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Showing toxin card for Aluminium antimonide (T3D1491)

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Version 1.0
Creation Date 2009-06-19 21:58:51
Update Date 2010-03-18 21:54:29
Accession Number T3D1491
Name Aluminium antimonide
Compound Type
  • Aluminum Compound
  • Antimony Compound
  • Inorganic Compound
Description Aluminium antimonide is a chemical compound of aluminum and antimony. It is used as a a semiconductor. Aluminum is the most abundant metal in the earth's crust and is always found combined with other elements such as oxygen, silicon, and fluorine. Antimony is a metallic element with the chemical symbol Sb and atomic number 51. Small amounts of antimony are found in the earth's crust. (R1131, R1128, R1129, S007)
Synonyms
  1. Aluminum antimonide
Chemical IUPAC Name alumanylidynestibane
Chemical Formula AlSb
Chemical Structure Structure
CAS Registry Number 25152-52-7
InChI Identifier InChI=1S/Al.Sb
InChI Key InChIKey=LVQULNGDVIKLPK-UHFFFAOYSA-N
PubChem Compound ID 24884164 Link Image
KEGG ID Not Available
UniProt ID Not Available
OMIM ID Not Available
ChEBI ID Not Available
BioCyc ID Not Available
SuperToxic ID Not Available
CTD ID Not Available
Stitch ID Aluminium antimonide Link Image
DrugBank ID Not Available
PDB ID Not Available
ACToR ID Not Available
Wikipedia Link Not Available
Monoisotopic Mass 147.885356
MOL File Show
PDB File Show
SDF File Show
SMILES [Al]#[Sb]
Appearance Black crystals.
Melting Point Not Available
Solubility Not Available
Predicted LogP -0.1944
Route of Exposure Oral (R1131) ; inhalation (R1131) ; dermal (R1131)
Mechanism of Action The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. Aluminum can also interact with estrogen receptors, increasing the expression of estrogen-related genes and contributing to the progression of breast cancer. Certain aluminum salts induce immune responses by activating inflammasomes. The inhalation data suggest that the myocardium is a target of antimony toxicity. It is possible that antimony affects circulating glucose by interfering with enzymes of the glycogenolysis and gluconeogenesis pathways. The mechanism of action of antimony remains unclear. However, some studies suggest that antimony combines with sulfhydryl groups including those in several enzymes important for tissue respiration. The antidotal action of BAL depends on its ability to prevent or break the union between antimony and vital enzymes. Moreover, the The cause of death is believed to be essentially the same as that in acute arsenic poisoning. (R276, R1131, S004, R1128, R1130, R1132)
Metabolism Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. Antimony is widely distributed throughout the body. The hair and skin contain the highest levels of antimony. The adrenal glands, lung, large intestine, trachea, cerebellum, and kidneys also contain relatively high levels of antimony. Blood is the main vehicle for the transport of absorbed antimony to various tissue compartments of the body. Antimony is a metal and, therefore, does not undergo catabolism. Antimony can covalently interact with sulfhydryl groups and phosphate, as well as numerous reversible binding interactions with endogenous ligands (e.g., proteins). It is not known if these interactions are toxicologically significant. Antimony is excreted via the urine and feces. Some of the fecal antimony may represent unabsorbed antimony that is cleared from the lung via mucociliary action into the esophagus to the gastrointestinal tract. (R1131, R1128)
Toxicity Values Not Available
Lethal Dose Not Available
Carcinogenicity (IARC Classification) 2B, possibly carcinogenic to humans. (R264)
Uses/Sources Aluminium antimonide is used as a a semiconductor. (S007)
Minimum Risk Level Intermediate Oral: 1.0 mg/kg/day (R260) Chronic Oral: 1.0 mg/kg/day (R260)
Health Effects Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer's disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. Dermal exposure to antimony can cause antimony spots (papules and pustules around sweat and sebaceous glands). Antimony poisoning can also lead to pneumoconiosis. Alterations in pulmonary function and other effects including chronic bronchitis, chronic emphysema, inactive tuberculosis, pleural adhesions, and irritation can result from inhalation of antimony. Increased blood pressure can also result from antimony poisoning. Myocardial depression, vasodilation and fluid loss may cause shock with hypotension, electrolyte disturbances and acute renal failure. Cerebral oedema, coma, convulsions, and death are possible. (R1131, R1128, R1129)
Symptoms Inhalating aluminum dust causes coughing and abnormal chest X-rays. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. Abdominal pain, vomiting, diarrhea can result from inhalation of antimony. Dyspnea, headache, vomiting,cough, conjunctivitis, and bloody purulent discharge from nose can result from inhalation exposure. Skin or eye contact can cause pain and redness of the exposed surface. (R692, R1131, R1128, R1129)
Treatment Following oral exposure to antimony, administer charcoal as a slurry (240 mL water/30 g charcoal). Following inhalation exposure, move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids. In case of eye exposure, irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. Following dermal exposure, remove contaminated clothing and wash exposed area thoroughly with soap and water. A physician may need to examine the area if irritation or pain persists. (R383)
General References
  • R1132 - Aimanianda V, Haensler J, Lacroix-Desmazes S, Kaveri SV, Bayry J: Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants. Trends Pharmacol Sci. 2009 Jun;30(6):287-95. Epub 2009 May 11. [PubMed Link Image]
  • R1130 - Darbre PD: Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J Appl Toxicol. 2006 May-Jun;26(3):191-7. [PubMed Link Image]
  • R1129 - Wikipedia. Aluminium. Last Updated 16 June 2009.
  • R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
  • S004 - Poon R, Chu I, Lecavalier P, Valli VE, Foster W, Gupta S, Thomas B: Effects of antimony on rats following 90-day exposure via drinking water. Food Chem Toxicol. 1998 Jan;36(1):21-35. [PubMed Link Image]
  • R383 - Rumack BH (2009). POISINDEX(R) Information System. Englewood, CO: Micromedex, Inc. CCIS Volume 141, edition expires Aug, 2009.
  • R692 - Hamilton A and Hardy HL (1974). Industrial Toxicology. 3rd ed. Acton, MA: Publishing Sciences Group, Inc.
  • R1128 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for aluminum. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R276 - Hayes WJ Jr. and Laws ER Jr. (eds) (1991). Handbook of Pesticide Toxicology. Volume 3. Classes of Pesticides. New York, NY: Academic Press, Inc.
  • R1131 - ATSDR - Agency for Toxic Substances and Disease Registry (1992). Toxicological profile for antimony. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • S007 - Wikipedia. Aluminium antimonide. Last Updated 25 March 2009.
Targets
  1. Estrogen receptor
  2. NACHT, LRR and PYD domains-containing protein 3
  3. Phosphorus
  4. Glutathione S-transferase A1
  5. Glutathione S-transferase A2
  6. Glutathione S-transferase A3
  7. Glutathione S-transferase Mu 4
  8. Glutathione S-transferase A5
  9. Glutathione S-transferase kappa 1
  10. Glutathione S-transferase Mu 1
  11. Glutathione S-transferase Mu 2
  12. Glutathione S-transferase Mu 3
  13. Glutathione S-transferase Mu 5
  14. Glutathione S-transferase omega-1
  15. Glutathione S-transferase omega-2
  16. Glutathione S-transferase P
  17. Glutathione S-transferase theta-1
  18. Glutathione S-transferase theta-2
  19. Glutathione S-transferase theta-4
