Showing toxin card for Aluminium arsenide (T3D1289)

Legend: toxin field target field

Version	1.0
Creation Date	2009-06-19 21:58:33
Update Date	2010-03-18 21:54:10
Accession Number	T3D1289
Name	Aluminium arsenide
Compound Type	Aluminum Compound Arsenic Compound Inorganic Compound
Description	Aluminum arsenide is a chemical compound of arsenic and aluminum. Arsenic is a chemical element that has the symbol As and atomic number 33. It is a poisonous metalloid that has many allotropic forms: yellow (molecular non-metallic) and several black and grey forms (metalloids) are a few that are seen. Three metalloidal forms of arsenic with different crystal structures are found free in nature (the minerals arsenopyrite and the much rarer arsenolamprite and pararsenolamprite), but it is more commonly found as a compound with other elements. Aluminum is the most abundant metal in the earth’s crust and is always found combined with other elements such as oxygen, silicon, and fluorine. (R1128, R1129, R004)
Synonyms	Aluminium arsenide Aluminum arsenide (alas) Gallium aluminum arsenide
Chemical IUPAC Name	alumanylidynearsane
Chemical Formula	AlAs
Chemical Structure
CAS Registry Number	22831-42-1
InChI Identifier	InChI=1S/Al.As
InChI Key	InChIKey=MDPILPRLPQYEEN-UHFFFAOYSA-N
PubChem Compound ID	89859
KEGG ID	Not Available
UniProt ID	Not Available
OMIM ID	Not Available
ChEBI ID	Not Available
BioCyc ID	Not Available
SuperToxic ID	Not Available
CTD ID	Not Available
Stitch ID	Aluminium arsenide
DrugBank ID	Not Available
PDB ID	Not Available
ACToR ID	Not Available
Wikipedia Link	Not Available
Monoisotopic Mass	101.903135
MOL File	Show
PDB File	Show
SDF File	Show
SMILES	[Al]#[As]
Appearance	Orange crystals.
Melting Point	1740 °C
Solubility	Not Available
Predicted LogP	0.55
Route of Exposure	Oral (R009) ; inhalation (R009) ; dermal (R009)
Mechanism of Action	Arsenic and its metabolites disrupt ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. Arsenic's carginogenicity is influenced by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. The binding of other arsenic protein targets may also cause altered DNA repair enzyme activity, altered DNA methylation patterns and cell proliferation. The main target organs of aluminum are the central nervous system and bone. Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. Aluminum's neurotoxicity is believed to involve several mechanisms. Changes in cytoskeletal protein functions as a results of altered phosphorylation, proteolysis, transport, and synthesis are believed to be one cause. Aluminum may induce neurobehavioral effects by affecting permeability of the blood-brain barrier, cholinergic activity, signal transduction pathways, lipid peroxidation, and impair neuronal glutamate nitric oxide-cyclic GMP pathway, as well as interfere with metabolism of essential trace elements because of similar coordination chemistries and consequent competitive interactions. Aluminum can also interact with estrogen receptors, increasing the expression of estrogen-related genes and contributing to the progression of breast cancer. Certain aluminum salts induce immune responses by activating inflammasomes. (R1128, R1130, R1132, R001, R054)
Metabolism	Arsenic is absorbed mainly by inhalation or ingestion, as to a lesser extent, dermal exposure. It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. Arsenic and its metabolites are primarily excreted in the urine. Arsenic is known to induce the metal-binding protein metallothionein, which decreases the toxic effects of arsenic and other metals by binding them and making them biologically inactive, as well as acting as an antioxidant. Aluminum is poorly absorbed following either oral or inhalation exposure and is essentially not absorbed dermally. The bioavailability of aluminum is strongly influenced by the aluminum compound and the presence of dietary constituents which can complex with aluminum and enhance or inhibit its absorption. Aluminum binds to various ligands in the blood and distributes to every organ, with highest concentrations found in bone and lung tissues. In living organisms, aluminum is believed to exist in four different forms: as free ions, as low-molecular-weight complexes, as physically bound macromolecular complexes, and as covalently bound macromolecular complexes. Absorbed aluminum is excreted principally in the urine and, to a lesser extent, in the bile, while unabsorbed aluminum is excreted in the faeces. (R1128, R055)
Toxicity Values	Not Available
Lethal Dose	Not Available
Carcinogenicity (IARC Classification)	1, carcinogenic to humans. (R264)
Uses/Sources	Not Available
Minimum Risk Level	Acute Oral: 0.005 mg/kg/day (Arsenic) (R260) Chronic Oral: 0.0003 mg/kg/day (Arsenic) (R260) Chronic Inhalation: 0.01 mg/m3 (Arsenic) (R260) Intermediate Oral: 1.0 mg/kg/day (Aluminum) (R260) Chronic Oral: 1.0 mg/kg/day (Aluminum) (R260)
Health Effects	Arsenic poisoning can lead to death from multi-system organ failure, probably from necrotic cell death, not apoptosis. Arsenic is also a known carcinogen, esepcially in skin, liver, bladder and lung cancers. Aluminum targets the nervous system and causes decreased nervous system performance and is associated with altered function of the blood-brain barrier. The accumulation of aluminum in the body may cause bone or brain diseases. High levels of aluminum have been linked to Alzheimer’s disease. A small percentage of people are allergic to aluminium and experience contact dermatitis, digestive disorders, vomiting or other symptoms upon contact or ingestion of products containing aluminium. (R1128, R1129, R001, R055)
Symptoms	Exposure to lower levels of arsenic can cause nausea and vomiting, decreased production of red and white blood cells, abnormal heart rhythm, and damage to blood vessels.
Treatment	Arsenic poisoning can be treated by chelation therapy, using chelating agents such as dimercaprol, EDTA or DMSA. Charcoal tablets may also be used for less severe cases. In addition, maintaining a diet high in sulfur helps eliminate arsenic from the body. (R055)
General References	R1132 - Aimanianda V, Haensler J, Lacroix-Desmazes S, Kaveri SV, Bayry J: Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants. Trends Pharmacol Sci. 2009 Jun;30(6):287-95. Epub 2009 May 11. [PubMed ] R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ] R1130 - Darbre PD: Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J Appl Toxicol. 2006 May-Jun;26(3):191-7. [PubMed ] R1129 - Wikipedia. Aluminium. Last Updated 16 June 2009. R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans. R1128 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for aluminum. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). R055 - Wikipedia. Arsenic toxicity. Last Updated 22 February 2009. R164 - Wikipedia. Metallothionein. Last Updated 20 December 2008. R009 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). R004 - Emsley, John (2001). Nature's Building Blocks: An A-Z Guide to the Elements. Oxford: Oxford University Press. R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill. R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
Targets	Estrogen receptor NACHT, LRR and PYD domains-containing protein 3 Phosphorus Actin, alpha cardiac muscle 1 Actin, alpha skeletal muscle Actin, aortic smooth muscle Actin, cytoplasmic 1 Actin, cytoplasmic 2 Actin, gamma-enteric smooth muscle Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DNA repair protein complementing XP-A cells Glucocorticoid receptor Glutathione reductase, mitochondrial Haptoglobin Hemoglobin subunit alpha Hemoglobin subunit beta Kelch-like ECH-associated protein 1 Poly [ADP-ribose] polymerase 1 Putative tubulin beta chain-like protein ENSP00000290377 Putative tubulin beta-4q chain Putative tubulin-like protein alpha-4B Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial Pyruvate dehydrogenase E1 component subunit beta, mitochondrial Pyruvate dehydrogenase protein X component, mitochondrial Thioredoxin reductase 1, cytoplasmic Thioredoxin reductase 2, mitochondrial Thioredoxin reductase 3 Tubulin alpha chain-like 3 Tubulin alpha-1A chain Tubulin alpha-1B chain Tubulin alpha-1C chain Tubulin alpha-3C/D chain Tubulin alpha-3E chain Tubulin alpha-4A chain Tubulin alpha-8 chain Tubulin beta chain Tubulin beta-1 chain Tubulin beta-2A chain Tubulin beta-2B chain Tubulin beta-2C chain Tubulin beta-3 chain Tubulin beta-4 chain Tubulin beta-6 chain Tubulin beta-8 chain Tubulin beta-8 chain B

Target 1 [top]

Target 1 ID

Target 1 Name

Estrogen receptor

Target 1 Mechanism of Action

Arsenic binds to the estrogen receptor. (R054)

Target 1 Description

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues

Target 1 Synonyms

ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1

Target 1 Gene Name

ESR1

Target 1 Protein Sequence

>Estrogen receptor

MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV

Target 1 Number of Residues

595

Target 1 Molecular Weight

66215.4

Target 1 Theoretical pI

8.14

Target 1 GO Classification

Function
steroid binding signal transducer activity receptor activity ligand-dependent nuclear receptor activity steroid hormone receptor activity binding nucleic acid binding DNA binding transcription factor activity
Process
regulation of biological process regulation of physiological process regulation of metabolism regulation of cellular metabolism regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism regulation of transcription regulation of transcription, DNA-dependent
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus

Target 1 General Function

Involved in estrogen receptor activity

Target 1 Pathways

Not Available

Target 1 Reactions

Not Available

Target 1 Signals

None

Target 1 Transmembrane Regions

None

Target 1 Essentiality

Non Essential

Target 1 Domain Function

PF00104:Hormone_recep PF02159:Oest_recep PF00105:zf-C4

Target 1 GenBank ID Protein

Not Available

Target 1 UniProtKB ID

P03372

Target 1 Cellular Location

Nucleus

Target 1 Gene Sequence

>63 bp

ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA

Target 1 GenBank Gene ID

Not Available

Target 1 GeneCard ID

ESR1

Target 1 GenAtlas ID

ESR1

Target 1 HGNC ID

HGNC:3467

Target 1 Chromosome Location

Not Available

Target 1 Locus

6q25.1

Target 1 SNPs

SNPJam Report Link Image

Target 1 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 1 General References

3754034; 3753802; 8600466; 14574404; 7476978; 10619354; 7916651; 7539106

Target 2 [top]

Target 2 ID

693

Target 2 Name

NACHT, LRR and PYD domains-containing protein 3

Target 2 Mechanism of Action

Certain aluminum salts induce immune responses by activating the NALP3 inflammasome, which in turn induces the production of interleukins. (R1132)

Target 2 Description

May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B signaling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18

Target 2 Synonyms

Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1; Angiotensin/vasopressin receptor AII/AVP-like

Target 2 Gene Name

NLRP3

Target 2 Protein Sequence

>NACHT, LRR and PYD domains-containing protein 3

MASTRCKLARYLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFN
GEEKAWAMAVWIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLE
YLSRISICKMKKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQE
REQELLAIGKTKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLD
WASGTLYQDRFDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMD
GFDELQGAFDEHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLL
DHPRHVEILGFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGL
KQQMESGKSLAQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAHLWGLCSLAADGIWNQKI
LFEESDLRNHGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEG
RTNVPGSRLKLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQ
QIRLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMD
HMVSSFCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVN
SHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGL
SHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSA
CCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCS
ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLS
TLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQ
EEKPELTVVFEPSW

Target 2 Number of Residues

1034

Target 2 Molecular Weight

117912.0

Target 2 Theoretical pI

6.58

Target 2 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 2 General Function

