenAtlas ID GSTA5 Link Image
Target 5 HGNC ID HGNC:19662 Link Image
Target 5 Chromosome Location Not Available
Target 5 Locus 6p12.1
Target 5 SNPs SNPJam Report Link Image
Target 5 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 5 General References 14574404; 12042665
Target 6 [top]
Target 6 ID 754
Target 6 Name Glutathione S-transferase kappa 1
Target 6 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 6 Description Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB)
Target 6 Synonyms
  1. Glutathione S-transferase subunit 13; GST 13-13; GST class-kappa; GSTK1-1; hGSTK1
Target 6 Gene Name GSTK1
Target 6 Protein Sequence >Glutathione S-transferase kappa 1 
MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLITGIMKDSGNKPPGLLP
RKGLYMANDLKLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRFLTAVNLEHPEMLEKASRE
LWMRVWSRNEDITEPQSILAAAEKAGMSAEQAQGLLEKIATPKVKNQLKETTEAACRYGA
FGLPITVAHVDGQTHMLFGSDRMELLAHLLGEKWMGPIPPAVNARL
Target 6 Number of Residues 226
Target 6 Molecular Weight 25496.6
Target 6 Theoretical pI 8.69
Target 6 GO Classification
Function
catalytic activity
oxidoreductase activity
disulfide oxidoreductase activity
protein disulfide oxidoreductase activity
Process
Not Available
Component
cell
periplasmic space
periplasmic space (sensu Gram-negative Bacteria)
Target 6 General Function Involved in glutathione transferase activity
Target 6 Pathways Not Available
Target 6 Reactions Not Available
Target 6 Signals
  • None
Target 6 Transmembrane Regions
  • None
Target 6 Essentiality Non Essential
Target 6 Domain Function PF01323:DSBA
Target 6 GenBank ID Protein Not Available
Target 6 UniProtKB ID Q9Y2Q3 Link Image
Target 6 Cellular Location Peroxisome
Target 6 Gene Sequence >681 bp 
ATGGGGCCCCTGCCGCGCACCGTGGAGCTCTTCTATGACGTGCTGTCCCCCTACTCCTGG
CTGGGCTTCGAGATCCTGTGCCGGTATCAGAATATCTGGAACATCAACCTGCAGTTGCGG
CCCAGCCTCATAACAGGGATCATGAAAGACAGTGGAAACAAGCCTCCAGGTCTGCTTCCC
CGCAAAGGACTATACATGGCAAATGACTTAAAGCTCCTGAGACACCATCTCCAGATTCCC
ATCCACTTCCCCAAGGATTTCTTGTCTGTGATGCTTGAAAAAGGAAGTTTGTCTGCCATG
CGTTTCCTCACCGCCGTGAACTTGGAGCATCCAGAGATGCTGGAGAAAGCGTCCCGGGAG
CTGTGGATGCGCGTCTGGTCAAGGAATGAAGACATCACCGAGCCGCAGAGCATCCTGGCG
GCTGCAGAGAAGGCTGGTATGTCTGCAGAACAAGCCCAGGGACTTCTGGAAAAGATCGCA
ACGCCAAAGGTGAAGAACCAGCTCAAGGAGACCACTGAGGCAGCCTGCAGATACGGAGCC
TTTGGGCTGCCCATCACCGTGGCCCATGTGGATGGCCAAACCCACATGTTATTTGGCTCT
GACCGGATGGAGCTGCTGGCGCACCTGCTGGGAGAGAAGTGGATGGGCCCTATACCTCCA
GCCGTGAATGCCAGACTTTAA
Target 6 GenBank Gene ID Not Available
Target 6 GeneCard ID GSTK1 Link Image
Target 6 GenAtlas ID GSTK1 Link Image
Target 6 HGNC ID HGNC:16906 Link Image
Target 6 Chromosome Location Not Available
Target 6 Locus 7q35
Target 6 SNPs SNPJam Report Link Image
Target 6 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 6 General References 14709161; 14742434; 11042152; 11230166; 15489334
Target 7 [top]
Target 7 ID 747
Target 7 Name Glutathione S-transferase Mu 1
Target 7 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 7 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 7 Synonyms
  1. GSTM1-1; GST class-mu 1; GSTM1a-1a; GSTM1b-1b; HB subunit 4; GTH4
Target 7 Gene Name GSTM1
Target 7 Protein Sequence >Glutathione S-transferase Mu 1 
MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK
Target 7 Number of Residues 218
Target 7 Molecular Weight 25711.6
Target 7 Theoretical pI 6.67
Target 7 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 7 General Function Involved in glutathione transferase activity
Target 7 Pathways Not Available
Target 7 Reactions Not Available
Target 7 Signals
  • None
Target 7 Transmembrane Regions
  • None
Target 7 Essentiality Non Essential
Target 7 Domain Function PF00043:GST_C PF02798:GST_N
Target 7 GenBank ID Protein Not Available
Target 7 UniProtKB ID P09488 Link Image
Target 7 Cellular Location Cytoplasm
Target 7 Gene Sequence >657 bp 
ATGCCCATGATACTGGGGTACTGGGACATCCGCGGGCTGGCCCACGCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTATGAGGAAAAGAAGTACACGATGGGGGACGCTCCTGAT
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAACGCCATCTTGTGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGACCATGGACAACCATATGCAGCTGGGCATGATCTGCTACAATCCAGAATTT
GAGAAACTGAAGCCAAAGTACTTGGAGGAACTCCCTGAAAAGCTAAAGCTCTACTCAGAG