  20. Microsomal glutathione S-transferase 1
  21. Microsomal glutathione S-transferase 2
  22. Microsomal glutathione S-transferase 3
  23. Maleylacetoacetate isomerase
Target 1 [top]
Target 1 ID 5
Target 1 Name Estrogen receptor
Target 1 Mechanism of Action Aluminum can also interact with estrogen receptors, increasing the expression of estrogen-related genes and contributing to the progression of breast cancer. (R1130)
Target 1 Description Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues
Target 1 Synonyms
  1. ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1
Target 1 Gene Name ESR1
Target 1 Protein Sequence >Estrogen receptor 
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Target 1 Number of Residues 595
Target 1 Molecular Weight 66215.4
Target 1 Theoretical pI 8.14
Target 1 GO Classification
Function
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 1 General Function Involved in estrogen receptor activity
Target 1 Pathways Not Available
Target 1 Reactions Not Available
Target 1 Signals
  • None
Target 1 Transmembrane Regions
  • None
Target 1 Essentiality Non Essential
Target 1 Domain Function PF00104:Hormone_recep PF02159:Oest_recep PF00105:zf-C4
Target 1 GenBank ID Protein Not Available
Target 1 UniProtKB ID P03372 Link Image
Target 1 Cellular Location Nucleus
Target 1 Gene Sequence >63 bp 
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA
Target 1 GenBank Gene ID Not Available
Target 1 GeneCard ID ESR1 Link Image
Target 1 GenAtlas ID ESR1 Link Image
Target 1 HGNC ID HGNC:3467 Link Image
Target 1 Chromosome Location Not Available
Target 1 Locus 6q25.1
Target 1 SNPs SNPJam Report Link Image
Target 1 Toxin References
  • R1130 - Darbre PD: Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J Appl Toxicol. 2006 May-Jun;26(3):191-7. [PubMed Link Image]
Target 1 General References 3754034; 3753802; 8600466; 14574404; 7476978; 10619354; 7916651; 7539106
Target 2 [top]
Target 2 ID 693
Target 2 Name NACHT, LRR and PYD domains-containing protein 3
Target 2 Mechanism of Action Certain aluminum salts induce immune responses by activating the NALP3 inflammasome, which in turn induces the production of interleukins. (R1132)
Target 2 Description May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18
Target 2 Synonyms
  1. Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1; Angiotensin/vasopressin receptor AII/AVP-like
Target 2 Gene Name NLRP3
Target 2 Protein Sequence >NACHT, LRR and PYD domains-containing protein 3 
MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFN
GEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLE
YLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQE
REQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLD
WASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMD
GFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLL
DHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGL
KQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKI
LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEG
RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ
QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD
HMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVN
SHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGL
SHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSA
CCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCS
ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLS
TLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQ
EEKPELTVVFEPSW
Target 2 Number of Residues 1034
Target 2 Molecular Weight 117912.0
Target 2 Theoretical pI 6.58
Target 2 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 2 General Function Involved in ATP binding
Target 2 Pathways Not Available
Target 2 Reactions Not Available
Target 2 Signals
  • None
Target 2 Transmembrane Regions
  • None
Target 2 Essentiality Non Essential
Target 2 Domain Function PF00560:LRR_1 PF05729:NACHT PF02758:PAAD_DAPIN
Target 2 GenBank ID Protein Not Available
Target 2 UniProtKB ID Q96P20 Link Image
Target 2 Cellular Location Cytoplasm
Target 2 Gene Sequence >3105 bp 
ATGGCAAGCACCCGCTGCAAGCTGGCCAGGTACCTGGAGGACCTGGAGGATGTGGACTTG
AAGAAATTTAAGATGCACTTAGAGGACTATCCTCCCCAGAAGGGCTGCATCCCCCTCCCG
AGGGGTCAGACAGAGAAGGCAGACCATGTGGATCTAGCCACGCTAATGATCGACTTCAAT
GGGGAGGAGAAGGCGTGGGCCATGGCCGTGTGGATCTTCGCTGCGATCAACAGGAGAGAC
CTTTATGAGAAAGCAAAAAGAGATGAGCCGAAGTGGGGTTCAGATAATGCACGTGTTTCG
AATCCCACTGTGATATGCCAGGAAGACAGCATTGAAGAGGAGTGGATGGGTTTACTGGAG
TACCTTTCGAGAATCTCTATTTGTAAAATGAAGAAAGATTACCGTAAGAAGTACAGAAAG
TACGTGAGAAGCAGATTCCAGTGCATTGAAGACAGGAATGCCCGTCTGGGTGAGAGTGTG
AGCCTCAACAAACGCTACACACGACTGCGTCTCATCAAGGAGCACCGGAGCCAGCAGGAG
AGGGAGCAGGAGCTTCTGGCCATCGGCAAGACCAAGACGTGTGAGAGCCCCGTGAGTCCC
ATTAAGATGGAGTTGCTGTTTGACCCCGATGATGAGCATTCTGAGCCTGTGCACACCGTG
GTGTTCCAGGGGGCGGCAGGGATTGGGAAAACAATCCTGGCCAGGAAGATGATGTTGGAC
TGGGCGTCGGGGACACTCTACCAAGACAGGTTTGACTATCTGTTCTATATCCACTGTCGG
GAGGTGAGCCTTGTGACACAGAGGAGCCTGGGGGACCTGATCATGAGCTGCTGCCCCGAC
CCAAACCCACCCATCCACAAGATCGTGAGAAAACCCTCCAGAATCCTCTTCCTCATGGAC
GGCTTCGATGAGCTGCAAGGTGCCTTTGACGAGCACATAGGACCGCTCTGCACTGACTGG
CAGAAGGCCGAGCGGGGAGACATTCTCCTGAGCAGCCTCATCAGAAAGAAGCTGCTTCCC
GAGGCCTCTCTGCTCATCACCACGAGACCTGTGGCCCTGGAGAAACTGCAGCACTTGCTG
GACCATCCTCGGCATGTGGAGATCCTGGGTTTCTCCGAGGCCAAAAGGAAAGAGTACTTC
TTCAAGTACTTCTCTGATGAGGCCCAAGCCAGGGCAGCCTTCAGTCTGATTCAGGAGAAC
GAGGTCCTCTTCACCATGTGCTTCATCCCCCTGGTCTGCTGGATCGTGTGCACTGGACTG
AAACAGCAGATGGAGAGTGGCAAGAGCCTTGCCCAGACATCCAAGACCACCACCGCGGTG
TACGTCTTCTTCCTTTCCAGTTTGCTGCAGCCCCGGGGAGGGAGCCAGGAGCACGGCCTC
TGCGCCCACCTCTGGGGGCTCTGCTCTTTGGCTGCAGATGGAATCTGGAACCAGAAAATC
CTGTTTGAGGAGTCCGACCTCAGGAATCATGGACTGCAGAAGGCGGATGTGTCTGCTTTC
CTGAGGATGAACCTGTTCCAAAAGGAAGTGGACTGCGAGAAGTTCTACAGCTTCATCCAC
ATGACTTTCCAGGAGTTCTTTGCCGCCATGTACTACCTGCTGGAAGAGGAAAAGGAAGGA
AGGACGAACGTTCCAGGGAGTCGTTTGAAGCTTCCCAGCCGAGACGTGACAGTCCTTCTG
GAAAACTATGGCAAATTCGAAAAGGGGTATTTGATTTTTGTTGTACGTTTCCTCTTTGGC
CTGGTAAACCAGGAGAGGACCTCCTACTTGGAGAAGAAATTAAGTTGCAAGATCTCTCAG
CAAATCAGGCTGGAGCTGCTGAAATGGATTGAAGTGAAAGCCAAAGCTAAAAAGCTGCAG
ATCCAGCCCAGCCAGCTGGAATTGTTCTACTGTTTGTACGAGATGCAGGAGGAGGACTTC
GTGCAAAGGGCCATGGACTATTTCCCCAAGATTGAGATCAATCTCTCCACCAGAATGGAC
CACATGGTTTCTTCCTTTTGCATTGAGAACTGTCATCGGGTGGAGTCACTGTCCCTGGGG
TTTCTCCATAACATGCCCAAGGAGGAAGAGGAGGAGGAAAAGGAAGGCCGACACCTTGAT
ATGGTGCAGTGTGTCCTCCCAAGCTCCTCTCATGCTGCCTGTTCTCATGGATTGGTGAAC
AGCCACCTCACTTCCAGTTTTTGCCGGGGCCTCTTTTCAGTTCTGAGCACCAGCCAGAGT
CTAACTGAATTGGACCTCAGTGACAATTCTCTGGGGGACCCAGGGATGAGAGTGTTGTGT
GAAACGCTCCAGCATCCTGGCTGTAACATTCGGAGATTGTGGTTGGGGCGCTGTGGCCTC
TCGCATGAGTGCTGCTTCGACATCTCCTTGGTCCTCAGCAGCAACCAGAAGCTGGTGGAG
CTGGACCTGAGTGACAACGCCCTCGGTGACTTCGGAATCAGACTTCTGTGTGTGGGACTG
AAGCACCTGTTGTGCAATCTGAAGAAGCTCTGGTTGGTCAGCTGCTGCCTCACATCAGCA
TGTTGTCAGGATCTTGCATCAGTATTGAGCACCAGCCATTCCCTGACCAGACTCTATGTG
GGGGAGAATGCCTTGGGAGACTCAGGAGTCGCAATTTTATGTGAAAAAGCCAAGAATCCA
CAGTGTAACCTGCAGAAACTGGGGTTGGTGAATTCTGGCCTTACGTCAGTCTGTTGTTCA
GCTTTGTCCTCGGTACTCAGCACTAATCAGAATCTCACGCACCTTTACCTGCGAGGCAAC
ACTCTCGGAGACAAGGGGATCAAACTACTCTGTGAGGGACTCTTGCACCCCGACTGCAAG
CTTCAGGTGTTGGAATTAGACAACTGCAACCTCACGTCACACTGCTGCTGGGATCTTTCC
ACACTTCTGACCTCCAGCCAGAGCCTGCGAAAGCTGAGCCTGGGCAACAATGACCTGGGC
GACCTGGGGGTCATGATGTTCTGTGAAGTGCTGAAACAGCAGAGCTGCCTCCTGCAGAAC
CTGGGGTTGTCTGAAATGTATTTCAATTATGAGACAAAAAGTGCGTTAGAAACACTTCAA
GAAGAAAAGCCTGAGCTGACCGTCGTCTTTGAGCCTTCTTGGTAG
Target 2 GenBank Gene ID Not Available
Target 2 GeneCard ID NLRP3 Link Image
Target 2 GenAtlas ID NLRP3 Link Image
Target 2 HGNC ID HGNC:16400 Link Image
Target 2 Chromosome Location Not Available
Target 2 Locus 1q44
Target 2 SNPs SNPJam Report Link Image
Target 2 Toxin References
  • R1132 - Aimanianda V, Haensler J, Lacroix-Desmazes S, Kaveri SV, Bayry J: Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants. Trends Pharmacol Sci. 2009 Jun;30(6):287-95. Epub 2009 May 11. [PubMed Link Image]