Involved in ATP binding

Target 2 Pathways

Not Available

Target 2 Reactions

Not Available

Target 2 Signals

None

Target 2 Transmembrane Regions

None

Target 2 Essentiality

Non Essential

Target 2 Domain Function

PF00560:LRR_1 PF05729:NACHT PF02758:PAAD_DAPIN

Target 2 GenBank ID Protein

Not Available

Target 2 UniProtKB ID

Q96P20

Target 2 Cellular Location

Cytoplasm

Target 2 Gene Sequence

>3105 bp

ATGGCAAGCACCCGCTGCAAGCTGGCCAGGTACCTGGAGGACCTGGAGGATGTGGACTTG
AAGAAATTTAAGATGCACTTAGAGGACTATCCTCCCCAGAAGGGCTGCATCCCCCTCCCG
AGGGGTCAGACAGAGAAGGCAGACCATGTGGATCTAGCCACGCTAATGATCGACTTCAAT
GGGGAGGAGAAGGCGTGGGCCATGGCCGTGTGGATCTTCGCTGCGATCAACAGGAGAGAC
CTTTATGAGAAAGCAAAAAGAGATGAGCCGAAGTGGGGTTCAGATAATGCACGTGTTTCG
AATCCCACTGTGATATGCCAGGAAGACAGCATTGAAGAGGAGTGGATGGGTTTACTGGAG
TACCTTTCGAGAATCTCTATTTGTAAAATGAAGAAAGATTACCGTAAGAAGTACAGAAAG
TACGTGAGAAGCAGATTCCAGTGCATTGAAGACAGGAATGCCCGTCTGGGTGAGAGTGTG
AGCCTCAACAAACGCTACACACGACTGCGTCTCATCAAGGAGCACCGGAGCCAGCAGGAG
AGGGAGCAGGAGCTTCTGGCCATCGGCAAGACCAAGACGTGTGAGAGCCCCGTGAGTCCC
ATTAAGATGGAGTTGCTGTTTGACCCCGATGATGAGCATTCTGAGCCTGTGCACACCGTG
GTGTTCCAGGGGGCGGCAGGGATTGGGAAAACAATCCTGGCCAGGAAGATGATGTTGGAC
TGGGCGTCGGGGACACTCTACCAAGACAGGTTTGACTATCTGTTCTATATCCACTGTCGG
GAGGTGAGCCTTGTGACACAGAGGAGCCTGGGGGACCTGATCATGAGCTGCTGCCCCGAC
CCAAACCCACCCATCCACAAGATCGTGAGAAAACCCTCCAGAATCCTCTTCCTCATGGAC
GGCTTCGATGAGCTGCAAGGTGCCTTTGACGAGCACATAGGACCGCTCTGCACTGACTGG
CAGAAGGCCGAGCGGGGAGACATTCTCCTGAGCAGCCTCATCAGAAAGAAGCTGCTTCCC
GAGGCCTCTCTGCTCATCACCACGAGACCTGTGGCCCTGGAGAAACTGCAGCACTTGCTG
GACCATCCTCGGCATGTGGAGATCCTGGGTTTCTCCGAGGCCAAAAGGAAAGAGTACTTC
TTCAAGTACTTCTCTGATGAGGCCCAAGCCAGGGCAGCCTTCAGTCTGATTCAGGAGAAC
GAGGTCCTCTTCACCATGTGCTTCATCCCCCTGGTCTGCTGGATCGTGTGCACTGGACTG
AAACAGCAGATGGAGAGTGGCAAGAGCCTTGCCCAGACATCCAAGACCACCACCGCGGTG
TACGTCTTCTTCCTTTCCAGTTTGCTGCAGCCCCGGGGAGGGAGCCAGGAGCACGGCCTC
TGCGCCCACCTCTGGGGGCTCTGCTCTTTGGCTGCAGATGGAATCTGGAACCAGAAAATC
CTGTTTGAGGAGTCCGACCTCAGGAATCATGGACTGCAGAAGGCGGATGTGTCTGCTTTC
CTGAGGATGAACCTGTTCCAAAAGGAAGTGGACTGCGAGAAGTTCTACAGCTTCATCCAC
ATGACTTTCCAGGAGTTCTTTGCCGCCATGTACTACCTGCTGGAAGAGGAAAAGGAAGGA
AGGACGAACGTTCCAGGGAGTCGTTTGAAGCTTCCCAGCCGAGACGTGACAGTCCTTCTG
GAAAACTATGGCAAATTCGAAAAGGGGTATTTGATTTTTGTTGTACGTTTCCTCTTTGGC
CTGGTAAACCAGGAGAGGACCTCCTACTTGGAGAAGAAATTAAGTTGCAAGATCTCTCAG
CAAATCAGGCTGGAGCTGCTGAAATGGATTGAAGTGAAAGCCAAAGCTAAAAAGCTGCAG
ATCCAGCCCAGCCAGCTGGAATTGTTCTACTGTTTGTACGAGATGCAGGAGGAGGACTTC
GTGCAAAGGGCCATGGACTATTTCCCCAAGATTGAGATCAATCTCTCCACCAGAATGGAC
CACATGGTTTCTTCCTTTTGCATTGAGAACTGTCATCGGGTGGAGTCACTGTCCCTGGGG
TTTCTCCATAACATGCCCAAGGAGGAAGAGGAGGAGGAAAAGGAAGGCCGACACCTTGAT
ATGGTGCAGTGTGTCCTCCCAAGCTCCTCTCATGCTGCCTGTTCTCATGGATTGGTGAAC
AGCCACCTCACTTCCAGTTTTTGCCGGGGCCTCTTTTCAGTTCTGAGCACCAGCCAGAGT
CTAACTGAATTGGACCTCAGTGACAATTCTCTGGGGGACCCAGGGATGAGAGTGTTGTGT
GAAACGCTCCAGCATCCTGGCTGTAACATTCGGAGATTGTGGTTGGGGCGCTGTGGCCTC
TCGCATGAGTGCTGCTTCGACATCTCCTTGGTCCTCAGCAGCAACCAGAAGCTGGTGGAG
CTGGACCTGAGTGACAACGCCCTCGGTGACTTCGGAATCAGACTTCTGTGTGTGGGACTG
AAGCACCTGTTGTGCAATCTGAAGAAGCTCTGGTTGGTCAGCTGCTGCCTCACATCAGCA
TGTTGTCAGGATCTTGCATCAGTATTGAGCACCAGCCATTCCCTGACCAGACTCTATGTG
GGGGAGAATGCCTTGGGAGACTCAGGAGTCGCAATTTTATGTGAAAAAGCCAAGAATCCA
CAGTGTAACCTGCAGAAACTGGGGTTGGTGAATTCTGGCCTTACGTCAGTCTGTTGTTCA
GCTTTGTCCTCGGTACTCAGCACTAATCAGAATCTCACGCACCTTTACCTGCGAGGCAAC
ACTCTCGGAGACAAGGGGATCAAACTACTCTGTGAGGGACTCTTGCACCCCGACTGCAAG
CTTCAGGTGTTGGAATTAGACAACTGCAACCTCACGTCACACTGCTGCTGGGATCTTTCC
ACACTTCTGACCTCCAGCCAGAGCCTGCGAAAGCTGAGCCTGGGCAACAATGACCTGGGC
GACCTGGGGGTCATGATGTTCTGTGAAGTGCTGAAACAGCAGAGCTGCCTCCTGCAGAAC
CTGGGGTTGTCTGAAATGTATTTCAATTATGAGACAAAAAGTGCGTTAGAAACACTTCAA
GAAGAAAAGCCTGAGCTGACCGTCGTCTTTGAGCCTTCTTGGTAG

Target 2 GenBank Gene ID

Not Available

Target 2 GeneCard ID

NLRP3

Target 2 GenAtlas ID

NLRP3

Target 2 HGNC ID

HGNC:16400 Link Image

Target 2 Chromosome Location

Not Available

Target 2 Locus

1q44

Target 2 SNPs

SNPJam Report Link Image

Target 2 Toxin References

R1132 - Aimanianda V, Haensler J, Lacroix-Desmazes S, Kaveri SV, Bayry J: Novel cellular and molecular mechanisms of induction of immune responses by aluminum adjuvants. Trends Pharmacol Sci. 2009 Jun;30(6):287-95. Epub 2009 May 11. [PubMed ]

Target 2 General References

11687797; 12355493; 11786556; 14662828; 16710414; 15489334; 11042152; 15030775; 17164409

Target 3 [top]

Target 3 ID

692

Target 3 Name

Phosphorus

Target 3 Mechanism of Action

Aluminum binds with dietary phosphorus and impairs gastrointestinal absorption of phosphorus. The decreased phosphate body burden results in osteomalacia (softening of the bones due to defective bone mineralization) and rickets. (R1128)

Target 3 Description

Not Available

Target 3 Synonyms

Not Available

Target 3 Gene Name

Not Available

Target 3 Protein Sequence

Not Available

Target 3 Number of Residues

Not Available

Target 3 Molecular Weight

0.0

Target 3 Theoretical pI

Not Available

Target 3 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 3 General Function

Not Available

Target 3 Pathways

Not Available

Target 3 Reactions

Not Available

Target 3 Signals

Not Available

Target 3 Transmembrane Regions

Not Available

Target 3 Essentiality

Not Available

Target 3 Domain Function

Not Available

Target 3 GenBank ID Protein

Not Available

Target 3 UniProtKB ID

Phosphorus Link Image

Target 3 Cellular Location

Not Available

Target 3 Gene Sequence

Not Available

Target 3 GenBank Gene ID

Not Available

Target 3 GeneCard ID

Not Available

Target 3 GenAtlas ID

Not Available

Target 3 HGNC ID

Not Available

Target 3 Chromosome Location

Not Available

Target 3 Locus

Not Available

Target 3 SNPs

Not Available

Target 3 Toxin References

R1128 - ATSDR - Agency for Toxic Substances and Disease Registry (2008). Toxicological profile for aluminum. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 3 General References

Not Available

Target 4 [top]

Target 4 ID

378

Target 4 Name

Actin, alpha cardiac muscle 1

Target 4 Mechanism of Action

Arsenic binds to actin. (R053)

Target 4 Description

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells

Target 4 Synonyms

Alpha-cardiac actin

Target 4 Gene Name

ACTC1

Target 4 Protein Sequence

>Actin, alpha cardiac muscle 1

MCDDEETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
LSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIS
KQEYDEAGPSIVHRKCF

Target 4 Number of Residues

377

Target 4 Molecular Weight

42018.6

Target 4 Theoretical pI

5.05

Target 4 GO Classification

Function
structural molecule activity structural constituent of cytoskeleton motor activity binding protein binding
Process
Not Available
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton actin cytoskeleton actin filament

Target 4 General Function

Cytoskeleton

Target 4 Pathways

Not Available

Target 4 Reactions

Not Available

Target 4 Signals

None

Target 4 Transmembrane Regions

None

Target 4 Essentiality

Non Essential

Target 4 Domain Function

PF00022:Actin

Target 4 GenBank ID Protein

Not Available

Target 4 UniProtKB ID

P68032

Target 4 Cellular Location

Cytoplasm, cytoskeleton

Target 4 Gene Sequence

Not Available

Target 4 GenBank Gene ID

Not Available

Target 4 GeneCard ID

ACTC1

Target 4 GenAtlas ID

ACTC1

Target 4 HGNC ID

HGNC:143

Target 4 Chromosome Location

Chromosome:15

Target 4 Locus

15q11-q14

Target 4 SNPs

SNPJam Report Link Image

Target 4 Toxin References

R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]

Target 4 General References

6310553; 15489334; 9563954; 10330430; 10966831; 14729850; 17947298; 18403758

Target 5 [top]

Target 5 ID

379

Target 5 Name

Actin, alpha skeletal muscle

Target 5 Mechanism of Action

Arsenic binds to actin. (R053)

Target 5 Description

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells

Target 5 Synonyms

Alpha-actin-1

Target 5 Gene Name

ACTA1

Target 5 Protein Sequence

>Actin, alpha skeletal muscle

MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
QSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
MSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIT
KQEYDEAGPSIVHRKCF

Target 5 Number of Residues

377

Target 5 Molecular Weight

42050.7

Target 5 Theoretical pI

5.05

Target 5 GO Classification

Function
structural molecule activity structural constituent of cytoskeleton motor activity binding protein binding
Process
Not Available
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton actin cytoskeleton actin filament

Target 5 General Function

Cytoskeleton

Target 5 Pathways

Not Available

Target 5 Reactions

Not Available

Target 5 Signals

None

Target 5 Transmembrane Regions

None

Target 5 Essentiality

Non Essential

Target 5 Domain Function

PF00022:Actin

Target 5 GenBank ID Protein

Not Available

Target 5 UniProtKB ID

P68133

Target 5 Cellular Location

Cytoplasm, cytoskeleton

Target 5 Gene Sequence

>1134 bp

CCCGCCCAGAAACTAGACACAATGTGCGACGAAGACGAGACCACCGCCCTCGTGTGCGAC
AATGGCTCCGGCCTGGTGAAAGCCGGCTTCGCCGGGGATGACGCCCCTAGGGCCGTGTTC
CCGTCCATCGTGGGCCGCCCCCGACACCAGGGCGTCATGGTCGGTATGGGTCAGAAAGAT
TCCTACGTGGGCGACGAGGCTCAGAGCAAGAGAGGTATCCTGACCCTGAAGTACCCTATC
GAGCACGGCATCATCACCAACTGGGATGACATGGAGAAGATCTGGCACCACACCTTCTAC
AACGAGCTTCGCGTGGCTCCCGAGGAGCACCCCACCCTGCTCACCGAAGCCCCCCTCAAT
CCCAAGGCCAACCGCGAGAAGATGACCCAGATCATGTTTGAGACCTTCAACGTGCCCGCC
ATGTACGTGGCCATCCAGGCCGTGCTGTCCCTCTACGCCTCCGGCAGGACCACCGGCATC
GTGCTGGACTCCGGCGACGGCGTCACCCACAACGTGCCCATTTATGAGGGCTACGCGCTG
CCGCACGCCATCATGCGCCTGGACCTGGCGGGCCGCGATCTTACCGACTACCTGATGAAG
ATCCTCACTGAGCGTGGCTACTCCTTCGTGACCACAGCTGAGCGCGAGATCGTGCGCGAC
ATCAAGGAGAAGCTGTGCTACGTGGCCCTGGACTTCGAGAACGAGATGGCGACGGCCGCC
TCCTCCTCCTCCCTGGAAAAGAGCTACGAGCTGCCAGACGGGCAGGTCATCACCATCGGC
AACGAGCGCTTCCGCTGCCCGGAGACGCTCTTCCAGCCCTCCTTCATCGGTATGGAGTCG
GCGGGCATTCACGAGACCACCTACAACAGCATCATGAAGTGTGACATCGACATCAGGAAG
GACCTGTATGCCAACAACGTCATGTCGGGGGGCACCACGATGTACCCTGGGATCGCTGAC
CGCATGCAGAAAGAGATCACCGCGCTGGCACCCAGCACCATGAAGATCAAGATCATCGCC
CCGCCGGAGCGCAAATACTCGGTGTGGATCGGCGGCTCCATCCTGGCCTCGCTGTCCACC
TTCCAGCAGATGTGGATCACCAAGCAGGAGTACGACGAGGCCGGCCCTTCCATC

