Showing toxin card for Ethyl cyanoacetate (T3D1680)

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Version	1.0
Creation Date	2009-06-22 16:08:26
Update Date	2010-03-18 21:54:47
Accession Number	T3D1680
Name	Ethyl cyanoacetate
Compound Type	Cyanide Compound Organic Compound
Description	Ethyl cyanoacetate is a chemical compound of cyanide.
Synonyms	Acetic Acid,2-cyano-, ethyl ester Acetic Acid,cyano,ethyl ester Cyanacetate ethyle Cyanacetate ethyle [german] Cyanoacetic Acid ethyl ester Cyanoacetic Acid, ethyl ester Cyanoacetic ester Estere cianoacetico Estere cianoacetico [italian] Ethyl cyanacetate Ethyl cyanoacetate Ethyl cyanoacetate [UN2666] [Keep away from food] Ethyl cyanoethanoate Ethyl ester of cyanoacetic Acid Ethylester kyseliny kyanoctove Ethylester kyseliny kyanoctove [czech] Malonic Acid ethyl ester nitrile Malonic Acid, ethyl ester nitrile NCCH2COOC2H5 ethyl cyanoacetate (ACD/Name 4.0)
Chemical IUPAC Name	ethyl 2-cyanoacetate
Chemical Formula	C₅H₇NO₂
Chemical Structure
CAS Registry Number	105-56-6
InChI Identifier	InChI=1S/C5H7NO2/c1-2-8-5(7)3-4-6/h2-3H2,1H3
InChI Key	InChIKey=ZIUSEGSNTOUIPT-UHFFFAOYSA-N
PubChem Compound ID	7764
KEGG ID	Not Available
UniProt ID	Not Available
OMIM ID	Not Available
ChEBI ID	Not Available
BioCyc ID	CPD-121
SuperToxic ID	Not Available
CTD ID	C007659
Stitch ID	Ethyl cyanoacetate
DrugBank ID	Not Available
PDB ID	Not Available
ACToR ID	3467
Wikipedia Link	Not Available
Monoisotopic Mass	113.047678
MOL File	Show
PDB File	Show
SDF File	Show
SMILES	CCOC(=O)CC#N
Appearance	Colorless liquid.
Melting Point	-22.5 oC
Solubility	20 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]
Predicted LogP	0.2295
Route of Exposure	Oral (R172) ; inhalation (R172) ; dermal (R172)
Mechanism of Action	Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. Cyanide is also known produce some of its toxic effects by binding to catalase, glutathione peroxidase, methemoglobin, hydroxocobalamin, phosphatase, tyrosinase, ascorbic acid oxidase, xanthine oxidase, succinic dehydrogenase, and Cu/Zn superoxide dismutase. Cyanide binds to the ferric ion of methemoglobin to form inactive cyanmethemoglobin. (R173)
Metabolism	Cyanide is rapidly alsorbed through oral, inhalation, and dermal routes and distributed throughout the body. Cyanide is mainly metabolized into thiocyanate by either rhodanese or 3-mercaptopyruvate sulfur transferase. Cyanide metabolites are excreted in the urine. (R172)
Toxicity Values	Not Available
Lethal Dose	200 to 300 milligrams for an adult human (cyanide salts). (R906)
Carcinogenicity (IARC Classification)	Not Available
Uses/Sources	Not Available
Minimum Risk Level	Not Available
Health Effects	Exposure to high levels of cyanide for a short time harms the brain and heart and can even cause coma, seizures, apnea, cardiac arrest and death. Chronic inhalation of cyanide causes breathing difficulties, chest pain, vomiting, blood changes, headaches, and enlargement of the thyroid gland. Skin contact with cyanide salts can irritate and produce sores. (R172, R173)
Symptoms	Cyanide poisoning is identified by rapid, deep breathing and shortness of breath, general weakness, giddiness, headaches, vertigo, confusion, convulsions/seizures and eventually loss of consciousness. (R172, R173)
Treatment	Antidotes to cyanide poisoning include hydroxocobalamin and sodium nitrite, which release the cyanide from the cytochrome system, and rhodanase, which is an enzyme occurring naturally in mammals that combines serum cyanide with thiosulfate, producing comparatively harmless thiocyanate. Oxygen therapy can also be administered. (R173)
General References	R906 - Baselt RC and Cravey RH (1989). Disposition of Toxic Drugs and Chemicals in Man. 3rd ed. Chicago, IL.: Year Book Medical Publishers. R172 - ATSDR - Agency for Toxic Substances and Disease Registry (2006). Toxicological profile for cyanide. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.
Targets	Alkaline phosphatase, placental-like Alkaline phosphatase, tissue-nonspecific isozyme Catalase Cytochrome c oxidase polypeptide 7A1, mitochondrial Cytochrome c oxidase polypeptide 7A2, mitochondrial Cytochrome c oxidase subunit 1 Cytochrome c oxidase subunit 2 Cytochrome c oxidase subunit 3 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial Cytochrome c oxidase subunit 4 isoform 2, mitochondrial Cytochrome c oxidase subunit 5A, mitochondrial Cytochrome c oxidase subunit 5B, mitochondrial Cytochrome c oxidase subunit 6A1, mitochondrial Cytochrome c oxidase subunit 6A2, mitochondrial Cytochrome c oxidase subunit 6B1 Cytochrome c oxidase subunit 6B2 Cytochrome c oxidase subunit 6C Cytochrome c oxidase subunit 7A3, mitochondrial Cytochrome c oxidase subunit 7B, mitochondrial Cytochrome c oxidase subunit 7B2, mitochondrial Cytochrome c oxidase subunit 7C, mitochondrial Cytochrome c oxidase subunit 8A, mitochondrial Cytochrome c oxidase subunit 8C, mitochondrial Epididymal secretory glutathione peroxidase Extracellular superoxide dismutase [Cu-Zn] Glutathione peroxidase 1 Glutathione peroxidase 2 Glutathione peroxidase 3 Glutathione peroxidase 6 Glutathione peroxidase 7 Glutathione reductase, mitochondrial Phospholipid hydroperoxide glutathione peroxidase, mitochondrial Probable glutathione peroxidase 8 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Superoxide dismutase [Cu-Zn] Tyrosinase

Target 1 [top]

Target 1 ID

174

Target 1 Name

Alkaline phosphatase, placental-like

Target 1 Mechanism of Action

Cyanide inhibits alkaline phosphatases. (R210)

Target 1 Description

A phosphate monoester + H(2)O = an alcohol + phosphate

Target 1 Synonyms

Alkaline phosphatase Nagao isozyme; Germ cell alkaline phosphatase; GCAP; PLAP-like; ALP-1

Target 1 Gene Name

ALPPL2

Target 1 Protein Sequence

>Alkaline phosphatase, placental-like

MQGPWVLLLLGLRLQLSLGIIPVEEENPDFWNRQAAEALGAAKKLQPAQTAAKNLIIFLG
DGMGVSTVTAARILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLC
GVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYA
HTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPDDY
SQGGTRLDGKNLVQEWLAKHQGARYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRD
STLDPSLMEMTEAALLLLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERA
GQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYVL
KDGARPDVTESESGSPEYRQQSAVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHV
MAFAACLEPYTACDLAPRAGTTDAAHPGPSVVPALLPLLAGTLLLLGTATAP

Target 1 Number of Residues

532

Target 1 Molecular Weight

57376.5

Target 1 Theoretical pI

6.31

Target 1 GO Classification

Function
Not Available
Process
physiological process metabolism
Component
Not Available

Target 1 General Function

Inorganic ion transport and metabolism

Target 1 Pathways

Not Available

Target 1 Reactions

Not Available

Target 1 Signals

1-19

Target 1 Transmembrane Regions

None

Target 1 Essentiality

Non Essential

Target 1 Domain Function

PF00245:Alk_phosphatase

Target 1 GenBank ID Protein

Not Available

Target 1 UniProtKB ID

P10696

Target 1 Cellular Location

Cell membrane

Target 1 Gene Sequence

>1599 bp

TTCCGCCTCGCCGCTCTCCGACTGCTTCCAGACATGCAGGGGCCCTGGGTGCTGCTCCTG
CTGGGCCTGAGGCTACAGCTCTCCCTGGGCATCATCCCAGTTGAGGAGGAGAACCCGGAC
TTCTGGAACCGCCAGGCAGCCGAGGCCCTGGGTGCCGCCAAGAAGCTGCAGCCTGCACAG
ACAGCCGCCAAGAACCTCATCATCTTCCTGGGTGACGGGATGGGGGTGTCTACGGTGACA
GCTGCCAGGATCCTAAAAGGGCAGAAGAAGGACAAACTGGGGCCTGAGACCTTCCTGGCC
ATGGACCGCTTCCCGTACGTGGCTCTGTCCAAGACATACAGTGTAGACAAGCATGTGCCA
GACAGTGGAGCCACAGCCACGGCCTACCTGTGCGGGGTCAAGGGCAACTTCCAGACCATT
GGCTTGAGTGCAGCCGCCCGCTTTAACCAGTGCAACACGACACGCGGCAACGAGGTCATC
TCCGTGATGAATCGGGCCAAGAAAGCAGGAAAGTCAGTGGGAGTGGTAACCACCACACGG
GTGCAGCATGCCTCGCCAGCCGGCACCTACGCCCACACGGTGAACCGCAACTGGTACTCG
GATGCCGACGTGCCTGCCTCGGCCCGCCAGGAGGGGTGCCAGGACATCGCCACGCAGCTC
ATCTCCAACATGGACATTGATGTGATCCTAGGTGGAGGCCGAAAGTACATGTTTCCCATG
GGGACCCCAGACCCTGAGTACCCAGATGACTACAGCCAAGGTGGGACCAGGCTGGACGGG
AAGAATCTGGTGCAGGAATGGCTGGCGAAGCACCAGGGTGCCCGGTACGTGTGGAACCGC
ACTGAGCTCCTGCAGGCTTCCCTGGACCCGTCTGTGACCCATCTCATGGGTCTCTTTGAG
CCTGGAGACATGAAATACGAGATCCACCGAGACTCCACACTGGACCCCTCCCTGATGGAG
ATGACAGAGGCTGCCCTGCTCCTGCTGAGCAGGAACCCCCGCGGCTTCTTCCTCTTCGTG
GAGGGTGGTCGCATCGACCATGGTCATCATGAAAGCAGGGCTTACCGGGCACTGACTGAG
ACGATCATGTTCGACGACGCCATTGAGAGGGCGGGCCAGCTCACCAGCGAGGAGGACACG
CTGAGCCTCGTCACTGCCGACCACTCCCACCTCTTCTCCTTCGGAGGCTACCCCCTGCGA
GGGAGCTCCATCTTCGGGCTGGCCCCTGGCAAGGCCCGGGACAGGAAGGCCTACACGGTC
CTCCTATACGGAAACGGTCCAGGCTATGTGCTCAAGGACGGCGCCCGGCCGGATGTTACG
GAGAGCGAGAGCGGGAGCCCCGAGTATCGGCAGCAGTCAGCAGTGCCCCTGGACGGAGAG
ACCCACGCAGGCGAGGACGTGGCGGTGTTCGCGCGCGGCCCGCAGGCGCACCTGGTTCAC
GGCGTGCAGGAGCAGACCTTCATAGCGCACGTCATGGCCTTCGCCGCCTGCCTGGAGCCC
TACACCGCCTGCGACCTGGCGCCCCGCGCCGGCACCACCGACGCCGCGCACCCGGGGCCG
TCCGTGGTCCCCGCGTTGCTTCCTCTGCTGGCAGGGACC

Target 1 GenBank Gene ID

Not Available

Target 1 GeneCard ID

ALPPL2

Target 1 GenAtlas ID

ALPPL2

Target 1 HGNC ID

HGNC:441

Target 1 Chromosome Location

Not Available

Target 1 Locus

2q37

Target 1 SNPs

SNPJam Report Link Image

Target 1 Toxin References

R210 - Gerbitz KD: Human alkaline phosphatases. II. Metalloenzyme properties of the enzyme from human liver. Hoppe Seylers Z Physiol Chem. 1977 Nov;358(11):1491-7. [PubMed ]

Target 1 General References

2834730; 2745460; 2297757; 2162249; 15815621; 15489334; 3443302; 3387245

Target 2 [top]

Target 2 ID

272

Target 2 Name

Alkaline phosphatase, tissue-nonspecific isozyme

Target 2 Mechanism of Action

Cyanide inhibits alkaline phosphatases. (R210)

Target 2 Description

This isozyme may play a role in skeletal mineralization

Target 2 Synonyms

AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme

Target 2 Gene Name

ALPL

Target 2 Protein Sequence

>Alkaline phosphatase, tissue-nonspecific isozyme

MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF

Target 2 Number of Residues

524

Target 2 Molecular Weight

57304.4

Target 2 Theoretical pI

6.66

Target 2 GO Classification

Function
Not Available
Process
physiological process metabolism
Component
Not Available

Target 2 General Function

Inorganic ion transport and metabolism

Target 2 Pathways

Not Available

Target 2 Reactions

Not Available

Target 2 Signals

1-17

Target 2 Transmembrane Regions

None

Target 2 Essentiality

Non Essential

Target 2 Domain Function

PF00245:Alk_phosphatase

Target 2 GenBank ID Protein

Not Available

Target 2 UniProtKB ID

P05186

Target 2 Cellular Location

Cell membrane

Target 2 Gene Sequence

>1575 bp

ATGATTTCACCATTCTTAGTACTGGCCATTGGCACCTGCCTTACTAACTCCTTAGTGCCA
GAGAAAGAGAAAGACCCCAAGTACTGGCGAGACCAAGCGCAAGAGACACTGAAATATGCC
CTGGAGCTTCAGAAGCTCAACACCAACGTGGCTAAGAATGTCATCATGTTCCTGGGAGAT
GGGATGGGTGTCTCCACAGTGACGGCTGCCCGCATCCTCAAGGGTCAGCTCCACCACAAC
CCTGGGGAGGAGACCAGGCTGGAGATGGACAAGTTCCCCTTCGTGGCCCTCTCCAAGACG
TACAACACCAAAGCCCAGGTCCCTGACAGCGCCGGCACCGCCACCGCCTACCTGTGTGGG
GTGAAGGCCAATGAGGGCACCGTGGGGGTAAGCGCAGCCACTGAGCGTTCCCGGTGCAAC
ACCACCCAGGGGAACGAGGTCACCTCCATCCTGCGCTGGGCCAAGGACGCTGGGAAATCT
GTGGGCATTGTGACCACCACGAGAGTGAACCATGCCACCCCCAGCGCCGCCTACGCCCAC
TCGGCTGACCGGGACTGGTACTCAGACAACGAGATGCCCCCTGAGGCCTTGAGCCAGGGC
TGTAAGGACATCGCCTACCAGCTCATGCATAACATCAGGGACATTGACGTGATCATGGGG
GGTGGCCGGAAATACATGTACCCCAAGAATAAAACTGATGTGGAGTATGAGAGTGACGAG
AAAGCCAGGGGCACGAGGCTGGACGGCCTGGACCTCGTTGACACCTGGAAGAGCTTCAAA
CCGAGACACAAGCACTCCCACTTCATCTGGAACCGCACGGAACTCCTGACCCTTGACCCC
CACAATGTGGACTACCTATTGGGTCTCTTCGAGCCGGGGGACATGCAGTACGAGCTGAAC
AGGAACAACGTGACGGACCCGTCACTCTCCGAGATGGTGGTGGTGGCCATCCAGATCCTG
CGGAAGAACCCCAAAGGCTTCTTCTTGCTGGTGGAAGGAGGCAGAATTGACCACGGGCAC
CATGAAGGAAAAGCCAAGCAGGCCCTGCATGAGGCGGTGGAGATGGACCGGGCCATCGGG
CAGGCAGGCAGCTTGACCTCCTCGGAAGACACTCTGACCGTGGTCACTGCGGACCATTCC
CACGTCTTCACATTTGGTGGATACACCCCCCGTGGCAACTCTATCTTTGGTCTGGCCCCC
ATGCTGAGTGACACAGACAAGAAGCCCTTCACTGCCATCCTGTATGGCAATGGGCCTGGC
TACAAGGTGGTGGGCGGTGAACGAGAGAATGTCTCCATGGTGGACTATGCTCACAACAAC
TACCAGGCGCAGTCTGCTGTGCCCCTGCGCCACGAGACCCACGGCGGGGAGGACGTGGCC
GTCTTCTCCAAGGGCCCCATGGCGCACCTGCTGCACGGCGTCCACGAGCAGAACTACGTC
CCCCACGTGATGGCGTATGCAGCCTGCATCGGGGCCAACCTCGGCCACTGTGCTCCTGCC
AGCTCGGCAGGCAGCCTTGCTGCAGGCCCCCTGCTGCTCGCGCTGGCCCTCTACCCCCTG
AGCGTCCTGTTCTGA