Target 2 General References 11687797; 12355493; 11786556; 14662828; 16710414; 15489334; 11042152; 15030775; 17164409
Target 3 [top]
Target 3 ID 692
Target 3 Name Phosphorus
Target 3 Mechanism of Action Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. (R1128)
Target 3 Description Not Available
Target 3 Synonyms Not Available
Target 3 Gene Name Not Available
Target 3 Protein Sequence Not Available
Target 3 Number of Residues Not Available
Target 3 Molecular Weight Not Available
Target 3 Theoretical pI Not Available
Target 3 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 3 General Function Not Available
Target 3 Pathways Not Available
Target 3 Reactions Not Available
Target 3 Signals Not Available
Target 3 Transmembrane Regions Not Available
Target 3 Essentiality Not Available
Target 3 Domain Function Not Available
Target 3 GenBank ID Protein Not Available
Target 3 UniProtKB ID Phosphorus Link Image
Target 3 Cellular Location Not Available
Target 3 Gene Sequence Not Available
Target 3 GenBank Gene ID Not Available
Target 3 GeneCard ID Not Available
Target 3 GenAtlas ID Not Available
Target 3 HGNC ID Not Available
Target 3 Chromosome Location Not Available
Target 3 Locus Not Available
Target 3 SNPs Not Available
Target 3 Toxin References
  • R1128 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for aluminum. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Target 3 General References Not Available
Target 4 [top]
Target 4 ID 750
Target 4 Name Glutathione S-transferase A1
Target 4 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 4 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 4 Synonyms
  1. GTH1; HA subunit 1; GST-epsilon; GSTA1-1; GST class-alpha member 1
Target 4 Gene Name GSTA1
Target 4 Protein Sequence >Glutathione S-transferase A1 
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAK
LALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
Target 4 Number of Residues 222
Target 4 Molecular Weight 25630.8
Target 4 Theoretical pI 9.34
Target 4 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 4 General Function Involved in glutathione transferase activity
Target 4 Pathways Not Available
Target 4 Reactions Not Available
Target 4 Signals
  • None
Target 4 Transmembrane Regions
  • None
Target 4 Essentiality Non Essential
Target 4 Domain Function PF00043:GST_C PF02798:GST_N
Target 4 GenBank ID Protein Not Available
Target 4 UniProtKB ID P08263 Link Image
Target 4 Cellular Location Cytoplasm
Target 4 Gene Sequence >669 bp 
TAACAAAGCTTAGAGAAACCTCCAGGAGACTGCTATCATGGCAGAGAAGCCCAAGCTCCA
CTACTTCAATGCACGGGGCAGAATGGAGTCCACCCGGTGGCTCCTGGCTGCAGCTGGAGT
AGAGTTTGAAGAGAAATTTATAAAATCTGCAGAAGATTTGGACAAGTTAAGAAATGATGG
ATATTTGATGTTCCAGCAAGTGCCAATGGTTGAGATTGATGGGATGAAGCTGGTGCAGAC
CAGAGCCATTCTCAACTACATTGCCAGCAAATACAACCTCTATGGGAAAGACATAAAGGA
GAGAGCCCTGATTGATATGTATATAGAAGGTATAGCAGATTTGGGTGAAATGATCCTCCT
TCTGCCCGTATGTCCACCTGAGGAAAAAGATGCCAAGCTTGCCTTGATCAAGGAGAAAAT
AAAAAATCGCTACTTCCCTGCCTTTGAAAAAGTCTTAAAGAGCCATGGACAAGACTACCT
TGTTGGCAACAAGCTGAGCCGGGCTGACATTCATCTGGTGGAACTTCTCTACTACGTCGA
GGAGCTTGACTCCAGTCTTATCTCCAGCTTCCCTCTGCTGAAGGCCCTGAAAACCAGAAT
CAGCAACCTGCCCACAGTGAAGAAGTTTCTACAGCCTGGCAGCCCAAGGAAGCCTCCCAT
GGATGAGAA
Target 4 GenBank Gene ID Not Available
Target 4 GeneCard ID GSTA1 Link Image
Target 4 GenAtlas ID GSTA1 Link Image
Target 4 HGNC ID HGNC:4626 Link Image
Target 4 Chromosome Location Not Available
Target 4 Locus 6p12.1
Target 4 SNPs SNPJam Report Link Image
Target 4 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 4 General References 3800996; 3036131; 3678589; 3031680; 1731620; 1330133; 15489334; 3138230; 8431482; 2604726
Target 5 [top]
Target 5 ID 752
Target 5 Name Glutathione S-transferase A2
Target 5 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 5 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 5 Synonyms
  1. GTH2; HA subunit 2; GST-gamma; GSTA2-2; GST class-alpha member 2
Target 5 Gene Name GSTA2
Target 5 Protein Sequence >Glutathione S-transferase A2 
MAEKPKLHYSNIRGRMESIRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKEKALIDMYIEGIADLGEMILLLPFSQPEEQDAK
LALIQEKTKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEESRKIFRF
Target 5 Number of Residues 222
Target 5 Molecular Weight 25663.7
Target 5 Theoretical pI 9.07
Target 5 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 5 General Function Involved in glutathione transferase activity
Target 5 Pathways Not Available
Target 5 Reactions Not Available
Target 5 Signals
  • None
Target 5 Transmembrane Regions
  • None
Target 5 Essentiality Non Essential
Target 5 Domain Function PF00043:GST_C PF02798:GST_N
Target 5 GenBank ID Protein Not Available
Target 5 UniProtKB ID P09210 Link Image
Target 5 Cellular Location Cytoplasm
Target 5 Gene Sequence >669 bp 
AGAAACCTCCAGGAGACTGCTACCATGGCAGAGAAGCCCAAGCTCCACTACTCCAATATA
CGGGGCAGAATGGAGTCCATCCGGTGGCTCCTGGCTGCAGCTGGAGTAGAGTTTGAAGAG
AAATTTATAAAATCTGCAGAAGATTTGGACAAGTTAAGAAATGATGGATATTTGATGTTC
CAGCAAGTGCCAATGGTTGAGATTGATGGGATGAAGCTGGTGCAGACCAGAGCCATTCTC
AACTACATTGCCAGCAAATACAACCTCTATGGGAAAGACATAAAGGAGAAAGCCCTGATT
GATATGTATATAGAAGGTATAGCAGATTTGGGTGAAATGATCCTTCTTCTGCCCTTTACT
CAACCTGAGGAACAAGATGCCAAGCTTGCCTTGATCCAAGAGAAAACAAAAAATCGCTAC
TTCCCTGCCTTTGAAAAAGTCTTAAAGAGCCACGGACAAGACTACCTTGTTGGCAACAAG
CTGAGCCGGGCTGACATTCACCTGGTGGAACTTCTCTACTACGTGGAAGAGCTTGACTCT
AGCCTTATTTCCAGCTTCCCTCTGCTGAAGGCCCTGAAAACCAGAATCAGTAACCTGCCC
ACAGTGAAGAAGTTTCTACAGCCTGGCAGCCCAAGGAAGCCTCCCATGGATGAGAAATCT
TTAGAAGAA
Target 5 GenBank Gene ID Not Available
Target 5 GeneCard ID GSTA2 Link Image
Target 5 GenAtlas ID GSTA2 Link Image
Target 5 HGNC ID HGNC:4627 Link Image
Target 5 Chromosome Location Not Available
Target 5 Locus 6p12.1
Target 5 SNPs SNPJam Report Link Image
Target 5 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 5 General References 3036131; 1329668; 1497629; 14574404; 15489334; 8431482; 2604726; 7892174; 11668220
Target 6 [top]
Target 6 ID 751
Target 6 Name Glutathione S-transferase A3
Target 6 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 6 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones. Efficiently catalyze obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione and delta(5)- pregnene-3,20-dione, precursors to testosterone and progesterone, respectively
Target 6 Synonyms
  1. Glutathione S-transferase A3-3; GST class-alpha member 3
Target 6 Gene Name GSTA3
Target 6 Protein Sequence >Glutathione S-transferase A3 
MAGKPKLHYFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGKLRNDGSLMFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYTEGMADLNEMILLLPLCRPEEKDAK
IALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDSSLISNFPL
LKALKTRISNLPTVKKFLQPGSPRKPPADAKALEEARKIFRF
Target 6 Number of Residues 222
Target 6 Molecular Weight 25301.4
Target 6 Theoretical pI 9.69
Target 6 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 6 General Function Involved in glutathione transferase activity
Target 6 Pathways Not Available
Target 6 Reactions Not Available
Target 6 Signals
  • None
Target 6 Transmembrane Regions
  • None
Target 6 Essentiality Non Essential
Target 6 Domain Function PF00043:GST_C PF02798:GST_N
Target 6 GenBank ID Protein Not Available
Target 6 UniProtKB ID Q16772 Link Image
Target 6 Cellular Location Cytoplasm
Target 6 Gene Sequence >669 bp 
ATGGCAGGGAAGCCCAAGCTTCACTACTTCAATGGACGGGGCAGAATGGAGCCCATCCGG
TGGCTCTTGGCTGCAGCTGGAGTGGAGTTTGAAGAGAAATTTATAGGATCTGCAGAAGAT
TTGGGAAAGTTAAGAAATGATGGGAGTTTGATGTTCCAGCAAGTACCAATGGTTGAGATT
GATGGGATGAAGTTGGTACAGACCAGAGCCATTCTCAACTACATTGCCAGCAAATACAAC
CTCTACGGGAAAGACATAAAGGAGAGAGCCCTAATTGATATGTATACAGAAGGTATGGCA
GATTTGAATGAAATGATCCTTCTTCTGCCCTTATGTCGACCTGAGGAAAAAGATGCCAAG
ATTGCCTTGATCAAAGAGAAAACAAAAAGTCGCTATTTCCCTGCCTTCGAAAAAGTGTTA
CAGAGCCATGGACAAGACTACCTTGTTGGCAACAAGCTGAGCCGGGCTGACATTAGCCTG
GTGGAACTTCTCTACTATGTGGAAGAGCTTGACTCCAGCCTTATCTCCAACTTCCCTCTG