Target 5 GenBank Gene ID

Not Available

Target 5 GeneCard ID

ACTA1

Target 5 GenAtlas ID

ACTA1

Target 5 HGNC ID

HGNC:129

Target 5 Chromosome Location

Not Available

Target 5 Locus

1q42.13

Target 5 SNPs

SNPJam Report Link Image

Target 5 Toxin References

R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]

Target 5 General References

6190133; 2907503; 10508519; 15489334; 10958653; 16916647; 18083107; 11333380; 11166164

Target 6 [top]

Target 6 ID

377

Target 6 Name

Actin, aortic smooth muscle

Target 6 Mechanism of Action

Arsenic binds to actin. (R053)

Target 6 Description

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells

Target 6 Synonyms

Alpha-actin-2; Cell growth-inhibiting gene 46 protein

Target 6 Gene Name

ACTA2

Target 6 Protein Sequence

>Actin, aortic smooth muscle

MCEEEDSTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEA
QSKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREK
MTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRL
DLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEK
SYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNV
LSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWIS
KQEYDEAGPSIVHRKCF

Target 6 Number of Residues

377

Target 6 Molecular Weight

42008.6

Target 6 Theoretical pI

5.05

Target 6 GO Classification

Function
structural molecule activity structural constituent of cytoskeleton motor activity binding protein binding
Process
Not Available
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton actin cytoskeleton actin filament

Target 6 General Function

Cytoskeleton

Target 6 Pathways

Not Available

Target 6 Reactions

Not Available

Target 6 Signals

None

Target 6 Transmembrane Regions

None

Target 6 Essentiality

Non Essential

Target 6 Domain Function

PF00022:Actin

Target 6 GenBank ID Protein

Not Available

Target 6 UniProtKB ID

P62736

Target 6 Cellular Location

Cytoplasm, cytoskeleton

Target 6 Gene Sequence

>1134 bp

ATGTGTGAAGAAGAGGACAGCACTGCCTTGGTGTGTGACAATGGCTCTGGGCTCTGTAAG
GCCGGCTTTGCTGGGGACGATGCTCCCAGGGCTGTTTTCCCATCCATTGTGGGACGTCCC
AGACATCAGGGGGTGATGGTGGGAATGGGACAAAAAGACAGCTACGTGGGTGACGAAGCA
CAGAGCAAAAGAGGAATCCTGACCCTGAAGTACCCGATAGAACATGGCATCATCACCAAC
TGGGACGACATGGAAAAGATCTGGCACCACTCTTTCTACAATGAGCTTCGTGTTGCCCCT
GAAGAGCATCCCACCCTGCTCACGGAGGCACCCCTGAACCCCAAGGCCAACCGGGAGAAA
ATGACTCAAATTATGTTTGAGACTTTCAATGTCCCAGCCATGTATGTGGCTATCCAGGCG
GTGCTGTCTCTCTATGCCTCTGGACGCACAACTGGCATCGTGCTGGACTCTGGAGATGGT
GTCACCCACAATGTCCCCATCTATGAGGGCTATGCCTTGCCCCATGCCATCATGCGTCTG
GATCTGGCTGGCCGAGATCTCACTGACTACCTCATGAAGATCCTGACTGAGCGTGGCTAT
TCCTTCGTTACTACTGCTGAGCGTGAGATTGTCCGGGACATCAAGGAGAAACTGTGTTAT
GTAGCTCTGGACTTTGAAAATGAGATGGCCACTGCCGCATCCTCATCCTCCCTTGAGAAG
AGTTACGAGTTGCCTGATGGGCAAGTGATCACCATCGGAAATGAACGTTTCCGCTGCCCA
GAGACCCTGTTCCAGCCATCCTTCATCGGGATGGAGTCTGCTGGCATCCATGAAACCACC
TACAACAGCATCATGAAGTGTGATATTGACATCAGGAAGGACCTCTATGCTAACAATGTC
CTATCAGGGGGCACCACTATGTACCCTGGCATTGCCGACCGAATGCAGAAGGAGATCACG
GCCCTAGCACCCAGCACCATGAAGATCAAGATCATTGCCCCTCCGGAGCGCAAATACTCT
GTCTGGATCGGTGGCTCCATCCTGGCCTCTCTGTCCACCTTCCAGCAGATGTGGATCAGC
AAACAGGAATACGATGAAGCCGGGCCTTCCATTGTCCACCGCAAATGCTTCTAA

Target 6 GenBank Gene ID

Not Available

Target 6 GeneCard ID

ACTA2

Target 6 GenAtlas ID

ACTA2

Target 6 HGNC ID

HGNC:130

Target 6 Chromosome Location

Chromosome:10

Target 6 Locus

10q23.3

Target 6 SNPs

SNPJam Report Link Image

Target 6 Toxin References

R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]

Target 6 General References

2701935; 2295650; 15164054; 15489334; 6330528; 2612915; 15555551; 17994018

Target 7 [top]

Target 7 ID

Target 7 Name

Actin, cytoplasmic 1

Target 7 Mechanism of Action

Arsenic binds to actin. (R053)

Target 7 Description

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells

Target 7 Synonyms

Beta-actin; Actin, cytoplasmic 1, N-terminally processed

Target 7 Gene Name

ACTB

Target 7 Protein Sequence

>Actin, cytoplasmic 1

MDDDIAALVVDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF

Target 7 Number of Residues

375

Target 7 Molecular Weight

41736.4

Target 7 Theoretical pI

5.15

Target 7 GO Classification

Function
structural molecule activity structural constituent of cytoskeleton motor activity binding protein binding
Process
Not Available
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton actin cytoskeleton actin filament

Target 7 General Function

Cytoskeleton

Target 7 Pathways

Not Available

Target 7 Reactions

Not Available

Target 7 Signals

None

Target 7 Transmembrane Regions

None

Target 7 Essentiality

Non Essential

Target 7 Domain Function

PF00022:Actin

Target 7 GenBank ID Protein

Not Available

Target 7 UniProtKB ID

P60709

Target 7 Cellular Location

Cytoplasm, cytoskeleton

Target 7 Gene Sequence

>1128 bp

ATGGATGATGATATCGCCGCGCTCGTCGTCGACAACGGCTCCGGCATGTGCAAGGCCGGC
TTCGCGGGCGACGATGCCCCCCGGGCCGTCTTCCCCTCCATCGTGGGGCGCCCCAGGCAC
CAGGGCGTGATGGTGGGCATGGGTCAGAAGGATTCCTATGTGGGCGACGAGGCCCAGAGC
AAGAGAGGCATCCTCACCCTGAAGTACCCCATCGAGCACGGCATCGTCACCAACTGGGAC
GACATGGAGAAAATCTGGCACCACACCTTCTACAATGAGCTGCGTGTGGCTCCCGAGGAG
CACCCCGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACCGCGAGAAGATGACC
CAGATCATGTTTGAGACCTTCAACACCCCAGCCATGTACGTTGCTATCCAGGCTGTGCTA
TCCCTGTACGCCTCTGGCCGTACCACTGGCATCGTGATGGACTCCGGTGACGGGGTCACC
CACACTGTGCCCATCTACGAGGGGTATGCCCTCCCCCATGCCATCCTGCGTCTGGACCTG
GCTGGCCGGGACCTGACTGACTACCTCATGAAGATCCTCACCGAGCGCGGCTACAGCTTC
ACCACCACGGCCGAGCGGGAAATCGTGCGTGACATTAAGGAGAAGCTGTGCTACGTCGCC
CTGGACTTCGAGCAAGAGATGGCCACGGCTGCTTCCAGCTCCTCCCTGGAGAAGAGCTAC
GAGCTGCCTGACGGCCAGGTCATCACCATTGGCAATGAGCGGTTCCGCTGCCCTGAGGCA
CTCTTCCAGCCTTCCTTCCTGGGCATGGAGTCCTGTGGCATCCACGAAACTACCTTCAAC
TCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCCAACACAGTGCTGTCT
GGCGGCACCACCATGTACCCTGGCATTGCCGACAGGATGCAGAAGGAGATCACTGCCCTG
GCACCCAGCACAATGAAGATCAAGATCATTGCTCCTCCTGAGCGCAAGTACTCCGTGTGG
ATCGGCGGCTCCATCCTGGCCTCGCTGTCCACCTTCCAGCAGATGTGGATCAGCAAGCAG
GAGTATGACGAGTCCGGCCCCTCCATCGTCCACCGCAAATGCTTCTAG

Target 7 GenBank Gene ID

Not Available

Target 7 GeneCard ID

ACTB

Target 7 GenAtlas ID

ACTB

Target 7 HGNC ID

HGNC:132

Target 7 Chromosome Location

Not Available

Target 7 Locus

7p15-p12

Target 7 SNPs

SNPJam Report Link Image

Target 7 Toxin References

R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]

Target 7 General References

6322116; 2994062; 1734024; 12853948; 15489334; 12665801; 6842590

Target 8 [top]

Target 8 ID

151

Target 8 Name

Actin, cytoplasmic 2

Target 8 Mechanism of Action

Arsenic binds to actin. (R053)

Target 8 Description

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells

Target 8 Synonyms

Gamma-actin; Actin, cytoplasmic 2, N-terminally processed

Target 8 Gene Name

ACTG1

Target 8 Protein Sequence

>Actin, cytoplasmic 2

MEEEIAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQS
KRGILTLKYPIEHGIVTNWDDMEKIWHHTFYNELRVAPEEHPVLLTEAPLNPKANREKMT
QIMFETFNTPAMYVAIQAVLSLYASGRTTGIVMDSGDGVTHTVPIYEGYALPHAILRLDL
AGRDLTDYLMKILTERGYSFTTTAEREIVRDIKEKLCYVALDFEQEMATAASSSSLEKSY
ELPDGQVITIGNERFRCPEALFQPSFLGMESCGIHETTFNSIMKCDVDIRKDLYANTVLS
GGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISKQ
EYDESGPSIVHRKCF

Target 8 Number of Residues

375

Target 8 Molecular Weight

41792.5

Target 8 Theoretical pI

5.16

Target 8 GO Classification

Function
structural molecule activity structural constituent of cytoskeleton motor activity binding protein binding
Process
Not Available
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton actin cytoskeleton actin filament

Target 8 General Function

Cytoskeleton

Target 8 Pathways

Not Available

Target 8 Reactions

Not Available

Target 8 Signals

None

Target 8 Transmembrane Regions

None

Target 8 Essentiality

Non Essential

Target 8 Domain Function

PF00022:Actin

Target 8 GenBank ID Protein

Not Available

Target 8 UniProtKB ID

P63261

Target 8 Cellular Location

Cytoplasm, cytoskeleton

Target 8 Gene Sequence

>1128 bp

ATGGAAGAAGAGATCGCCGCGCTGGTCATTGACAATGGCTCCGGCATGTGCAAAGCTGGT
TTTGCTGGGGACGACGCTCCCCGAGCCGTGTTTCCTTCCATCGTCGGGCGCCCCAGACAC
CAGGGCGTCATGGTGGGCATGGGCCAGAAGGACTCCTACGTGGGCGACGAGGCCCAGAGC
AAGCGTGGCATCCTGACCCTGAAGTACCCCATTGAGCATGGCATCGTCACCAACTGGGAC
GACATGGAGAAGATCTGGCACCACACCTTCTACAACGAGCTGCGCGTGGCCCCGGAGGAG
CACCCAGTGCTGCTGACCGAGGCCCCCCTGAACCCCAAGGCCAACAGAGAGAAGATGACT
CAGATTATGTTTGAGACCTTCAACACCCCGGCCATGTACGTGGCCATCCAGGCCGTGCTG
TCCCTCTACGCCTCTGGGCGCACCACTGGCATTGTCATGGACTCTGGAGACGGGGTCACC
CACACGGTGCCCATCTACGAGGGCTACGCCCTCCCCCACGCCATCCTGCGTCTGGACCTG
GCTGGCCGGGACCTGACCGACTACCTCATGAAGATCCTCACTGAGCGAGGCTACAGCTTC
ACCACCACGGCCGAGCGGGAAATCGTGCGCGACATCAAGGAGAAGCTGTGCTACGTCGCC
CTGGACTTCGAGCAGGAGATGGCCACCGCCGCATCCTCCTCTTCTCTGGAGAAGAGCTAC
GAGCTGCCCGATGGCCAGGTCATCACCATTGGCAATGAGCGGTTCCGGTGTCCGGAGGCG
CTGTTCCAGCCTTCCTTCCTGGGTATGGAATCTTGCGGCATCCACGAGACCACCTTCAAC
TCCATCATGAAGTGTGACGTGGACATCCGCAAAGACCTGTACGCCAACACGGTGCTGTCG
GGCGGCACCACCATGTACCCGGGCATTGCCGACAGGATGCAGAAGGAGATCACCGCCCTG
GCGCCCAGCACCATGAAGATCAAGATCATCGCACCCCCAGAGCGCAAGTACTCGGTGTGG
ATCGGTGGCTCCATCCTGGCCTCACTGTCCACCTTCCAGCAGATGTGGATTAGCAAGCAG
GAGTACGACGAGTCGGGCCCCTCCATCGTCCACCGCAAATGCTTCTAA