Target 2 GenBank Gene ID

Not Available

Target 2 GeneCard ID

ALPL

Target 2 GenAtlas ID

ALPL

Target 2 HGNC ID

HGNC:438

Target 2 Chromosome Location

Not Available

Target 2 Locus

1p36.12

Target 2 SNPs

SNPJam Report Link Image

Target 2 Toxin References

R210 - Gerbitz KD: Human alkaline phosphatases. II. Metalloenzyme properties of the enzyme from human liver. Hoppe Seylers Z Physiol Chem. 1977 Nov;358(11):1491-7. [PubMed ]

Target 2 General References

3532105; 3165380; 2928120; 9747027; 16710414; 15489334; 3954357; 1458595; 14517339

Target 3 [top]

Target 3 ID

249

Target 3 Name

Catalase

Target 3 Mechanism of Action

Cyanide inhibits catalase. (R211)

Target 3 Description

Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells

Target 3 Synonyms

Not Available

Target 3 Gene Name

CAT

Target 3 Protein Sequence

>Catalase

MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDE
MAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGES
GSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPD
MVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQ
GIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLT
KVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPD
THRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALE
HSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVK
NFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL

Target 3 Number of Residues

527

Target 3 Molecular Weight

59755.8

Target 3 Theoretical pI

7.41

Target 3 GO Classification

Function
tetrapyrrole binding heme binding binding ion binding cation binding transition metal ion binding iron ion binding antioxidant activity peroxidase activity catalase activity
Process
oxygen and reactive oxygen species metabolism response to oxidative stress physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 3 General Function

Inorganic ion transport and metabolism

Target 3 Pathways

Not Available

Target 3 Reactions

Not Available

Target 3 Signals

None

Target 3 Transmembrane Regions

None

Target 3 Essentiality

Non Essential

Target 3 Domain Function

PF00199:Catalase PF06628:Catalase-rel

Target 3 GenBank ID Protein

Not Available

Target 3 UniProtKB ID

P04040

Target 3 Cellular Location

Peroxisome

Target 3 Gene Sequence

>1584 bp

ATGGCTGACAGCCGGGATCCCGCCAGCGACCAGATGCAGCACTGGAAGGAGCAGCGGGCC
GCGCAGAAAGCTGATGTCCTGACCACTGGAGCTGGTAACCCAGTAGGAGACAAACTTAAT
GTTATTACAGTAGGGCCCCGTGGGCCCCTTCTTGTTCAGGATGTGGTTTTCACTGATGAA
ATGGCTCATTTTGACCGAGAGAGAATTCCTGAGAGAGTTGTGCATGCTAAAGGAGCAGGG
GCCTTTGGCTACTTTGAGGTCACACATGACATTACCAAATACTCCAAGGCAAAGGTATTT
GAGCATATTGGAAAGAAGACTCCCATCGCAGTTCGGTTCTCCACTGTTGCTGGAGAATCG
GGTTCAGCTGACACAGTTCGGGACCCTCGTGGGTTTGCAGTGAAATTTTACACAGAAGAT
GGTAACTGGGATCTCGTTGGAAATAACACCCCCATTTTCTTCATCAGGGATCCCATATTG
TTTCCATCTTTTATCCACAGCCAAAAGAGAAATCCTCAGACACATCTGAAGGATCCGGAC
ATGGTCTGGGACTTCTGGAGCCTACGTCCTGAGTCTCTGCATCAGGTTTCTTTCTTGTTC
AGTGATCGGGGGATTCCAGATGGACATCGCCACATGAATGGATATGGATCACATACTTTC
AAGCTGGTTAATGCAAATGGGGAGGCAGTTTATTGCAAATTCCATTATAAGACTGACCAG
GGCATCAAAAACCTTTCTGTTGAAGATGCGGCGAGACTTTCCCAGGAAGATCCTGACTAT
GGCATCCGGGATCTTTTTAACGCCATTGCCACAGGAAAGTACCCCTCCTGGACTTTTTAC
ATCCAGGTCATGACATTTAATCAGGCAGAAACTTTTCCATTTAATCCATTCGATCTCACC
AAGGTTTGGCCTCACAAGGACTACCCTCTCATCCCAGTTGGTAAACTGGTCTTAAACCGG
AATCCAGTTAATTACTTTGCTGAGGTTGAACAGATAGCCTTCGACCCAAGCAACATGCCA
CCTGGCATTGAGGCCAGTCCTGACAAAATGCTTCAGGGCCGCCTTTTTGCCTATCCTGAC
ACTCACCGCCATCGCCTGGGACCCAATTATCTTCATATACCTGTGAACTGTCCCTACCGT
GCTCGAGTGGCCAACTACCAGCGTGATGGCCCGATGTGCATGCAGGACAATCAGGGTGGT
GCTCCAAATTACTACCCCAACAGCTTTGGTGCTCCGGAACAACAGCCTTCTGCCCTGGAG
CACAGCATCCAATATTCTGGAGAAGTGCGGAGATTCAACACTGCCAATGATGATAACGTT
ACTCAGGTGCGGGCATTCTATGTGAACGTGCTGAATGAGGAACAGAGGAAACGTCTGTGT
GAGAACATTGCCGGCCACCTGAAGGATGCACAAATTTTCATCCAGAAGAAAGCGGTCAAG
AACTTCACTGAGGTCCACCCTGACTACGGGAGCCACATCCAGGCTCTTCTGGACAAGTAC
AATGCTGAGAAGCCTAAGAATGCGATTCACACCTTTGTGCAGTCCGGATCTCACTTGGCG
GCAAGGGAGAAGGCAAATCTGTGA

Target 3 GenBank Gene ID

Not Available

Target 3 GeneCard ID

CAT

Target 3 GenAtlas ID

CAT

Target 3 HGNC ID

HGNC:1516

Target 3 Chromosome Location

Chromosome:11

Target 3 Locus

11p13

Target 3 SNPs

SNPJam Report Link Image

Target 3 Toxin References

R211 - Kang YS, Lee DH, Yoon BJ, Oh DC: Purification and characterization of a catalase from photosynthetic bacterium Rhodospirillum rubrum S1 grown under anaerobic conditions. J Microbiol. 2006 Apr;44(2):185-91. [PubMed ]

Target 3 General References

3755525; 3755526; 11728823; 14702039; 16554811; 15489334; 8282800; 12665801

Target 4 [top]

Target 4 ID

116

Target 4 Name

Cytochrome c oxidase polypeptide 7A1, mitochondrial

Target 4 Mechanism of Action

Cyanide is an inhibitor of cytochrome c oxidase in the fourth complex of the electron transport chain (found in the membrane of the mitochondria of eukaryotic cells). It complexes with the ferric iron atom in this enzyme. The binding of cyanide to this cytochrome prevents transport of electrons from cytochrome c oxidase to oxygen. As a result, the electron transport chain is disrupted and the cell can no longer aerobically produce ATP for energy. Tissues that mainly depend on aerobic respiration, such as the central nervous system and the heart, are particularly affected. (R173)

Target 4 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 4 Synonyms

Cytochrome c oxidase polypeptide VIIa-heart; Cytochrome c oxidase subunit VIIa-H; COX VIIa-M

Target 4 Gene Name

COX7A1

Target 4 Protein Sequence

>Cytochrome c oxidase polypeptide 7A1, mitochondrial

MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLC
LGGTVYSLYSLGWASFPRN

Target 4 Number of Residues

Target 4 Molecular Weight

9117.4

Target 4 Theoretical pI

10.52

Target 4 GO Classification

Function
transporter activity electron transporter activity catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 4 General Function

Involved in cytochrome-c oxidase activity

Target 4 Pathways

Not Available

Target 4 Reactions

Not Available

Target 4 Signals

None

Target 4 Transmembrane Regions

47-75

Target 4 Essentiality

Non Essential

Target 4 Domain Function

PF02238:COX7a

Target 4 GenBank ID Protein

Not Available

Target 4 UniProtKB ID

P24310

Target 4 Cellular Location

Mitochondrion inner membrane

Target 4 Gene Sequence

>240 bp

ATGCAGGCCCTTCGGGTGTCCCAGGCGCTGATCCGCTCCTTCAGCTCCACCGCCCGGAAC
CGCTTTCAGAACCGAGTGCGCGAGAAACAGAAGCTCTTCCAGGAGGACAATGACATCCCG
TTGTACCTGAAGGGCGGCATCGTTGACAACATCCTGTACCGAGTGACAATGACGCTGTGT
CTGGGCGGCACTGTCTACAGCTTGTACTCCCTTGGCTGGGCCTCCTTCCCCAGGAATTAA

Target 4 GenBank Gene ID

Not Available

Target 4 GeneCard ID

COX7A1

Target 4 GenAtlas ID

COX7A1

Target 4 HGNC ID

HGNC:2287

Target 4 Chromosome Location

Chromosome:19

Target 4 Locus

19q13.1

Target 4 SNPs

SNPJam Report Link Image

Target 4 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 4 General References

1327965; 9344674; 11997101; 10335655; 15057824; 15489334; 1309697

Target 5 [top]

Target 5 ID

Target 5 Name

Cytochrome c oxidase polypeptide 7A2, mitochondrial

Target 5 Mechanism of Action

Target 5 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 5 Synonyms

Cytochrome c oxidase polypeptide VIIa-liver/heart; Cytochrome c oxidase subunit VIIa-L; VIIaL

Target 5 Gene Name

COX7A2

Target 5 Protein Sequence

>Cytochrome c oxidase polypeptide 7A2, mitochondrial

MLRNLLALRQIGQRTISTASRRHFKNKVPEKQKLFQEDDEIPLYLKGGVADALLYRATMI
LTVGGTAYAIYELAVASFPKKQE

Target 5 Number of Residues

Target 5 Molecular Weight

9395.9

Target 5 Theoretical pI

10.27

Target 5 GO Classification

Function
transporter activity electron transporter activity catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 5 General Function

Involved in cytochrome-c oxidase activity

Target 5 Pathways

Not Available

Target 5 Reactions

Not Available

Target 5 Signals

None

Target 5 Transmembrane Regions

53-75

Target 5 Essentiality

Non Essential

Target 5 Domain Function

PF02238:COX7a

Target 5 GenBank ID Protein

Not Available

Target 5 UniProtKB ID

P14406

Target 5 Cellular Location

Mitochondrion inner membrane

Target 5 Gene Sequence

>252 bp

ATGCTGCGGAATCTGCTGGCTCTTCGTCAGATTGGGCAGAGGACGATAAGCACTGCTTCC
CGCAGGCATTTTAAAAATAAAGTTCCGGAGAAGCAAAAACTGTTCCAGGAGGATGATGAA
ATTCCACTGTATCTAAAGGGTGGGGTAGCTGATGCCCTCCTGTATAGAGCCACCATGATT
CTTACAGTTGGTGGAACAGCATATGCCATATATGAGCTGGCTGTGGCTTCATTTCCCAAG
AAGCAGGAGTGA

Target 5 GenBank Gene ID

Not Available

Target 5 GeneCard ID

COX7A2

Target 5 GenAtlas ID

COX7A2

Target 5 HGNC ID

HGNC:2288

Target 5 Chromosome Location

Not Available

Target 5 Locus

6q12

Target 5 SNPs

SNPJam Report Link Image

Target 5 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 5 General References

2550906; 11004498; 14702039; 14574404; 15489334; 1309697

Target 6 [top]

Target 6 ID

170

Target 6 Name

Cytochrome c oxidase subunit 1

Target 6 Mechanism of Action

Target 6 Description

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B

Target 6 Synonyms

Cytochrome c oxidase polypeptide I

Target 6 Gene Name

MT-CO1

Target 6 Protein Sequence

>Cytochrome c oxidase subunit 1

MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAELGQPGNLLGNDHIYNVIVTA
HAFVMIFFMVMPIMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMVEA
GAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQ
TPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGH
PEVYILILPGFGMISHIVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGMDVD
TRAYFTSATMIIAIPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGGLTGIVLAN
SSLDIVLHDTYYVVAHFHYVLSMGAVFAIMGGFIHWFPLFSGYTLDQTYAKIHFTIMFIG
VNLTFFPQHFLGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMIFMIWEAFASKR
KVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Target 6 Number of Residues

513

Target 6 Molecular Weight

57040.9

Target 6 Theoretical pI

6.70

Target 6 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell membrane

Target 6 General Function

Energy production and conversion

Target 6 Pathways

Energy metabolism; oxidative phosphorylation

Target 6 Reactions

Not Available

Target 6 Signals

None

Target 6 Transmembrane Regions

20-42
57-79
100-122
147-169
182-204
236-258
271-293
303-325
337-359
374-396
409-431
451-473

Target 6 Essentiality

Non Essential

Target 6 Domain Function

PF00115:COX1

Target 6 GenBank ID Protein

Not Available

Target 6 UniProtKB ID

P00395

Target 6 Cellular Location

Mitochondrion inner membrane

Target 6 Gene Sequence

>957 bp

ATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCATTCCTA
ATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTGGTA
GGCCCCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCC
CTAAAACCCGCCACATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACC
ATCGCTCTTCTACTATGAACCCCCCTCCCCATACCCAACCCCCTGGTCAACCTCAACCTA
GGCCTCCTATTTATTCTAGCCACCTCTAGCCTAGCCGTTTACTCAATCCTCTGATCAGGG
TGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGCAGTAGCCCAAACAATC
TCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGCTCCTTT
AACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCC
TTGGCCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTT
GCCGAAGGGGAGTCCGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTC
GCCCTATTCTTCATAGCCGAATACACAAACATTATTATAATAAACACCCTCACCACTACA
ATCTTCCTAGGAACAACATATGACGCACTCTCCCCTGAACTCTACACAACATATTTTGTC
ACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAACAGCATACCCCCGATTC
CGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTAGCATTA
CTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTAA

Target 6 GenBank Gene ID

Not Available

Target 6 GeneCard ID

MT-CO1

Target 6 GenAtlas ID

MT-CO1

Target 6 HGNC ID

HGNC:7419

Target 6 Chromosome Location

Chromosome:MT
HGNC chromosome: mitochondria

Target 6 Locus

Not Available

Target 6 SNPs

SNPJam Report Link Image

Target 6 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 6 General References

7219534; 7530363; 12949126; 11130070; 12840039; 14760490; 6260957; 1757091; 1322638; 9389715

Target 7 [top]

Target 7 ID

Target 7 Name

Cytochrome c oxidase subunit 2

Target 7 Mechanism of Action

Target 7 Description

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1

Target 7 Synonyms

Cytochrome c oxidase polypeptide II

Target 7 Gene Name

MT-CO2

Target 7 Protein Sequence

>Cytochrome c oxidase subunit 2

MAHAAQVGLQDATSPIMEELITFHDHALMIIFLICFLVLYALFLTLTTKLTNTNISDAQE
METVWTILPAIILVLIALPSLRILYMTDEVNDPSLTIKSIGHQWYWTYEYTDYGGLIFNS
YMLPPLFLEPGDLRLLDVDNRVVLPIEAPIRMMITSQDVLHSWAVPTLGLKTDAIPGRLN
QTTFTATRPGVYYGQCSEICGANHSFMPIVLELIPLKIFEMGPVFTL

Target 7 Number of Residues

227

Target 7 Molecular Weight

25564.7

Target 7 Theoretical pI

4.44

Target 7 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity binding ion binding cation binding transition metal ion binding copper ion binding
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
organelle membrane organelle inner membrane cell membrane intrinsic to membrane integral to membrane

Target 7 General Function

Energy production and conversion

Target 7 Pathways

Not Available

Target 7 Reactions

Not Available

Target 7 Signals

None

Target 7 Transmembrane Regions

27-48
63-82

Target 7 Essentiality

Non Essential

Target 7 Domain Function

PF00116:COX2 PF02790:COX2_TM

Target 7 GenBank ID Protein

Not Available

Target 7 UniProtKB ID

P00403

Target 7 Cellular Location

Mitochondrion inner membrane

Target 7 Gene Sequence

>684 bp

ATGGCACATGCAGCGCAAGTAGGTCTACAAGACGCTACTTCCCCTATCATAGAAGAGCTT
ATCACCTTTCATGATCACGCCCTCATAATCATTTTCCTTATCTGCTTCCTAGTCCTGTAT
GCCCTTTTCCTAACACTCACAACAAAACTAACTAATACTAACATCTCAGACGCTCAGGAA
ATAGAAACCGTCTGAACTATCCTGCCCGCCATCATCCTAGTCCTCATCGCCCTCCCATCC
CTACGCATCCTTTACATAACAGACGAGGTCAACGATCCCTCCCTTACCATCAAATCAATT
GGCCACCAATGGTACTGAACCTACGAGTACACCGACTACGGCGGACTAATCTTCAACTCC
TACATACTTCCCCCATTATTCCTAGAACCAGGCGACCTGCGACTCCTTGACGTTGACAAT
CGAGTAGTACTCCCGATTGAAGCCCCCATTCGTATAATAATTACATCACAAGACGTCTTG
CACTCATGAGCTGTCCCCACATTAGGCTTAAAAACAGATGCAATTCCCGGACGTCTAAAC
CAAACCACTTTCACCGCTACACGACCGGGGGTATACTACGGTCAATGCTCTGAAATCTGT
GGAGCAAACCACAGTTTCATGCCCATCGTCCTAGAATTAATTCCCCTAAAAATCTTTGAA
ATAGGGCCCGTATTTACCCTATAG