CTGAAGGCCCTGAAAACCAGAATCAGCAACCTGCCCACGGTGAAGAAGTTTCTACAGCCT
GGCAGCCCAAGGAAGCCTCCCGCAGATGCAAAAGCTTTAGAAGAAGCCAGAAAGATTTTC
AGGTTTTAA
Target 6 GenBank Gene ID Not Available
Target 6 GeneCard ID GSTA3 Link Image
Target 6 GenAtlas ID GSTA3 Link Image
Target 6 HGNC ID HGNC:4628 Link Image
Target 6 Chromosome Location Not Available
Target 6 Locus 6p12.1
Target 6 SNPs SNPJam Report Link Image
Target 6 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 6 General References 8307579; 11418619; 14574404; 15489334; 9480897
Target 7 [top]
Target 7 ID 749
Target 7 Name Glutathione S-transferase Mu 4
Target 7 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 7 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1- chloro-2,4-dinitrobenzene
Target 7 Synonyms
  1. GSTM4-4; GST class-mu 4; GTS-Mu2
Target 7 Gene Name GSTM4
Target 7 Protein Sequence >Glutathione S-transferase Mu 4 
MSMTLGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQAMDVSNQLARVCYSPDF
EKLKPEYLEELPTMMQHFSQFLGKRPWFVGDKITFVDFLAYDVLDLHRIFEPNCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPKPLYTRVAVWGNK
Target 7 Number of Residues 218
Target 7 Molecular Weight 25561.1
Target 7 Theoretical pI 5.69
Target 7 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 7 General Function Involved in glutathione transferase activity
Target 7 Pathways Not Available
Target 7 Reactions Not Available
Target 7 Signals
  • None
Target 7 Transmembrane Regions
  • None
Target 7 Essentiality Non Essential
Target 7 Domain Function PF00043:GST_C PF02798:GST_N
Target 7 GenBank ID Protein Not Available
Target 7 UniProtKB ID Q03013 Link Image
Target 7 Cellular Location Cytoplasm
Target 7 Gene Sequence >657 bp 
ATGTCCATGACACTGGGGTACTGGGACATCCGCGGGCTGGCCCACGCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTACGAGGAAAAGAAGTATACGATGGGGGACGCTCCTGAC
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTAGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAACGCCATCCTGTGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGGCTATGGACGTCTCCAATCAGCTGGCCAGAGTCTGCTACAGCCCTGACTTT
GAGAAACTGAAGCCAGAATACTTGGAGGAACTTCCTACAATGATGCAGCACTTCTCACAG
TTCCTGGGGAAGAGGCCATGGTTTGTTGGAGACAAGATCACCTTTGTAGATTTCCTCGCC
TATGATGTCCTTGACCTCCACCGTATATTTGAGCCCAACTGCTTGGACGCCTTTCCAAAT
CTGAAGGACTTCATCTCCCGCTTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAAACCTCTGTACACAAGGGTGGCTGTCTGGGGCAACAAGTAA
Target 7 GenBank Gene ID Not Available
Target 7 GeneCard ID GSTM4 Link Image
Target 7 GenAtlas ID GSTM4 Link Image
Target 7 HGNC ID HGNC:4636 Link Image
Target 7 Chromosome Location Not Available
Target 7 Locus 1p13.3
Target 7 SNPs SNPJam Report Link Image
Target 7 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 7 General References 8349586; 8471052; 8373352; 15489334; 2006920; 8203914; 10587441
Target 8 [top]
Target 8 ID 759
Target 8 Name Glutathione S-transferase A5
Target 8 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 8 Description RX + glutathione = HX + R-S-glutathione
Target 8 Synonyms
  1. Glutathione S-transferase A5-5; GST class-alpha member 5
Target 8 Gene Name GSTA5
Target 8 Protein Sequence >Glutathione S-transferase A5 
MAEKPKLHYSNARGSMESIRWLLAAAGVELEEKFLESAEDLDKLRNDGSLLFQQVPMVEI
DGMKLVQTRAILNYIASKYNLYGKDMKERALIDMYTEGIVDLTEMILLLLICQPEERDAK
TALVKEKIKNRYFPAFEKVLKSHRQDYLVGNKLSWADIHLVELFYYVEELDSSLISSFPL
LKALKTRISNLPTVKKFLQPGSQRKPPMDEKSLEEARKIFRF
Target 8 Number of Residues 222
Target 8 Molecular Weight 25721.7
Target 8 Theoretical pI 8.37
Target 8 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 8 General Function Involved in glutathione transferase activity
Target 8 Pathways Not Available
Target 8 Reactions Not Available
Target 8 Signals
  • None
Target 8 Transmembrane Regions
  • None
Target 8 Essentiality Non Essential
Target 8 Domain Function PF00043:GST_C PF02798:GST_N
Target 8 GenBank ID Protein Not Available
Target 8 UniProtKB ID Q7RTV2 Link Image
Target 8 Cellular Location Cytoplasm (By similarity)
Target 8 Gene Sequence Not Available
Target 8 GenBank Gene ID Not Available
Target 8 GeneCard ID GSTA5 Link Image
Target 8 GenAtlas ID GSTA5 Link Image
Target 8 HGNC ID HGNC:19662 Link Image
Target 8 Chromosome Location Not Available
Target 8 Locus 6p12.1
Target 8 SNPs SNPJam Report Link Image
Target 8 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 8 General References 14574404; 12042665
Target 9 [top]
Target 9 ID 754
Target 9 Name Glutathione S-transferase kappa 1
Target 9 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 9 Description Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB)
Target 9 Synonyms
  1. Glutathione S-transferase subunit 13; GST 13-13; GST class-kappa; GSTK1-1; hGSTK1
Target 9 Gene Name GSTK1
Target 9 Protein Sequence >Glutathione S-transferase kappa 1 
MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLITGIMKDSGNKPPGLLP
RKGLYMANDLKLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRFLTAVNLEHPEMLEKASRE
LWMRVWSRNEDITEPQSILAAAEKAGMSAEQAQGLLEKIATPKVKNQLKETTEAACRYGA
FGLPITVAHVDGQTHMLFGSDRMELLAHLLGEKWMGPIPPAVNARL
Target 9 Number of Residues 226
Target 9 Molecular Weight 25496.6
Target 9 Theoretical pI 8.69
Target 9 GO Classification
Function
catalytic activity
oxidoreductase activity
disulfide oxidoreductase activity
protein disulfide oxidoreductase activity
Process
Not Available
Component
cell
periplasmic space
periplasmic space (sensu Gram-negative Bacteria)
Target 9 General Function Involved in glutathione transferase activity
Target 9 Pathways Not Available
Target 9 Reactions Not Available
Target 9 Signals
  • None
Target 9 Transmembrane Regions
  • None
Target 9 Essentiality Non Essential
Target 9 Domain Function PF01323:DSBA
Target 9 GenBank ID Protein Not Available
Target 9 UniProtKB ID Q9Y2Q3 Link Image
Target 9 Cellular Location Peroxisome
Target 9 Gene Sequence >681 bp 
ATGGGGCCCCTGCCGCGCACCGTGGAGCTCTTCTATGACGTGCTGTCCCCCTACTCCTGG
CTGGGCTTCGAGATCCTGTGCCGGTATCAGAATATCTGGAACATCAACCTGCAGTTGCGG
CCCAGCCTCATAACAGGGATCATGAAAGACAGTGGAAACAAGCCTCCAGGTCTGCTTCCC
CGCAAAGGACTATACATGGCAAATGACTTAAAGCTCCTGAGACACCATCTCCAGATTCCC
ATCCACTTCCCCAAGGATTTCTTGTCTGTGATGCTTGAAAAAGGAAGTTTGTCTGCCATG
CGTTTCCTCACCGCCGTGAACTTGGAGCATCCAGAGATGCTGGAGAAAGCGTCCCGGGAG
CTGTGGATGCGCGTCTGGTCAAGGAATGAAGACATCACCGAGCCGCAGAGCATCCTGGCG
GCTGCAGAGAAGGCTGGTATGTCTGCAGAACAAGCCCAGGGACTTCTGGAAAAGATCGCA
ACGCCAAAGGTGAAGAACCAGCTCAAGGAGACCACTGAGGCAGCCTGCAGATACGGAGCC
TTTGGGCTGCCCATCACCGTGGCCCATGTGGATGGCCAAACCCACATGTTATTTGGCTCT
GACCGGATGGAGCTGCTGGCGCACCTGCTGGGAGAGAAGTGGATGGGCCCTATACCTCCA
GCCGTGAATGCCAGACTTTAA
Target 9 GenBank Gene ID Not Available
Target 9 GeneCard ID GSTK1 Link Image
Target 9 GenAtlas ID GSTK1 Link Image
Target 9 HGNC ID HGNC:16906 Link Image
Target 9 Chromosome Location Not Available
Target 9 Locus 7q35
Target 9 SNPs SNPJam Report Link Image
Target 9 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 9 General References 14709161; 14742434; 11042152; 11230166; 15489334
Target 10 [top]
Target 10 ID 747
Target 10 Name Glutathione S-transferase Mu 1
Target 10 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 10 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 10 Synonyms
  1. GSTM1-1; GST class-mu 1; GSTM1a-1a; GSTM1b-1b; HB subunit 4; GTH4
Target 10 Gene Name GSTM1
Target 10 Protein Sequence >Glutathione S-transferase Mu 1 
MPMILGYWDIRGLAHAIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILCYIARKHNLCGETEEEKIRVDILENQTMDNHMQLGMICYNPEF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGNKITFVDFLVYDVLDLHRIFEPKCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFSKMAVWGNK
Target 10 Number of Residues 218
Target 10 Molecular Weight 25711.6
Target 10 Theoretical pI 6.67
Target 10 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 10 General Function Involved in glutathione transferase activity
Target 10 Pathways Not Available
Target 10 Reactions Not Available