Target 8 GenBank Gene ID

Not Available

Target 8 GeneCard ID

ACTG1

Target 8 GenAtlas ID

ACTG1

Target 8 HGNC ID

HGNC:144

Target 8 Chromosome Location

Chromosome:17

Target 8 Locus

17q25

Target 8 SNPs

SNPJam Report Link Image

Target 8 Toxin References

R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]

Target 8 General References

3737401; 2837653; 14702039; 15489334; 12665801; 3472224

Target 9 [top]

Target 9 ID

380

Target 9 Name

Actin, gamma-enteric smooth muscle

Target 9 Mechanism of Action

Arsenic binds to actin. (R053)

Target 9 Description

Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells

Target 9 Synonyms

Smooth muscle gamma-actin; Gamma-2-actin; Alpha-actin-3

Target 9 Gene Name

ACTG2

Target 9 Protein Sequence

>Actin, gamma-enteric smooth muscle

MCEEETTALVCDNGSGLCKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQ
SKRGILTLKYPIEHGIITNWDDMEKIWHHSFYNELRVAPEEHPTLLTEAPLNPKANREKM
TQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLD
LAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKS
YELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVL
SGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWISK
PEYDEAGPSIVHRKCF

Target 9 Number of Residues

376

Target 9 Molecular Weight

41876.5

Target 9 Theoretical pI

5.16

Target 9 GO Classification

Function
structural molecule activity structural constituent of cytoskeleton motor activity binding protein binding
Process
Not Available
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton actin cytoskeleton actin filament

Target 9 General Function

Cytoskeleton

Target 9 Pathways

Not Available

Target 9 Reactions

Not Available

Target 9 Signals

None

Target 9 Transmembrane Regions

None

Target 9 Essentiality

Non Essential

Target 9 Domain Function

PF00022:Actin

Target 9 GenBank ID Protein

Not Available

Target 9 UniProtKB ID

P63267

Target 9 Cellular Location

Cytoplasm, cytoskeleton

Target 9 Gene Sequence

>1131 bp

ATGTGTGAAGAGGAGACCACCGCGCTCGTGTGTGACAATGGCTCTGGCCTGTGCAAGGCA
GGCTTCGCAGGAGATGATGCCCCCCGGGCTGTCTTCCCCTCCATTGTGGGCCGCCCTCGC
CACCAGGGTGTGATGGTGGGAATGGGCCAGAAAGACAGCTATGTGGGGGATGAGGCTCAG
AGCAAGCGAGGGATCCTAACTCTCAAATACCCCATTGAACACGGCATCATCACCAACTGG
GATGACATGGAGAAGATCTGGCACCACTCCTTCTACAATGAGCTGCGTGTAGCACCTGAA
GAGCACCCCACCCTGCTCACAGAGGCTCCCCTAAATCCCAAGGCCAACAGGGAAAAGATG
ACCCAGATCATGTTTGAAACCTTCAATGTCCCTGCCATGTACGTCGCCATTCAAGCTGTG
CTCTCCCTCTATGCCTCTGGCCGCACGACAGGCATCGTCCTGGATTCAGGTGATGGCGTC
ACCCACAATGTCCCCATCTATGAAGGCTATGCCCTGCCCCATGCCATCATGCGCCTGGAC
TTGGCTGGCCGTGACCTCACGGACTACCTCATGAAGATCCTCACAGAGAGAGGCTATTCC
TTTGTGACCACAGCTGAGAGAGAAATTGTGCGAGACATCAAGGAGAAGCTGTGCTATGTG
GCCCTGGATTTTGAGAATGAGATGGCCACAGCAGCTTCCTCTTCCTCCCTGGAGAAGAGC
TATGAGCTGCCAGATGGGCAGGTTATCACCATTGGCAATGAGCGCTTCCGCTGCCCTGAG
ACCCTCTTCCAGCCTTCCTTTATTGGCATGGAGTCCGCTGGAATTCATGAGACAACCTAC
AATTCCATCATGAAGTGTGACATTGACATCCGTAAGGACTTATATGCCAACAATGTCCTC
TCTGGGGGCACCACCATGTACCCTGGCATTGCTGACAGGATGCAGAAGGAGATCACAGCC
CTGGCCCCCAGCACCATGAAGATCAAGATTATTGCTCCCCCAGAGCGGAAGTACTCAGTC
TGGATCGGGGGCTCTATCCTGGCCTCTCTCTCCACCTTCCAGCAGATGTGGATCAGCAAG
CCTGAGTATGATGAGGCAGGGCCCTCCATTGTCCACAGGAAGTGCTTCTAA

Target 9 GenBank Gene ID

Not Available

Target 9 GeneCard ID

ACTG2

Target 9 GenAtlas ID

ACTG2

Target 9 HGNC ID

HGNC:145

Target 9 Chromosome Location

Not Available

Target 9 Locus

2p13.1

Target 9 SNPs

SNPJam Report Link Image

Target 9 Toxin References

R053 - Menzel DB, Hamadeh HK, Lee E, Meacher DM, Said V, Rasmussen RE, Greene H, Roth RN: Arsenic binding proteins from human lymphoblastoid cells. Toxicol Lett. 1999 Mar 29;105(2):89-101. [PubMed ]

Target 9 General References

2377475; 1710027; 14702039; 15815621; 15489334

Target 10 [top]

Target 10 ID

276

Target 10 Name

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Target 10 Mechanism of Action

Arsenic disrupts ATP production through several mechanisms. At the level of the citric acid cycle, arsenic inhibits pyruvate dehydrogenase and by competing with phosphate it uncouples oxidative phosphorylation, thus inhibiting energy-linked reduction of NAD+, mitochondrial respiration, and ATP synthesis. Hydrogen peroxide production is also increased, which might form reactive oxygen species and oxidative stress. (R001)

Target 10 Description

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3)

Target 10 Synonyms

Pyruvate dehydrogenase complex E2 subunit; PDC-E2; PDCE2; E2; Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex; 70 kDa mitochondrial autoantigen of primary biliary cirrhosis; PBC; M2 antigen complex 70 kDa subunit

Target 10 Gene Name

DLAT

Target 10 Protein Sequence

>Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

MWRVCARRAQNVAPWAGLEARWTALQEVPGTPRVTSRSGPAPARRNSVTTGYGGVRALCG
WTPSSGATPRNRLLLQLLGSPGRRYYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGDKIN
EGDLIAEVETDKATVGFESLEECYMAKILVAEGTRDVPIGAIICITVGKPEDIEAFKNYT
LDSSAAPTPQAAPAPTPAATASPPTPSAQAPGSSYPPHMQVLLPALSPTMTMGTVQRWEK
KVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADI
SAFADYRPTEVTDLKPQVPPPTPPPVAAVPPTPQPLAPTPSAPCPATPAGPKGRVFVSPL
AKKLAVEKGIDLTQVKGTGPDGRITKKDIDSFVPSKVAPAPAAVVPPTGPGMAPVPTGVF
TDIPISNIRRVIAQRLMQSKQTIPHYYLSIDVNMGEVLLVRKELNKILEGRSKISVNDFI
IKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGVETIAND
VVSLATKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLVPA
DNEKGFDVASMMSVTLSCDHRVVDGAVGAQWLAEFRKYLEKPITMLL

Target 10 Number of Residues

647

Target 10 Molecular Weight

68996.0

Target 10 Theoretical pI

7.94

Target 10 GO Classification

Function
binding protein binding acetyltransferase activity S-acetyltransferase activity dihydrolipoyllysine-residue acetyltransferase activity catalytic activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring groups other than amino-acyl groups acyltransferase activity
Process
cellular metabolism alcohol metabolism monosaccharide metabolism hexose metabolism glucose metabolism glucose catabolism glycolysis physiological process metabolism
Component
protein complex pyruvate dehydrogenase complex

Target 10 General Function

Energy production and conversion

Target 10 Pathways

Not Available

Target 10 Reactions

Not Available

Target 10 Signals

None

Target 10 Transmembrane Regions

None

Target 10 Essentiality

Non Essential

Target 10 Domain Function

PF00198:2-oxoacid_dh PF00364:Biotin_lipoyl PF02817:E3_binding

Target 10 GenBank ID Protein

Not Available

Target 10 UniProtKB ID

P10515

Target 10 Cellular Location

Mitochondrion matrix

Target 10 Gene Sequence

Not Available

Target 10 GenBank Gene ID

Not Available

Target 10 GeneCard ID

DLAT

Target 10 GenAtlas ID

DLAT

Target 10 HGNC ID

HGNC:2896

Target 10 Chromosome Location

Chromosome:11

Target 10 Locus

11q23.1

Target 10 SNPs

SNPJam Report Link Image

Target 10 Toxin References

R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.

Target 10 General References

16554811; 3174635; 3191998; 9649469; 16049940

Target 11 [top]

Target 11 ID

271

Target 11 Name

DNA repair protein complementing XP-A cells

Target 11 Mechanism of Action

Arsenic binding of XPA is believed to induce carcinogenesis by affecting DNA repair. (R054)

Target 11 Description

Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation

Target 11 Synonyms

Xeroderma pigmentosum group A-complementing protein

Target 11 Gene Name

XPA

Target 11 Protein Sequence

>DNA repair protein complementing XP-A cells

MAAADGALPEAAALEQPAELPASVRASIERKRQRALMLRQARLAARPYSATAAAATGGMA
NVKAAPKIIDTGGGFILEEEEEEEQKIGKVVHQPGPVMEFDYVICEECGKEFMDSYLMNH
FDLPTCDNCRDADDKHKLITKTEAKQEYLLKDCDLEKREPPLKFIVKKNPHHSQWGDMKL
YLKLQIVKRSLEVWGSQEALEEAKEVRQENREKMKQKKFDKKVKELRRAVRSSVWKRETI
VHQHEYGPEENLEDDMYRKTCTMCGHELTYEKM

Target 11 Number of Residues

273

Target 11 Molecular Weight

31367.7

Target 11 Theoretical pI

6.72

Target 11 GO Classification

Function
binding nucleic acid binding DNA binding damaged DNA binding
Process
physiological process metabolism cellular metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism DNA metabolism DNA repair nucleotide-excision repair
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus

Target 11 General Function

Involved in damaged DNA binding

Target 11 Pathways

Not Available

Target 11 Reactions

Not Available

Target 11 Signals

None

Target 11 Transmembrane Regions

None

Target 11 Essentiality

Non Essential

Target 11 Domain Function

PF05181:XPA_C PF01286:XPA_N

Target 11 GenBank ID Protein

Not Available

Target 11 UniProtKB ID

P23025

Target 11 Cellular Location

Nucleus

Target 11 Gene Sequence

>822 bp

ATGGCGGCGGCCGACGGGGCTTTGCCGGAGGCGGCGGCTTTAGAGCAACCCGCGGAGCTG
CCTGCCTCGGTGCGGGCGAGTATCGAGCGGAAGCGGCAGCGGGCACTGATGCTGCGCCAG
GCCCGGCTGGCTGCCCGGCCCTACTCGGCGACGGCGGCTGCGGCTACTGGAGGCATGGCT
AATGTAAAAGCAGCCCCAAAGATAATTGACACAGGAGGAGGCTTCATTTTAGAAGAGGAA
GAAGAAGAAGAACAGAAAATTGGAAAAGTTGTTCATCAACCAGGACCTGTTATGGAATTT
GATTATGTAATATGCGAAGAATGTGGGAAAGAATTTATGGATTCTTATCTTATGAACCAC
TTTGATTTGCCAACTTGTGATAACTGCAGAGATGCTGATGATAAACACAAGCTTATAACC
AAAACAGAGGCAAAACAAGAATATCTTCTGAAAGACTGTGATTTAGAAAAAAGAGAGCCA
CCTCTTAAATTTATTGTGAAGAAGAATCCACATCATTCACAATGGGGTGATATGAAACTC
TACTTAAAGTTACAGATTGTGAAGAGGTCTCTTGAAGTTTGGGGTAGTCAAGAAGCATTA
GAAGAAGCAAAGGAAGTCCGACAGGAAAACCGAGAAAAAATGAAACAGAAGAAATTTGAT
AAAAAAGTAAAAGAATTGCGGCGAGCAGTAAGAAGCAGCGTGTGGAAAAGGGAGACGATT
GTTCATCAACATGAGTATGGACCAGAAGAAAACCTAGAAGATGACATGTACCGTAAGACT
TGTACTATGTGTGGCCATGAACTGACATATGAAAAAATGTGA

Target 11 GenBank Gene ID

Not Available

Target 11 GeneCard ID

XPA

Target 11 GenAtlas ID

XPA

Target 11 HGNC ID

HGNC:12814 Link Image

Target 11 Chromosome Location

Not Available

Target 11 Locus

9q22.3

Target 11 SNPs

SNPJam Report Link Image

Target 11 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 11 General References

2234061; 15164053; 15489334; 8294029; 8543191; 1918083; 1601884

Target 12 [top]

Target 12 ID

Target 12 Name

Glucocorticoid receptor

Target 12 Mechanism of Action

Arsenic binds to the glucocorticoid receptor. (R054)

Target 12 Description

Receptor for glucocorticoids (GC). Has a dual mode of action:as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity)