TTTCTGGGGAAGCGGCCATGGTTTGCAGGAAACAAGATCACTTTTGTAGATTTTCTCGTC
TATGATGTCCTTGACCTCCACCGTATATTTGAGCCCAAGTGCTTGGACGCCTTCCCAAAT
CTGAAGGACTTCATCTCCCGCTTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAGACCTGTGTTCTCAAAGATGGCTGTCTGGGGCAACAAGTAG
Target 7 GenBank Gene ID Not Available
Target 7 GeneCard ID GSTM1 Link Image
Target 7 GenAtlas ID GSTM1 Link Image
Target 7 HGNC ID HGNC:4632 Link Image
Target 7 Chromosome Location Not Available
Target 7 Locus 1p13.3
Target 7 SNPs SNPJam Report Link Image
Target 7 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 7 General References 3419925; 3174634; 15489334; 8471052; 7822249; 2110160; 3979555
Target 8 [top]
Target 8 ID 756
Target 8 Name Glutathione S-transferase Mu 2
Target 8 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 8 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 8 Synonyms
  1. GSTM2-2; GST class-mu 2
Target 8 Gene Name GSTM2
Target 8 Protein Sequence >Glutathione S-transferase Mu 2 
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDF
EKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
Target 8 Number of Residues 218
Target 8 Molecular Weight 25744.4
Target 8 Theoretical pI 6.29
Target 8 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 8 General Function Involved in glutathione transferase activity
Target 8 Pathways Not Available
Target 8 Reactions Not Available
Target 8 Signals
  • None
Target 8 Transmembrane Regions
  • None
Target 8 Essentiality Non Essential
Target 8 Domain Function PF00043:GST_C PF02798:GST_N
Target 8 GenBank ID Protein Not Available
Target 8 UniProtKB ID P28161 Link Image
Target 8 Cellular Location Cytoplasm
Target 8 Gene Sequence >657 bp 
ATGCCCATGACACTGGGGTACTGGAACATCCGCGGGCTGGCCCATTCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTACGAGGAAAAGAAGTACACGATGGGGGACGCTCCTGAT
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGACTCACAAGATCACCCAGAGCAATGCCATCCTGCGGTACATT
GCCCGCAAGCACAACCTGTGCGGGGAATCAGAAAAGGAGCAGATTCGCGAAGACATTTTG
GAGAACCAGTTTATGGACAGCCGTATGCAGCTGGCCAAACTCTGCTATGACCCAGATTTT
GAGAAACTGAAACCAGAATACCTGCAGGCACTCCCTGAAATGCTGAAGCTCTACTCACAG
TTTCTGGGGAAGCAGCCATGGTTTCTTGGGGACAAGATCACCTTTGTGGATTTCATCGCT
TATGATGTCCTTGAGAGAAACCAAGTATTTGAGCCCAGCTGCCTGGATGCCTTCCCAAAC
CTGAAGGACTTCATCTCCCGATTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAGACCTGTGTTCACAAAGATGGCTGTCTGGGGCAACAAGTAG
Target 8 GenBank Gene ID Not Available
Target 8 GeneCard ID GSTM2 Link Image
Target 8 GenAtlas ID GSTM2 Link Image
Target 8 HGNC ID HGNC:4634 Link Image
Target 8 Chromosome Location Not Available
Target 8 Locus 1p13.3
Target 8 SNPs SNPJam Report Link Image
Target 8 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 8 General References 2034681; 15489334; 8373352; 8182750
Target 9 [top]
Target 9 ID 755
Target 9 Name Glutathione S-transferase Mu 3
Target 9 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 9 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers
Target 9 Synonyms
  1. GSTM3-3; GST class-mu 3; hGSTM3-3
Target 9 Gene Name GSTM3
Target 9 Protein Sequence >Glutathione S-transferase Mu 3 
MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLD
FPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCY
SSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLD
EFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC
Target 9 Number of Residues 225
Target 9 Molecular Weight 26559.3
Target 9 Theoretical pI 5.19
Target 9 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 9 General Function Involved in glutathione transferase activity
Target 9 Pathways Not Available
Target 9 Reactions Not Available
Target 9 Signals
  • None
Target 9 Transmembrane Regions
  • None
Target 9 Essentiality Non Essential
Target 9 Domain Function PF00043:GST_C PF02798:GST_N
Target 9 GenBank ID Protein Not Available
Target 9 UniProtKB ID P21266 Link Image
Target 9 Cellular Location Cytoplasm
Target 9 Gene Sequence >678 bp 
ATGTCGTGCGAGTCGTCTATGGTTCTCGGGTACTGGGATATTCGTGGGCTGGCGCACGCC
ATCCGCCTGCTCCTGGAGTTCACGGATACCTCTTATGAGGAGAAACGGTACACGTGCGGG
GAAGCTCCTGACTATGATCGAAGCCAATGGCTGGATGTGAAATTCAAGCTAGACCTGGAC
TTTCCTAATCTGCCCTACCTCCTGGATGGGAAGAACAAGATCACCCAGAGCAATGCCATC
TTGCGCTACATCGCTCGCAAGCACAACATGTGTGGTGAGACTGAAGAAGAAAAGATTCGA