Target 10 Signals
  • None
Target 10 Transmembrane Regions
  • None
Target 10 Essentiality Non Essential
Target 10 Domain Function PF00043:GST_C PF02798:GST_N
Target 10 GenBank ID Protein Not Available
Target 10 UniProtKB ID P09488 Link Image
Target 10 Cellular Location Cytoplasm
Target 10 Gene Sequence >657 bp 
ATGCCCATGATACTGGGGTACTGGGACATCCGCGGGCTGGCCCACGCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTATGAGGAAAAGAAGTACACGATGGGGGACGCTCCTGAT
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAACGCCATCTTGTGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGACCATGGACAACCATATGCAGCTGGGCATGATCTGCTACAATCCAGAATTT
GAGAAACTGAAGCCAAAGTACTTGGAGGAACTCCCTGAAAAGCTAAAGCTCTACTCAGAG
TTTCTGGGGAAGCGGCCATGGTTTGCAGGAAACAAGATCACTTTTGTAGATTTTCTCGTC
TATGATGTCCTTGACCTCCACCGTATATTTGAGCCCAAGTGCTTGGACGCCTTCCCAAAT
CTGAAGGACTTCATCTCCCGCTTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAGACCTGTGTTCTCAAAGATGGCTGTCTGGGGCAACAAGTAG
Target 10 GenBank Gene ID Not Available
Target 10 GeneCard ID GSTM1 Link Image
Target 10 GenAtlas ID GSTM1 Link Image
Target 10 HGNC ID HGNC:4632 Link Image
Target 10 Chromosome Location Not Available
Target 10 Locus 1p13.3
Target 10 SNPs SNPJam Report Link Image
Target 10 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 10 General References 3419925; 3174634; 15489334; 8471052; 7822249; 2110160; 3979555
Target 11 [top]
Target 11 ID 756
Target 11 Name Glutathione S-transferase Mu 2
Target 11 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 11 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 11 Synonyms
  1. GSTM2-2; GST class-mu 2
Target 11 Gene Name GSTM2
Target 11 Protein Sequence >Glutathione S-transferase Mu 2 
MPMTLGYWNIRGLAHSIRLLLEYTDSSYEEKKYTMGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGTHKITQSNAILRYIARKHNLCGESEKEQIREDILENQFMDSRMQLAKLCYDPDF
EKLKPEYLQALPEMLKLYSQFLGKQPWFLGDKITFVDFIAYDVLERNQVFEPSCLDAFPN
LKDFISRFEGLEKISAYMKSSRFLPRPVFTKMAVWGNK
Target 11 Number of Residues 218
Target 11 Molecular Weight 25744.4
Target 11 Theoretical pI 6.29
Target 11 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 11 General Function Involved in glutathione transferase activity
Target 11 Pathways Not Available
Target 11 Reactions Not Available
Target 11 Signals
  • None
Target 11 Transmembrane Regions
  • None
Target 11 Essentiality Non Essential
Target 11 Domain Function PF00043:GST_C PF02798:GST_N
Target 11 GenBank ID Protein Not Available
Target 11 UniProtKB ID P28161 Link Image
Target 11 Cellular Location Cytoplasm
Target 11 Gene Sequence >657 bp 
ATGCCCATGACACTGGGGTACTGGAACATCCGCGGGCTGGCCCATTCCATCCGCCTGCTC
CTGGAATACACAGACTCAAGCTACGAGGAAAAGAAGTACACGATGGGGGACGCTCCTGAT
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGACTCACAAGATCACCCAGAGCAATGCCATCCTGCGGTACATT
GCCCGCAAGCACAACCTGTGCGGGGAATCAGAAAAGGAGCAGATTCGCGAAGACATTTTG
GAGAACCAGTTTATGGACAGCCGTATGCAGCTGGCCAAACTCTGCTATGACCCAGATTTT
GAGAAACTGAAACCAGAATACCTGCAGGCACTCCCTGAAATGCTGAAGCTCTACTCACAG
TTTCTGGGGAAGCAGCCATGGTTTCTTGGGGACAAGATCACCTTTGTGGATTTCATCGCT
TATGATGTCCTTGAGAGAAACCAAGTATTTGAGCCCAGCTGCCTGGATGCCTTCCCAAAC
CTGAAGGACTTCATCTCCCGATTTGAGGGCTTGGAGAAGATCTCTGCCTACATGAAGTCC
AGCCGCTTCCTCCCAAGACCTGTGTTCACAAAGATGGCTGTCTGGGGCAACAAGTAG
Target 11 GenBank Gene ID Not Available
Target 11 GeneCard ID GSTM2 Link Image
Target 11 GenAtlas ID GSTM2 Link Image
Target 11 HGNC ID HGNC:4634 Link Image
Target 11 Chromosome Location Not Available
Target 11 Locus 1p13.3
Target 11 SNPs SNPJam Report Link Image
Target 11 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 11 General References 2034681; 15489334; 8373352; 8182750
Target 12 [top]
Target 12 ID 755
Target 12 Name Glutathione S-transferase Mu 3
Target 12 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 12 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers
Target 12 Synonyms
  1. GSTM3-3; GST class-mu 3; hGSTM3-3
Target 12 Gene Name GSTM3
Target 12 Protein Sequence >Glutathione S-transferase Mu 3 
MSCESSMVLGYWDIRGLAHAIRLLLEFTDTSYEEKRYTCGEAPDYDRSQWLDVKFKLDLD
FPNLPYLLDGKNKITQSNAILRYIARKHNMCGETEEEKIRVDIIENQVMDFRTQLIRLCY
SSDHEKLKPQYLEELPGQLKQFSMFLGKFSWFAGEKLTFVDFLTYDILDQNRIFDPKCLD
EFPNLKAFMCRFEALEKIAAYLQSDQFCKMPINNKMAQWGNKPVC
Target 12 Number of Residues 225
Target 12 Molecular Weight 26559.3
Target 12 Theoretical pI 5.19
Target 12 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 12 General Function Involved in glutathione transferase activity
Target 12 Pathways Not Available
Target 12 Reactions Not Available
Target 12 Signals
  • None
Target 12 Transmembrane Regions
  • None
Target 12 Essentiality Non Essential
Target 12 Domain Function PF00043:GST_C PF02798:GST_N
Target 12 GenBank ID Protein Not Available
Target 12 UniProtKB ID P21266 Link Image
Target 12 Cellular Location Cytoplasm
Target 12 Gene Sequence >678 bp 
ATGTCGTGCGAGTCGTCTATGGTTCTCGGGTACTGGGATATTCGTGGGCTGGCGCACGCC
ATCCGCCTGCTCCTGGAGTTCACGGATACCTCTTATGAGGAGAAACGGTACACGTGCGGG
GAAGCTCCTGACTATGATCGAAGCCAATGGCTGGATGTGAAATTCAAGCTAGACCTGGAC
TTTCCTAATCTGCCCTACCTCCTGGATGGGAAGAACAAGATCACCCAGAGCAATGCCATC
TTGCGCTACATCGCTCGCAAGCACAACATGTGTGGTGAGACTGAAGAAGAAAAGATTCGA
GTGGACATCATAGAGAACCAAGTAATGGATTTCCGCACACAACTGATAAGGCTCTGTTAC
AGCTCTGACCACGAAAAACTGAAGCCTCAGTACTTGGAAGAGCTACCTGGACAACTGAAA
CAATTCTCCATGTTTCTGTGGAAATTCTCATGGTTTGCCGGGGAAAAGCTCACCTTTGTG
GATTTTCTCACCTATGATATCTTGGATCAGAACCGTATATTTGACCCCAAGTGCCTGGAT
GAGTTCCCAAACCTGAAGGCTTTCATGTGCCGTTTTGAGGCTTTGGAGAAAATCGCTGCC
TACTTACAGTCTGATCAGTTCTGCAAGATGCCCATCAACAACAAGATGGCCCAGTGGGGC
AACAAGCCTGTATGCTGA
Target 12 GenBank Gene ID Not Available
Target 12 GeneCard ID GSTM3 Link Image
Target 12 GenAtlas ID GSTM3 Link Image
Target 12 HGNC ID HGNC:4635 Link Image
Target 12 Chromosome Location Not Available
Target 12 Locus 1p13.3
Target 12 SNPs SNPJam Report Link Image
Target 12 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 12 General References 2345169; 9882431; 15489334; 8373352; 8218382; 10587441
Target 13 [top]
Target 13 ID 763
Target 13 Name Glutathione S-transferase Mu 5
Target 13 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 13 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 13 Synonyms
  1. GSTM5-5; GST class-mu 5
Target 13 Gene Name GSTM5
Target 13 Protein Sequence >Glutathione S-transferase Mu 5 
MPMTLGYWDIRGLAHAIRLLLEYTDSSYVEKKYTLGDAPDYDRSQWLNEKFKLGLDFPNL
PYLIDGAHKITQSNAILRYIARKHNLCGETEEEKIRVDILENQVMDNHMELVRLCYDPDF
EKLKPKYLEELPEKLKLYSEFLGKRPWFAGDKITFVDFLAYDVLDMKRIFEPKCLDAFLN
LKDFISRFEGLKKISAYMKSSQFLRGLLFGKSATWNSK
Target 13 Number of Residues 218
Target 13 Molecular Weight 25674.5
Target 13 Theoretical pI 7.49
Target 13 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 13 General Function Involved in glutathione transferase activity
Target 13 Pathways Not Available
Target 13 Reactions Not Available
Target 13 Signals
  • None
Target 13 Transmembrane Regions
  • None
Target 13 Essentiality Non Essential
Target 13 Domain Function PF00043:GST_C PF02798:GST_N
Target 13 GenBank ID Protein Not Available
Target 13 UniProtKB ID P46439 Link Image
Target 13 Cellular Location Cytoplasm
Target 13 Gene Sequence >657 bp 
ATGCCCATGACTCTGGGGTACTGGGACATCCGTGGGCTGGCCCACGCCATCCGCTTGCTC
CTGGAATACACAGACTCAAGCTATGTGGAAAAGAAGTACACGATGGGGGACGCTCCTGAC
TATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTG
CCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAATGCCATCCTGCGCTACATT
GCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTG
GAGAACCAGGTTATGGATAACCACATGGAGCTGGTCAGACTGTGCTATGACCCAGATTTT
GAGAAACTGAAGCCAAAATACTTGGAGGAACTCCCTGAAAAGCTAAAGCTCTACTCAGAG
TTTCTGGGGAAGCGGCCATGGTTTGCAGGAGACAAGATCACCTTTGTGGATTTCCTTGCC
TATGATGTCCTTGACATGAAGCGTATATTTGAGCCCAAGTGCTTGGACGCCTTCCTAAAC
TTGAAGGACTTCATCTCCCGCTTTGAGGGTTTGAAGAAGATCTCTGCCTACATGAAGTCC
AGCCAATTCCTCCGAGGTCTTTTGTTTGGAAAGTCAGCTACATGGAACAGCAAATAG
Target 13 GenBank Gene ID Not Available
Target 13 GeneCard ID GSTM5 Link Image