Target 12 Synonyms

GR; Nuclear receptor subfamily 3 group C member 1

Target 12 Gene Name

NR3C1

Target 12 Protein Sequence

>Glucocorticoid receptor

MDSKESLTPGREENPSSVLAQERGDVMDFYKTLRGGATVKVSASSPSLAVASQSDSKQRR
LLVDFPKGSVSNAQQPDLSKAVSLSMGLYMGETETKVMGNDLGFPQQGQISLSSGETDLK
LLEESIANLNRSTSVPENPKSSASTAVSAAPTEKEFPKTHSDVSSEQQHLKGQTGTNGGN
VKLYTTDQSTFDILQDLEFSSGSPGKETNESPWRSDLLIDENCLLSPLAGEDDSFLLEGN
SNEDCKPLILPDTKPKIKDNGDLVLSSPSNVTLPQVKTEKEDFIELCTPGVIKQEKLGTV
YCQASFPGANIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPIFNVIPPIPVG
SENWNRCQGSGDDNLTSLGTLNFPGRTVFSNGYSSPSMRPDVSSPPSSSSTATTGPPPKL
CLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRK
CLQAGMNLEARKTKKKIKGIQQATTGVSQETSENPGNKTIVPATLPQLTPTLVSLLEVIE
PEVLYAGYDSSVPDSTWRIMTTLNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSW
MFLMAFALGWRSYRQSSANLLCFAPDLIINEQRMTLPCMYDQCKHMLYVSSELHRLQVSY
EEYLCMKTLLLLSSVPKDGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTK
LLDSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK

Target 12 Number of Residues

777

Target 12 Molecular Weight

85658.6

Target 12 Theoretical pI

6.31

Target 12 GO Classification

Function
transcription factor activity steroid binding signal transducer activity receptor activity ligand-dependent nuclear receptor activity steroid hormone receptor activity glucocorticoid receptor activity binding nucleic acid binding DNA binding
Process
regulation of biological process regulation of physiological process regulation of metabolism regulation of cellular metabolism regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism regulation of transcription regulation of transcription, DNA-dependent
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus

Target 12 General Function

Involved in glucocorticoid receptor activity

Target 12 Pathways

Not Available

Target 12 Reactions

Not Available

Target 12 Signals

None

Target 12 Transmembrane Regions

None

Target 12 Essentiality

Non Essential

Target 12 Domain Function

PF02155:GCR PF00104:Hormone_recep PF00105:zf-C4

Target 12 GenBank ID Protein

Not Available

Target 12 UniProtKB ID

P04150

Target 12 Cellular Location

Cytoplasm. Nucleus

Target 12 Gene Sequence

>2334 bp

ATGGACTCCAAAGAATCATTAACTCCTGGTAGAGAAGAAAACCCCAGCAGTGTGCTTGCT
CAGGAGAGGGGAGATGTGATGGACTTCTATAAAACCCTAAGAGGAGGAGCTACTGTGAAG
GTTTCTGCGTCTTCACCCTCACTGGCTGTCGCTTCTCAATCAGACTCCAAGCAGCGAAGA
CTTTTGGTTGATTTTCCAAAAGGCTCAGTAAGCAATGCGCAGCAGCCAGATCTGTCCAAA
GCAGTTTCACTCTCAATGGGACTGTATATGGGAGAGACAGAAACAAAAGTGATGGGAAAT
GACCTGGGATTCCCACAGCAGGGCCAAATCAGCCTTTCCTCGGGGGAAACAGACTTAAAG
CTTTTGGAAGAAAGCATTGCAAACCTCAATAGGTCGACCAGTGTTCCAGAGAACCCCAAG
AGTTCAGCATCCACTGCTGTGTCTGCTGCCCCCACAGAGAAGGAGTTTCCAAAAACTCAC
TCTGATGTATCTTCAGAACAGCAACATTTGAAGGGCCAGACTGGCACCAACGGTGGCAAT
GTGAAATTGTATACCACAGACCAAAGCACCTTTGACATTTTGCAGGATTTGGAGTTTTCT
TCTGGGTCCCCAGGTAAAGAGACGAATGAGAGTCCTTGGAGATCAGACCTGTTGATAGAT
GAAAACTGTTTGCTTTCTCCTCTGGCGGGAGAAGACGATTCATTCCTTTTGGAAGGAAAC
TCGAATGAGGACTGCAAGCCTCTCATTTTACCGGACACTAAACCCAAAATTAAGGATAAT
GGAGATCTGGTTTTGTCAAGCCCCAGTAATGTAACACTGCCCCAAGTGAAAACAGAAAAA
GAAGATTTCATCGAACTCTGCACCCCTGGGGTAATTAAGCAAGAGAAACTGGGCACAGTT
TACTGTCAGGCAAGCTTTCCTGGAGCAAATATAATTGGTAATAAAATGTCTGCCATTTCT
GTTCATGGTGTGAGTACCTCTGGAGGACAGATGTACCACTATGACATGAATACAGCATCC
CTTTCTCAACAGCAGGATCAGAAGCCTATTTTTAATGTCATTCCACCAATTCCCGTTGGT
TCCGAAAATTGGAATAGGTGCCAAGGATCTGGAGATGACAACTTGACTTCTCTGGGGACT
CTGAACTTCCCTGGTCGAACAGTTTTTTCTAATGGCTATTCAAGCCCCAGCATGAGACCA
GATGTAAGCTCTCCTCCATCCAGCTCCTCAACAGCAACAACAGGACCACCTCCCAAACTC
TGCCTGGTGTGCTCTGATGAAGCTTCAGGATGTCATTATGGAGTCTTAACTTGTGGAAGC
TGTAAAGTTTTCTTCAAAAGAGCAGTGGAAGGACAGCACAATTACCTATGTGCTGGAAGG
AATGATTGCATCATCGATAAAATTCGAAGAAAAAACTGCCCAGCATGCCGCTATCGAAAA
TGTCTTCAGGCTGGAATGAACCTGGAAGCTCGAAAAACAAAGAAAAAAATAAAAGGAATT
CAGCAGGCCACTACAGGAGTCTCACAAGAAACCTCTGAAAATCCTGGTAACAAAACAATA
GTTCCTGCAACGTTACCACAACTCACCCCTACCCTGGTGTCACTGTTGGAGGTTATTGAA
CCTGAAGTGTTATATGCAGGATATGATAGCTCTGTTCCAGACTCAACTTGGAGGATCATG
ACTACGCTCAACATGTTAGGAGGGCGGCAAGTGATTGCAGCAGTGAAATGGGCAAAGGCA
ATACCAGGTTTCAGGAACTTACACCTGGATGACCAAATGACCCTACTGCAGTACTCCTGG
ATGTTTCTTATGGCATTTGCTCTGGGGTGGAGATCATATAGACAATCAAGTGCAAACCTG
CTGTGTTTTGCTCCTGATCTGATTATTAATGAGCAGAGAATGACTCTACCCTGCATGTAC
GACCAATGTAAACACATGCTGTATGTTTCCTCTGAGTTACACAGGCTTCAGGTATCTTAT
GAAGAGTATCTCTGTATGAAAACCTTACTGCTTCTCTCTTCAGTTCCTAAGGACGGTCTG
AAGAGCCAAGAGCTATTTGATGAAATTAGAATGACCTACATCAAAGAGCTAGGAAAAGCC
ATTGTCAAGAGGGAAGGAAACTCCAGCCAGAACTGGCAGCGGTTTTATCAACTGACAAAA
CTCTTGGATTCTATGCATGAAGTGGTTGAAAATCTCCTTAACTATTGCTTCCAAACATTT
TTGGATAAGACCATGAGTATTGAATTCCCCGAGATGTTAGCTGAAATCATCACCAATCAG
ATACCAAAATATTCAAATGGAAATATCAAAAAACTTCTGTTTCATCAAAAGTGA

Target 12 GenBank Gene ID

Not Available

Target 12 GeneCard ID

NR3C1

Target 12 GenAtlas ID

NR3C1

Target 12 HGNC ID

HGNC:7978

Target 12 Chromosome Location

Not Available

Target 12 Locus

5q31.3

Target 12 SNPs

SNPJam Report Link Image

Target 12 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 12 General References

2867473; 1707881; 17974005; 15372022; 15489334; 2026589; 1958537

Target 13 [top]

Target 13 ID

Target 13 Name

Glutathione reductase, mitochondrial

Target 13 Mechanism of Action

Arsenic binds glutathione reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)

Target 13 Description

Maintains high levels of reduced glutathione in the cytosol

Target 13 Synonyms

GRase; GR

Target 13 Gene Name

GSR

Target 13 Protein Sequence

>Glutathione reductase, mitochondrial

MALLPRALSAGAGPSWRRAARAFRGFLLLLPEPAALTRALSRAMACRQEPQPQGPPPAAG
AVASYDYLVIGGGSGGLASARRAAELGARAAVVESHKLGGTCVNVGCVPKKVMWNTAVHS
EFMHDHADYGFPSCEGKFNWRVIKEKRDAYVSRLNAIYQNNLTKSHIEIIRGHAAFTSDP
KPTIEVSGKKYTAPHILIATGGMPSTPHESQIPGASLGITSDGFFQLEELPGRSVIVGAG
YIAVEMAGILSALGSKTSLMIRHDKVLRSFDSMISTNCTEELENAGVEVLKFSQVKEVKK
TLSGLEVSMVTAVPGRLPVMTMIPDVDCLLWAIGRVPNTKDLSLNKLGIQTDDKGHIIVD
EFQNTNVKGIYAVGDVCGKALLTPVAIAAGRKLAHRLFEYKEDSKLDYNNIPTVVFSHPP
IGTVGLTEDEAIHKYGIENVKTYSTSFTPMYHAVTKRKTKCVMKMVCANKEEKVVGIHMQ
GLGCDEMLQGFAVAVKMGATKADFDNTVAIHPTSSEELVTLR

Target 13 Number of Residues

522

Target 13 Molecular Weight

56256.6

Target 13 Theoretical pI

8.66

Target 13 GO Classification

Function
disulfide oxidoreductase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding FAD binding catalytic activity oxidoreductase activity transporter activity electron transporter activity glutathione-disulfide reductase activity
Process
generation of precursor metabolites and energy electron transport physiological process metabolism cellular metabolism cofactor metabolism coenzyme metabolism glutathione metabolism
Component
cell intracellular cytoplasm

Target 13 General Function

RNA processing and modification

Target 13 Pathways

Not Available

Target 13 Reactions

Not Available

Target 13 Signals

None

Target 13 Transmembrane Regions

None

Target 13 Essentiality

Non Essential

Target 13 Domain Function

PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim

Target 13 GenBank ID Protein

Not Available

Target 13 UniProtKB ID

P00390

Target 13 Cellular Location

Mitochondrion. Cytoplasm

Target 13 Gene Sequence

>1440 bp

ATGGCCTGCAGGCAGGAGCCGCAGCCGCAGGGCCCGCCGCCCGCTGCTGGCGCCGTGGCC
TCCTATGACTACCTGGTGATCGGGGGCGGCTCGGGCGGGCTGGCCAGCGCGCGCAGGGCG
GCCGAGCTGGGTGCCAGGGCCGCCGTGGTGGAGAGCCACAAGCTGGGTGGCACTTGCGTG
AATGTTGGATGTGTACCCAAAAAGGTAATGTGGAACACAGCTGTCCACTCTGAATTCATG
CATGATCATGCTGATTATGGCTTTCCAAGTTGTGAGGGTAAATTCAATTGGCGTGTTATT
AAGGAAAAGCGGGATGCCTATGTGAGCCGCCTGAATGCCATCTATCAAAACAATCTCACC
AAGTCCCATATAGAAATCATCCGTGGCCATGCAGCCTTCACGAGTGATCCCAAGCCCACA
ATAGAGGTCAGTGGGAAAAAGTACACCGCCCCACACATCCTGATCGCCACAGGTGGTATG
CCCTCCACCCCTCATGAGAGCCAGATCCCCGGTGCCAGCTTAGGAATAACCAGCGATGGA
TTTTTTCAGCTGGAAGAATTGCCCGGCCGCAGCGTCATTGTTGGTGCAGGTTACATTGCT
GTGGAGATGGCAGGGATCCTGTCAGCCCTGGGTTCTAAGACATCACTGATGATACGGCAT
GATAAGGTACTTAGAAGTTTTGATTCAATGATCAGCACCAACTGCACGGAGGAGCTGGAG
AACGCTGGCGTGGAGGTGCTGAAGTTCTCCCAGGTCAAGGAGGTTAAAAAGACTTTGTCG
GGCTTGGAAGTCAGCATGGTTACTGCAGTTCCCGGTAGGCTACCAGTCATGACCATGATT
CCAGATGTTGACTGCCTGCTCTGGGCCATTGGGCGGGTCCCGAATACCAAGGACCTGAGT
TTAAACAAACTGGGGATTCAAACCGATGACAAGGGTCATATCATCGTAGACGAATTCCAG
AATACCAACGTCAAAGGCATCTATGCAGTTGGGGATGTATGTGGAAAAGCTCTTCTTACT
CCAGTTGCAATAGCTGCTGGCCGAAAACTTGCCCATCGACTTTTTGAATATAAGGAAGAT
TCCAAATTAGATTATAACAACATCCCAACTGTGGTCTTCAGCCACCCCCCTATTGGGACA
GTGGGACTCACGGAAGATGAAGCCATTCATAAATATGGAATAGAAAATGTGAAGACCTAT
TCAACGAGCTTTACCCCGATGTATCACGCAGTTACCAAAAGGAAAACAAAATGTGTGATG
AAAATGGTCTGTGCTAACAAGGAAGAAAAGGTGGTTGGGATCCATATGCAGGGACTTGGG
TGTGATGAAATGCTGCAGGGTTTTGCTGTTGCAGTGAAGATGGGAGCAACGAAGGCAGAC
TTTGACAACACAGTCGCCATTCACCCTACCTCTTCAGAAGAGCTGGTCACACTTCGTTGA