GTGGACATCATAGAGAACCAAGTAATGGATTTCCGCACACAACTGATAAGGCTCTGTTAC
AGCTCTGACCACGAAAAACTGAAGCCTCAGTACTTGGAAGAGCTACCTGGACAACTGAAA
CAATTCTCCATGTTTCTGTGGAAATTCTCATGGTTTGCCGGGGAAAAGCTCACCTTTGTG
GATTTTCTCACCTATGATATCTTGGATCAGAACCGTATATTTGACCCCAAGTGCCTGGAT
GAGTTCCCAAACCTGAAGGCTTTCATGTGCCGTTTTGAGGCTTTGGAGAAAATCGCTGCC
TACTTACAGTCTGATCAGTTCTGCAAGATGCCCATCAACAACAAGATGGCCCAGTGGGGC
AACAAGCCTGTATGCTGA
Target 9 GenBank Gene ID Not Available
Target 9 GeneCard ID GSTM3 Link Image
Target 9 GenAtlas ID GSTM3 Link Image
Target 9 HGNC ID HGNC:4635 Link Image
Target 9 Chromosome Location Not Available
Target 9 Locus 1p13.3
Target 9 SNPs SNPJam Report Link Image
Target 9 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 9 General References 2345169; 9882431; 15489334; 8373352; 8218382; 10587441
Target 10 [top]
Target 10 ID 763
Target 10 Name Glutathione S-transferase Mu 5
Target 10 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 10 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 10 Synonyms
  1. GSTM5-5; GST class-mu 5
Target 10 Gene Name GSTM5
Target 10 Protein Sequence >Glutathione S-transferase Mu 5 
MPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILENQVMDNHMELVRLCYDPDF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGDKITFVDFLAYDVLDMKRIFEPKCLDAFLN
LKDFISRFEGLKKISAYMKSSQFLRGLLFGKSATWNSK
Target 10 Number of Residues 218
Target 10 Molecular Weight 25674.5
Target 10 Theoretical pI 7.49
Target 10 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 10 General Function Involved in glutathione transferase activity
Target 10 Pathways Not Available
Target 10 Reactions Not Available
Target 10 Signals
  • None
Target 10 Transmembrane Regions
  • None
Target 10 Essentiality Non Essential
Target 10 Domain Function PF00043:GST_C PF02798:GST_N
Target 10 GenBank ID Protein Not Available
Target 10 UniProtKB ID P46439 Link Image
Target 10 Cellular Location Cytoplasm
Target 10 Gene Sequence >657 bp 
ATGCCCATGACTCTGGGGTACTGGGACATCCGTGGGCTGGCCCACGCCATCCGCTTGCTC
CTGGAATACACAGACTCAAGCTATGTGGAAAAGAAGTACACGATGGGGGACGCTCCTGAC
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAATGCCATCCTGCGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGGTTATGGATAACCACATGGAGCTGGTCAGACTGTGCTATGACCCAGATTTT
GAGAAACTGAAGCCAAAATACTTGGAGGAACTCCCTGAAAAGCTAAAGCTCTACTCAGAG
TTTCTGGGGAAGCGGCCATGGTTTGCAGGAGACAAGATCACCTTTGTGGATTTCCTTGCC
TATGATGTCCTTGACATGAAGCGTATATTTGAGCCCAAGTGCTTGGACGCCTTCCTAAAC
TTGAAGGACTTCATCTCCCGCTTTGAGGGTTTGAAGAAGATCTCTGCCTACATGAAGTCC
AGCCAATTCCTCCGAGGTCTTTTGTTTGGAAAGTCAGCTACATGGAACAGCAAATAG
Target 10 GenBank Gene ID Not Available
Target 10 GeneCard ID GSTM5 Link Image
Target 10 GenAtlas ID GSTM5 Link Image
Target 10 HGNC ID HGNC:4637 Link Image
Target 10 Chromosome Location Not Available
Target 10 Locus 1p13.3
Target 10 SNPs SNPJam Report Link Image
Target 10 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 10 General References 8473333; 15489334
Target 11 [top]
Target 11 ID 753
Target 11 Name Glutathione S-transferase omega-1
Target 11 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 11 Description Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities
Target 11 Synonyms
  1. GSTO 1-1
Target 11 Gene Name GSTO1
Target 11 Protein Sequence >Glutathione S-transferase omega-1 
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKP
EWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELF
SKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPW
FERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYG
L
Target 11 Number of Residues 241
Target 11 Molecular Weight 27565.6
Target 11 Theoretical pI 6.54
Target 11 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
cell
intracellular
cytoplasm
Target 11 General Function Posttranslational modification, protein turnover, chaperones
Target 11 Pathways Not Available
Target 11 Reactions Not Available
Target 11 Signals
  • None
Target 11 Transmembrane Regions
  • None
Target 11 Essentiality Non Essential
Target 11 Domain Function PF00043:GST_C PF02798:GST_N
Target 11 GenBank ID Protein Not Available
Target 11 UniProtKB ID P78417 Link Image
Target 11 Cellular Location Cytoplasm
Target 11 Gene Sequence >726 bp 
ATGTCCGGGGAGTCAGCCAGGAGCTTGGGGAAGGGAAGCGCGCCCCCGGGGCCGGTCCCG