Target 7 GenBank Gene ID

Not Available

Target 7 GeneCard ID

MT-CO2

Target 7 GenAtlas ID

MT-CO2

Target 7 HGNC ID

HGNC:7421

Target 7 Chromosome Location

Chromosome:MT
HGNC chromosome: mitochondria

Target 7 Locus

Not Available

Target 7 SNPs

SNPJam Report Link Image

Target 7 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 7 General References

7219534; 2550900; 226894; 7530363; 8277847; 12949126; 11130070; 12840039; 14760490

Target 8 [top]

Target 8 ID

Target 8 Name

Cytochrome c oxidase subunit 3

Target 8 Mechanism of Action

Target 8 Description

Subunits I, II and III form the functional core of the enzyme complex

Target 8 Synonyms

Cytochrome c oxidase polypeptide III

Target 8 Gene Name

MT-CO3

Target 8 Protein Sequence

>Cytochrome c oxidase subunit 3

MTHQSHAYHMVKPSPWPLTGALSALLMTSGLAMWFHFHSMTLLMLGLLTNTLTMYQWWRD
VTRESTYQGHHTPPVQKGLRYGMILFITSEVFFFAGFFWAFYHSSLAPTPQLGGHWPPTG
ITPLNPLEVPLLNTSVLLASGVSITWAHHSLMENNRNQMIQALLITILLGLYFTLLQASE
YFESPFTISDGIYGSTFFVATGFHGLHVIIGSTFLTICFIRQLMFHFTSKHHFGFEAAAW
YWHFVDVVWLFLYVSIYWWGS

Target 8 Number of Residues

261

Target 8 Molecular Weight

29950.6

Target 8 Theoretical pI

7.34

Target 8 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell membrane

Target 8 General Function

Energy production and conversion

Target 8 Pathways

Not Available

Target 8 Reactions

Not Available

Target 8 Signals

None

Target 8 Transmembrane Regions

15-35
42-59
81-101
127-147
159-179
197-217
239-259

Target 8 Essentiality

Non Essential

Target 8 Domain Function

PF00510:COX3

Target 8 GenBank ID Protein

Not Available

Target 8 UniProtKB ID

P00414

Target 8 Cellular Location

Mitochondrion inner membrane

Target 8 Gene Sequence

>956 bp

ATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCATTCCTA
ATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTTGTA
GGCCCCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCC
CTAAAACCCGCCACATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACC
ATCGCTCTTCTACTATGAACCCCCCTCCCCATACCCAACCCCCTGGTCAACCTCAACCTA
GGCCTCCTATTTATTCTAGCCACCTCTAGCCTAGCCGTTTACTCAATCCTCTGATCAGGG
TGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGCAGTAGCCCAAACAATC
TCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGCTCCTTT
AACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCC
TTGGCCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTT
GCCGAAGGGGAGTCCGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTC
GCCCTATTCTTCATAGCCGAATACACAAACATTATTATAATAAACACCCTCACCACTACA
ATCTTCCTAGGAACAACATATGACGCACTCTCCCCTGAACTCTACACAACATATTTTGTC
ACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAACAGCATACCCCCGATTC
CGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTAGCATTA
CTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTA

Target 8 GenBank Gene ID

Not Available

Target 8 GeneCard ID

MT-CO3

Target 8 GenAtlas ID

MT-CO3

Target 8 HGNC ID

HGNC:7422

Target 8 Chromosome Location

Chromosome:MT
HGNC chromosome: mitochondria

Target 8 Locus

Not Available

Target 8 SNPs

SNPJam Report Link Image

Target 8 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 8 General References

7219534; 16776823; 1757091; 8240356; 7496173; 8630495; 9461455

Target 9 [top]

Target 9 ID

221

Target 9 Name

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

Target 9 Mechanism of Action

Target 9 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 9 Synonyms

Cytochrome c oxidase subunit IV isoform 1; COX IV-1; Cytochrome c oxidase polypeptide IV

Target 9 Gene Name

COX4I1

Target 9 Protein Sequence

>Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

MLATRVFSLVGKRAISTSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQK
ALKEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMW
QKHYVYGPLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWKK

Target 9 Number of Residues

169

Target 9 Molecular Weight

19576.6

Target 9 Theoretical pI

10.12

Target 9 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 9 General Function

Involved in cytochrome-c oxidase activity

Target 9 Pathways

Not Available

Target 9 Reactions

Not Available

Target 9 Signals

None

Target 9 Transmembrane Regions

103-120

Target 9 Essentiality

Non Essential

Target 9 Domain Function

PF02936:COX4

Target 9 GenBank ID Protein

Not Available

Target 9 UniProtKB ID

P13073

Target 9 Cellular Location

Mitochondrion inner membrane

Target 9 Gene Sequence

>510 bp

GCGGCGGGCGGTGGCGGCAGAATGTTGGCTACCAGGGTATTTAGCCTAGTTGGCAAGCGA
GCAATTTCCACCTCTGTGTGTGTACGAGCTCATGAAAGTGTTGTGAAGAGCGAAGACTTT
TCGCTCCCAGCTTATATGGATCGGCGTGACCACCCCTTGCCGGAGGTGGCCCATGTCAAG
CACCTGTCTGCCAGCCAGAAGGCACTGAAGGAGAAGGAGAAGGCCTCCTGGAGCAGCCTC
TCCATGGATGAGAAAGTCGAGTTGTATCGCATTAAGTTCAAGGAGAGCTTTGCTGAGATG
AACAGGGGCTCGAACGAGTGGAAGACGGTTGTGGGCGGTGCCATGTTCTTCATCGGTTTC
ACCGCGCTCGTTATCATGTGGCAGAAGCACTATGTGTACGGCCCCCTCCCGCAAAGCTTT
GACAAAGAGTGGGTGGCCAAGCAGACCAAGAGGATGCTGGACATGAAGGTGAACCCCATC
CAGGGCTTAGCCTCCAAGTGGGACTACGAA

Target 9 GenBank Gene ID

Not Available

Target 9 GeneCard ID

COX4I1

Target 9 GenAtlas ID

COX4I1

Target 9 HGNC ID

HGNC:2265

Target 9 Chromosome Location

Chromosome:16

Target 9 Locus

16q22-qter

Target 9 SNPs

SNPJam Report Link Image

Target 9 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 9 General References

2444497; 2157630; 15489334; 10337626; 1311608

Target 10 [top]

Target 10 ID

Target 10 Name

Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

Target 10 Mechanism of Action

Target 10 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 10 Synonyms

Cytochrome c oxidase subunit IV isoform 2; COX IV-2

Target 10 Gene Name

COX4I2

Target 10 Protein Sequence

>Cytochrome c oxidase subunit 4 isoform 2, mitochondrial

MLPRAAWSLVLRKGGGGRRGMHSSEGTTRGGGKMSPYTNCYAQRYYPMPEEPFCTELNAE
EQALKEKEKGSWTQLTHAEKVALYRLQFNETFAEMNRRSNEWKTVMGCVFFFIGFAALVI
WWQRVYVFPPKPITLTDERKAQQLQRMLDMKVNPVQGLASRWDYEKKQWKK

Target 10 Number of Residues

171

Target 10 Molecular Weight

20010.0

Target 10 Theoretical pI

10.13

Target 10 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 10 General Function

Involved in cytochrome-c oxidase activity

Target 10 Pathways

Not Available

Target 10 Reactions

Not Available

Target 10 Signals

None

Target 10 Transmembrane Regions

105-127

Target 10 Essentiality

Non Essential

Target 10 Domain Function

PF02936:COX4

Target 10 GenBank ID Protein

Not Available

Target 10 UniProtKB ID

Q96KJ9

Target 10 Cellular Location

Mitochondrion inner membrane

Target 10 Gene Sequence

>516 bp

ATGCTCCCCAGAGCTGCCTGGAGCTTGGTGCTGAGGAAAGGTGGAGGTGGAAGACGAGGG
ATGCACAGCTCAGAAGGCACCACCCGTGGTGGGGGGAAGATGTCCCCCTACACCAACTGC
TATGCCCAGCGCTACTACCCCATGCCAGAAGAGCCCTTCTGCACAGAACTCAACGCTGAG
GAGCAGGCCCTGAAGGAGAAGGAGAAGGGAAGCTGGACCCAGCTGACCCACGCCGAAAAG
GTGGCCTTGTACCGGCTCCAGTTCAATGAGACCTTTGCGGAGATGAACCGTCGCTCCAAT
GAGTGGAAGACAGTGATGGGTTGTGTCTTCTTCTTCATTGGATTCGCAGCTCTGGTGATT
TGGTGGCAGCGGGTCTACGTATTTCCTCCAAAGCCGATCACCTTGACGGACGAGCGGAAA
GCCCAGCAGCTGCAGCGCATGCTGGACATGAAGGTGAATCCTGTGCAGGGCCTGGCCTCC
CACTGGGACTATGAGAAGAAGCAGTGGAAGAAGTGA

Target 10 GenBank Gene ID

Not Available

Target 10 GeneCard ID

COX4I2

Target 10 GenAtlas ID

COX4I2

Target 10 HGNC ID

HGNC:16232 Link Image

Target 10 Chromosome Location

Chromosome:20

Target 10 Locus

20q11.21

Target 10 SNPs

SNPJam Report Link Image

Target 10 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 10 General References

11311561; 11780052; 15489334; 19268275

Target 11 [top]

Target 11 ID

220

Target 11 Name

Cytochrome c oxidase subunit 5A, mitochondrial

Target 11 Mechanism of Action

Target 11 Description

This is the heme A-containing chain of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 11 Synonyms

Cytochrome c oxidase polypeptide Va

Target 11 Gene Name

COX5A

Target 11 Protein Sequence

>Cytochrome c oxidase subunit 5A, mitochondrial

MLGAALRRCAVAATTRADPRGLLHSARTPGPAVAIQSVRCYSHGSQETDEEFDARWVTYF
NKPDIDAWELRKGINTLVTYDMVPEPKIIDAALRACRRLNDFASTVRILEVVKDKAGPHK
EIYPYVIQELRPTLNELGISTPEELGLDKV

Target 11 Number of Residues

150

Target 11 Molecular Weight

16762.0

Target 11 Theoretical pI

6.78

Target 11 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 11 General Function

Involved in cytochrome-c oxidase activity

Target 11 Pathways

Not Available

Target 11 Reactions

Not Available

Target 11 Signals

None

Target 11 Transmembrane Regions

None

Target 11 Essentiality

Non Essential

Target 11 Domain Function

PF02284:COX5A

Target 11 GenBank ID Protein

Not Available

Target 11 UniProtKB ID

P20674

Target 11 Cellular Location

Mitochondrion inner membrane

Target 11 Gene Sequence

>453 bp

ATGCTGGGCGCCGCTCTCCGCCGCTGCGCTGTGGCCGCAACCACCCGGGCCGACCCTCGA
GGCCTCCTGCACTCCGCCCGGACCCCCGGCCCCGCCGTGGCTATCCAGTCAGTTCGCTGC
TATTCCCATGGGTCACAGGAGACAGATGAGGAGTTTGATGCTCGCTGGGTAACATACTTC
AACAAGCCAGATATAGATGCCTGGGAATTGCGTAAAGGGATAAACACACTTGTTACCTAT
GATATGGTTCCAGAGCCCAAAATCATTGATGCTGCTTTGCGGGCATGCAGACGGTTAAAT
GATTTTGCTAGTCTAGTTCGAATCCTAGAGGTTGTTAAGGACAAAGCAGGACCTCATAAG
GAAATCTACCCCTATGTCATCCAGGAACTTAGACCAACTTTAAATGAACTGGGAATCTCC
ACTCCGGAGGAACTGGGCCTTGACAAAGTGTAA

Target 11 GenBank Gene ID

Not Available

Target 11 GeneCard ID

COX5A

Target 11 GenAtlas ID

COX5A

Target 11 HGNC ID

HGNC:2267

Target 11 Chromosome Location

Chromosome:15

Target 11 Locus

15q24.1

Target 11 SNPs

SNPJam Report Link Image

Target 11 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 11 General References

2853101; 18197981; 16572171; 15489334; 8313870; 7498159

Target 12 [top]

Target 12 ID

200

Target 12 Name

Cytochrome c oxidase subunit 5B, mitochondrial

Target 12 Mechanism of Action

Target 12 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 12 Synonyms

Cytochrome c oxidase polypeptide Vb

Target 12 Gene Name

COX5B

Target 12 Protein Sequence

>Cytochrome c oxidase subunit 5B, mitochondrial

MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLD
PYNVLAPKGASGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHY
KLVPQQLAH

Target 12 Number of Residues

129

Target 12 Molecular Weight

13695.6

Target 12 Theoretical pI

9.00

Target 12 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
envelope organelle envelope mitochondrial envelope

Target 12 General Function

Involved in cytochrome-c oxidase activity

Target 12 Pathways

Not Available

Target 12 Reactions

Not Available

Target 12 Signals

None

Target 12 Transmembrane Regions

None

Target 12 Essentiality

Non Essential

Target 12 Domain Function

PF01215:COX5B

Target 12 GenBank ID Protein

Not Available

Target 12 UniProtKB ID

P10606

Target 12 Cellular Location

Mitochondrion inner membrane

Target 12 Gene Sequence

>390 bp

.TTTTTTTTTTTTTCCAATGCAATGGCTTCAAGGTTACTTCGCGGAGCTGGAACGCTGGC
CGCGCAGGCCCTGAGGGCTCGCGGCCCCAGTGGCGCGGCCGCGATGCGCTCCATGGCATC
TGGAGGTGGTGTTCCCACTGATGAAGAGCAGGCGACTGGGTTGGAGAGGGAGATCATGCT
GGCTGCAAAGAAGGGACTGGACCCATACAATGTACTGGCCCCAAAGGGAGCTTCAGGCAC
CAGGGAAGACCCTAATTTAGTCCCCTCCATCTCCAACAAGAGAATAGTAGGCTGCATCTG
TGAAGAGGACAATACCAGCGTCGTCTGGTTTTGGCTGCACAAAGGGCAGGCCCAGCGATG
CCCCCGCTGTGGAGCCCATTACAAGCTGGT

Target 12 GenBank Gene ID

Not Available

Target 12 GeneCard ID

COX5B

Target 12 GenAtlas ID

COX5B

Target 12 HGNC ID

HGNC:2269

Target 12 Chromosome Location

Not Available

Target 12 Locus

2cen-q13

Target 12 SNPs

SNPJam Report Link Image

Target 12 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 12 General References

2840351; 1646156; 15489334; 8806766; 8313870

Target 13 [top]

Target 13 ID

146

Target 13 Name

Cytochrome c oxidase subunit 6A1, mitochondrial

Target 13 Mechanism of Action

Target 13 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 13 Synonyms

Cytochrome c oxidase polypeptide VIa-liver

Target 13 Gene Name

COX6A1

Target 13 Protein Sequence

>Cytochrome c oxidase subunit 6A1, mitochondrial

MAVVGVSSVSRLLGRSRPQLGRPMSSGAHGEEGSARMWKTLTFFVALPGVAVSMLNVYLK
SHHGEHERPEFIAYPHLRIRTKPFPWGDGNHTLFHNPHVNPLPTGYEDE

Target 13 Number of Residues

109

Target 13 Molecular Weight

12154.8

Target 13 Theoretical pI

9.70

Target 13 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
envelope organelle envelope mitochondrial envelope

Target 13 General Function

Involved in cytochrome-c oxidase activity

Target 13 Pathways

Not Available

Target 13 Reactions

Not Available

Target 13 Signals

None

Target 13 Transmembrane Regions

40-59

Target 13 Essentiality

Non Essential

Target 13 Domain Function

PF02046:COX6A

Target 13 GenBank ID Protein

Not Available

Target 13 UniProtKB ID

P12074

Target 13 Cellular Location

Mitochondrion inner membrane

Target 13 Gene Sequence

Not Available

Target 13 GenBank Gene ID

Not Available

Target 13 GeneCard ID

COX6A1

Target 13 GenAtlas ID

COX6A1

Target 13 HGNC ID

HGNC:2277

Target 13 Chromosome Location

Chromosome:12

Target 13 Locus

12q24.2|12q24.2

Target 13 SNPs

SNPJam Report Link Image

Target 13 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 13 General References

14702039; 16541075; 15489334; 2549515; 1286669

Target 14 [top]

Target 14 ID

Target 14 Name

Cytochrome c oxidase subunit 6A2, mitochondrial

Target 14 Mechanism of Action

Target 14 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 14 Synonyms

Cytochrome c oxidase polypeptide VIa-heart; COXVIAH

Target 14 Gene Name

COX6A2

Target 14 Protein Sequence

>Cytochrome c oxidase subunit 6A2, mitochondrial

MALPLRPLTRGLASAAKGGHGGAGARTWRLLTFVLALPSVALCTFNSYLHSGHRPRPEFR
PYQHLRIRTKPYPWGDGNHTLFHNSHVNPLPTGYEHP

Target 14 Number of Residues

Target 14 Molecular Weight

10815.3

Target 14 Theoretical pI

11.37

Target 14 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
envelope organelle envelope mitochondrial envelope