Target 13 GenBank Gene ID

Not Available

Target 13 GeneCard ID

GSR

Target 13 GenAtlas ID

GSR

Target 13 HGNC ID

HGNC:4623

Target 13 Chromosome Location

Not Available

Target 13 Locus

8p21.1

Target 13 SNPs

SNPJam Report Link Image

Target 13 Toxin References

R009 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 13 General References

2185014; 10708558; 16421571; 15489334; 7060551; 923580; 15592455; 7334521

Target 14 [top]

Target 14 ID

222

Target 14 Name

Haptoglobin

Target 14 Mechanism of Action

Arsenic binds to haptoglobin. (R052)

Target 14 Description

Haptoglobin combines with free plasma hemoglobin, preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin, while making the hemoglobin accessible to degradative enzymes

Target 14 Synonyms

Haptoglobin alpha chain; Haptoglobin beta chain

Target 14 Gene Name

Target 14 Protein Sequence

>Haptoglobin

MSALGAVIALLLWGQLFAVDSGNDVTDIADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRT
EGDGVYTLNDKKQWINKAVGDKLPECEADDGCPKPPEIAHGYVEHSVRYQCKNYYKLRTE
GDGVYTLNNEKQWINKAVGDKLPECEAVCGKPKNPANPVQRILGGHLDAKGSFPWQAKMV
SHHNLTTGATLINEQWLLTTAKNLFLNHSENATAKDIAPTLTLYVGKKQLVEIEKVVLHP
NYSQVDIGLIKLKQKVSVNERVMPICLPSKDYAEVGRVGYVSGWGRNANFKFTDHLKYVM
LPVADQDQCIRHYEGSTVPEKKTPKSPVGVQPILNEHTFCAGMSKYQEDTCYGDAGSAFA
VHDLEEDTWYATGILSFDKSCAVAEYGVYVKVTSIQDWVQKTIAEN

Target 14 Number of Residues

406

Target 14 Molecular Weight

45205.1

Target 14 Theoretical pI

6.56

Target 14 GO Classification

Function
catalytic activity hydrolase activity peptidase activity endopeptidase activity serine-type endopeptidase activity binding protein binding hemoglobin binding
Process
physiological process metabolism macromolecule metabolism protein metabolism cellular protein metabolism proteolysis
Component
extracellular region

Target 14 General Function

Involved in hemoglobin binding

Target 14 Pathways

Not Available

Target 14 Reactions

Not Available

Target 14 Signals

1-18

Target 14 Transmembrane Regions

None

Target 14 Essentiality

Non Essential

Target 14 Domain Function

PF00089:Trypsin

Target 14 GenBank ID Protein

Not Available

Target 14 UniProtKB ID

P00738

Target 14 Cellular Location

Secreted

Target 14 Gene Sequence

>1221 bp

DDEISITE.AGACCAACCAAGATGAGTGCCCTGGGAGCTGTCATTGCCCTCCTGCTCTGG
GGACAGCTTTTTGCAGTGGACTCAGGCAATGATGTCACGGATATCGCAGATGACGGCTGC
CCGAAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTTCGCTACCAGTGTAAG
AACTACTACAAACTGCGCACAGAAGGAGATGGAGTATACACCTTAAATAATAAGAAGCAG
TGGATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGATGACGGCTGCCCG
AAGCCCCCCGAGATTGCACATGGCTATGTGGAGCACTCGGTCCGCTACCAGTGTAAGAAC
TACTACAAACTGCGCACAGAAGGAGATGGAGTGTACACCTTAAACAATGAGAAGCAGTGG
ATAAATAAGGCTGTTGGAGATAAACTTCCTGAATGTGAAGCAGTATGTGGGAAGCCCAAG
AATCCGGCAAACCCAGTGCAGCGGATCCTAGGTGGACACCTTGATGCCAAAGGCAGCTTT
CCCTGGCAGGCTAAGATGGTTTCCCACCATAATCTCACCACAGGTGCCACGCTGATCAAT
GAACAATGGCTGCTGACCACGGCTAAAAATCTCTTCCTGAACCATTCAGAAAATGCAACA
GCGAAAGACATTGCCCCTACTTTAACACTCTATGTGGGGAAAAAGCAGCTTGTAGAGATT
GAGAAGGTTGTTCTACACCCTAACTACTCCCAGGTAGATATTGGGCTCATCAAACTCAAA
CAGAAGGTGTCTGTTAATGAGAGAGTGATGCCCATCTGCCTACCTTCAAAGGATTATGCA
GAAGTAGGGCGTGTGGGTTATGTTTCTGGCTGGGGGCGAAATGCCAATTTTAAATTTACT
GACCATCTGAAGTATGTCATGCTGCCTGTGGCTGACCAAGACCAATGCATAAGGCATTAT
GAAGGCAGCACAGTCCCCGAAAAGAAGACACCGAAGAGCCCTGTAGGGGTGCAGCCCATA
CTGAATGAACACACCTTCTGTGCTGGCATGTCTAAGTACCAAGAAGACACCTGCTATGGC
GATGCGGGCAGTGCCTTTGCCGTTCACGACCTGGAGGAGGACACCTGGTATGCGACTGGG
ATCTTAAGCTTTGATAAGAGCTGTGCTGTGGCTGAGTATGGTGTGTATGTGAAGGTGACT
TCCATCCAGGACTGGGTTCAG

Target 14 GenBank Gene ID

Not Available

Target 14 GeneCard ID

Target 14 GenAtlas ID

Target 14 HGNC ID

HGNC:5141

Target 14 Chromosome Location

Chromosome:16

Target 14 Locus

16q22.1

Target 14 SNPs

SNPJam Report Link Image

Target 14 Toxin References

R052 - Naranmandura H, Suzuki KT: Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous-hemoglobin-haptoglobin complex. Chem Res Toxicol. 2008 Mar;21(3):678-85. Epub 2008 Feb 2. [PubMed ]

Target 14 General References

6688992; 6310599; 6546723; 6330675; 4018023; 2987228; 1478675; 14702039; 15489334

Target 15 [top]

Target 15 ID

Target 15 Name

Hemoglobin subunit alpha

Target 15 Mechanism of Action

Arsenic binds to hemoglobin. (R052)

Target 15 Description

Involved in oxygen transport from the lung to the various peripheral tissues

Target 15 Synonyms

Hemoglobin alpha chain; Alpha-globin

Target 15 Gene Name

HBA1

Target 15 Protein Sequence

>Hemoglobin subunit alpha

MVLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHG
KKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTP
AVHASLDKFLASVSTVLTSKYR

Target 15 Number of Residues

142

Target 15 Molecular Weight

15257.4

Target 15 Theoretical pI

9.09

Target 15 GO Classification

Function
oxygen binding binding
Process
gas transport oxygen transport physiological process cellular physiological process transport
Component
protein complex hemoglobin complex

Target 15 General Function

Involved in heme binding

Target 15 Pathways

Not Available

Target 15 Reactions

Not Available

Target 15 Signals

None

Target 15 Transmembrane Regions

None

Target 15 Essentiality

Non Essential

Target 15 Domain Function

PF00042:Globin

Target 15 GenBank ID Protein

Not Available

Target 15 UniProtKB ID

P69905

Target 15 Cellular Location

Not Available

Target 15 Gene Sequence

>429 bp

ATGGTGCTGTCTCCTGCCGACAAGACCAACGTCAAGGCCGCCTGGGGCAAGGTTGGCGCG
CACGCTGGCGAGTATGGTGCGGAGGCCCTGGAGAGGATGTTCCTGTCCTTCCCCACCACC
AAGACCTACTTCCCGCACTTCGACCTGAGCCACGGCTCTGCCCAGGTTAAGGGCCACGGC
AAGAAGGTGGCCGACGCGCTGACCAACGCCGTGGCGCACGTGGACGACATGCCCAACGCG
CTGTCCGCCCTGAGCGACCTGCACGCGCACAAGCTTCGGGTGGACCCGGTCAACTTCAAG
CTCCTAAGCCACTGCCTGCTGGTGACCCTGGCCGCCCACCTCCCCGCCGAGTTCACCCCT
GCGGTGCACGCCTCCCTGGACAAGTTCCTGGCTTCTGTGAGCACCGTGCTGACCTCCAAA
TACCGTTAA

Target 15 GenBank Gene ID

Not Available

Target 15 GeneCard ID

HBA1

Target 15 GenAtlas ID

HBA1

Target 15 HGNC ID

HGNC:4823

Target 15 Chromosome Location

Chromosome:16

Target 15 Locus

16p13.3

Target 15 SNPs

SNPJam Report Link Image

Target 15 Toxin References

R052 - Naranmandura H, Suzuki KT: Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous-hemoglobin-haptoglobin complex. Chem Res Toxicol. 2008 Mar;21(3):678-85. Epub 2008 Feb 2. [PubMed ]

Target 15 General References

7448866; 6244294; 6452630; 6946451; 11410421; 11402454; 16728641

Target 16 [top]

Target 16 ID

Target 16 Name

Hemoglobin subunit beta

Target 16 Mechanism of Action

Arsenic binds to hemoglobin. (R052)

Target 16 Description

LVV-hemorphin-7 potentiates the activity of bradykinin, causing a decrease in blood pressure

Target 16 Synonyms

Hemoglobin beta chain; Beta-globin; LVV-hemorphin-7

Target 16 Gene Name

HBB

Target 16 Protein Sequence

>Hemoglobin subunit beta

MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPK
VKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFG
KEFTPPVQAAYQKVVAGVANALAHKYH

Target 16 Number of Residues

147

Target 16 Molecular Weight

15998.3

Target 16 Theoretical pI

7.32

Target 16 GO Classification

Function
oxygen binding binding tetrapyrrole binding heme binding
Process
physiological process cellular physiological process transport gas transport oxygen transport
Component
protein complex hemoglobin complex

Target 16 General Function

Involved in heme binding

Target 16 Pathways

Not Available

Target 16 Reactions

Not Available

Target 16 Signals

None

Target 16 Transmembrane Regions

None

Target 16 Essentiality

Non Essential

Target 16 Domain Function

PF00042:Globin

Target 16 GenBank ID Protein

Not Available

Target 16 UniProtKB ID

P68871

Target 16 Cellular Location

Not Available

Target 16 Gene Sequence

>444 bp

ATGGTNCAYYTNACNCCNGTGGAGAAGTCYGCYGTNACNGCNCTNTGGGGYAAGGTNAAY
GTGGATGAAGYYGGYGGYGAGGCCCTGGGCAGNCTGCTNGTGGTCTACCCTTGGACCCAG
AGGTTCTTNGANTCNTTYGGGGATCTGNNNACNCCNGANGCAGTTATGGGCAACCCTAAG
GTGAAGGCTCATGGCAAGAAAGTGCTCGGTGCCTTTAGTGATGGCCTGGCTCACCTGGAC
AACCTCAAGGGCACCTTTGCCACACTGAGTGAGCTGCACTGTGACAAGCTNCAYGTGGAT
CCTGAGAACTTCAGGCTNCTNGGCAACGTGYTNGTCTGYGTGCTGGCCCATCACTTTGGC
AAAGAATTCACCCCACCAGTGCANGCNGCCTATCAGAAAGTGGTNGCTGGTGTNGCTAAT
GCCCTGGCCCACAAGTATCACTAA

Target 16 GenBank Gene ID

Not Available

Target 16 GeneCard ID

HBB

Target 16 GenAtlas ID

HBB

Target 16 HGNC ID

HGNC:4827

Target 16 Chromosome Location

Chromosome:11

Target 16 Locus

11p15.5

Target 16 SNPs

SNPJam Report Link Image

Target 16 Toxin References

R052 - Naranmandura H, Suzuki KT: Identification of the major arsenic-binding protein in rat plasma as the ternary dimethylarsinous-hemoglobin-haptoglobin complex. Chem Res Toxicol. 2008 Mar;21(3):678-85. Epub 2008 Feb 2. [PubMed ]

Target 16 General References

1019344; 6254664; 16175509

Target 17 [top]

Target 17 ID

Target 17 Name

Kelch-like ECH-associated protein 1

Target 17 Mechanism of Action

Arsenic binds to kelch-like ECH-associated protein 1. (R054)