Target 13 GenAtlas ID GSTM5 Link Image
Target 13 HGNC ID HGNC:4637 Link Image
Target 13 Chromosome Location Not Available
Target 13 Locus 1p13.3
Target 13 SNPs SNPJam Report Link Image
Target 13 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 13 General References 8473333; 15489334
Target 14 [top]
Target 14 ID 753
Target 14 Name Glutathione S-transferase omega-1
Target 14 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 14 Description Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities
Target 14 Synonyms
  1. GSTO 1-1
Target 14 Gene Name GSTO1
Target 14 Protein Sequence >Glutathione S-transferase omega-1 
MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININLKNKP
EWFFKKNPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELF
SKVPSLVGSFIRSQNKEDYAGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPW
FERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYG
L
Target 14 Number of Residues 241
Target 14 Molecular Weight 27565.6
Target 14 Theoretical pI 6.54
Target 14 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
cell
intracellular
cytoplasm
Target 14 General Function Posttranslational modification, protein turnover, chaperones
Target 14 Pathways Not Available
Target 14 Reactions Not Available
Target 14 Signals
  • None
Target 14 Transmembrane Regions
  • None
Target 14 Essentiality Non Essential
Target 14 Domain Function PF00043:GST_C PF02798:GST_N
Target 14 GenBank ID Protein Not Available
Target 14 UniProtKB ID P78417 Link Image
Target 14 Cellular Location Cytoplasm
Target 14 Gene Sequence >726 bp 
ATGTCCGGGGAGTCAGCCAGGAGCTTGGGGAAGGGAAGCGCGCCCCCGGGGCCGGTCCCG
GAGGGCTCGATCCGCATCTACAGCATGAGGTTCTGCCCGTTTGCTGAGAGGACGCGTCTA
GTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAATAAGCCT
GAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGT
CAGCTGATCTACGAGTCTGCCATCACCTGTGAGTACCTGGATGAAGCATACCCAGGGAAG
AAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAGTTGTTT
TCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCT
GGCCTAAAAGAAGAATTTCGTAAAGAATTTACCAAGCTAGAGGAGGTTCTGACTAATAAG
AAGACGACCTTCTTTGGTGGCAATTCTATCTCTATGATTGATTACCTCATCTGGCCCTGG
TTTGAACGGCTGGAAGCAATGAAGTTAAATGAGTGTGTAGACCACACTCCAAAACTGAAA
CTGTGGATGGCAGCCATGAAGGAAGATCCCACAGTCTCAGCCCTGCTTACTAGTGAGAAA
GACTGGCAAGGTTTCCTAGAGCTCTACTTACAGAACAGCCCTGAGGCCTGTGACTATGGG
CTCTGA
Target 14 GenBank Gene ID Not Available
Target 14 GeneCard ID GSTO1 Link Image
Target 14 GenAtlas ID GSTO1 Link Image
Target 14 HGNC ID HGNC:13312 Link Image
Target 14 Chromosome Location Chromosome:10
Target 14 Locus 10q25.1
Target 14 SNPs SNPJam Report Link Image
Target 14 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 14 General References 10783391; 12928150; 17974005; 15164054; 15489334; 11271497; 12618591
Target 15 [top]
Target 15 ID 757
Target 15 Name Glutathione S-transferase omega-2
Target 15 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 15 Description RX + glutathione = HX + R-S-glutathione
Target 15 Synonyms
  1. GSTO-2
Target 15 Gene Name GSTO2
Target 15 Protein Sequence >Glutathione S-transferase omega-2 
MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKP
EWYYTKHPFGHIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKMLLELF
CKVPHLTKECLVALRCGRECTNLKAALRQEFSNLEEILEYQNTTFFGGTCISMIDYLLWP
WFERLDVYGILDCVSHTPALRLWISAMKWDPTVCALLMDKSIFQGFLNLYFQNNPNAFDF
GLC
Target 15 Number of Residues 243
Target 15 Molecular Weight 28253.5
Target 15 Theoretical pI 7.62
Target 15 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
cell
intracellular
cytoplasm
Target 15 General Function Posttranslational modification, protein turnover, chaperones
Target 15 Pathways Not Available
Target 15 Reactions Not Available
Target 15 Signals
  • None
Target 15 Transmembrane Regions
  • None
Target 15 Essentiality Non Essential
Target 15 Domain Function PF02798:GST_N
Target 15 GenBank ID Protein Not Available
Target 15 UniProtKB ID Q9H4Y5 Link Image
Target 15 Cellular Location Not Available
Target 15 Gene Sequence >732 bp 
ATGTCTGGGGATGCGACCAGGACCCTGGGGAAAGGAAGCCAGCCCCCAGGGCCAGTCCCG
GAGGGGCTGATCCGCATCTACAGCATGAGGTTCTGCCCCTATTCTCACAGGACCCGCCTC
GTCCTCAAGGCCAAAGACATCAGACATGAAGTGGTCAACATTAACCTGAGAAACAAGCCT
GAATGGTACTATACAAAGCACCCTTTTGGCCACATTCCTGTCCTGGAGACCAGCCAATGT
CAACTGATCTATGAATCTGTTATTGCTTGTGAGTACCTGGATGATGCTTATCCAGGAAGG
AAGCTGTTTCCATATGACCCTTATGAACGAGCTCGCCAAAAGATGTTATTGGAGCTATTT
TGTAAGGTCCCACATTTGACCAAGGAGTGCCTGGTAGCGTTGAGATGTGGGAGAGAATGC
ACTAATCTGAAGGCAGCCCTGCGTCAGGAATTCAGCAACCTGGAAGAGATTCTTGAGTAT
CAGAACACCACCTTCTTTGGTGGAACCTGTATATCCATGATTGATTACCTCCTCTGGCCC
TGGTTTGAGCGGCTGGATGTGTATGGGATACTGGACTGTGTGAGCCACACGCCAGCCCTG
CGGCTCTGGATATCAGCCATGAAGTGGGACCCCACAGTCTGTGCTCTTCTCATGGATAAG
AGCATTTTCCAGGGCTTCTTGAATCTCTATTTTCAGAACAACCCTAATGCCTTTGACTTT
GGGCTGTGCTGA
Target 15 GenBank Gene ID Not Available
Target 15 GeneCard ID GSTO2 Link Image
Target 15 GenAtlas ID GSTO2 Link Image
Target 15 HGNC ID HGNC:23064 Link Image
Target 15 Chromosome Location Chromosome:10
Target 15 Locus 10q25.1
Target 15 SNPs SNPJam Report Link Image
Target 15 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 15 General References 14702039; 15164054; 15489334; 12618591
Target 16 [top]
Target 16 ID 543
Target 16 Name Glutathione S-transferase P
Target 16 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 16 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles
Target 16 Synonyms
  1. GST class-pi; GSTP1-1
Target 16 Gene Name GSTP1
Target 16 Protein Sequence >Glutathione S-transferase P 
MPPYTVVYFPVRGRCAALRMLLADQGQSWKEEVVTVETWQEGSLKASCLYGQLPKFQDGD
LTLYQSNTILRHLGRTLGLYGKDQQEAALVDMVNDGVEDLRCKYISLIYTNYEAGKDDYV
KALPGQLKPFETLLSQNQGGKTFIVGDQISFADYNLLDLLLIHEVLAPGCLDAFPLLSAY
VGRLSARPKLKAFLASPEYVNLPINGNGKQ
Target 16 Number of Residues 210
Target 16 Molecular Weight 23355.6
Target 16 Theoretical pI 5.30
Target 16 GO Classification
Function
catalytic activity
transferase activity
transferase activity, transferring alkyl or aryl (other than methyl) groups
glutathione transferase activity
Process
physiological process
metabolism
Component
Not Available
Target 16 General Function Involved in glutathione transferase activity
Target 16 Pathways Not Available
Target 16 Reactions Not Available
Target 16 Signals
  • None
Target 16 Transmembrane Regions
  • None
Target 16 Essentiality Non Essential
Target 16 Domain Function PF00043:GST_C PF02798:GST_N
Target 16 GenBank ID Protein Not Available
Target 16 UniProtKB ID P09211 Link Image
Target 16 Cellular Location Not Available
Target 16 Gene Sequence >633 bp 
ATGCCGCCCTACACCGTGGTCTATTTCCCAGTTCGAGGCCGCTGCGCGGCCCTGCGCATG
CTGCTGGCAGATCAGGGCCAGAGCTGGAAGGAGGAGGTGGTGACCGTGGAGACGTGGCAG
GAGGGCTCACTCAAAGCCTCCTGCCTATACGGGCAGCTCCCCAAGTTCCAGGACGGAGAC
CTCACCCTGTACCAGTCCAATACCATCCTGCGTCACCTGGGCCGCACCCTTGGGCTCTAT
GGGAAGGACCAGCAGGAGGCAGCCCTGGTGGACATGGTGAATGACGGCGTGGAGGACCTC
CGCTGCAAATACATCTCCCTCATCTACACCAACTATGAGGCGGGCAAGGATGACTATGTG
AAGGCACTGCCCGGGCAACTGAAGCCTTTTGAGACCCTGCTGTCCCAGAACCAGGGAGGC
AAGACCTTCATTGTGGGAGACCAGATCTCCTTCGCTGACTACAACCTGCTGGACTTGCTG
CTGATCCATGAGGTCCTAGCCCCTGGCTGCCTGGATGCGTTCCCCCTGCTCTCAGCATAT
GTGGGGCGCCTCAGCGCCCGGCCCAAGCTCAAGGCCTTCCTGGCCTCCCCTGAGTACGTG
AACCTCCCCATCAATGGCAACGGGAAACAGTGA
Target 16 GenBank Gene ID Not Available
Target 16 GeneCard ID GSTP1 Link Image
Target 16 GenAtlas ID GSTP1 Link Image
Target 16 HGNC ID HGNC:4638 Link Image
Target 16 Chromosome Location Chromosome:11
Target 16 Locus 11q13
Target 16 SNPs SNPJam Report Link Image
Target 16 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 16 General References 3664469; 3196325; 2542132; 2466554; 9092542; 15489334
Target 17 [top]
Target 17 ID 678
Target 17 Name Glutathione S-transferase theta-1
Target 17 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 17 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide
Target 17 Synonyms
  1. GST class-theta-1; Glutathione transferase T1-1