Target 14 General Function

Involved in cytochrome-c oxidase activity

Target 14 Pathways

Not Available

Target 14 Reactions

Not Available

Target 14 Signals

None

Target 14 Transmembrane Regions

None

Target 14 Essentiality

Non Essential

Target 14 Domain Function

PF02046:COX6A

Target 14 GenBank ID Protein

Not Available

Target 14 UniProtKB ID

Q02221

Target 14 Cellular Location

Mitochondrion inner membrane

Target 14 Gene Sequence

>294 bp

ATGGCTTTGCCTCTGAGGCCCCTGACCCGGGGCTTGGCCAGCGCTGCCAAAGGAGGCCAC
GGAGGAGCAGGAGCTCGTACCTGGCGTCTGCTGACCTTCGTGCTGGCGCTGCCCAGCGTG
GCCCTCTGCACCTTCAACTCCTATCTCCACTCGGGCCACCGCGAGCGCCCCGAGTTCCGT
CCCTACCAACACCTCCGCATCCGCACCAAGCCCTACCCCTGGGGGGACGGCAACCACACT
CTGTTCCACAATAGCCACGTGAACCCTCTGCCCACGGGCTACGAACACCCCTGA

Target 14 GenBank Gene ID

Not Available

Target 14 GeneCard ID

COX6A2

Target 14 GenAtlas ID

COX6A2

Target 14 HGNC ID

HGNC:2279

Target 14 Chromosome Location

Chromosome:16

Target 14 Locus

16p

Target 14 SNPs

SNPJam Report Link Image

Target 14 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 14 General References

1327966; 9177785; 15489334

Target 15 [top]

Target 15 ID

Target 15 Name

Cytochrome c oxidase subunit 6B1

Target 15 Mechanism of Action

Target 15 Description

Connects the two COX monomers into the physiological dimeric form (By similarity)

Target 15 Synonyms

Cytochrome c oxidase subunit VIb isoform 1; COX VIb-1

Target 15 Gene Name

COX6B1

Target 15 Protein Sequence

>Cytochrome c oxidase subunit 6B1

MAEDMETKIKNYKTAPFDSRFPNQNQTRNCWQNYLDFHRCQKAMTAKGGDISVCEWYQRV
YQSLCPTSWVTDWDEQRAEGTFPGKI

Target 15 Number of Residues

Target 15 Molecular Weight

10192.3

Target 15 Theoretical pI

7.13

Target 15 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
organelle membrane-bound organelle intracellular membrane-bound organelle mitochondrion

Target 15 General Function

Involved in cytochrome-c oxidase activity

Target 15 Pathways

Not Available

Target 15 Reactions

Not Available

Target 15 Signals

None

Target 15 Transmembrane Regions

None

Target 15 Essentiality

Non Essential

Target 15 Domain Function

PF02297:COX6B

Target 15 GenBank ID Protein

Not Available

Target 15 UniProtKB ID

P14854

Target 15 Cellular Location

Mitochondrion intermembrane space (By similarity)

Target 15 Gene Sequence

>261 bp

ATGGCGGAAGACATGGAGACCAAAATCAAGAACTACAAGACCGCCCCTTTTGACAGCCGC
TTCCCCAACCAGAACCAGACTAGAAACTGCTGGCAGAACTACCTGGACTTCCACCGCTGT
CAGAAGGCAATGACCGCTAAAGGAGGCGATATCTCTGTGTGCGAATGGTACCAGCGTGTG
TACCAGTCCCTCTGCCCCACATCCTGGGTCACAGACTGGGATGAGCAACGGGCTGAAGGC
ACGTTTCCCGGGAAGATCTGA

Target 15 GenBank Gene ID

Not Available

Target 15 GeneCard ID

COX6B1

Target 15 GenAtlas ID

COX6B1

Target 15 HGNC ID

HGNC:2280

Target 15 Chromosome Location

Chromosome:19

Target 15 Locus

19q13.1

Target 15 SNPs

SNPJam Report Link Image

Target 15 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 15 General References

2537962; 2172092; 1651883; 14702039; 15057824; 15489334; 1647217

Target 16 [top]

Target 16 ID

Target 16 Name

Cytochrome c oxidase subunit 6B2

Target 16 Mechanism of Action

Target 16 Description

Connects the two COX monomers into the physiological dimeric form (By similarity)

Target 16 Synonyms

Cytochrome c oxidase subunit VIb isoform 2; COX VIb-2; Cytochrome c oxidase subunit VIb, testis-specific isoform; Cancer/testis antigen 59; CT59

Target 16 Gene Name

COX6B2

Target 16 Protein Sequence

>Cytochrome c oxidase subunit 6B2

MLDVEAQEPPKGKWSTPPFDPRFPSQNQIRNCYQNFLDYHRCLKTRTRRGKSTQPCEYYF
RVYHSLCPISWVESWNEQIKNGIFAGKI

Target 16 Number of Residues

Target 16 Molecular Weight

10528.9

Target 16 Theoretical pI

9.25

Target 16 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
organelle membrane-bound organelle intracellular membrane-bound organelle mitochondrion

Target 16 General Function

Involved in cytochrome-c oxidase activity

Target 16 Pathways

Not Available

Target 16 Reactions

Not Available

Target 16 Signals

None

Target 16 Transmembrane Regions

None

Target 16 Essentiality

Non Essential

Target 16 Domain Function

PF02297:COX6B

Target 16 GenBank ID Protein

Not Available

Target 16 UniProtKB ID

Q6YFQ2

Target 16 Cellular Location

Mitochondrion intermembrane space (By similarity)

Target 16 Gene Sequence

>267 bp

ATGTTGGATGTGGAAGCCCAGGAGCCCCCCAAGGGGAAATGGTCGACGCCGCCCTTCGAC
CCGCGCTTCCCCAGCCAGAACCAGATCCGTAACTGCTACCAGAACTTCCTGGACTACCAC
CGCTGCCTCAAGACCAGGACCCGCCGCGGGAAGAGCACGCAGCCCTGCGAGTACTATTTC
CGCGTGTACCACTCGCTGTGCCCCATCAGCTGGGTGGAGAGCTGGAACGAGCAGATCAAG
AACGGGATTTTCGCCGGCAAAATCTGA

Target 16 GenBank Gene ID

Not Available

Target 16 GeneCard ID

COX6B2

Target 16 GenAtlas ID

COX6B2

Target 16 HGNC ID

HGNC:24380 Link Image

Target 16 Chromosome Location

Chromosome:19

Target 16 Locus

19q13.42

Target 16 SNPs

SNPJam Report Link Image

Target 16 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 16 General References

12874793; 14702039; 15489334; 15905330

Target 17 [top]

Target 17 ID

Target 17 Name

Cytochrome c oxidase subunit 6C

Target 17 Mechanism of Action

Target 17 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 17 Synonyms

Cytochrome c oxidase polypeptide VIc

Target 17 Gene Name

COX6C

Target 17 Protein Sequence

>Cytochrome c oxidase subunit 6C

MAPEVLPKPRMRGLLARRLRNHMAVAFVLSLGVAALYKFRVADQRKKAYADFYRNYDVMK
DFEEMRKAGIFQSVK

Target 17 Number of Residues

Target 17 Molecular Weight

8781.4

Target 17 Theoretical pI

10.98

Target 17 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 17 General Function

Involved in cytochrome-c oxidase activity

Target 17 Pathways

Not Available

Target 17 Reactions

Not Available

Target 17 Signals

None

Target 17 Transmembrane Regions

14-54

Target 17 Essentiality

Non Essential

Target 17 Domain Function

PF02937:COX6C

Target 17 GenBank ID Protein

Not Available

Target 17 UniProtKB ID

P09669

Target 17 Cellular Location

Mitochondrion inner membrane

Target 17 Gene Sequence

>228 bp

ATGGCTCCCGAAGTTTTGCCAAAACCTCGGATGCGTGGCCTTCTGGCCAGGCGTCTGCGA
AATCATATGGCTGTAGCATTCGTGCTATCCCTGGGGGTTGCAGCTTTGTATAAGTTTCGT
GTGGCTGATCAAAGAAAGAAGGCATACGCAGATTTCTACAGAAACTACGATGTCATGAAA
GATTTTGAGGAGATGAGGAAGGCTGGTATCTTTCAGAGTGTAAAGTAA

Target 17 GenBank Gene ID

Not Available

Target 17 GeneCard ID

COX6C

Target 17 GenAtlas ID

COX6C

Target 17 HGNC ID

HGNC:2285

Target 17 Chromosome Location

Not Available

Target 17 Locus

8q22-q23

Target 17 SNPs

SNPJam Report Link Image

Target 17 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 17 General References

2849755; 10072584; 15489334

Target 18 [top]

Target 18 ID

389

Target 18 Name

Cytochrome c oxidase subunit 7A3, mitochondrial

Target 18 Mechanism of Action

Target 18 Description

Not Available

Target 18 Synonyms

Cytochrome c oxidase subunit VIIa 3

Target 18 Gene Name

COX7AP2

Target 18 Protein Sequence

>Cytochrome c oxidase subunit 7A3, mitochondrial

MLWNLLALHQIGQRTISTASHRHFKNKVPEKQKLFQEDDGIPLYLKGGIADALLHRATMI
LTVGGTAYAIYQLAVASFPNKGVTSIIPAITWFTFIQLSMDQKSDK

Target 18 Number of Residues

106

Target 18 Molecular Weight

11840.7

Target 18 Theoretical pI

10.14

Target 18 GO Classification

Function
transporter activity electron transporter activity catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 18 General Function

Involved in cytochrome-c oxidase activity

Target 18 Pathways

Not Available

Target 18 Reactions

Not Available

Target 18 Signals

None

Target 18 Transmembrane Regions

None

Target 18 Essentiality

Non Essential

Target 18 Domain Function

PF02238:COX7a

Target 18 GenBank ID Protein

Not Available

Target 18 UniProtKB ID

O60397

Target 18 Cellular Location

Mitochondrion inner membrane (By similarity)

Target 18 Gene Sequence

>321 bp

ATGCTGTGGAATCTGCTGGCTCTTCATCAGATTGGGCAGAGGACCATAAGCACTGCTTCC
CACAGGCATTTTAAAAATAAAGTTCCAGAGAAACAAAAACTGTTCCAGGAGGATGATGGA
ATTCCACTGTATCTAAAGGGTGGGATAGCTGATGCCCTCCTTCATAGAGCCACCATGATT
CTTACAGTTGGTGGAACAGCATATGCCATATATCAGCTGGCTGTGGCTTCATTTCCCAAT
AAAGGAGTGACTTCAATCATCCCAGCAATCACTTGGTTCACATTCATTCAGCTCTCTATG
GACCAGAAATCTGATAAATGA

Target 18 GenBank Gene ID

Not Available

Target 18 GeneCard ID

COX7AP2

Target 18 GenAtlas ID

COX7AP2

Target 18 HGNC ID

HGNC:2290

Target 18 Chromosome Location

Not Available

Target 18 Locus

Not Available

Target 18 SNPs

SNPJam Report Link Image

Target 18 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 18 General References

15815621

Target 19 [top]

Target 19 ID

192

Target 19 Name

Cytochrome c oxidase subunit 7B, mitochondrial

Target 19 Mechanism of Action

Target 19 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 19 Synonyms

Cytochrome c oxidase polypeptide VIIb

Target 19 Gene Name

COX7B

Target 19 Protein Sequence

>Cytochrome c oxidase subunit 7B, mitochondrial

MFPLVKSALNRLQVRSIQQTMARQSHQKRTPDFHDKYGNAVLASGATFCIVTWTYVATQV
GIEWNLSPVGRVTPKEWRNQ

Target 19 Number of Residues

Target 19 Molecular Weight

9160.5

Target 19 Theoretical pI

10.87

Target 19 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell membrane organelle membrane organelle inner membrane mitochondrial inner membrane mitochondrial electron transport chain

Target 19 General Function

Involved in cytochrome-c oxidase activity

Target 19 Pathways

Not Available

Target 19 Reactions

Not Available

Target 19 Signals

None

Target 19 Transmembrane Regions

33-59

Target 19 Essentiality

Non Essential

Target 19 Domain Function

PF05392:COX7B

Target 19 GenBank ID Protein

Not Available

Target 19 UniProtKB ID

P24311

Target 19 Cellular Location

Mitochondrion inner membrane (By similarity)

Target 19 Gene Sequence

>243 bp

ATGTTTCCCTTGGTCAAAAGCGCACTAAATCGTCTCCAAGTTCGAAGCATTCAGCAAACA
ATGGCAAGGCAGAGCCACCAGAAACGTACACCTGATTTTCATGACAAATACGGTAATGCT
GTATTAGCTAGTGGAGCCACTTTCTGTATTGTTACATGGACATATGTAGCAACACAAGTC
GGAATAGAATGGAACCTGTCCCCTGTTGGCAGAGTTACCCCAAAGGAATGGAGGAATCAG
TAA

Target 19 GenBank Gene ID

Not Available

Target 19 GeneCard ID

COX7B

Target 19 GenAtlas ID

COX7B

Target 19 HGNC ID

HGNC:2291

Target 19 Chromosome Location

Not Available

Target 19 Locus

Not Available

Target 19 SNPs

SNPJam Report Link Image

Target 19 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 19 General References

8382530; 15772651; 15489334; 1309697

Target 20 [top]

Target 20 ID

Target 20 Name

Cytochrome c oxidase subunit 7B2, mitochondrial

Target 20 Mechanism of Action

Target 20 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 20 Synonyms

Cytochrome c oxidase polypeptide VIIb2

Target 20 Gene Name

COX7B2

Target 20 Protein Sequence

>Cytochrome c oxidase subunit 7B2, mitochondrial

MMFPLARNALSSLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQ
IGIEWNLSPVGRVTPKEWKHQ

Target 20 Number of Residues

Target 20 Molecular Weight

9077.4

Target 20 Theoretical pI

10.37

Target 20 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell membrane organelle membrane organelle inner membrane mitochondrial inner membrane mitochondrial electron transport chain

Target 20 General Function

Involved in cytochrome-c oxidase activity

Target 20 Pathways

Not Available

Target 20 Reactions

Not Available

Target 20 Signals

None

Target 20 Transmembrane Regions

34-60

Target 20 Essentiality

Non Essential

Target 20 Domain Function

PF05392:COX7B

Target 20 GenBank ID Protein

Not Available

Target 20 UniProtKB ID

Q8TF08

Target 20 Cellular Location

Mitochondrion inner membrane (By similarity)

Target 20 Gene Sequence

>243 bp

ATGTTTCCCTTGGCCAGAAATGCACTAAGCAGTCTCAAGATTCAAAGCATTCTGCAAAGC
ATGGCAAGACATAGCCATGTAAAACACTCACCAGATTTTCATGATAAATATGGTAATGCT
GTGCTAGCCAGTGGAACTGCTTTCTGTGTTGCTACATGGGTGTTTACAGCCACTCAGATT
GGAATAGAATGGAACCTATCCCCTGTTGGCAGAGTTACCCCAAAAGAGTGGAAACATCAG
TAA

Target 20 GenBank Gene ID

Not Available

Target 20 GeneCard ID

COX7B2

Target 20 GenAtlas ID

COX7B2

Target 20 HGNC ID

HGNC:24381 Link Image

Target 20 Chromosome Location

Not Available

Target 20 Locus

4p12

Target 20 SNPs

SNPJam Report Link Image

Target 20 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 20 General References

15489334; 15623157

Target 21 [top]

Target 21 ID

109

Target 21 Name

Cytochrome c oxidase subunit 7C, mitochondrial

Target 21 Mechanism of Action

Target 21 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 21 Synonyms

Cytochrome c oxidase polypeptide VIIc

Target 21 Gene Name

COX7C

Target 21 Protein Sequence

>Cytochrome c oxidase subunit 7C, mitochondrial

MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWSLLAKMCLYFGSAFATPFLVVRHQL
LKT

Target 21 Number of Residues

Target 21 Molecular Weight

7245.4

Target 21 Theoretical pI

10.88

Target 21 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 21 General Function

Involved in cytochrome-c oxidase activity

Target 21 Pathways

Not Available

Target 21 Reactions

Not Available

Target 21 Signals

None

Target 21 Transmembrane Regions

34-60

Target 21 Essentiality

Non Essential

Target 21 Domain Function

PF02935:COX7C

Target 21 GenBank ID Protein

Not Available

Target 21 UniProtKB ID

P15954

Target 21 Cellular Location

Mitochondrion inner membrane (By similarity)

Target 21 Gene Sequence

>192 bp

ATGTTGGGCCAGAGCATCCGGAGGTTCACAACCTCTGTGGTCCGTAGGAGCCACTATGAG
GAGGGCCCTGGGAAGAATTTGCCATTTTCAGTGGAAAACAAGTGGTCGTTACTAGCTAAG
ATGTGTTTGTACTTTGGATCTGCATTTGCTACACCCTTCCTTGTAGTAAGACACCAACTG
CTTAAAACATAA