Target 17 Description

Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome

Target 17 Synonyms

Cytosolic inhibitor of Nrf2; INrf2; Kelch-like protein 19

Target 17 Gene Name

KEAP1

Target 17 Protein Sequence

>Kelch-like ECH-associated protein 1

MQPDPRPSGAGACCRFLPLQSQCPEGAGDAVMYASTECKAEVTPSQHGNRTFSYTLEDHT
KQAFGIMNELRLSQQLCDVTLQVKYQDAPAAQFMAHKVVLASSSPVFKAMFTNGLREQGM
EVVSIEGIHPKVMERLIEFAYTASISMGEKCVLHVMNGAVMYQIDSVVRACSDFLVQQLD
PSNAIGIANFAEQIGCVELHQRAREYIYMHFGEVAKQEEFFNLSHCQLVTLISRDDLNVR
CESEVFHACINWVKYDCEQRRFYVQALLRAVRCHSLTPNFLQMQLQKCEILQSDSRCKDY
LVKIFEELTLHKPTQVMPCRAPKVGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQV
PRSGLAGCVVGGLLYAVGGRNNSPDGNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGV
IDGHIYAVGGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGFDG
TNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQDQLNSVERYDVE
TETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFLDSVECYDPDTDTWSEVTRMTSG
RSGVGVAVTMEPCRKQIDQQNCTC

Target 17 Number of Residues

624

Target 17 Molecular Weight

69665.8

Target 17 Theoretical pI

6.42

Target 17 GO Classification

Function
binding protein binding
Process
Not Available
Component
Not Available

Target 17 General Function

Involved in regulation of transcription

Target 17 Pathways

Not Available

Target 17 Reactions

Not Available

Target 17 Signals

None

Target 17 Transmembrane Regions

None

Target 17 Essentiality

Non Essential

Target 17 Domain Function

PF07707:BACK PF00651:BTB PF01344:Kelch_1

Target 17 GenBank ID Protein

Not Available

Target 17 UniProtKB ID

Q14145

Target 17 Cellular Location

Cytoplasm. Nucleus

Target 17 Gene Sequence

>1875 bp

ATGCAGCCAGATCCCAGGCCTAGCGGGGCTGGGGCCTGCTGCCGATTCCTGCCCCTGCAG
TCACAGTGCCCTGAGGGGGCAGGGGACGCGGTGATGTACGCCTCCACTGAGTGCAAGGCG
GAGGTGACGCCCTCCCAGCATGGCAACCGCACCTTCAGCTACACCCTGGAGGATCATACC
AAGCAGGCCTTTGGCATCATGAACGAGCTGCGGCTCAGCCAGCAGCTGTGTGACGTCACA
CTGCAGGTCAAGTACCAGGATGCACCGGCCGCCCAGTTCATGGCCCACAAGGTGGTGCTG
GCCTCATCCAGCCCTGTCTTCAAGGCCATGTTCACCAACGGGCTGCGGGAGCAGGGCATG
GAGGTGGTGTCCATTGAGGGTATCCACCCCAAGGTCATGGAGCGCCTCATTGAATTCGCC
TACACGGCCTCCATCTCCATGGGCGAGAAGTGTGTCCTCCACGTCATGAACGGTGCTGTC
ATGTACCAGATCGACAGCGTTGTCCGTGCCTGCAGTGACTTCCTGGTGCAGCAGCTGGAC
CCCAGCAATGCCATCGGCATCGCCAACTTCGCTGAGCAGATTGGCTGTGTGGAGTTGCAC
CAGCGTGCCCGGGAGTACATCTACATGCATTTTGGGGAGGTGGCCAAGCAAGAGGAGTTC
TTCAACCTGTCCCACTGCCAACTGGTGACCCTCATCAGCCGGGACGACCTGAACGTGCGC
TGCGAGTCCGAGGTCTTCCACGCCTGCATCAACTGGGTCAAGTACGACTGCGAACAGCGA
CGGTTCTACGTCCAGGCGCTGCTGCGGGCCGTGCGCTGCCACTCGTTGACGCCGAACTTC
CTGCAGATGCAGCTGCAGAAGTGCGAGATCCTGCAGTCCGACTCCCGCTGCAAGGACTAC
CTGGTCAAGATCTTCGAGGAGCTCACCCTGCACAAGCCCACGCAGGTGATGCCCTGCCGG
GCGCCCAAGGTGGGCCGCCTGATCTACACCGCGGGCGGCTACTTCCGACAGTCGCTCAGC
TACCTGGAGGCTTACAACCCCAGTGACGGCACCTGGCTCCGGTTGGCGGACCTGCAGGTG
CCGCGGAGCGGCCTGGCCGGCTGCGTGGTGGGCGGGCTGTTGTACGCCGTGGGCGGCAGG
AACAACTCGCCCGACGGCAACACCGACTCCAGCGCCCTGGACTGTTACAACCCCATGACC
AATCAGTGGTCGCCCTGCGCCCCCATGAGCGTGCCCCGTAACCGCATCGGGGTGGGGGTC
ATCGATGGCCACATCTATGCCGTCGGCGGCTCCCACGGCTGCATCCACCACAACAGTGTG
GAGAGGTATGAGCCAGAGCGGGATGAGTGGCACTTGGTGGCCCCAATGCTGACACGAAGG
ATCGGGGTGGGCGTGGCTGTCCTCAATCGTCTCCTTTATGCCGTGGGGGGCTTTGACGGG
ACAAACCGCCTTAATTCAGCTGAGTGTTACTACCCAGAGAGGAACGAGTGGCGAATGATC
ACAGCAATGAACACCATCCGAAGCGGGGCAGGCGTCTGCGTCCTGCACAACTGTATCTAT
GCTGCTGGGGGCTATGATGGTCAGGACCAGCTGAACAGCGTGGAGCGCTACGATGTGGAA
ACAGAGACGTGGACTTTCGTAGCCCCCATGAAGCACCGGCGAAGTGCCCTGGGGATCACT
GTCCACCAGGGGAGAATCTACGTCCTTGGAGGCTATGATGGTCACACGTTCCTGGACAGT
GTGGAGTGTTACGACCCAGATACAGACACCTGGAGCGAGGTGACCCGAATGACATCGGGC
CGGAGTGGGGTGGGCGTGGCTGTCACCATGGAGCCCTGCCGGAAGCAGATTGACCAGCAG
AACTGTACCTGTTGA

Target 17 GenBank Gene ID

Not Available

Target 17 GeneCard ID

KEAP1

Target 17 GenAtlas ID

KEAP1

Target 17 HGNC ID

HGNC:23177 Link Image

Target 17 Chromosome Location

Chromosome:19

Target 17 Locus

19p13.2

Target 17 SNPs

SNPJam Report Link Image

Target 17 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 17 General References

8590280; 15489334; 14585973; 15379550; 15572695; 15657435; 17046835; 18691976

Target 18 [top]

Target 18 ID

Target 18 Name

Poly [ADP-ribose] polymerase 1

Target 18 Mechanism of Action

Arsenic binding of PARP-1 is believed to induce carcinogenesis by affecting DNA repair. (R054)

Target 18 Description

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP- ribosyl)ation of APLF and CHFR

Target 18 Synonyms

PARP-1; ADPRT; NAD(+) ADP-ribosyltransferase 1; Poly[ADP-ribose] synthetase 1

Target 18 Gene Name

PARP1

Target 18 Protein Sequence

>Poly [ADP-ribose] polymerase 1

MAESSDKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKV
GHSIRHPDVEVDGFSELRWDDQQKVKKTAEAGGVTGKGQDGIGSKAEKTLGDFAAEYAKS
NRSTCKGCMEKIEKGQVRLSKKMVDPEKPQLGMIDRWYHPGCFVKNREELGFRPEYSASQ
LKGFSLLATEDKEALKKQLPGVKSEGKRKGDEVDGVDEVAKKKSKKEKDKDSKLEKALKA
QNDLIWNIKDELKKVCSTNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEECSG
QLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPKEFREISYLKKLKVKKQDRIFPPE
TSASVAATPPPSTASAPAAVNSSASADKPLSNMKILTLGKLSRNKDEVKAMIEKLGGKLT
GTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDVSASTKSLQELFLAHILSP
WGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGINKSEKRMKLTLKGGAAVDPDSGLE
HSAHVLEKGGKVFSATLGLVDIVKGTNSYYKLQLLEDDKENRYWIFRSWGRVGTVIGSNK
LEQMPSKEDAIEHFMKLYEEKTGNAWHSKNFTKYPKKFYPLEIDYGQDEEAVKKLTVNPG
TKSKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSEVQQAV
SQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNADSVQAKVEMLDNLLDIEVAYSLLRG
GSDDSSKDPIDVNYEKLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIE
REGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGYMFGKGIYFADM
VSKSANYCHTSQGDPIGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSA
NISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNFKTSLW

Target 18 Number of Residues

1014

Target 18 Molecular Weight

113082.9

Target 18 Theoretical pI

9.34

Target 18 GO Classification

Function
NAD+ ADP-ribosyltransferase activity NAD+ ADP-ribosyltransferase activity catalytic activity transferase activity transferase activity, transferring glycosyl groups transferase activity, transferring pentosyl groups NAD+ ADP-ribosyltransferase activity binding nucleic acid binding DNA binding
Process
macromolecule metabolism biopolymer metabolism biopolymer modification protein modification protein amino acid ADP-ribosylation physiological process metabolism cellular metabolism nucleobase, nucleoside, nucleotide and nucleic acid metabolism DNA metabolism
Component
organelle membrane-bound organelle intracellular membrane-bound organelle nucleus cell intracellular

Target 18 General Function

Involved in DNA binding

Target 18 Pathways

Not Available

Target 18 Reactions

Not Available

Target 18 Signals

None

Target 18 Transmembrane Regions

None

Target 18 Essentiality

Non Essential

Target 18 Domain Function

PF00533:BRCT PF08063:PADR1 PF00644:PARP PF02877:PARP_reg PF05406:WGR PF00645:zf-PARP

Target 18 GenBank ID Protein

Not Available

Target 18 UniProtKB ID

P09874

Target 18 Cellular Location

Nucleus

Target 18 Gene Sequence

>3045 bp

TGCGGCAGCTAGGGAGGATGGCGGAGTCTTCGGATAAGCTCTATCGAGTCGAGTACGCCA
AGAGCGGGCGCGCCTCTTGCAAGAAATGCAGCGAGAGCATCCCCAAGGACTCGCTCCGGA
TGGCCATCATGGTGCAGTCGCCCATGTTTGATGGAAAAGTCCCACACTGGTACCACTTCT
CCTGCTTCTGGAAGGTGGGCCACTCCATCCGGCACCCTGACGTTCAGGTGGATGGGTTCT
CTGAGCTTCGGTGGGATGACCAGCAGAAAGTCAAGAAGACAGCGGAAGCTGGAGGAGTGA
CAGGCAAAGGCCAGGATGGAATTGGTAGCAAGGCAGAGAAGACTCTGGGTGACTTTGCAG
CAGAGTATGCCAAGTCCAACAGAAGTACGTGCAAGGGGTGTATGGAGAAGATAGAAAAGG
GCCAGGTGCGCCTGTCCAAGAAGATGGTGGACCCGGAGAAGCCACAGCTAGGCATGATTG
ACCGCTGGTACCATCCAGGCTGCTTTGTCAAGAACAGGGAGGAGCTGGGTTTCCGGCCCG
AGTACAGTGCGAGTCAGCTCAAGGGCTTCAGCCTCCTTGCTACAGAGGATAAAGAAGCCC
TGAAGAAGCAGCTCCCAGGAGTCAAGAGTGAAGGAAAGAGAAAAGGCGATGAGGTGGATG
GAGTGGATGAAGTGGCGAAGAAGAAATCTAAAAAAGAAAAAGACAAGGATAGTAAGCTTG
AAAAAGCCCTAAAGGCTCAGAACGACCTGATCTGGAACATCAAGGACGAGCTAAAGAAAG
TGTGTTCAACTAATGACCTGAAGGAGCTACTCATCTTCAACAAGCAGCAAGTGCCTTCTG
GGGAGTCGGCGATCTTGGACCGAGTAGCTGATGGCATGGTGTTCGGTGCCCTCCTTCCCT
GCGAGGAATGCTCGGGTCAGCTGGTCTTCAAGAGCGATGCCTATTACTGCACTGGGGACG
TCACTGCCTGGACCAAGTGTATGGTCAAGACACAGACACCCAACCGGAAGGAGTGGGTAA
CCCCAAAGGAATTCCGAGAAATCTCTTACCTCAAGAAATTGAAGGTTAAAAAGCAGGACC
GTATATTCCCCCCAGAAACCAGCGCCTCCGTGGCGGCCACGCCTCCGCCCTCCACAGCCT
CGGCTCCTGCTGCTGTGAACTCCTCTGCTTCAGCAGATAAGCCATTATCCAACATGAAGA
TCCTGACTCTCGGGAAGCTGTCCCGGAACAAGGATGAAGTGAAGGCCATGATTGAGAAAC
TCGGGGGGAAGTTGACGGGGACGGCCAACAAGGCTTCCCTGTGCATCAGCACCAAAAAGG
AGGTGGAAAAGATGAATAAGAAGATGGAGGAAGTAAAGGAAGCCAACATCCGAGTTGTGT
CTGAGGACTTCCTCCAGGACGTCTCCGCCTCCACCAAGAGCCTTCAGGAGTTGTTCTTAG
CGCACATCTTGTCCCCTTGGGGGGCAGAGGTGAAGGCAGAGCCTGTTGAAGTTGTGGCCC
CAAGAGGGAAGTCAGGGGCTGCGCTCTCCAAAAAAAGCAAGGGCCAGGTCAAGGAGGAAG
GTATCAACAAATCTGAAAAGAGAATGAAATTAACTCTTAAAGGAGGAGCAGCTGTGGATC
CTGATTCTGGACTGGAACACTCTGCGCATGTCCTGGAGAAAGGTGGGAAGGTCTTCAGTG
CCACCCTTGGCCTGGTGGACATCGTTAAAGGAACCAACTCCTACTACAAGCTGCAGCTTC
TGGAGGACGACAAGGAAAACAGGTATTGGATATTCAGGTCCTGGGGCCGTGTGGGTACGG
TGATCGGTAGCAACAAACTGGAACAGATGCCGTCCAAGGAGGATGCCATTGAGCACTTCA
TGAAATTATATGAAGAAAAAACCGGGAACGCTTGGCACTCCAAAAATTTCACGAAGTATC
CCAAAAAGTTCTACCCCCTGGAGATTGACTATGGCCAGGATGAAGAGGCAGTGAAGAAGC
TGACAGTAAATCCTGGCACCAAGTCCAAGCTCCCCAAGCCAGTTCAGGACCTCATCAAGA
TGATCTTTGATGTGGAAAGTATGAAGAAAGCCATGGTGGAGTATGAGATCGACCTTCAGA
AGATGCCCTTGGGGAAGCTGAGCAAAAGGCAGATCCAGGCCGCATACTCCATCCTCAGTG
AGGTCCAGCAGGCGGTGTCTCAGGGCAGCAGCGACTCTCAGATCCTGGATCTCTCAAATC
GCTTTTACACCCTGATCCCCCACGACTTTGGGATGAAGAAGCCTCCGCTCCTGAACAATG
CAGACAGTGTGCAGGCCAAGGTGGAAATGCTTGACAACCTGCTGGACATCGAGGTGGCCT
ACAGTCTGCTCAGGGGAGGGTCTGATGATAGCAGCAAGGATCCCATCGATGTCAACTATG
AGAAGCTCAAAACTGACATTAAGGTGGTTGACAGAGATTCTGAAGAAGCCGAGATCATCA
GGAAGTATGTTAAGAACACTCATGCAACCACACACAATGCGTATGACTTGGAAGTCATCG
ATATCTTTAAGATAGAGCGTGAAGGCGAATGCCAGCGTTACAAGCCCTTTAAGCAGCTTC
ATAACCGAAGATTGCTGTGGCACGGGTCCAGGACCACCAACTTTGCTGGGATCCTGTCCC
AGGGTCTTCGGATAGCCCCGCCTGAAGCGCCCGTGACAGGCTACATGTTTGGTAAAGGGA
TCTATTTCGCTGACATGGTCTCCAAGAGTGCCAACTACTGCCATACGTCTCAGGGAGACC
CAATAGGCTTAATCCTGTTGGGAGAAGTTGCCCTTGGAAACATGTATGAACTGAAGCACG
CTTCACATATCAGCAAGTTACCCAAGGGCAAGCACAGTGTCAAAGGTTTGGGCAAAACTA
CCCCTGATCCTTCAGCTAACATTAGTCTGGATGGTGTAGACGTTCCTCTTGGGACCGGGA
TTTCATCTGGTGTGAATGACACCTCTCTACTATATAACGAGTACATTGTCTATGATATTG
CTCAGGTAAATCTGAAGTATCTGCTGAAACTGAAATTCAATTTTA