GAGGGCTCGATCCGCATCTACAGCATGAGGTTCTGCCCGTTTGCTGAGAGGACGCGTCTA
GTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAATAAGCCT
GAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGT
CAGCTGATCTACGAGTCTGCCATCACCTGTGAGTACCTGGATGAAGCATACCCAGGGAAG
AAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAGTTGTTT
TCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCT
GGCCTAAAAGAAGAATTTCGTAAAGAATTTACCAAGCTAGAGGAGGTTCTGACTAATAAG
AAGACGACCTTCTTTGGTGGCAATTCTATCTCTATGATTGATTACCTCATCTGGCCCTGG
TTTGAACGGCTGGAAGCAATGAAGTTAAATGAGTGTGTAGACCACACTCCAAAACTGAAA
CTGTGGATGGCAGCCATGAAGGAAGATCCCACAGTCTCAGCCCTGCTTACTAGTGAGAAA
GACTGGCAAGGTTTCCTAGAGCTCTACTTACAGAACAGCCCTGAGGCCTGTGACTATGGG
CTCTGA
Target 11 GenBank Gene ID Not Available
Target 11 GeneCard ID GSTO1 Link Image
Target 11 GenAtlas ID GSTO1 Link Image
Target 11 HGNC ID HGNC:13312 Link Image
Target 11 Chromosome Location Chromosome:10
Target 11 Locus 10q25.1
Target 11 SNPs SNPJam Report Link Image
Target 11 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 11 General References 10783391; 12928150; 17974005; 15164054; 15489334; 11271497; 12618591
Target 12 [top]
Target 12 ID 757
Target 12 Name Glutathione S-transferase omega-2
Target 12 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 12 Description RX + glutathione = HX + R-S-glutathione
Target 12 Synonyms
  1. GSTO-2
Target 12 Gene Name GSTO2
Target 12 Protein Sequence >Glutathione S-transferase omega-2 
MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKP
EWYYTKHPFGHIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKMLLELF
CKVPHLTKECLVALRCGRECTNLKAALRQEFSNLEEILEYQNTTFFGGTCISMIDYLLWP
WFERLDVYGILDCVSHTPALRLWISAMKWDPTVCALLMDKSIFQGFLNLYFQNNPNAFDF
GLC
Target 12 Number of Residues 243
Target 12 Molecular Weight 28253.5
Target 12 Theoretical pI 7.62
Target 12 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
cell
intracellular
cytoplasm
Target 12 General Function Posttranslational modification, protein turnover, chaperones
Target 12 Pathways Not Available
Target 12 Reactions Not Available
Target 12 Signals
  • None
Target 12 Transmembrane Regions
  • None
Target 12 Essentiality Non Essential
Target 12 Domain Function PF02798:GST_N
Target 12 GenBank ID Protein Not Available
Target 12 UniProtKB ID Q9H4Y5 Link Image
Target 12 Cellular Location Not Available
Target 12 Gene Sequence >732 bp 
ATGTCTGGGGATGCGACCAGGACCCTGGGGAAAGGAAGCCAGCCCCCAGGGCCAGTCCCG
GAGGGGCTGATCCGCATCTACAGCATGAGGTTCTGCCCCTATTCTCACAGGACCCGCCTC
GTCCTCAAGGCCAAAGACATCAGACATGAAGTGGTCAACATTAACCTGAGAAACAAGCCT
GAATGGTACTATACAAAGCACCCTTTTGGCCACATTCCTGTCCTGGAGACCAGCCAATGT
CAACTGATCTATGAATCTGTTATTGCTTGTGAGTACCTGGATGATGCTTATCCAGGAAGG
AAGCTGTTTCCATATGACCCTTATGAACGAGCTCGCCAAAAGATGTTATTGGAGCTATTT
TGTAAGGTCCCACATTTGACCAAGGAGTGCCTGGTAGCGTTGAGATGTGGGAGAGAATGC
ACTAATCTGAAGGCAGCCCTGCGTCAGGAATTCAGCAACCTGGAAGAGATTCTTGAGTAT
CAGAACACCACCTTCTTTGGTGGAACCTGTATATCCATGATTGATTACCTCCTCTGGCCC
TGGTTTGAGCGGCTGGATGTGTATGGGATACTGGACTGTGTGAGCCACACGCCAGCCCTG
CGGCTCTGGATATCAGCCATGAAGTGGGACCCCACAGTCTGTGCTCTTCTCATGGATAAG
AGCATTTTCCAGGGCTTCTTGAATCTCTATTTTCAGAACAACCCTAATGCCTTTGACTTT
GGGCTGTGCTGA
Target 12 GenBank Gene ID Not Available
Target 12 GeneCard ID GSTO2 Link Image
Target 12 GenAtlas ID GSTO2 Link Image
Target 12 HGNC ID HGNC:23064 Link Image
Target 12 Chromosome Location Chromosome:10
Target 12 Locus 10q25.1
Target 12 SNPs SNPJam Report Link Image
Target 12 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 12 General References 14702039; 15164054; 15489334; 12618591
Target 13 [top]
Target 13 ID 543
Target 13 Name Glutathione S-transferase P
Target 13 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 13 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 13 Synonyms
  1. GST class-pi; GSTP1-1
Target 13 Gene Name GSTP1
Target 13 Protein Sequence >Glutathione S-transferase P 
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
Target 13 Number of Residues 210
Target 13 Molecular Weight 23355.6
Target 13 Theoretical pI 5.30
Target 13 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 13 General Function Involved in glutathione transferase activity
Target 13 Pathways Not Available
Target 13 Reactions Not Available
Target 13 Signals