Target 21 GenBank Gene ID

Not Available

Target 21 GeneCard ID

COX7C

Target 21 GenAtlas ID

COX7C

Target 21 HGNC ID

HGNC:2292

Target 21 Chromosome Location

Not Available

Target 21 Locus

5q14

Target 21 SNPs

SNPJam Report Link Image

Target 21 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 21 General References

2155413; 10072584; 15489334; 1309697

Target 22 [top]

Target 22 ID

Target 22 Name

Cytochrome c oxidase subunit 8A, mitochondrial

Target 22 Mechanism of Action

Target 22 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 22 Synonyms

Cytochrome c oxidase polypeptide VIII-liver/heart; Cytochrome c oxidase subunit 8-2

Target 22 Gene Name

COX8A

Target 22 Protein Sequence

>Cytochrome c oxidase subunit 8A, mitochondrial

MSVLTPLLLRGLTGSARRLPVPRAKIHSLPPEGKLGIMELAVGLTSCFVTFLLPAGWILS
HLETYRRPE

Target 22 Number of Residues

Target 22 Molecular Weight

7579.0

Target 22 Theoretical pI

10.83

Target 22 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 22 General Function

Involved in cytochrome-c oxidase activity

Target 22 Pathways

Not Available

Target 22 Reactions

Not Available

Target 22 Signals

None

Target 22 Transmembrane Regions

37-60

Target 22 Essentiality

Non Essential

Target 22 Domain Function

PF02285:COX8

Target 22 GenBank ID Protein

Not Available

Target 22 UniProtKB ID

P10176

Target 22 Cellular Location

Mitochondrion inner membrane

Target 22 Gene Sequence

>210 bp

ATGTCCGTCCTGACGCCGCTGCTGCTGCGGGGCTTGACAGGCTCGGCCCGGCGGCTCCCA
GTGCCGCGCGCCAAGATCCATTCGTTGCCGCCGGAGGGGAAGCTTGGGATCATGGAATTG
GCCGTTGGGCTTACCTCCTGCTTCGTGACCTTCCTCCTGCCAGCGGGCTGGATCCTGTCA
CACCTGGAGACCTACAGGAGGCCAGAGTGA

Target 22 GenBank Gene ID

Not Available

Target 22 GeneCard ID

COX8A

Target 22 GenAtlas ID

COX8A

Target 22 HGNC ID

HGNC:2294

Target 22 Chromosome Location

Chromosome:11

Target 22 Locus

11q12-q13

Target 22 SNPs

SNPJam Report Link Image

Target 22 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 22 General References

2543673; 15489334; 2847943

Target 23 [top]

Target 23 ID

176

Target 23 Name

Cytochrome c oxidase subunit 8C, mitochondrial

Target 23 Mechanism of Action

Target 23 Description

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport

Target 23 Synonyms

Cytochrome c oxidase polypeptide 8 isoform 3; Cytochrome c oxidase polypeptide VIII isoform 3; COX VIII-3; Cytochrome c oxidase subunit 8-3

Target 23 Gene Name

COX8C

Target 23 Protein Sequence

>Cytochrome c oxidase subunit 8C, mitochondrial

MPLLRGRCPARRHYRRLALLGLQPAPRFAHSGPPRQRPLSAAEMAVGLVVFFTTFLTPAA
YVLGNLKQFRRN

Target 23 Number of Residues

Target 23 Molecular Weight

8128.6

Target 23 Theoretical pI

12.58

Target 23 GO Classification

Function
catalytic activity oxidoreductase activity heme-copper terminal oxidase activity cytochrome-c oxidase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 23 General Function

Involved in cytochrome-c oxidase activity

Target 23 Pathways

Not Available

Target 23 Reactions

Not Available

Target 23 Signals

None

Target 23 Transmembrane Regions

41-64

Target 23 Essentiality

Non Essential

Target 23 Domain Function

PF02285:COX8

Target 23 GenBank ID Protein

Not Available

Target 23 UniProtKB ID

Q7Z4L0

Target 23 Cellular Location

Mitochondrion inner membrane

Target 23 Gene Sequence

>219 bp

ATGCCTCTCCTGCGTGGGCGCTGTCCTGCCCGTCGCCACTACCGCCGCTTGGCCCTGCTC
GGCCTGCAGCCCGCTCCCCGCTTCGCCCACTCGGGGCCCCCGCGCCAGCGGCCCCTGTCT
GCCGCGGAAATGGCTGTTGGACTTGTGGTGTTTTTTACGACCTTCTTAACACCAGCTGCA
TATGTGCTAGGCAACCTGAAGCAGTTCAGAAGGAATTAG

Target 23 GenBank Gene ID

Not Available

Target 23 GeneCard ID

COX8C

Target 23 GenAtlas ID

COX8C

Target 23 HGNC ID

HGNC:24382 Link Image

Target 23 Chromosome Location

Chromosome:14

Target 23 Locus

14q32.13

Target 23 SNPs

SNPJam Report Link Image

Target 23 Toxin References

R173 - Wikipedia. Cyanide poisoning. Last Updated 30 March 2009.

Target 23 General References

12909344; 15489334

Target 24 [top]

Target 24 ID

129

Target 24 Name

Epididymal secretory glutathione peroxidase

Target 24 Mechanism of Action

Cyanide inhibits glutathione peroxidases. (R212)

Target 24 Description

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathionine peroxidase-like protective system against peroxide damage in sperm membrane lipids

Target 24 Synonyms

Epididymis-specific glutathione peroxidase-like protein; EGLP

Target 24 Gene Name

GPX5

Target 24 Protein Sequence

>Epididymal secretory glutathione peroxidase

MTTQLRVVHLLPLLLACFVQTSPKQEKMKMDCHKDEKGTIYDYEAIALNKNEYVSFKQYV
GKHILFVNVATYCGLTAQYPELNALQEELKPYGLVVLGFPCNQFGKQEPGDNKEILPGLK
YVRPGGGFVPSFQLFEKGDVNGEKEQKVFSFLKHSCPHPSEILGTFKSISWDPVKVHDIR
WNFEKFLVGPDGIPVMRWSHRATVSSVKTDILAYLKQFKTK

Target 24 Number of Residues

221

Target 24 Molecular Weight

25202.1

Target 24 Theoretical pI

8.89

Target 24 GO Classification

Function
antioxidant activity peroxidase activity glutathione peroxidase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism response to oxidative stress
Component
Not Available

Target 24 General Function

Posttranslational modification, protein turnover, chaperones

Target 24 Pathways

Not Available

Target 24 Reactions

Not Available

Target 24 Signals

1-21

Target 24 Transmembrane Regions

None

Target 24 Essentiality

Non Essential

Target 24 Domain Function

PF00255:GSHPx

Target 24 GenBank ID Protein

Not Available

Target 24 UniProtKB ID

O75715

Target 24 Cellular Location

Secreted

Target 24 Gene Sequence

Not Available

Target 24 GenBank Gene ID

Not Available

Target 24 GeneCard ID

GPX5

Target 24 GenAtlas ID

GPX5

Target 24 HGNC ID

HGNC:4557

Target 24 Chromosome Location

Not Available

Target 24 Locus

6p22.1

Target 24 SNPs

SNPJam Report Link Image

Target 24 Toxin References

R212 - Kraus RJ, Ganther HE: Reaction of cyanide with glutathione peroxidase. Biochem Biophys Res Commun. 1980 Oct 16;96(3):1116-22. [PubMed ]

Target 24 General References

9639555; 14574404

Target 25 [top]

Target 25 ID

296

Target 25 Name

Extracellular superoxide dismutase [Cu-Zn]

Target 25 Mechanism of Action

Cyanide inhibits superoxide dismutase [Cu-Zn]. (R209)

Target 25 Description

Protect the extracellular space from toxic effect of reactive oxygen intermediates by converting superoxide radicals into hydrogen peroxide and oxygen

Target 25 Synonyms

EC-SOD

Target 25 Gene Name

SOD3

Target 25 Protein Sequence

>Extracellular superoxide dismutase [Cu-Zn]

MLALLCSCLLLAAGASDAWTGEDSAEPNSDSAEWIRDMYAKVTEIWQEVMQRRDDDGALH
AACQVQPSATLDAAQPRVTGVVLFRQLAPRAKLDAFFALEGFPTEPNSSSRAIHVHQFGD
LSQGCESTGPHYNPLAVPHPQHPGDFGNFAVRDGSLWRYRAGLAASLAGPHSIVGRAVVV
HAGEDDLGRGGNQASVENGNAGRRLACCVVGVCGPGLWERQAREHSERKKRRRESECKAA

Target 25 Number of Residues

240

Target 25 Molecular Weight

25850.7

Target 25 Theoretical pI

6.59

Target 25 GO Classification

Function
binding ion binding metal ion binding catalytic activity oxidoreductase activity oxidoreductase activity, acting on superoxide radicals as acceptor superoxide dismutase activity copper, zinc superoxide dismutase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism superoxide metabolism
Component
Not Available

Target 25 General Function

Inorganic ion transport and metabolism

Target 25 Pathways

Not Available

Target 25 Reactions

Not Available

Target 25 Signals

1-18

Target 25 Transmembrane Regions

None

Target 25 Essentiality

Non Essential

Target 25 Domain Function

PF00080:Sod_Cu

Target 25 GenBank ID Protein

Not Available

Target 25 UniProtKB ID

P08294

Target 25 Cellular Location

Secreted, extracellular space

Target 25 Gene Sequence

>723 bp

ATGCTGGCGCTACTGTGTTCCTGCCTGCTCCTGGCAGCCGGTGCCTCGGACGCCTGGACG
GGCGAGGACTCGGCGGAGCCCAACTCTGACTCGGCGGAGTGGATCCGAGACATGTACGCC
AAGGTCACGGAGATCTGGCAGGAGGTCATGCAGCGGCGGGACGACGACGGCACGCTCCAC
GCCGCCTGCCAGGTGCAGCCGTCGGCCACGCTGGACGCCGCGCAGCCCCGGGTGACCGGC
GTCGTCCTCTTCCGGCAGCTTGCGCCCCGCGCCAAGCTCGACGCCTTCTTCGCCCTGGAG
GGCTTCCCGACCGAGCCGAACAGCTCCAGCCGCGCCATCCACGTGCACCAGTTCGGGGAC
CTGAGCCAGGGCTGCGAGTCCACCGGGCCCCACTACAACCCGCTGGCCGTGCCGCACCCG
CAGCACCCGGGCGACTTCGGCAACTTCGCGGTCCGCGACGGCAGCCTCTGGAGGTACCGC
GCCGGCCTGGCCGCCTCGCTCGCGGGCCCGCACTCCATCGTGGGCCGGGCCGTGGTCGTC
CACGCTGGCGAGGACGACCTGGGCCGCGGCGGCAACCAGGCCAGCGTGGAGAACGGGAAC
GCGGGCCGGCGGCTGGCCTGCTGCGTGGTGGGCGTGTGCGGGCCCGGGCTCTGGGAGCGC
CAGGCGCGGGAGCACTCAGAGCGCAAGAAGCGGCGGCGCGAGAGCGAGTGCAAGGCCGCC
TGA

Target 25 GenBank Gene ID

Not Available

Target 25 GeneCard ID

SOD3

Target 25 GenAtlas ID

SOD3

Target 25 HGNC ID

HGNC:11181 Link Image

Target 25 Chromosome Location

Not Available

Target 25 Locus

4p15.3-p15.1

Target 25 SNPs

SNPJam Report Link Image

Target 25 Toxin References

R209 - Lee WG, Hwang JH, Na BK, Cho JH, Lee HW, Cho SH, Kong Y, Song CY, Kim TS: Functional expression of a recombinant copper/zinc superoxide dismutase of filarial nematode, Brugia malayi. J Parasitol. 2005 Feb;91(1):205-8. [PubMed ]

Target 25 General References

3476950; 7959763; 15489334; 1505778; 16087389; 16335952; 19159218; 8034674

Target 26 [top]

Target 26 ID

148

Target 26 Name

Glutathione peroxidase 1

Target 26 Mechanism of Action

Cyanide inhibits glutathione peroxidases. (R212)

Target 26 Description

Protects the hemoglobin in erythrocytes from oxidative breakdown

Target 26 Synonyms

GSHPx-1; GPx-1; Cellular glutathione peroxidase

Target 26 Gene Name

GPX1

Target 26 Protein Sequence

>Glutathione peroxidase 1

MCAARLAAAAAQSVYAFSARPLAGGEPVSLGSLRGKVLLIENVASLUGTTVRDYTQMNEL
QRRLGPRGLVVLGFPCNQFGHQENAKNEEILNSLKYVRPGGGFEPNFMLFEKCEVNGAGA
HPLFAFLREALPAPSDDATALMTDPKLITWSPVCRNDVAWNFEKFLVGPDGVPLRRYSRR
FQTIDIEPDIEALLSQGPSCA

Target 26 Number of Residues

201

Target 26 Molecular Weight

21945.8

Target 26 Theoretical pI

6.51

Target 26 GO Classification

Function
antioxidant activity peroxidase activity glutathione peroxidase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism response to oxidative stress
Component
Not Available

Target 26 General Function

Posttranslational modification, protein turnover, chaperones

Target 26 Pathways

Not Available

Target 26 Reactions

Not Available

Target 26 Signals

None

Target 26 Transmembrane Regions

None

Target 26 Essentiality

Non Essential

Target 26 Domain Function

PF00255:GSHPx

Target 26 GenBank ID Protein

Not Available

Target 26 UniProtKB ID

P07203

Target 26 Cellular Location

Cytoplasm

Target 26 Gene Sequence

>606 bp

ATGTGTGCTGCTCGGCTAGCGGCGGCGGCGGCCCAGTCGGTGTATGCCTTCTCGGCGCGC
CCGTTGGCCGGCGGGGAGCCTGTGAGCCTGGGCTCCCTGCGGGGCAAGGTACTACTTATC
GAGAATGTGGCGTCCCTCTGAGGCACCACGGTCCGGGACTACACCCAGATGAACGAGCTG
CAGCGGCGCCTCGGACCCCGGGGCCTGGTGGTGCTCGGCTTCCCGTGCAACCAGTTTGGG
CATCAGGAGAACGCCAAGAACGAAGAGATTCTGAATTCCCTCAAGTACGTCCGGCCTGGT
GGTGGGTTCGAGCCCAACTTCATGCTCTTCGAGAAGTGCGAGGTGAACGGTGCGGGGGCG
CACCCTCTCTTCGCCTTCCTGCGGGAGGCCCTGCCAGCTCCCAGCGACGACGCCACCGCG
CTTATGACCGACCCCAAGCTCATCACCTGGTCTCCGGTGTGTCGCAACGATGTTGCCTGG
AACTTTGAGAAGTTCCTGGTGGGCCCTGACGGTGTGCCCCTACGCAGGTACAGCCGCCGC
TTCCAGACCATTGACATCGAGCCTGACATCGAAGCCCTGCTGTCTCAAGGGCCCAGCTGT
GCCTAG

Target 26 GenBank Gene ID

Not Available

Target 26 GeneCard ID

GPX1

Target 26 GenAtlas ID

GPX1

Target 26 HGNC ID

HGNC:4553

Target 26 Chromosome Location

Not Available

Target 26 Locus

3p21.3

Target 26 SNPs

SNPJam Report Link Image

Target 26 Toxin References

R212 - Kraus RJ, Ganther HE: Reaction of cyanide with glutathione peroxidase. Biochem Biophys Res Commun. 1980 Oct 16;96(3):1116-22. [PubMed ]

Target 26 General References

3658677; 3697069; 2955287; 2307470; 1556108; 16641997; 15489334

Target 27 [top]

Target 27 ID

Target 27 Name

Glutathione peroxidase 2

Target 27 Mechanism of Action

Cyanide inhibits glutathione peroxidases. (R212)

Target 27 Description

Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors

Target 27 Synonyms

GSHPx-2; GPx-2; Glutathione peroxidase-gastrointestinal; GSHPx-GI; Glutathione peroxidase-related protein 2; Gastrointestinal glutathione peroxidase; GPRP

Target 27 Gene Name

GPX2

Target 27 Protein Sequence

>Glutathione peroxidase 2

MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRR
LVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLK
DKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEP
DIKRLLKVAI

Target 27 Number of Residues

190

Target 27 Molecular Weight

21953.8

Target 27 Theoretical pI

7.93

Target 27 GO Classification

Function
antioxidant activity peroxidase activity glutathione peroxidase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism response to oxidative stress
Component
Not Available