Target 17 Gene Name GSTT1
Target 17 Protein Sequence >Glutathione S-transferase theta-1 
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGQHLSDAFAQVNPLKKVPALKDG
DFTLTESVAILLYLTRKYKVPDYWYPQDLQARARVDEYLAWQHTTLRRSCLRALWHKVMF
PVFLGEPVSPQTLAATLAELDVTLQLLEDKFLQNKAFLTGPHISLADLVAITELMHPVGA
GCQVFEGRPKLATWRQRVEAAVGEDLFQEAHEVILKAKDFPPADPTIKQKLMPWVLAMIR
Target 17 Number of Residues 240
Target 17 Molecular Weight 27334.8
Target 17 Theoretical pI 7.60
Target 17 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 17 General Function Posttranslational modification, protein turnover, chaperones
Target 17 Pathways Not Available
Target 17 Reactions Not Available
Target 17 Signals
  • None
Target 17 Transmembrane Regions
  • None
Target 17 Essentiality Non Essential
Target 17 Domain Function PF00043:GST_C PF02798:GST_N
Target 17 GenBank ID Protein Not Available
Target 17 UniProtKB ID P30711 Link Image
Target 17 Cellular Location Cytoplasm
Target 17 Gene Sequence >723 bp 
ATGGGTCTGGAGCTCTACCTGGACCTGCTGTCCCAGCCCTGCCGCGCTGTTTACATCTTT
GCCAAGAAGAACGACATTCCCTTCGAGCTGCGCATCGTGGATCTGATTAAAGGTCAGCAC
TTAAGCGATGCCTTTGCCCAGGTGAACCCCCTCAAGAAGGTGCCGGCCTTGAAGGACGGG
GACTTCACCTTGACGGAGAGTGTGGCCATCCTGCTCTACCTGACGCGCAAATATAAGGTC
CCTGACTACTGGTACCCTCAGGACCTGCAGGCCCGTGCCCGTGTGGATGAGTACCTGGCA
TGGCAGCACACGACTCTGCGGAGAAGCTGCCTCCGGGCCTTGTGGCATAAGGTGATGTTC
CCTGTGTTCCTGGGTGGGCCAGTATCTCCCCAGACACTGGCAGCCACCCTGGCAGAGTTG
GATGTGACCCTGCAGTTGCTCGAGGACAAGTTCCTCCAGAACAAGGCCTTCCTTACTGGT
CCTCACATCTCCTTAGCTGACCTCGTAGCCATCACGGAGCTGATGCATCCCGTGGGTGCT
GGCTGCCAAGTCTTCGAAGGCCGACCCAAGCTGGCCACATGGCGGCAGCGCGTGGAGGCA
GCAGTGGGGGAGGACCTCTTCCAGGAGGCCCATGAGGTCATTCTGAAGGCCAAGGACTTC
CCACCTGCAGACCCCACCATAAAGCAGAAGCTGATGCCCTGGGTGCTGGCCATGATCCGG
TGA
Target 17 GenBank Gene ID Not Available
Target 17 GeneCard ID GSTT1 Link Image
Target 17 GenAtlas ID GSTT1 Link Image
Target 17 HGNC ID HGNC:4641 Link Image
Target 17 Chromosome Location Chromosome:22
Target 17 Locus 22q11.23
Target 17 SNPs SNPJam Report Link Image
Target 17 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 17 General References 8198545; 9434735; 10975610; 10591208; 15489334; 1848757; 8761485
Target 18 [top]
Target 18 ID 746
Target 18 Name Glutathione S-transferase theta-2
Target 18 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 18 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity
Target 18 Synonyms
  1. GST class-theta-2
Target 18 Gene Name GSTT2
Target 18 Protein Sequence >Glutathione S-transferase theta-2 
MGLELFLDLVSQPSRAVYIFAKKNGIPLELRTVDLVKGQHKSKEFLQINSLGKLPTLKDG
DFILTESSAILIYLSCKYQTPDHWYPSDLQARARVHEYLGWHADCIRGTFGIPLWVQVLG
PLIGVQVPEEKVERNRTAMDQALQWLEDKFLGDRPFLAGQQVTLADLMALEELMQPVALG
YELFEGRPRLAAWRGRVEAFLGAELCQEAHSIILSILEQAAKKTLPTPSPEAYQAMLLRI
ARIP
Target 18 Number of Residues 244
Target 18 Molecular Weight 27506.7
Target 18 Theoretical pI 6.36
Target 18 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 18 General Function Posttranslational modification, protein turnover, chaperones
Target 18 Pathways Not Available
Target 18 Reactions Not Available
Target 18 Signals
  • None
Target 18 Transmembrane Regions
  • None
Target 18 Essentiality Non Essential
Target 18 Domain Function PF00043:GST_C PF02798:GST_N
Target 18 GenBank ID Protein Not Available
Target 18 UniProtKB ID P30712 Link Image
Target 18 Cellular Location Cytoplasm
Target 18 Gene Sequence >735 bp 
ATGGGCCTAGAGCTGTTTCTTGACCTGGTGTCCCAGCCCAGCCGCGCCGTCTACATCTTC
GCCAAGAAGAATGGCATCCCCTTAGAGCTGCGCACCGTGGATTTGGTCAAAGGGCAGCAC
AAGAGCAAGGAGTTCTTGCAGATCAACAGCCTGGGGAAACTGCCGACGCTCAAGGATGGT
GATTTCATCTTGACCGAAAGCTCGGCCATCCTGATTTACCTGAGCTGTAAGTACCAGACG
CCGGACCACTGGTATCCATCTGACCTGCAGGCTCGTGCCCGTGTTCATGAGTACCTGGGC
TGGCATGCCGACTGCATCCGTGGCACCTTTGGTATACCCCTGTGGGTCCAGGTGTTGGGG
CCACTCATTGGGGTCCAGGTGCCCGAGGAGAAGGTGGAACGCAACAGGACTGCCATGGAC
CAGGCCCTGCAATGGCTGGAGGACAAGTTCCTGGGGGACAGGCCCTTCCTCGCTGGCCAG
CAGGTGACACTGGCTGATCTCATGGCCCTGGAGGAGCTGATGCAGCCGGTGGCTCTCGGC
TACGAACTGTTTGAGGGACGGCCACGACTGGCAGCATGGCGTGGACGAGTGGAGGCTTTC
CTGGGTGCTGAGCTATGCCAGGAGGCCCACAGCATCATCTTGAGCATCCTGGAACAGGCG
GCCAAGAAAACCCTCCCAACACCCTCACCAGAGGCCTATCAGGCTATGCTGCTTCGAATC
GCCAGGATCCCCTGA
Target 18 GenBank Gene ID Not Available
Target 18 GeneCard ID GSTT2 Link Image
Target 18 GenAtlas ID GSTT2 Link Image
Target 18 HGNC ID HGNC:4642 Link Image
Target 18 Chromosome Location Chromosome:22
Target 18 Locus 22q11.2|22q11.23
Target 18 SNPs SNPJam Report Link Image
Target 18 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 18 General References 7789971; 10975610; 15461802; 10591208; 15489334; 1417752; 8761485; 9551553
Target 19 [top]
Target 19 ID 764
Target 19 Name Glutathione S-transferase theta-4
Target 19 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 19 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity)
Target 19 Synonyms
  1. GST class-theta-4
Target 19 Gene Name GSTT4
Target 19 Protein Sequence >Glutathione S-transferase theta-4 
MGLELYLDLLSQPCRAVYIFAKKNDIPFELRIVDLIKGHHHSKEYIDINPLRKLPSLKDG
KFILSESAAILYYLCRKYSAPSHWCPPDLHARARVDEFVAWQHTAFQLPMKKIVWLKLLI
PKITGEEVSAEKMEHAVEEVKNSLQLFEEYFLQDKMFITGNQISLADLVAVVEMMQPMAA
NYNVFLNSSKLAEWRMQVELNIGSGLFREAHDRLMQLADWDFSTLDSMVKENISELLKKS
R
Target 19 Number of Residues 241
Target 19 Molecular Weight 27959.3
Target 19 Theoretical pI 6.72
Target 19 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 19 General Function Posttranslational modification, protein turnover, chaperones
Target 19 Pathways Not Available
Target 19 Reactions Not Available
Target 19 Signals
  • None
Target 19 Transmembrane Regions
  • None
Target 19 Essentiality Non Essential
Target 19 Domain Function PF00043:GST_C PF02798:GST_N
Target 19 GenBank ID Protein Not Available
Target 19 UniProtKB ID A8MPT4 Link Image
Target 19 Cellular Location Cytoplasm (By similarity)
Target 19 Gene Sequence Not Available
Target 19 GenBank Gene ID Not Available
Target 19 GeneCard ID GSTT4 Link Image
Target 19 GenAtlas ID Not Available
Target 19 HGNC ID Not Available
Target 19 Chromosome Location Not Available
Target 19 Locus Not Available
Target 19 SNPs SNPJam Report Link Image
Target 19 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 19 General References 10591208
Target 20 [top]
Target 20 ID 758
Target 20 Name Microsomal glutathione S-transferase 1
Target 20 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 20 Description Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity
Target 20 Synonyms
  1. Microsomal GST-1; Microsomal GST-I
Target 20 Gene Name MGST1
Target 20 Protein Sequence >Microsomal glutathione S-transferase 1 
MVDLTQVMDDEVFMAFASYATIILSKMMLMSTATAFYRLTRKVFANPEDCVAFGKGENAK
KYLRTDDRVERVRRAHLNDLENIIPFLGIGLLYSLSGPDPSTAILHFRLFVGARIYHTIA
YLTPLPQPNRALSFFVGYGVTLSMAYRLLKSKLYL
Target 20 Number of Residues 155
Target 20 Molecular Weight 17598.5
Target 20 Theoretical pI 9.71
Target 20 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 20 General Function Involved in glutathione transferase activity
Target 20 Pathways Not Available
Target 20 Reactions Not Available
Target 20 Signals
  • None
Target 20 Transmembrane Regions
  • 15-37
Target 20 Essentiality Non Essential
Target 20 Domain Function PF01124:MAPEG
Target 20 GenBank ID Protein Not Available
Target 20 UniProtKB ID P10620 Link Image
Target 20 Cellular Location Microsome (By similarity). Mitochondrion outer membrane
Target 20 Gene Sequence >468 bp 
ATTCCAGACCAAAATTGAAAAAATGGTTGACCTCACCCAGGTAATGGATGATGAAGTATT
CATGGCTTTTGCATCCTATGCAACAATTATTCTTTCAAAAATGATGCTTATGAGTACTGC
AACTGCATTCTATAGATTGACAAGAAAGGTTTTTGCCAATCCAGAAGACTGTGTAGCATT
TGGCAAAGGAGAAAATGCCAAGAAGTATCTTCGAACAGATGACAGAGTAGAACGTGTACG
CAGAGCCCACCTGAATGACCTTGAAAATATTATTCCATTTCTTGGAATTGGCCTCCTGTA
TTCCTTGAGTGGTCCCGACCCCTCTACAGCCATCCTGCACTTCAGACTATTTGTCGGAGC
ACGGATCTACCACACCATTGCATATTTGACACCCCTTCCCCAGCCAAATAGAGCTTTGAG
TTTTTTTGTTGGATATGGAGTTACTCTTTCCATGGCTTACAGGTTGCT