  • None
Target 13 Transmembrane Regions
  • None
Target 13 Essentiality Non Essential
Target 13 Domain Function PF00043:GST_C PF02798:GST_N
Target 13 GenBank ID Protein Not Available
Target 13 UniProtKB ID P09211 Link Image
Target 13 Cellular Location Not Available
Target 13 Gene Sequence >633 bp 
ATGCCGCCCTACACCGTGGTCTATTTCCCAGTTCGAGGCCGCTGCGCGGCCCTGCGCATG
CTGCTGGCAGATCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAGACGTGGCAG
GAGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGAC
CTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTAT
GGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTC
CGCTGCAAATACATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTG
AAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGC
AAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTG
CTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATAT
GTGGGGCGCCTCAGCGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTG
AACCTCCCCATCAATGGCAACGGGAAACAGTGA
Target 13 GenBank Gene ID Not Available
Target 13 GeneCard ID GSTP1 Link Image
Target 13 GenAtlas ID GSTP1 Link Image
Target 13 HGNC ID HGNC:4638 Link Image
Target 13 Chromosome Location Chromosome:11
Target 13 Locus 11q13
Target 13 SNPs SNPJam Report Link Image
Target 13 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 13 General References 3664469; 3196325; 2542132; 2466554; 9092542; 15489334
Target 14 [top]
Target 14 ID 678
Target 14 Name Glutathione S-transferase theta-1
Target 14 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 14 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide
Target 14 Synonyms
  1. GST class-theta-1; Glutathione transferase T1-1
Target 14 Gene Name GSTT1
Target 14 Protein Sequence >Glutathione S-transferase theta-1 
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDG
DFTLTESVAILLYLTRKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMF
PVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGA
GCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADPTIKQKLMPWVLAMIR
Target 14 Number of Residues 240
Target 14 Molecular Weight 27334.8
Target 14 Theoretical pI 7.60
Target 14 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 14 General Function Posttranslational modification, protein turnover, chaperones
Target 14 Pathways Not Available
Target 14 Reactions Not Available
Target 14 Signals
  • None
Target 14 Transmembrane Regions
  • None
Target 14 Essentiality Non Essential
Target 14 Domain Function PF00043:GST_C PF02798:GST_N
Target 14 GenBank ID Protein Not Available
Target 14 UniProtKB ID P30711 Link Image
Target 14 Cellular Location Cytoplasm
Target 14 Gene Sequence >723 bp 
ATGGGTCTGGAGCTCTACCTGGACCTGCTGTCCCAGCCCTGCCGCGCTGTTTACATCTTT
GCCAAGAAGAACGACATTCCCTTCGAGCTGCGCATCGTGGATCTGATTAAAGGTCAGCAC
TTAAGCGATGCCTTTGCCCAGGTGAACCCCCTCAAGAAGGTGCCGGCCTTGAAGGACGGG
GACTTCACCTTGACGGAGAGTGTGGCCATCCTGCTCTACCTGACGCGCAAATATAAGGTC
CCTGACTACTGGTACCCTCAGGACCTGCAGGCCCGTGCCCGTGTGGATGAGTACCTGGCA
TGGCAGCACACGACTCTGCGGAGAAGCTGCCTCCGGGCCTTGTGGCATAAGGTGATGTTC
CCTGTGTTCCTGGGTGGGCCAGTATCTCCCCAGACACTGGCAGCCACCCTGGCAGAGTTG
GATGTGACCCTGCAGTTGCTCGAGGACAAGTTCCTCCAGAACAAGGCCTTCCTTACTGGT
CCTCACATCTCCTTAGCTGACCTCGTAGCCATCACGGAGCTGATGCATCCCGTGGGTGCT
GGCTGCCAAGTCTTCGAAGGCCGACCCAAGCTGGCCACATGGCGGCAGCGCGTGGAGGCA
GCAGTGGGGGAGGACCTCTTCCAGGAGGCCCATGAGGTCATTCTGAAGGCCAAGGACTTC
CCACCTGCAGACCCCACCATAAAGCAGAAGCTGATGCCCTGGGTGCTGGCCATGATCCGG
TGA
Target 14 GenBank Gene ID Not Available
Target 14 GeneCard ID GSTT1 Link Image
Target 14 GenAtlas ID GSTT1 Link Image
Target 14 HGNC ID HGNC:4641 Link Image
Target 14 Chromosome Location Chromosome:22
Target 14 Locus 22q11.23
Target 14 SNPs SNPJam Report Link Image
Target 14 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 14 General References 8198545; 9434735; 10975610; 10591208; 15489334; 1848757; 8761485
Target 15 [top]
Target 15 ID 746
Target 15 Name Glutathione S-transferase theta-2
Target 15 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 15 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity
Target 15 Synonyms
  1. GST class-theta-2
Target 15 Gene Name GSTT2
Target 15 Protein Sequence >Glutathione S-transferase theta-2 
MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDG
DFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLG
PLIGVQVPEEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALG
YELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRI
ARIP
Target 15 Number of Residues 244
Target 15 Molecular Weight 27506.7
Target 15 Theoretical pI 6.36
Target 15 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 15 General Function Posttranslational modification, protein turnover, chaperones
Target 15 Pathways Not Available
Target 15 Reactions Not Available
Target 15 Signals
  • None
Target 15 Transmembrane Regions
  • None
Target 15 Essentiality Non Essential
Target 15 Domain Function PF00043:GST_C PF02798:GST_N
Target 15 GenBank ID Protein Not Available
Target 15 UniProtKB ID P30712 Link Image
Target 15 Cellular Location Cytoplasm
Target 15 Gene Sequence >735 bp 
ATGGGCCTAGAGCTGTTTCTTGACCTGGTGTCCCAGCCCAGCCGCGCCGTCTACATCTTC
GCCAAGAAGAATGGCATCCCCTTAGAGCTGCGCACCGTGGATTTGGTCAAAGGGCAGCAC
AAGAGCAAGGAGTTCTTGCAGATCAACAGCCTGGGGAAACTGCCGACGCTCAAGGATGGT
GATTTCATCTTGACCGAAAGCTCGGCCATCCTGATTTACCTGAGCTGTAAGTACCAGACG
CCGGACCACTGGTATCCATCTGACCTGCAGGCTCGTGCCCGTGTTCATGAGTACCTGGGC
TGGCATGCCGACTGCATCCGTGGCACCTTTGGTATACCCCTGTGGGTCCAGGTGTTGGGG
CCACTCATTGGGGTCCAGGTGCCCGAGGAGAAGGTGGAACGCAACAGGACTGCCATGGAC
CAGGCCCTGCAATGGCTGGAGGACAAGTTCCTGGGGGACAGGCCCTTCCTCGCTGGCCAG
CAGGTGACACTGGCTGATCTCATGGCCCTGGAGGAGCTGATGCAGCCGGTGGCTCTCGGC
TACGAACTGTTTGAGGGACGGCCACGACTGGCAGCATGGCGTGGACGAGTGGAGGCTTTC
CTGGGTGCTGAGCTATGCCAGGAGGCCCACAGCATCATCTTGAGCATCCTGGAACAGGCG
GCCAAGAAAACCCTCCCAACACCCTCACCAGAGGCCTATCAGGCTATGCTGCTTCGAATC
GCCAGGATCCCCTGA
Target 15 GenBank Gene ID Not Available
Target 15 GeneCard ID GSTT2 Link Image
Target 15 GenAtlas ID GSTT2 Link Image
Target 15 HGNC ID HGNC:4642 Link Image
Target 15 Chromosome Location Chromosome:22
Target 15 Locus 22q11.2|22q11.23
Target 15 SNPs SNPJam Report Link Image
Target 15 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 15 General References 7789971; 10975610; 15461802; 10591208; 15489334; 1417752; 8761485; 9551553
Target 16 [top]
Target 16 ID 764
Target 16 Name Glutathione S-transferase theta-4
Target 16 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 16 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity)
Target 16 Synonyms
  1. GST class-theta-4
Target 16 Gene Name GSTT4
Target 16 Protein Sequence >Glutathione S-transferase theta-4 
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGHHHSKEYIDINPLRKLPSLKDG
KFILSESAAILYYLCRKYSAPSHWCPPDLHARARVDEFVAWQHTAFQLPMKKIVWLKLLI
PKITGEEVSAEKMEHAVEEVKNSLQLFEEYFLQDKMFITGNQISLADLVAVVEMMQPMAA
NYNVFLNSSKLAEWRMQVELNIGSGLFREAHDRLMQLADWDFSTLDSMVKENISELLKKS
R
Target 16 Number of Residues 241
Target 16 Molecular Weight 27959.3
Target 16 Theoretical pI 6.72
Target 16 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 16 General Function Posttranslational modification, protein turnover, chaperones
Target 16 Pathways Not Available
Target 16 Reactions Not Available
Target 16 Signals
  • None
Target 16 Transmembrane Regions
  • None
Target 16 Essentiality Non Essential
Target 16 Domain Function PF00043:GST_C PF02798:GST_N
Target 16 GenBank ID Protein Not Available
Target 16 UniProtKB ID A8MPT4 Link Image
Target 16 Cellular Location Cytoplasm (By similarity)
Target 16 Gene Sequence Not Available
Target 16 GenBank Gene ID Not Available
Target 16 GeneCard ID GSTT4 Link Image
Target 16 GenAtlas ID Not Available
Target 16 HGNC ID Not Available
Target 16 Chromosome Location Not Available
Target 16 Locus Not Available
Target 16 SNPs SNPJam Report Link Image
Target 16 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 16 General References 10591208
Target 17 [top]
Target 17 ID 758
Target 17 Name Microsomal glutathione S-transferase 1
Target 17 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 17 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity
Target 17 Synonyms
  1. Microsomal GST-1; Microsomal GST-I
Target 17 Gene Name MGST1
Target 17 Protein Sequence >Microsomal glutathione S-transferase 1 
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAK
KYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIA
YLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
Target 17 Number of Residues 155
Target 17 Molecular Weight 17598.5