Target 27 General Function

Posttranslational modification, protein turnover, chaperones

Target 27 Pathways

Not Available

Target 27 Reactions

Not Available

Target 27 Signals

None

Target 27 Transmembrane Regions

None

Target 27 Essentiality

Non Essential

Target 27 Domain Function

PF00255:GSHPx

Target 27 GenBank ID Protein

Not Available

Target 27 UniProtKB ID

P18283

Target 27 Cellular Location

Cytoplasm

Target 27 Gene Sequence

>573 bp

ATGGCTTTCATTGCCAAGTCCTTCTATGACCTCAGTGCCATCAGCCTGGATGGGGAGAAG
GTAGATTTCAATACGTTCCGGGGCAGGGCCGTGCTGATTGAGAATGTGCGTTCGCTCTGA
GGCACAACCACCCGGGACTTCACCCAGCTCAACGAGCTGCAATGCCGCTTTCCCAGGCGC
CTGGTGGTCCTTGGCTTCCCTTGCAACCAATTTGGACATCAGGAGAACAGTCAGAATGAG
GAGATCCTGAACAGTCTCAAGTATGTCCGTCCTGGGGGTGGATACCAGCCCACCTTCACC
CTTGTCCAAAAATGTGAGGTGAATGGGCAGAACGAGCATCCTGTCTTCGCCTACCTGAAG
GACAAGCTCCCCTACCCTTATGATGACCCATTTTCCCTCATGACCGATCCCAAGCTCATC
ATTTGGAGCCCTGTGCGCCGCTCAGATGTGGCCTGGAACTTTGAGAAGTTCCTCATAGGG
CCGGAGGGAGAGCCCTTCCGACGCTACAGCCGCACCTTCCCAACCATCAACATTGAGCCT
GACATCAAGCGCCTCCTTAAAGTTGCCATATAG

Target 27 GenBank Gene ID

Not Available

Target 27 GeneCard ID

GPX2

Target 27 GenAtlas ID

GPX2

Target 27 HGNC ID

HGNC:4554

Target 27 Chromosome Location

Chromosome:14

Target 27 Locus

14q24.1

Target 27 SNPs

SNPJam Report Link Image

Target 27 Toxin References

R212 - Kraus RJ, Ganther HE: Reaction of cyanide with glutathione peroxidase. Biochem Biophys Res Commun. 1980 Oct 16;96(3):1116-22. [PubMed ]

Target 27 General References

2388849; 8428933; 10806356; 12508121; 15489334

Target 28 [top]

Target 28 ID

179

Target 28 Name

Glutathione peroxidase 3

Target 28 Mechanism of Action

Cyanide inhibits glutathione peroxidases. (R212)

Target 28 Description

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione

Target 28 Synonyms

GSHPx-3; GPx-3; Extracellular glutathione peroxidase; Plasma glutathione peroxidase; GSHPx-P; GPx-P

Target 28 Gene Name

GPX3

Target 28 Protein Sequence

>Glutathione peroxidase 3

MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYA
GKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLK
YVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIR
WNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK

Target 28 Number of Residues

226

Target 28 Molecular Weight

25552.2

Target 28 Theoretical pI

8.29

Target 28 GO Classification

Function
antioxidant activity peroxidase activity glutathione peroxidase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism response to oxidative stress
Component
Not Available

Target 28 General Function

Posttranslational modification, protein turnover, chaperones

Target 28 Pathways

Not Available

Target 28 Reactions

Not Available

Target 28 Signals

1-20

Target 28 Transmembrane Regions

None

Target 28 Essentiality

Non Essential

Target 28 Domain Function

PF00255:GSHPx

Target 28 GenBank ID Protein

Not Available

Target 28 UniProtKB ID

P22352

Target 28 Cellular Location

Secreted

Target 28 Gene Sequence

>681 bp

ATGGCCCGGCTGCTGCAGGCGTCCTGCCTGCTTTCCCTGCTCCTGGCCGGCTTCGTCTCG
CAGAGCCGGGGACAAGAGAAGTCGAAGATGGACTGCCATGGTGGCATAAGTGGCACCATT
TACGAGTACGGAGCCCTCACCATTGATGGGGAGGAGTACATCCCCTTCAAGCAGTATGCT
GGCAAATACGTCCTCTTTGTCAACGTGGCCAGCTACTGAGGCCTGACGGGCCAGTACATT
GAACTGAATGCACTACAGGAAGAGCTTGCACCATTCGGTCTGGTCATTCTGGGCTTTCCC
TGCAACCAATTTGGAAAACAGGAACCAGGAGAGAACTCAGAGATCCTTCCTACCCTCAAG
TATGTCCGACCAGGTGGAGGCTTTGTCCCTAATTTCCAGCTCTTTGAGAAAGGGGATGTC
AATGGAGAGAAAGAGCAGAAATTCTACACTTTCCTAAAGAACTCCTGTCCTCCCACCTCG
GAGCTCCTGGGTACATCTGACCGCCTCTTCTGGGAACCCATGAAGGTTCACGACATCCGC
TGGAACTTTGAGAAGTTCCTGGTGGGGCCAGATGGTATACCCATCATGCGCTGGCACCAC
CGGACCACGGTCAGCAACGTCAAGATGGACATCCTGTCCTACATGAGGCGGCAGGCAGCC
CTGGGGGTCAAGAGGAAGTAA

Target 28 GenBank Gene ID

Not Available

Target 28 GeneCard ID

GPX3

Target 28 GenAtlas ID

GPX3

Target 28 HGNC ID

HGNC:4555

Target 28 Chromosome Location

Not Available

Target 28 Locus

5q23

Target 28 SNPs

SNPJam Report Link Image

Target 28 Toxin References

R212 - Kraus RJ, Ganther HE: Reaction of cyanide with glutathione peroxidase. Biochem Biophys Res Commun. 1980 Oct 16;96(3):1116-22. [PubMed ]

Target 28 General References

2229017; 1339300; 8056346; 10970826; 16641997; 15489334; 1897960

Target 29 [top]

Target 29 ID

Target 29 Name

Glutathione peroxidase 6

Target 29 Mechanism of Action

Cyanide inhibits glutathione peroxidases. (R212)

Target 29 Description

2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

Target 29 Synonyms

Not Available

Target 29 Gene Name

GPX6

Target 29 Protein Sequence

>Glutathione peroxidase 6

MFQQFQASCLVLFFLVGFAQQTLKPQNRKVDCNKGVTGTIYEYGALTLNGEEYIQFKQFA
GKHVLFVNVAAYUGLAAQYPELNALQEELKNFGVIVLAFPCNQFGKQEPGTNSEILLGLK
YVCPGSGFVPSFQLFEKGDVNGEKEQKVFTFLKNSCPPTSDLLGSSSQLFWEPMKVHDIR
WNFEKFLVGPDGVPVMHWFHQAPVSTVKSDILEYLKQFNTH

Target 29 Number of Residues

221

Target 29 Molecular Weight

24970.5

Target 29 Theoretical pI

6.66

Target 29 GO Classification

Function
antioxidant activity peroxidase activity glutathione peroxidase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism response to oxidative stress
Component
Not Available

Target 29 General Function

Posttranslational modification, protein turnover, chaperones

Target 29 Pathways

Not Available

Target 29 Reactions

Not Available

Target 29 Signals

1-19

Target 29 Transmembrane Regions

None

Target 29 Essentiality

Non Essential

Target 29 Domain Function

PF00255:GSHPx

Target 29 GenBank ID Protein

Not Available

Target 29 UniProtKB ID

P59796

Target 29 Cellular Location

Secreted (By similarity)

Target 29 Gene Sequence

>666 bp

ATGTTCCAGCAGTTCCAGGCCTCCTGTCTTGTCCTGTTTTTCCTGGTTGGCTTTGCTCAG
CAGACCCTAAAGCCTCAAAATAGGAAGGTGGATTGCAACAAAGGGGTAACAGGCACCATC
TATGAGTATGGAGCCCTCACCCTCAACGGCGAGGAGTACATCCAATTCAAGCAGTTTGCA
GGCAAGCACGTCCTGTTTGTCAATGTGGCCGCCTATTGAGGCTTGGCAGCTCAGTATCCT
GAACTGAATGCACTACAGGAGGAGCTGAAGAATTTTGGTGTCATTGTGTTGGCCTTTCCC
TGCAACCAGTTTGGAAAACAAGAACCAGGAACAAACTCAGAAATACTTCTTGGTCTCAAG
TATGTGTGTCCAGGTAGTGGCTTTGTCCCCAGTTTCCAGCTCTTTGAGAAAGGGGATGTG
AATGGAGAAAAAGAACAGAAGGTCTTTACTTTCCTGAAGAACTCCTGCCCTCCGACCTCT
GATCTTTTGGGCTCATCAAGCCAACTCTTCTGGGAGCCCATGAAGGTCCATGATATCCGC
TGGAACTTTGAGAAATTTCTGGTGGGGCCCGATGGAGTCCCTGTCATGCATTGGTTCCAC
CAGGCTCCAGTCAGCACAGTCAAGTCAGACATCCTGGAGTACCTAAAGCAGTTCAATACC
CACTAG

Target 29 GenBank Gene ID

Not Available

Target 29 GeneCard ID

GPX6

Target 29 GenAtlas ID

GPX6

Target 29 HGNC ID

HGNC:4558

Target 29 Chromosome Location

Not Available

Target 29 Locus

6p22.1

Target 29 SNPs

SNPJam Report Link Image

Target 29 Toxin References

R212 - Kraus RJ, Ganther HE: Reaction of cyanide with glutathione peroxidase. Biochem Biophys Res Commun. 1980 Oct 16;96(3):1116-22. [PubMed ]

Target 29 General References

12775843; 14574404

Target 30 [top]

Target 30 ID

239

Target 30 Name

Glutathione peroxidase 7

Target 30 Mechanism of Action

Cyanide inhibits glutathione peroxidases. (R212)

Target 30 Description

2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

Target 30 Synonyms

CL683

Target 30 Gene Name

GPX7

Target 30 Protein Sequence

>Glutathione peroxidase 7

MVAATVAAAWLLLWAAACAQQEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFT
DQHYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDSNKEIESFARRTYSVSFPMFSKIAV
TGTGAHPAFKYLAQTSGKEPTWNFWKYLVAPDGKVVGAWDPTVSVEEVRPQITALVRKLI
LLKREDL

Target 30 Number of Residues

187

Target 30 Molecular Weight

20995.9

Target 30 Theoretical pI

8.46

Target 30 GO Classification

Function
antioxidant activity peroxidase activity glutathione peroxidase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism response to oxidative stress
Component
Not Available

Target 30 General Function

Posttranslational modification, protein turnover, chaperones

Target 30 Pathways

Not Available

Target 30 Reactions

Not Available

Target 30 Signals

1-19

Target 30 Transmembrane Regions

None

Target 30 Essentiality

Non Essential

Target 30 Domain Function

PF00255:GSHPx

Target 30 GenBank ID Protein

Not Available

Target 30 UniProtKB ID

Q96SL4

Target 30 Cellular Location

Secreted (Potential)

Target 30 Gene Sequence

>564 bp

ATGGTGGCGGCGACGGTGGCAGCGGCGTGGCTGCTCCTGTGGGCTGCGGCCTGCGCGCAG
CAGGAGCAGGACTTCTACGACTTCAAGGCGGTCAACATCCGGGGCAAACTGGTGTCGCTG
GAGAAGTACCGCGGATCGGTGTCCCTGGTGGTGAATGTGGCCAGCGAGTGCGGCTTCACA
GACCAGCACTACCGAGCCCTGCAGCAGCTGCAGCGAGACCTGGGCCCCCACCACTTTAAC
GTGCTCGCCTTCCCCTGCAACCAGTTTGGCCAACAGGAGCCTGACAGCAACAAGGAGATT
GAGAGCTTTGCCCGCCGCACCTACAGTGTCTCATTCCCCATGTTTAGCAAGATTGCAGTC
ACCGGTACTGGTGCCCATCCTGCCTTCAAGTACCTGGCCCAGACTTCTGGGAAGGAGCCC
ACCTGGAACTTCTGGAAGTACCTAGTAGCCCCAGATGGAAAGGTGGTAGGGGCTTGGGAC
CCAACTGTGTCAGTGGAGGAGGTCAGACCCCAGATCACAGCGCTCGTGAGGAAGCTCATC
CTACTGAAGCGAGAAGACTTATAA

Target 30 GenBank Gene ID

Not Available

Target 30 GeneCard ID

GPX7

Target 30 GenAtlas ID

GPX7

Target 30 HGNC ID

HGNC:4559

Target 30 Chromosome Location

Not Available

Target 30 Locus

1p32

Target 30 SNPs

SNPJam Report Link Image

Target 30 Toxin References

R212 - Kraus RJ, Ganther HE: Reaction of cyanide with glutathione peroxidase. Biochem Biophys Res Commun. 1980 Oct 16;96(3):1116-22. [PubMed ]

Target 30 General References

12975309; 14702039; 16710414; 15489334

Target 31 [top]

Target 31 ID

Target 31 Name

Glutathione reductase, mitochondrial

Target 31 Mechanism of Action

Cyanide inhibits glutathione reductase. (R213)

Target 31 Description

Maintains high levels of reduced glutathione in the cytosol

Target 31 Synonyms

GRase; GR

Target 31 Gene Name

GSR

Target 31 Protein Sequence

>Glutathione reductase, mitochondrial

MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

Target 31 Number of Residues

522

Target 31 Molecular Weight

56256.6

Target 31 Theoretical pI

8.66

Target 31 GO Classification

Function
disulfide oxidoreductase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding FAD binding catalytic activity oxidoreductase activity transporter activity electron transporter activity glutathione-disulfide reductase activity
Process
generation of precursor metabolites and energy electron transport physiological process metabolism cellular metabolism cofactor metabolism coenzyme metabolism glutathione metabolism
Component
cell intracellular cytoplasm

Target 31 General Function

RNA processing and modification

Target 31 Pathways

Not Available

Target 31 Reactions

Not Available

Target 31 Signals

None

Target 31 Transmembrane Regions

None

Target 31 Essentiality

Non Essential

Target 31 Domain Function

PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim

Target 31 GenBank ID Protein

Not Available

Target 31 UniProtKB ID

P00390

Target 31 Cellular Location

Mitochondrion. Cytoplasm

Target 31 Gene Sequence

>1440 bp

ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCC
TCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCG
GCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTG
AATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCTGAATTCATG
CATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATT
AAGGAAAAGCGGGATGCCTATGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACC
AAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCCAAGCCCACA
ATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATG
CCCTCCACCCCTCATGAGAGCCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGA
TTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGTTACATTGCT
GTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCAT
GATAAGGTACTTAGAAGTTTTGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAG
AACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGTCAAGGAGGTTAAAAAGACTTTGTCG
GGCTTGGAAGTCAGCATGGTTACTGCAGTTCCCGGTAGGCTACCAGTCATGACCATGATT
CCAGATGTTGACTGCCTGCTCTGGGCCATTGGGCGGGTCCCGAATACCAAGGACCTGAGT
TTAAACAAACTGGGGATTCAAACCGATGACAAGGGTCATATCATCGTAGACGAATTCCAG
AATACCAACGTCAAAGGCATCTATGCAGTTGGGGATGTATGTGGAAAAGCTCTTCTTACT
CCAGTTGCAATAGCTGCTGGCCGAAAACTTGCCCATCGACTTTTTGAATATAAGGAAGAT
TCCAAATTAGATTATAACAACATCCCAACTGTGGTCTTCAGCCACCCCCCTATTGGGACA
GTGGGACTCACGGAAGATGAAGCCATTCATAAATATGGAATAGAAAATGTGAAGACCTAT
TCAACGAGCTTTACCCCGATGTATCACGCAGTTACCAAAAGGAAAACAAAATGTGTGATG
AAAATGGTCTGTGCTAACAAGGAAGAAAAGGTGGTTGGGATCCATATGCAGGGACTTGGG
TGTGATGAAATGCTGCAGGGTTTTGCTGTTGCAGTGAAGATGGGAGCAACGAAGGCAGAC
TTTGACAACACAGTCGCCATTCACCCTACCTCTTCAGAAGAGCTGGTCACACTTCGTTGA

Target 31 GenBank Gene ID

Not Available

Target 31 GeneCard ID

GSR

Target 31 GenAtlas ID

GSR

Target 31 HGNC ID

HGNC:4623

Target 31 Chromosome Location

Not Available

Target 31 Locus

8p21.1

Target 31 SNPs

SNPJam Report Link Image

Target 31 Toxin References

R213 - Ardelt BK, Borowitz JL, Isom GE: Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication. Toxicology. 1989 Jun 1;56(2):147-54. [PubMed ]

Target 31 General References

2185014; 10708558; 16421571; 15489334; 7060551; 923580; 15592455; 7334521

Target 32 [top]

Target 32 ID

112

Target 32 Name

Phospholipid hydroperoxide glutathione peroxidase, mitochondrial

Target 32 Mechanism of Action

Cyanide inhibits glutathione peroxidases. (R212)

Target 32 Description

Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity)

Target 32 Synonyms

PHGPx; GPX-4

Target 32 Gene Name

GPX4

Target 32 Protein Sequence

>Phospholipid hydroperoxide glutathione peroxidase, mitochondrial

MSLGRLCRLLKPALLCGALAAPGLAGTMCASRDDWRCARSMHEFSAKDIDGHMVNLDKYR
GFVCIVTNVASQUGKTEVNYTQLVDLHARYAECGLRILAFPCNQFGKQEPGSNEEIKEFA
AGYNVKFDMFSKICVNGDDAHPLWKWMKIQPKGKGILGNAIKWNFTKFLIDKNGCVVKRY
GPMEEPLVIEKDLPHYF