Target 20 GenBank Gene ID Not Available
Target 20 GeneCard ID MGST1 Link Image
Target 20 GenAtlas ID MGST1 Link Image
Target 20 HGNC ID HGNC:7061 Link Image
Target 20 Chromosome Location Chromosome:12
Target 20 Locus 12p12.3-p12.1
Target 20 SNPs SNPJam Report Link Image
Target 20 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 20 General References 3372534; 8812420; 10524215; 15489334
Target 21 [top]
Target 21 ID 760
Target 21 Name Microsomal glutathione S-transferase 2
Target 21 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 21 Description Can catalyze the production of LTC4 from LTA4 and reduced glutathione. Can catalyze the conjugation of 1-chloro-2,4- dinitrobenzene with reduced glutathione
Target 21 Synonyms
  1. Microsomal GST-2; Microsomal GST-II
Target 21 Gene Name MGST2
Target 21 Protein Sequence >Microsomal glutathione S-transferase 2 
MAGNSILLAAVSILSACQQSYFALQVGKARLKYKVTPPAVTGSPEFERVFRAQQNCVEFY
PIFIITLWMAGWYFNQVFATCLGLVYIYGRHLYFWGYSEAAKKRITGFRLSLGILALLTL
LGALGIANSFLDEYLDLNIAKKLRRQF
Target 21 Number of Residues 147
Target 21 Molecular Weight 16620.4
Target 21 Theoretical pI 9.88
Target 21 GO Classification
Function
enzyme regulator activity
enzyme activator activity
Process
physiological process
metabolism
cellular metabolism
organic acid metabolism
carboxylic acid metabolism
fatty acid metabolism
icosanoid metabolism
leukotriene metabolism
Component
cell
membrane
intrinsic to membrane
integral to membrane
Target 21 General Function Involved in enzyme activator activity
Target 21 Pathways Not Available
Target 21 Reactions Not Available
Target 21 Signals
  • None
Target 21 Transmembrane Regions
  • 6-26
  • 59-79
  • 111-131
Target 21 Essentiality Non Essential
Target 21 Domain Function PF01124:MAPEG
Target 21 GenBank ID Protein Not Available
Target 21 UniProtKB ID Q99735 Link Image
Target 21 Cellular Location Endoplasmic reticulum membrane
Target 21 Gene Sequence >444 bp 
ATGGCCGGGAACTCGATCCTGCTGGCTGCTGTCTCTATTCTCTCGGCCTGTCAGCAAAGT
TATTTTGCTTTGCAAGTTGGAAAGGCAAGATTAAAATACAAAGTTACGCCCCCAGCAGTC
ACTGGGTCACCAGAGTTTGAGAGAGTATTTCGGGCACAACAAAACTGTGTGGAGTTTTAT
CCTATATTCATAATTACATTGTGGATGGCTGGGTGGTATTTCAACCAAGTTTTTGCTACT
TGTCTGGGTCTGGTGTACATATATGGCCGTCACCTATACTTCTGGGGATATTCAGAAGCT
GCTAAAAAACGGATCACCGGTTTCCGACTGAGTCTGGGGATTTTGGCCTTGTTGACCCTC
CTAGGTGCCCTGGGAATTGCAAACAGCTTTCTGGATGAATATCTGGACCTCAATATTGCC
AAGAAACTGAGGCGGCAATTCTAA
Target 21 GenBank Gene ID Not Available
Target 21 GeneCard ID MGST2 Link Image
Target 21 GenAtlas ID MGST2 Link Image
Target 21 HGNC ID HGNC:7063 Link Image
Target 21 Chromosome Location Not Available
Target 21 Locus 4q28.3
Target 21 SNPs SNPJam Report Link Image
Target 21 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 21 General References 8703034; 15489334
Target 22 [top]
Target 22 ID 762
Target 22 Name Microsomal glutathione S-transferase 3
Target 22 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 22 Description Also functions as a glutathione peroxidase
Target 22 Synonyms
  1. Microsomal GST-3; Microsomal GST-III
Target 22 Gene Name MGST3
Target 22 Protein Sequence >Microsomal glutathione S-transferase 3 
MAVLSKEYGFVLLTGAASFIMVAHLAINVSKARKKYKVEYPIMYSTDPENGHIFNCIQRA
HQNTLEVYPPFLFFLAVGGVYHPRIASGLGLAWIVGRVLYAYGYYTGEPSKRSRGALGSI
ALLGLVGTTVCSAFQHLGWVKSGLGSGPKCCH
Target 22 Number of Residues 152
Target 22 Molecular Weight 16516.2
Target 22 Theoretical pI 9.68
Target 22 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 22 General Function Involved in glutathione transferase activity
Target 22 Pathways Not Available
Target 22 Reactions Not Available
Target 22 Signals
  • None
Target 22 Transmembrane Regions
  • 9-29
  • 71-91
  • 120-140
Target 22 Essentiality Non Essential
Target 22 Domain Function PF01124:MAPEG
Target 22 GenBank ID Protein Not Available
Target 22 UniProtKB ID O14880 Link Image
Target 22 Cellular Location Endoplasmic reticulum membrane
Target 22 Gene Sequence >459 bp 
ATGGCTGTCCTCTCTAAGGAATATGGTTTTGTGCTTCTAACTGGTGCTGCCAGCTTTATA
ATGGTGGCCCACCTAGCCATCAATGTTTCCAAGGCCCGCAAGAAGTACAAAGTGGAGTAT
CCTATCATGTACAGCACGGACCCTGAAAATGGGCACATCTTCAACTGCATTCAGCGAGCC
CACCAGAACACGTTGGAAGTGTATCCTCCCTTCTTATTTTTTCTAGCTGTTGGAGGTGTT
TACCACCCGCGTATAGCTTCTGGCCTGGGCTTGGCCTGGATTGTTGGACGAGTTCTTTAT
GCTTATGGCTATTACACGGGAGAACCCAGCAAGCGTAGTCGAGGAGCCCTGGGGTCCATC
GCCCTCCTGGGCTTGGTGGGCACAACTGTGTGCTCTGCTTTCCAGCATCTTGGTTGGGTT
AAAAGTGGCTTGGGCAGTGGACCCAAATGCTGCCATTAA
Target 22 GenBank Gene ID Not Available
Target 22 GeneCard ID MGST3 Link Image
Target 22 GenAtlas ID MGST3 Link Image
Target 22 HGNC ID HGNC:7064 Link Image
Target 22 Chromosome Location Not Available
Target 22 Locus 1q23
Target 22 SNPs SNPJam Report Link Image
Target 22 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 22 General References 9278457; 16710414; 15489334
Target 23 [top]
Target 23 ID 761
Target 23 Name Maleylacetoacetate isomerase
Target 23 Mechanism of Action Trivalent antimony inhibits glutathione-S-transferases from human erythrocytes, reducing their detoxification ability. (R269)
Target 23 Description Bifunctional enzyme showing minimal glutathione- conjugating activity with ethacrynic acid and 7-chloro-4- nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Has also low glutathione peroxidase activity with T- butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid
Target 23 Synonyms
  1. MAAI; Glutathione S-transferase zeta 1; GSTZ1-1
Target 23 Gene Name GSTZ1
Target 23 Protein Sequence >Maleylacetoacetate isomerase 
MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVP
TLKIDGITIHQSLAIIEYLEETRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK
QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL
TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
Target 23 Number of Residues 216
Target 23 Molecular Weight 24181.9
Target 23 Theoretical pI 8.71
Target 23 GO Classification
Function
catalytic activity
Process
physiological process
metabolism
cellular metabolism
amino acid and derivative metabolism
amino acid metabolism
aromatic amino acid family metabolism
Component
cell
intracellular
cytoplasm
Target 23 General Function Posttranslational modification, protein turnover, chaperones
Target 23 Pathways Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine:step 5/6
Target 23 Reactions Not Available
Target 23 Signals
  • None
Target 23 Transmembrane Regions
  • None
Target 23 Essentiality Non Essential
Target 23 Domain Function PF00043:GST_C PF02798:GST_N
Target 23 GenBank ID Protein Not Available
Target 23 UniProtKB ID O43708 Link Image
Target 23 Cellular Location Cytoplasm (By similarity)
Target 23 Gene Sequence >651 bp 
ATGCAGGCGGGGAAGCCCATCCTCTATTCCTATTTCCGAAGCTCCTGCTCATGGAGAGTT
CGAATTGCTCTGGCCTTGAAAGGCATCGACTACAAGACGGTGCCCATCAATCTCATAAAG
GATGGGGGCCAACAGTTTTCTAAGGACTTCCAGGCACTGAATCCTATGAAGCAGGTGCCA
ACCCTGAAGATTGATGGAATCACCATTCACCAGTCACTGGCCATCATTGAGTATCTAGAG
GAGACGCGTCCCACTCCGCGACTTCTGCCTCAGGACCCAAAGAAGAGGGCCAGCGTGCGT
ATGATTTCTGACCTCATCGCTGGTGGCATCCAGCCCCTGCAGAACCTGTCTGTCCTGAAG
CAAGTGGGAGAGGAGATGCAGCTGACCTGGGCCCAGAACGCCATCACTTGTGGCTTTAAC
GCCCTGGAGCAGATCCTACAGAGCACAGCGGGCATATACTGTGTAGGAGACGAGGTGACC
ATGGCTGATCTGTGCTTGGTGCCTCAGGTGGCAAATGCTGAAAGATTCAAGGTGGATCTC
ACCCCCTACCCTACCATCAGCTCCATCAACAAGAGGCTGCTGGTCTTGGAGGCCTTCCAG
GTGTCTCACCCCTGCCGGCAGCCAGATACACCCACTGAGCTGAGGGCCTAG
Target 23 GenBank Gene ID Not Available
Target 23 GeneCard ID GSTZ1 Link Image
Target 23 GenAtlas ID GSTZ1 Link Image
Target 23 HGNC ID HGNC:4643 Link Image
Target 23 Chromosome Location Chromosome:14
Target 23 Locus 14q24.3
Target 23 SNPs SNPJam Report Link Image
Target 23 Toxin References
  • R269 - Wikipedia. Ethanol. Last Updated 15 May 2009.
Target 23 General References 9417084; 9396740; 9925947; 10373324; 12508121; 15489334; 9531472

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.