Target 17 Theoretical pI 9.71
Target 17 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 17 General Function Involved in glutathione transferase activity
Target 17 Pathways Not Available
Target 17 Reactions Not Available
Target 17 Signals
  • None
Target 17 Transmembrane Regions
  • 15-37
Target 17 Essentiality Non Essential
Target 17 Domain Function PF01124:MAPEG
Target 17 GenBank ID Protein Not Available
Target 17 UniProtKB ID P10620 Link Image
Target 17 Cellular Location Microsome (By similarity). Mitochondrion outer membrane
Target 17 Gene Sequence >468 bp 
ATTCCAGACCAAAATTGAAAAAATGGTTGACCTCACCCAGGTAATGGATGATGAAGTATT
CATGGCTTTTGCATCCTATGCAACAATTATTCTTTCAAAAATGATGCTTATGAGTACTGC
AACTGCATTCTATAGATTGACAAGAAAGGTTTTTGCCAATCCAGAAGACTGTGTAGCATT
TGGCAAAGGAGAAAATGCCAAGAAGTATCTTCGAACAGATGACAGAGTAGAACGTGTACG
CAGAGCCCACCTGAATGACCTTGAAAATATTATTCCATTTCTTGGAATTGGCCTCCTGTA
TTCCTTGAGTGGTCCCGACCCCTCTACAGCCATCCTGCACTTCAGACTATTTGTCGGAGC
ACGGATCTACCACACCATTGCATATTTGACACCCCTTCCCCAGCCAAATAGAGCTTTGAG
TTTTTTTGTTGGATATGGAGTTACTCTTTCCATGGCTTACAGGTTGCT
Target 17 GenBank Gene ID Not Available
Target 17 GeneCard ID MGST1 Link Image
Target 17 GenAtlas ID MGST1 Link Image
Target 17 HGNC ID HGNC:7061 Link Image
Target 17 Chromosome Location Chromosome:12
Target 17 Locus 12p12.3-p12.1
Target 17 SNPs SNPJam Report Link Image
Target 17 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 17 General References 3372534; 8812420; 10524215; 15489334
Target 18 [top]
Target 18 ID 760
Target 18 Name Microsomal glutathione S-transferase 2
Target 18 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 18 Description Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione
Target 18 Synonyms
  1. Microsomal GST-2; Microsomal GST-II
Target 18 Gene Name MGST2
Target 18 Protein Sequence >Microsomal glutathione S-transferase 2 
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY
PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL
LGALGIANSFLDEYLDLNIAKKLRRQF
Target 18 Number of Residues 147
Target 18 Molecular Weight 16620.4
Target 18 Theoretical pI 9.88
Target 18 GO Classification
Function
enzyme regulator activity
enzyme activator activity
Process
physiological process
metabolism
cellular metabolism
organic acid metabolism
carboxylic acid metabolism
fatty acid metabolism
icosanoid metabolism
leukotriene metabolism
Component
cell
membrane
intrinsic to membrane
integral to membrane
Target 18 General Function Involved in enzyme activator activity
Target 18 Pathways Not Available
Target 18 Reactions Not Available
Target 18 Signals
  • None
Target 18 Transmembrane Regions
  • 6-26
  • 59-79
  • 111-131
Target 18 Essentiality Non Essential
Target 18 Domain Function PF01124:MAPEG
Target 18 GenBank ID Protein Not Available
Target 18 UniProtKB ID Q99735 Link Image
Target 18 Cellular Location Endoplasmic reticulum membrane
Target 18 Gene Sequence >444 bp 
ATGGCCGGGAACTCGATCCTGCTGGCTGCTGTCTCTATTCTCTCGGCCTGTCAGCAAAGT
TATTTTGCTTTGCAAGTTGGAAAGGCAAGATTAAAATACAAAGTTACGCCCCCAGCAGTC
ACTGGGTCACCAGAGTTTGAGAGAGTATTTCGGGCACAACAAAACTGTGTGGAGTTTTAT
CCTATATTCATAATTACATTGTGGATGGCTGGGTGGTATTTCAACCAAGTTTTTGCTACT
TGTCTGGGTCTGGTGTACATATATGGCCGTCACCTATACTTCTGGGGATATTCAGAAGCT
GCTAAAAAACGGATCACCGGTTTCCGACTGAGTCTGGGGATTTTGGCCTTGTTGACCCTC
CTAGGTGCCCTGGGAATTGCAAACAGCTTTCTGGATGAATATCTGGACCTCAATATTGCC
AAGAAACTGAGGCGGCAATTCTAA
Target 18 GenBank Gene ID Not Available
Target 18 GeneCard ID MGST2 Link Image
Target 18 GenAtlas ID MGST2 Link Image
Target 18 HGNC ID HGNC:7063 Link Image
Target 18 Chromosome Location Not Available
Target 18 Locus 4q28.3
Target 18 SNPs SNPJam Report Link Image
Target 18 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 18 General References 8703034; 15489334
Target 19 [top]
Target 19 ID 762
Target 19 Name Microsomal glutathione S-transferase 3
Target 19 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 19 Description Also functions as a glutathione peroxidase
Target 19 Synonyms
  1. Microsomal GST-3; Microsomal GST-III
Target 19 Gene Name MGST3
Target 19 Protein Sequence >Microsomal glutathione S-transferase 3 
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRA
HQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSI
ALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
Target 19 Number of Residues 152
Target 19 Molecular Weight 16516.2
Target 19 Theoretical pI 9.68
Target 19 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 19 General Function Involved in glutathione transferase activity
Target 19 Pathways Not Available
Target 19 Reactions Not Available
Target 19 Signals
  • None
Target 19 Transmembrane Regions
  • 9-29
  • 71-91
  • 120-140
Target 19 Essentiality Non Essential
Target 19 Domain Function PF01124:MAPEG
Target 19 GenBank ID Protein Not Available
Target 19 UniProtKB ID O14880 Link Image
Target 19 Cellular Location Endoplasmic reticulum membrane
Target 19 Gene Sequence >459 bp 
ATGGCTGTCCTCTCTAAGGAATATGGTTTTGTGCTTCTAACTGGTGCTGCCAGCTTTATA
ATGGTGGCCCACCTAGCCATCAATGTTTCCAAGGCCCGCAAGAAGTACAAAGTGGAGTAT
CCTATCATGTACAGCACGGACCCTGAAAATGGGCACATCTTCAACTGCATTCAGCGAGCC
CACCAGAACACGTTGGAAGTGTATCCTCCCTTCTTATTTTTTCTAGCTGTTGGAGGTGTT
TACCACCCGCGTATAGCTTCTGGCCTGGGCTTGGCCTGGATTGTTGGACGAGTTCTTTAT
GCTTATGGCTATTACACGGGAGAACCCAGCAAGCGTAGTCGAGGAGCCCTGGGGTCCATC
GCCCTCCTGGGCTTGGTGGGCACAACTGTGTGCTCTGCTTTCCAGCATCTTGGTTGGGTT
AAAAGTGGCTTGGGCAGTGGACCCAAATGCTGCCATTAA
Target 19 GenBank Gene ID Not Available
Target 19 GeneCard ID MGST3 Link Image
Target 19 GenAtlas ID MGST3 Link Image
Target 19 HGNC ID HGNC:7064 Link Image
Target 19 Chromosome Location Not Available
Target 19 Locus 1q23
Target 19 SNPs SNPJam Report Link Image
Target 19 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 19 General References 9278457; 16710414; 15489334
Target 20 [top]
Target 20 ID 761
Target 20 Name Maleylacetoacetate isomerase
Target 20 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 20 Description Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid
Target 20 Synonyms
  1. MAAI; Glutathione S-transferase zeta 1; GSTZ1-1
Target 20 Gene Name GSTZ1
Target 20 Protein Sequence >Maleylacetoacetate isomerase 
MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVP
TLKIDGITIHQSLAIIEYLEETRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK
QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL
TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
Target 20 Number of Residues 216
Target 20 Molecular Weight 24181.9
Target 20 Theoretical pI 8.71
Target 20 GO Classification
Function
catalytic activity
Process
physiological process
metabolism
cellular metabolism
amino acid and derivative metabolism
amino acid metabolism
aromatic amino acid family metabolism
Component
cell
intracellular
cytoplasm
Target 20 General Function Posttranslational modification, protein turnover, chaperones
Target 20 Pathways Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine:step 5/6
Target 20 Reactions Not Available
Target 20 Signals
  • None
Target 20 Transmembrane Regions
  • None
Target 20 Essentiality Non Essential
Target 20 Domain Function PF00043:GST_C PF02798:GST_N
Target 20 GenBank ID Protein Not Available
Target 20 UniProtKB ID O43708 Link Image
Target 20 Cellular Location Cytoplasm (By similarity)
Target 20 Gene Sequence >651 bp 
ATGCAGGCGGGGAAGCCCATCCTCTATTCCTATTTCCGAAGCTCCTGCTCATGGAGAGTT
CGAATTGCTCTGGCCTTGAAAGGCATCGACTACAAGACGGTGCCCATCAATCTCATAAAG
GATGGGGGCCAACAGTTTTCTAAGGACTTCCAGGCACTGAATCCTATGAAGCAGGTGCCA
ACCCTGAAGATTGATGGAATCACCATTCACCAGTCACTGGCCATCATTGAGTATCTAGAG
GAGACGCGTCCCACTCCGCGACTTCTGCCTCAGGACCCAAAGAAGAGGGCCAGCGTGCGT
ATGATTTCTGACCTCATCGCTGGTGGCATCCAGCCCCTGCAGAACCTGTCTGTCCTGAAG
CAAGTGGGAGAGGAGATGCAGCTGACCTGGGCCCAGAACGCCATCACTTGTGGCTTTAAC
GCCCTGGAGCAGATCCTACAGAGCACAGCGGGCATATACTGTGTAGGAGACGAGGTGACC
ATGGCTGATCTGTGCTTGGTGCCTCAGGTGGCAAATGCTGAAAGATTCAAGGTGGATCTC
ACCCCCTACCCTACCATCAGCTCCATCAACAAGAGGCTGCTGGTCTTGGAGGCCTTCCAG
GTGTCTCACCCCTGCCGGCAGCCAGATACACCCACTGAGCTGAGGGCCTAG
Target 20 GenBank Gene ID Not Available
Target 20 GeneCard ID GSTZ1 Link Image
Target 20 GenAtlas ID GSTZ1 Link Image
Target 20 HGNC ID HGNC:4643 Link Image
Target 20 Chromosome Location Chromosome:14
Target 20 Locus 14q24.3
Target 20 SNPs SNPJam Report Link Image
Target 20 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 20 General References 9417084; 9396740; 9925947; 10373324; 12508121; 15489334; 9531472

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