Target 32 Number of Residues

197

Target 32 Molecular Weight

22174.5

Target 32 Theoretical pI

8.48

Target 32 GO Classification

Function
antioxidant activity peroxidase activity glutathione peroxidase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism response to oxidative stress
Component
Not Available

Target 32 General Function

Posttranslational modification, protein turnover, chaperones

Target 32 Pathways

Not Available

Target 32 Reactions

Not Available

Target 32 Signals

None

Target 32 Transmembrane Regions

None

Target 32 Essentiality

Non Essential

Target 32 Domain Function

PF00255:GSHPx

Target 32 GenBank ID Protein

Not Available

Target 32 UniProtKB ID

P36969

Target 32 Cellular Location

Mitochondrion. Cytoplasm

Target 32 Gene Sequence

>594 bp

ATGAGCCTCGGCCGCCTTTGCCGCCTACTGAAGCCGGCGCTGCTCTGTGGGGCTCTGGCC
GCGCCTGGCCTGGCCGGGACCATGTGCGCGTCCCGGGACGACTGGCGCTGTGCGCGCTCC
ATGCACGAGTTTTCCGCCAAGGACATCGACGGGCACATGGTTAACCTGGACAAGTACCGG
GGCTTCGTGTGCATCGTCACCAACGTGGCCTCCCAGTGAGGCAAGACCGAAGTAAACTAC
ACTCAGCTCGTCGACCTGCACGCCCGATACGCTGAGTGTGGTTTGCGGATCCTGGCCTTC
CCGTGTAACCAGTTCGGGAAGCAGGAGCCAGGGAGTAACGAAGAGATCAAAGAGTTCGCC
GCGGGCTACAACGTCAAATTCGATATGTTCAGCAAGATCTGCGTGAACGGGGACGACGCC
CACCCGCTGTGGAAGTGGATGAAGATCCAACCCAAGGGCAAGGGCATCCTGGGAAATGCC
ATCAAGTGGAACTTCACCAAGTTCCTCATCGACAAGAACGGCTGCGTGGTGAAGCGCTAC
GGACCCATGGAGGAGCCCCTGGTGATAGAGAAGGACCTGCCCCACTATTTCTAG

Target 32 GenBank Gene ID

Not Available

Target 32 GeneCard ID

GPX4

Target 32 GenAtlas ID

GPX4

Target 32 HGNC ID

HGNC:4556

Target 32 Chromosome Location

Chromosome:19

Target 32 Locus

19p13.3

Target 32 SNPs

SNPJam Report Link Image

Target 32 Toxin References

R212 - Kraus RJ, Ganther HE: Reaction of cyanide with glutathione peroxidase. Biochem Biophys Res Commun. 1980 Oct 16;96(3):1116-22. [PubMed ]

Target 32 General References

8039723; 9705830; 15057824; 15489334; 17630701; 12606444

Target 33 [top]

Target 33 ID

390

Target 33 Name

Probable glutathione peroxidase 8

Target 33 Mechanism of Action

Cyanide inhibits glutathione peroxidases. (R212)

Target 33 Description

2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O

Target 33 Synonyms

Not Available

Target 33 Gene Name

GPX8

Target 33 Protein Sequence

>Probable glutathione peroxidase 8

MEPLAAYPLKCSGPRAKVFAVLLSIVLCTVTLFLLQLKFLKPKINSFYAFEVKDAKGRTV
SLEKYKGKVSLVVNVASDCQLTDRNYLGLKELHKEFGPSHFSVLAFPCNQFGESEPRPSK
EVESFARKNYGVTFPIFHKIKILGSEGEPAFRFLVDSSKKEPRWNFWKYLVNPEGQVVKF
WRPEEPIEVIRPDIAALVRQVIIKKKEDL

Target 33 Number of Residues

209

Target 33 Molecular Weight

23908.8

Target 33 Theoretical pI

9.93

Target 33 GO Classification

Function
antioxidant activity peroxidase activity glutathione peroxidase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism response to oxidative stress
Component
Not Available

Target 33 General Function

Posttranslational modification, protein turnover, chaperones

Target 33 Pathways

Not Available

Target 33 Reactions

Not Available

Target 33 Signals

None

Target 33 Transmembrane Regions

18-40

Target 33 Essentiality

Non Essential

Target 33 Domain Function

PF00255:GSHPx

Target 33 GenBank ID Protein

Not Available

Target 33 UniProtKB ID

Q8TED1

Target 33 Cellular Location

Membrane

Target 33 Gene Sequence

>630 bp

ATGGAGCCTCTTGCAGCTTACCCGCTAAAATGTTCCGGGCCCAGAGCAAAGGTATTTGCA
GTTTTGCTGTCTATAGTTCTATGCACAGTAACGCTATTTCTTCTACAACTAAAATTCCTC
AAACCTAAAATCAACAGCTTTTATGCCTTTGAAGTGAAGGATGCAAAAGGAAGAACTGTT
TCTCTGGAAAAGTATAAAGGCAAAGTTTCACTAGTTGTAAACGTGGCCAGTGACTGCCAA
CTCACAGACAGAAATTACTTAGGGCTGAAGGAACTGCACAAAGAGTTTGGACCATCCCAC
TTCAGCGTGTTGGCTTTTCCCTGCAATCAGTTTGGAGAATCGGAGCCCCGCCCAAGCAAG
GAAGTAGAATCTTTTGCAAGAAAAAACTACGGAGTAACTTTCCCCATCTTCCACAAGATT
AAGATTCTAGGATCTGAAGGAGAACCTGCATTTAGATTTCTTGTTGATTCTTCAAAGAAG
GAACCAAGGTGGAATTTTTGGAAGTATCTTGTCAACCCTGAGGGTCAAGTTGTGAAGTTC
TGGAGGCCAGAGGAGCCCATTGAAGTCATCAGGCCTGACATAGCAGCTCTGGTTAGACAA
GTGATCATAAAAAAGAAAGAGGATCTATGA

Target 33 GenBank Gene ID

Not Available

Target 33 GeneCard ID

GPX8

Target 33 GenAtlas ID

GPX8

Target 33 HGNC ID

HGNC:33100 Link Image

Target 33 Chromosome Location

Not Available

Target 33 Locus

Not Available

Target 33 SNPs

SNPJam Report Link Image

Target 33 Toxin References

R212 - Kraus RJ, Ganther HE: Reaction of cyanide with glutathione peroxidase. Biochem Biophys Res Commun. 1980 Oct 16;96(3):1116-22. [PubMed ]

Target 33 General References

12975309; 14702039; 15489334

Target 34 [top]

Target 34 ID

300

Target 34 Name

Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

Target 34 Mechanism of Action

Cyanide inhibits succinate dehydrogenases. (R213)

Target 34 Description

Mono-heme cytochrome b. May act as a mediator of low potential couples in an electron flow through cardiac complex II. Is involved in system II of the mitochondrial electron transport chain which is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)

Target 34 Synonyms

Succinate dehydrogenase complex subunit C; Integral membrane protein CII-3; QPs-1; QPs1; Succinate-ubiquinone oxidoreductase cytochrome B large subunit; CYBL

Target 34 Gene Name

SDHC

Target 34 Protein Sequence

>Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNRPLSPHITIYS
WSLPMAMSICHRGTGIALSAGVSLFGMSALLLPGNFESYLELVKSLCLGPALIHTAKFAL
VFPLMYHTWNGIRHLMWDLGKGLKIPQLYQSGVVVLVLTVLSSMGLAAM

Target 34 Number of Residues

169

Target 34 Molecular Weight

18610.0

Target 34 Theoretical pI

10.12

Target 34 GO Classification

Function
catalytic activity oxidoreductase activity oxidoreductase activity, acting on the CH-CH group of donors succinate dehydrogenase activity
Process
electron transport physiological process metabolism cellular metabolism generation of precursor metabolites and energy energy derivation by oxidation of organic compounds main pathways of carbohydrate metabolism tricarboxylic acid cycle
Component
cell membrane

Target 34 General Function

Energy production and conversion

Target 34 Pathways

Carbohydrate metabolism; tricarboxylic acid cycle

Target 34 Reactions

Not Available

Target 34 Signals

None

Target 34 Transmembrane Regions

71-93
105-127
147-168

Target 34 Essentiality

Non Essential

Target 34 Domain Function

PF01127:Sdh_cyt

Target 34 GenBank ID Protein

Not Available

Target 34 UniProtKB ID

Q99643

Target 34 Cellular Location

Mitochondrion inner membrane

Target 34 Gene Sequence

>510 bp

ATGGCTGCGCTGTTGCTGAGACACGTTGGTCGTCATTGCCTCCGAGCCCACTTTAGCCCT
CAGCTCTGTATCAGAAATGCTGTTCCTTTGGGAACCACGGCCAAAGAAGAGATGGAGCGG
TTCTGGAATAAGAATATAGGTTCAAACCGTCCTCTGTCTCCCCACATTACTATCTACAGT
TGGTCTCTTCCCATGGCGATGTCCATCTGCCACCGTGGCACTGGTATTGCTTTGAGTGCA
GGGGTCTCTCTTTTTGGCATGTCGGCCCTGTTACTCCCTGGGAACTTTGAGTCTTATTTG
GAACTTGTGAAGTCCCTGTGTCTGGGGCCAGCACTGATCCACACAGCTAAGTTTGCACTT
GTCTTCCCTCTCATGTATCATACCTGGAATGGGATCCGACACTTGATGTGGGACCTAGGA
AAAGGCCTGAAGATTCCCCAGCTATACCAGTCTGGAGTGGTTGTCCTGGTTCTTACTGTG
TTGTCCTCTATGGGGCTGGCAGCCATGTGA

Target 34 GenBank Gene ID

Not Available

Target 34 GeneCard ID

SDHC

Target 34 GenAtlas ID

SDHC

Target 34 HGNC ID

HGNC:10682 Link Image

Target 34 Chromosome Location

Not Available

Target 34 Locus

Not Available

Target 34 SNPs

SNPJam Report Link Image

Target 34 Toxin References

R213 - Ardelt BK, Borowitz JL, Isom GE: Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication. Toxicology. 1989 Jun 1;56(2):147-54. [PubMed ]

Target 34 General References

9533030; 9714607; 16710414; 15489334; 11062460; 17804857

Target 35 [top]

Target 35 ID

301

Target 35 Name

Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

Target 35 Mechanism of Action

Cyanide inhibits succinate dehydrogenases. (R213)

Target 35 Description

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity)

Target 35 Synonyms

CybS; Succinate-ubiquinone reductase membrane anchor subunit; QPs3; CII-4; Succinate dehydrogenase complex subunit D; Succinate-ubiquinone oxidoreductase cytochrome b small subunit

Target 35 Gene Name

SDHD

Target 35 Protein Sequence

>Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial

MAVLWRLSAVCGALGGRALLLRTPVVRPAHISAFLQDRPIPEWCGVQHIHLSPSHHSGSK
AASLHWTSERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGLGQVVTDYVHGDAL
QKAAKAGLLALSALTFAGLCYFNYHDVGICKAVAMLWKL

Target 35 Number of Residues

159

Target 35 Molecular Weight

17042.8

Target 35 Theoretical pI

8.75

Target 35 GO Classification

Function
binding tetrapyrrole binding heme binding
Process
electron transport physiological process metabolism cellular metabolism generation of precursor metabolites and energy energy derivation by oxidation of organic compounds main pathways of carbohydrate metabolism tricarboxylic acid cycle
Component
cell membrane intrinsic to membrane integral to membrane envelope organelle envelope mitochondrial envelope

Target 35 General Function

Involved in electron carrier activity

Target 35 Pathways

Carbohydrate metabolism; tricarboxylic acid cycle

Target 35 Reactions

Not Available

Target 35 Signals

None

Target 35 Transmembrane Regions

64-85
91-111
121-142

Target 35 Essentiality

Non Essential

Target 35 Domain Function

PF05328:CybS

Target 35 GenBank ID Protein

Not Available

Target 35 UniProtKB ID

O14521

Target 35 Cellular Location

Mitochondrion inner membrane

Target 35 Gene Sequence

>480 bp

ATGGCGGTTCTCTGGAGGCTGAGTGCCGTTTGCGGTGCCCTAGGAGGCCGAGCTCTGTTG
CTTCGAACTCCAGTGGTCAGACCTGCTCATATCTCAGCATTTCTTCAGGACCGACCTATC
CCAGAATGGTGTGGAGTGCAGCACATACACTTGTCACCGAGCCACCATTCTGGCTCCAAG
GCTGCATCTCTCCACTGGACTAGCGAGAGGGTTGTCAGTGTTTTGCTCCTGGGTCTGCTT
CCGGCTGCTTATTTGAATCCTTGCTCTGCGATGGACTATTCCCTGGCTGCAGCCCTCACT
CTTCATGGTCACTGGGGCCTTGGACAAGTTGTTACTGACTATGTTCATGGGGATGCCTTG
CAGAAAGCTGCCAAGGCAGGGCTTTTGGCACTTTCAGCTTTAACCTTTGCTGGGCTTTGC
TATTTCAACTATCACGATGTGGGCATCTGCAAAGCTGTTGCCATGCTGTGGAAGCTCTGA

Target 35 GenBank Gene ID

Not Available

Target 35 GeneCard ID

SDHD

Target 35 GenAtlas ID

SDHD

Target 35 HGNC ID

HGNC:10683 Link Image

Target 35 Chromosome Location

Chromosome:11

Target 35 Locus

11q23

Target 35 SNPs

SNPJam Report Link Image

Target 35 Toxin References

R213 - Ardelt BK, Borowitz JL, Isom GE: Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication. Toxicology. 1989 Jun 1;56(2):147-54. [PubMed ]

Target 35 General References

9533030; 10482792; 16303743; 16554811; 15489334; 11156372

Target 36 [top]

Target 36 ID

298

Target 36 Name

Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

Target 36 Mechanism of Action

Cyanide inhibits succinate dehydrogenases. (R213)

Target 36 Description

Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)

Target 36 Synonyms

Flavoprotein subunit of complex II; Fp

Target 36 Gene Name

SDHA

Target 36 Protein Sequence

>Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDSISAQYPVVDH
EFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWR
WHFYDTVKGSDWLGDQDAIHYMTEQAPAAVVELENYGMPFSRTEDGKIYQRAFGGQSLKF
GKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIE
DGSIHRIRAKNTVVATGGYGRTYFSCTSAHTSTGDGTAMITRAGLPCQDLEFVQFHPTGI
YGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPE
KDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQ
VLRHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIEESCRPGDK
VPPIKPNAGEESVMNLDKLRFADGSIRTSELRLSMQKSMQNHAAVFRVGSVLQEGCGKIS
KLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVR
IDEYDYSKPIQGQQKKPFEEHWRKHTLSYVDVGTGKVTLEYRPVIDKTLNEADCATVPPA
IRSY

Target 36 Number of Residues

664

Target 36 Molecular Weight

72691.0

Target 36 Theoretical pI

7.41

Target 36 GO Classification

Function
binding nucleotide binding purine nucleotide binding adenyl nucleotide binding FAD binding oxidoreductase activity, acting on the CH-CH group of donors catalytic activity oxidoreductase activity
Process
energy derivation by oxidation of organic compounds main pathways of carbohydrate metabolism tricarboxylic acid cycle physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
Not Available

Target 36 General Function

Energy production and conversion

Target 36 Pathways

Carbohydrate metabolism; tricarboxylic acid cycle

Target 36 Reactions

Not Available

Target 36 Signals

None

Target 36 Transmembrane Regions

None

Target 36 Essentiality

Non Essential

Target 36 Domain Function

PF00890:FAD_binding_2 PF02910:Succ_DH_flav_C

Target 36 GenBank ID Protein

Not Available

Target 36 UniProtKB ID

P31040

Target 36 Cellular Location

Mitochondrion inner membrane

Target 36 Gene Sequence

>1995 bp

ATGTCGGGGGTCCGGGGCCTGTCGCGGCTGCTGAGCGCTCGGCGCCTGGCGCTGGCCAAG
GCGTGGCCAACAGTGTTGCAAACAGGAACCCGAGGTTTTCACTTCACTGTTGATGGGAAC
AAGAGGGCATCTGCTAAAGTTTCAGATTCCATTTCTGCTCAGTATCCAGTAGTGGATCAT
GAATTTGATGCAGTGGTGGTAGGCGCTGGAGGGGCAGGCTTGCGAGCTGCATTTGGCCTT
TCTGAGGCAGGGTTTAATACAGCATGTGTTACCAAGCTGTTTCCTACCAGGTCACACACT
GTTGCAGCACAGGGAGGAATCAATGCTGCTCTGGGGAACATGGAGGAGGACAACTGGAGG
TGGCATTTCTACGACACCGTGAAGGGCTCCGACTGGCTGGGGGACCAGGATGCCATCCAC
TACATGACGGAGCAGGCCCCCGCCGCCGTGGTCGAGCTAGAAAATTATGGCATGCCGTTT
AGCAGAACTGAAGATGGGAAGATTTATCAGCGTGCATTTGGTGGACAGAGCCTCAAGTTT
GGAAAGGGCGGGCAGGCCCATCGGTGCTGCTGTGTGGCTGATCGGACTGGCCACTCGCTA
TTGCACACCTTATATGGACGGTCTCTGCGATATGATACCAGCTATTTTGTGGAGTATTTT
GCCTTGGATCTCCTGATGGAGAACGGGGAGTGCCGTGGTGTCATCGCACTGTGCATAGAG
GACGGGTCCATCCATCGCATAAGAGCAAAGAACACTGTTGTTGCCACAGGAGGCTACGGG
CGCACCTACTTCAGCTGCACGTCTGCCCACACCAGCACTGGCGACGGCACGGCCATGATC
ACCAGGGCAGGCCTTCCTTGCCAGGACCTAGAGTTTGTTCAGTTCCACCCTACAGGCATA
TATGGTGCTGGTTGTCTCATTACGGAAGGATGTCGTGGAGAGGGAGGCATTCTCATTAAC
AGTCAAGGCGAAAGGTTTATGGAGCGATACGCCCCTGTCGCGAAGGACCTGGCGTCTAGA
GATGTGGTGTCTCGGTCCATGACTCTGGAGATCCGAGAAGGAAGAGGCTGTGGCCCTGAG
AAAGATCACGTCTACCTGCAGCTGCACCACCTACCTCCAGAGCAGCTGGCCACGCGCCTG
CCTGGCATTTCAGAGACAGCCATGATCTTCGCTGGCGTGGACGTCACGAAGGAGCCGATC
CCTGTCCTCCCCACCGTGCATTATAACATGGGCGGCATTCCCACCAACTACAAGGGGCAG
GTCCTGAGGCACGTGAATGGCCAGGATCAGATTGTGCCCGGCCTGTACGCCTGTGGGGAG
GCCGCCTGTGCCTCGGTACATGGTGCCAACCGCCTCGGGGCAAACTCGCTCTTGGACCTG
GTTGTCTTTGGTCGGGCATGTGCCCTGAGCATCGAAGAGTCATGCAGGCCTGGAGATAAA
GTCCCTCCAATTAAACCAAACGCTGGGGAAGAATCTGTCATGAATCTTGACAAATTGAGA
TTTGCTGATGGAAGCATAAGAACATCGGAACTGCGACTCAGCATGCAGAAGTCAATGCAA
AATCATGCTGCCGTGTTCCGTGTGGGAAGCGTGTTGCAAGAAGGTTGTGGGAAAATCAGC
AAGCTCTATGGAGACCTAAAGCACCTGAAGACGTTCGACCGGGGAATGGTCTGGAACACG
GACCTGGTGGAGACCCTGGAGCTGCAGAACCTGATGCTGTGTGCGCTGCAGACCATCTAC
GGAGCAGAGGCACGGAAGGAGTCACGGGGCGCGCATGCCAGGGAAGACTACAAGGTGCGG
ATTGATGAGTACGATTACTCCAAGCCCATCCAGGGGCAACAGAAGAAGCCCTTTGAGGAG
CACTGGAGGAAGCACACCCTGTCCTATGTGGACGTTGGCACTGGGAAGGTCACTCTGGAA
TATAGACCCGTGATCGACAAAACTTTGAACGAGGCTGACTGTGCCACCGTCCCGCCAGCC
ATTCGCTCCTACTGA

Target 36 GenBank Gene ID

Not Available

Target 36 GeneCard ID

SDHA

Target 36 GenAtlas ID

SDHA

Target 36 HGNC ID

HGNC:10680 Link Image

Target 36 Chromosome Location

Not Available

Target 36 Locus

5p15

Target 36 SNPs

SNPJam Report Link Image

Target 36 Toxin References

R213 - Ardelt BK, Borowitz JL, Isom GE: Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication. Toxicology. 1989 Jun 1;56(2):147-54. [PubMed ]

Target 36 General References

7798181; 8142412; 10746566; 15489334; 7550341; 15242332; 19628817; 12794685

Target 37 [top]

Target 37 ID

299

Target 37 Name

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Target 37 Mechanism of Action

Cyanide inhibits succinate dehydrogenases. (R213)

Target 37 Description

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q)

Target 37 Synonyms

Iron-sulfur subunit of complex II; Ip

Target 37 Gene Name

SDHB

Target 37 Protein Sequence

>Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQT
YEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN
LNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKL
DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL
YRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV

Target 37 Number of Residues

280

Target 37 Molecular Weight

31629.4

Target 37 Theoretical pI

8.92

Target 37 GO Classification

Function
catalytic activity oxidoreductase activity binding ion binding cation binding transition metal ion binding iron ion binding transporter activity electron transporter activity
Process
energy derivation by oxidation of organic compounds main pathways of carbohydrate metabolism tricarboxylic acid cycle physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell membrane

Target 37 General Function

Energy production and conversion

Target 37 Pathways

Carbohydrate metabolism; tricarboxylic acid cycle

Target 37 Reactions

Not Available

Target 37 Signals

None

Target 37 Transmembrane Regions

None

Target 37 Essentiality

Non Essential

Target 37 Domain Function

PF00111:Fer2

Target 37 GenBank ID Protein

Not Available

Target 37 UniProtKB ID

P21912

Target 37 Cellular Location

Mitochondrion inner membrane

Target 37 Gene Sequence

>843 bp

ATGGCGGCGGTGGTCGCACTCTCCTTGAGGCGCCGGTTGCCGGCCACAACCCTTGGCGGA
GCCTGCCTGCAGGCCTCCCGAGGAGCCCAGACAGCTGCAGCCACAGCTCCCCGTATCAAG
AAATTTGCCATCTATCGATGGGACCCAGACAAGGCTGGAGACAAACCTCATATGCAGACT
TATAAGGTTGACCTTAATAAATGTGGCCCCATGGTATTGGATGCTTTAATCAAGATTAAG
AATGAAGTTGACTCTACTTTGACCTTCCGAAGATCATGCAGAGAAGGCATCTGTGGCTCT
TGTGCAATGAACATCAATGGAGGCAACACTCTAGCTTGCACCCGAAGGATTGACACCAAC
CTCAATAAGGTCTCAAAAATCTACCCTCTTCCACACATGTATGTGATAAAGGATCTTGTT
CCCGATTTGAGCAACTTCTATGCACAGTACAAATCCATTGAGCCTTATTTGAAGAAGAAG
GATGAATCTCAGGAAGGCAAGCAGCAGTATCTGCAGTCCATAGAAGAGCGTGAGAAACTG
GACGGGCTCTACGAGTGCATTCTCTGTGCCTGCTGTAGCACCAGCTGCCCCAGCTACTGG
TGGAACGGAGACAAATATCTGGGGCCTGCAGTTCTTATGCAGGCCTATCGCTGGATGATT
GACTCCAGAGATGACTTCACAGAGGAGCGCCTGGCCAAGCTGCAGGACCCATTCTCTCTA
TACCGCTGCCACACCATCATGAACTGCACAAGGACCTGTCCTAAGGGTCTGAATCCAGGG
AAAGCTATTGCAGAGATCAAGAAAATGATGGCAACCTATAAGGAGAAGAAAGCTTCAGTT
TAA

Target 37 GenBank Gene ID

Not Available

Target 37 GeneCard ID

SDHB

Target 37 GenAtlas ID

SDHB

Target 37 HGNC ID

HGNC:10681 Link Image

Target 37 Chromosome Location

Not Available

Target 37 Locus

1p36.1-p35

Target 37 SNPs

SNPJam Report Link Image

Target 37 Toxin References

R213 - Ardelt BK, Borowitz JL, Isom GE: Brain lipid peroxidation and antioxidant protectant mechanisms following acute cyanide intoxication. Toxicology. 1989 Jun 1;56(2):147-54. [PubMed ]

Target 37 General References

7622059; 16710414; 15489334; 2302193; 2494655; 11404820; 12213855; 11897817

Target 38 [top]

Target 38 ID

207

Target 38 Name

Superoxide dismutase [Cu-Zn]

Target 38 Mechanism of Action

Cyanide inhibits superoxide dismutase [Cu-Zn]. (R209)

Target 38 Description

Destroys radicals which are normally produced within the cells and which are toxic to biological systems

Target 38 Synonyms

Not Available

Target 38 Gene Name

SOD1

Target 38 Protein Sequence

>Superoxide dismutase [Cu-Zn]

MATKAVCVLKGDGPVQGIINFEQKESNGPVKVWGSIKGLTEGLHGFHVHEFGDNTAGCTS
AGPHFNPLSRKHGGPKDEERHVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGRTLVV
HEKADDLGKGGNEESTKTGNAGSRLACGVIGIAQ

Target 38 Number of Residues

154

Target 38 Molecular Weight

15935.7

Target 38 Theoretical pI

6.07

Target 38 GO Classification

Function
binding ion binding metal ion binding catalytic activity oxidoreductase activity oxidoreductase activity, acting on superoxide radicals as acceptor superoxide dismutase activity copper, zinc superoxide dismutase activity
Process
physiological process metabolism cellular metabolism oxygen and reactive oxygen species metabolism superoxide metabolism
Component
Not Available

Target 38 General Function

Inorganic ion transport and metabolism

Target 38 Pathways

Not Available

Target 38 Reactions

Not Available

Target 38 Signals

None

Target 38 Transmembrane Regions

None

Target 38 Essentiality

Non Essential

Target 38 Domain Function

PF00080:Sod_Cu

Target 38 GenBank ID Protein

Not Available

Target 38 UniProtKB ID

P00441

Target 38 Cellular Location

Cytoplasm

Target 38 Gene Sequence

>465 bp

ATGGCGACGAAGGCCGTGTGCGTGCTGAAGGGCGACGGCCCAGTGCAGGGCATCATCAAT
TTCGAGCAGAAGGAAAGTAATGGACCAGTGAAGGTGTGGGGAAGCATTAAAGGACTGACT
GAAGGCCTGCATGGATTCCATGTTCATGAGTTTGGAGATAATACAGCAGGCTGTACCAGT
GCAGGTCCTCACTTTAATCCTCTATCCAGAAAACACGGTGGGCCAAAGGATGAAGAGAGG
CATGTTGGAGACTTGGGCAATGTGACTGCTGACAAAGATGGTGTGGCCGATGTGTCTATT
GAAGATTCTGTGATCTCACTCTCAGGAGACCATTGCATCATTGGCCGCACACTGGTGGTC
CATGAAAAAGCAGATGACTTGGGCAAAGGTGGAAATGAAGAAAGTACAAAGACAGGAAAC
GCTGGAAGTCGTTTGGCTTGTGGTGTAATTGGGATCGCCCAATAA

Target 38 GenBank Gene ID

Not Available

Target 38 GeneCard ID

SOD1

Target 38 GenAtlas ID

SOD1

Target 38 HGNC ID

HGNC:11179 Link Image

Target 38 Chromosome Location

Chromosome:21

Target 38 Locus

21q22.1|21q22.11

Target 38 SNPs

SNPJam Report Link Image

Target 38 Toxin References

R209 - Lee WG, Hwang JH, Na BK, Cho JH, Lee HW, Cho SH, Kong Y, Song CY, Kim TS: Functional expression of a recombinant copper/zinc superoxide dismutase of filarial nematode, Brugia malayi. J Parasitol. 2005 Feb;91(1):205-8. [PubMed ]

Target 38 General References

6577438; 3160582; 3889846; 2853161; 14702039

Target 39 [top]

Target 39 ID

216

Target 39 Name

Tyrosinase

Target 39 Mechanism of Action

Cyanide inhibits tyrosinase. (R214)

Target 39 Description

This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone

Target 39 Synonyms

Monophenol monooxygenase; Tumor rejection antigen AB; SK29-AB; LB24-AB

Target 39 Gene Name

TYR

Target 39 Protein Sequence

>Tyrosinase

MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILL
SNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVR
RNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMH
YYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRD
AEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRN
PGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQS
SMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGH
NRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLG
AAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL

Target 39 Number of Residues

529

Target 39 Molecular Weight

60392.7

Target 39 Theoretical pI

6.05

Target 39 GO Classification

Function
catalytic activity oxidoreductase activity
Process
physiological process metabolism
Component
Not Available

Target 39 General Function

Involved in copper ion binding

Target 39 Pathways

Not Available

Target 39 Reactions

Not Available

Target 39 Signals

1-18

Target 39 Transmembrane Regions

477-497

Target 39 Essentiality

Non Essential

Target 39 Domain Function

PF00264:Tyrosinase

Target 39 GenBank ID Protein

Not Available

Target 39 UniProtKB ID

P14679

Target 39 Cellular Location

Melanosome membrane

Target 39 Gene Sequence

>1590 bp

ATGCTCCTGGCTGTTTTGTACTGCCTGCTGTGGAGTTTCCAGACCTCCGCTGGCCATTTC
CCTAGAGCCTGTGTCTCCTCTAAGAACCTGATGGAGAAGGAATGCTGTCCACCGTGGAGC
GGGGACAGGAGTCCCTGTGGCCAGCTTTCAGGCAGAGGTTCCTGTCAGAATATCCTTCTG
TCCAATGCACCACTTGGGCCTCAATTTCCCTTCACAGGGGTGGATGACCGGGAGTCGTGG
CCTTCCGTCTTTTATAATAGGACCTGCCAGTGCTCTGGCAACTTCATGGGATTCAACTGT
GGAAACTGCAAGTTTGGCTTTTGGGGACCAAACTGCACAGAGAGACGACTCTTGGTGAGA
AGAAACATCTTCGATTTGAGTGCCCCAGAGAAGGACAAATTTTTTGCCTACCTCACTTTA
GCAAAGCATACCATCAGCTCAGACTATGTCATCCCCATAGGGACCTATGGCCAAATGAAA
AATGGATCAACACCCATGTTTAACGACATCAATATTTATGACCTCTTTGTCTGGATGCAT
TATTATGTGTCAATGGATGCACTGCTTGGGGGATCTGAAATCTGGAGAGACATTGATTTT
GCCCATGAAGCACCAGCTTTTCTGCCTTGGCATAGACTCTTCTTGTTGCGGTGGGAACAA
GAAATCCAGAAGCTGACAGGAGATGAAAACTTCACTATTCCATATTGGGACTGGCGGGAT
GCAGAAAAGTGTGACATTTGCACAGATGAGTACATGGGAGGTCAGCACCCCACAAATCCT
AACTTACTCAGCCCAGCATCATTCTTCTCCTCTTGGCAGATTGTCTGTAGCCGATTGGAG
GAGTACAACAGCCATCAGTCTTTATGCAATGGAACGCCCGAGGGACCTTTACGGCGTAAT
CCTGGAAACCATGACAAATCCAGAACCCCAAGGCTCCCCTCTTCAGCTGATGTAGAATTT
TGCCTGAGTTTGACCCAATATGAATCTGGTTCCATGGATAAAGCTGCCAATTTCAGCTTT
AGAAATACACTGGAAGGATTTGCTAGTCCACTTACTGGGATAGCGGATGCCTCTCAAAGC
AGCATGCACAATGCCTTGCACATCTATATGAATGGAACAATGTCCCAGGTACAGGGATCT
GCCAACGATCCTATCTTCCTTCTTCACCATGCATTTGTTGACAGTATTTTTGAGCAGTGG
CTCCGAAGGCACCGTCCTCTTCAAGAAGTTTATCCAGAAGCCAATGCACCCATTGGACAT
AACCGGGAATCCTACATGGTTCCTTTTATACCACTGTACAGAAATGGTGATTTCTTTATT
TCATCCAAAGATCTGGGCTATGACTATAGCTATCTACAAGATTCAGACCCAGACTCTTTT
CAAGACTACATTAAGTCCTATTTGGAACAAGCGAGTCGGATCTGGTCATGGCTCCTTGGG
GCGGCGATGGTAGGGGCCGTCCTCACTGCCCTGCTGGCAGGGCTTGTGAGCTTGCTGTGT
CGTCACAAGAGAAAGCAGCTTCCTGAAGAAAAGCAGCCACTCCTCATGGAGAAAGAGGAT
TACCACAGCTTGTATCAGAGCCATTTATAA

Target 39 GenBank Gene ID

Not Available

Target 39 GeneCard ID

TYR

Target 39 GenAtlas ID

TYR

Target 39 HGNC ID

HGNC:12442 Link Image

Target 39 Chromosome Location

Chromosome:11

Target 39 Locus

11q14-q21

Target 39 SNPs

SNPJam Report Link Image

Target 39 Toxin References

R214 - Laufer Z, Beckett RP, Minibayeva FV: Co-occurrence of the multicopper oxidases tyrosinase and laccase in lichens in sub-order peltigerineae. Ann Bot (Lond). 2006 Nov;98(5):1035-42. Epub 2006 Sep 1. [PubMed ]

Target 39 General References

1903356; 2823263; 2499655; 1711223; 8340755; 11153699; 15489334; 2480811; 2504160

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.