Target 18 GenBank Gene ID

Not Available

Target 18 GeneCard ID

PARP1

Target 18 GenAtlas ID

PARP1

Target 18 HGNC ID

HGNC:270

Target 18 Chromosome Location

Not Available

Target 18 Locus

1q41-q42

Target 18 SNPs

SNPJam Report Link Image

Target 18 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 18 General References

3120710; 2824474; 2891139; 2513174; 15489334; 2125269; 2108670

Target 19 [top]

Target 19 ID

425

Target 19 Name

Putative tubulin beta chain-like protein ENSP00000290377

Target 19 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 19 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 19 Synonyms

Not Available

Target 19 Gene Name

Not Available

Target 19 Protein Sequence

>Putative tubulin beta chain-like protein ENSP00000290377

MDSVRSGPFGQVLRPDNFIFGQCGAGNNWAKGRYTEGAELTESVMDVVRKEAESCDCLQG
FQLTHSLGGGTGSGMVTLLISKIREEYPDRIINTFSILPSPKVSDTVVEPYNATLSVHQL
IENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRK
LAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMRAARDPRHGRYLT
AAAIFQGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAICDIPPRGLKMSASFIGNNA
AIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAKE
EEDEEYAEEEVA

Target 19 Number of Residues

372

Target 19 Molecular Weight

41774.7

Target 19 Theoretical pI

4.50

Target 19 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 19 General Function

Cell cycle control, cell division, chromosome partitioning

Target 19 Pathways

Not Available

Target 19 Reactions

Not Available

Target 19 Signals

None

Target 19 Transmembrane Regions

None

Target 19 Essentiality

Non Essential

Target 19 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 19 GenBank ID Protein

Not Available

Target 19 UniProtKB ID

A6NKZ8

Target 19 Cellular Location

Cytoplasmic

Target 19 Gene Sequence

Not Available

Target 19 GenBank Gene ID

Not Available

Target 19 GeneCard ID

Not Available

Target 19 GenAtlas ID

Not Available

Target 19 HGNC ID

Not Available

Target 19 Chromosome Location

Not Available

Target 19 Locus

Not Available

Target 19 SNPs

Not Available

Target 19 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 19 General References

15164053

Target 20 [top]

Target 20 ID

426

Target 20 Name

Putative tubulin beta-4q chain

Target 20 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 20 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 20 Synonyms

Not Available

Target 20 Gene Name

TUBB4Q

Target 20 Protein Sequence

>Putative tubulin beta-4q chain

MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVRSGPFAEVFRPDNFISRQCGAGNNWAKGRYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATVSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSQGSQQYRALTVAELTQQMFDAKNMM
AARDPRHGCYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNIKTAVCDIPPWG
LKMSVTFTGNNTAVQELKRVSEQFTATFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSE
YQQYQDATAEGEGV

Target 20 Number of Residues

434

Target 20 Molecular Weight

48434.2

Target 20 Theoretical pI

4.91

Target 20 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 20 General Function

Cell cycle control, cell division, chromosome partitioning

Target 20 Pathways

Not Available

Target 20 Reactions

Not Available

Target 20 Signals

None

Target 20 Transmembrane Regions

None

Target 20 Essentiality

Non Essential

Target 20 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 20 GenBank ID Protein

Not Available

Target 20 UniProtKB ID

Q99867

Target 20 Cellular Location

Cytoplasmic

Target 20 Gene Sequence

Not Available

Target 20 GenBank Gene ID

Not Available

Target 20 GeneCard ID

TUBB4Q

Target 20 GenAtlas ID

TUBB4Q

Target 20 HGNC ID

HGNC:12413 Link Image

Target 20 Chromosome Location

Not Available

Target 20 Locus

4q35

Target 20 SNPs

SNPJam Report Link Image

Target 20 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 20 General References

10828619

Target 21 [top]

Target 21 ID

427

Target 21 Name

Putative tubulin-like protein alpha-4B

Target 21 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 21 Description

Not Available

Target 21 Synonyms

Alpha-tubulin 4B

Target 21 Gene Name

TUBA4B

Target 21 Protein Sequence

>Putative tubulin-like protein alpha-4B

MRHQQTERQDPSQPLSRQHGTYRQIFHPEQLITGKEDAANNYAWGHYTIGKEFIDLLLDR
IRKLADQCTGLQGFLVFHSLGRGTGSDVTSFLMEWLSVNYGKKSKLGFSIYPAPQVSTAM
VQPYNSILTTHTTLEHSDCAFMVDNKAIYDICHCNLDIERPTYTNLNRLISQIVSSITAS
LRFDGALNVDLTEFQTNLVSYLTSTSPWPPMHQSSLQKRYTTSSCWWQRLPMPALSLPTR
W

Target 21 Number of Residues

241

Target 21 Molecular Weight

27551.0

Target 21 Theoretical pI

7.93

Target 21 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 21 General Function

Involved in GTP binding

Target 21 Pathways

Not Available

Target 21 Reactions

Not Available

Target 21 Signals

None

Target 21 Transmembrane Regions

None

Target 21 Essentiality

Non Essential

Target 21 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 21 GenBank ID Protein

Not Available

Target 21 UniProtKB ID

Q9H853

Target 21 Cellular Location

Cytoplasmic

Target 21 Gene Sequence

>726 bp

ATGCGGCACCAGCAGACAGAGAGACAAGACCCCAGCCAGCCCCTGTCCAGGCAGCATGGC
ACATACCGCCAGATCTTCCATCCAGAGCAGCTCATCACAGGCAAGGAAGATGCTGCCAAT
AACTATGCCTGGGGCCACTACACCATTGGGAAGGAGTTCATCGACCTGCTACTGGACCGG
ATTCGGAAGCTGGCTGACCAGTGCACAGGACTTCAGGGCTTCCTGGTGTTCCACAGCCTT
GGTCGGGGCACTGGCTCTGACGTCACCTCATTCCTGATGGAGTGGCTTTCTGTTAACTAT
GGCAAGAAATCCAAGCTGGGATTCTCCATCTACCCAGCCCCCCAGGTGTCTACAGCCATG
GTCCAGCCCTACAACTCTATCCTGACCACCCACACCACCCTGGAGCACTCAGACTGTGCC
TTCATGGTGGACAACAAAGCAATCTATGACATCTGCCACCGCAACCTAGACATTGAGCGC
CCAACCTACACCAACCTCAATCGCCTCATTAGCCAAATTGTCTCCTCCATCACAGCTTCT
CTGCGCTTTGACGGGGCCCTCAATGTGGACCTGACAGAGTTCCAGACCAACCTGGTGTCC
TACCTCACATCCACTTCCCCCTGGCCACCTATGCACCAGTCATCTCTGCAGAAAAAGTAT
ACCACGAGCAGCTGTCGGTGGCAGAGATTACCAATGCCTGCTTTGAGCCTGCCAACCAGA
TGGTGA

Target 21 GenBank Gene ID

Not Available

Target 21 GeneCard ID

TUBA4B

Target 21 GenAtlas ID

TUBA4B

Target 21 HGNC ID

HGNC:18637 Link Image

Target 21 Chromosome Location

Not Available

Target 21 Locus

Not Available

Target 21 SNPs

SNPJam Report Link Image

Target 21 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 21 General References

14702039; 15815621

Target 22 [top]

Target 22 ID

273

Target 22 Name

Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

Target 22 Mechanism of Action

Target 22 Description

Target 22 Synonyms

PDHE1-A type I

Target 22 Gene Name

PDHA1

Target 22 Protein Sequence

>Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

MRKMLAAVSRVLSGASQKPASRVLVASRNFANDATFEIKKCDLHRLEEGPPVTTVLTRED
GLKYYRMMQTVRRMELKADQLYKQKIIRGFCHLCDGQEACCVGLEAGINPTDHLITAYRA
HGFTFTRGLSVREILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGIALA
CKYNGKDEVCLTLYGDGAANQGQIFEAYNMAALWKLPCIFICENNRYGMGTSVERAAAST
DYYKRGDFIPGLRVDGMDILCVREATRFAAAYCRSGKGPILMELQTYRYHGHSMSDPGVS
YRTREEIQEVRSKSDPIMLLKDRMVNSNLASVEELKEIDVEVRKEIEDAAQFATADPEPP
LEELGYHIYSSDPPFEVRGANQWIKFKSVS

Target 22 Number of Residues

390

Target 22 Molecular Weight

43295.3

Target 22 Theoretical pI

8.14

Target 22 GO Classification

Function
catalytic activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Process
physiological process metabolism
Component
Not Available

Target 22 General Function

Energy production and conversion

Target 22 Pathways

Not Available

Target 22 Reactions

Not Available

Target 22 Signals

None

Target 22 Transmembrane Regions

None

Target 22 Essentiality

Non Essential

Target 22 Domain Function

PF00676:E1_dh

Target 22 GenBank ID Protein

Not Available

Target 22 UniProtKB ID

P08559

Target 22 Cellular Location

Mitochondrion matrix

Target 22 Gene Sequence

>1173 bp

GCCTGTGCTTCATGAGGAAGATGCTCGCCGCCGTCTCCCGCGTGCTGTCTGGCGCTTCTC
AGAAGCCGGCAAGCAGAGTGCTGGTAGCATCCCGTAATTTTGCAAATGATGCTACATTTG
AAATTAAGAAATGTGACCTTCACCGGCTGGAAGAAGGCCCTCCTGTCACAACAGTGCTCA
CCAGGGAGGATGGGCTCAAATACTACAGGATGATGCAGACTGTACGCCGAATGGAGTTGA
AAGCAGATCAGCTGTATAAACAGAAAATTATTCGTGGTTTCTGTCACTTGTGTGATGGTC
AGGAAGCTTGCTGTGTGGGCCTGGAGGCCGGCATCAACCCCACAGACCATCTCATCACAG
CCTACCGGGCTCACGGCTTTACTTTCACCCGGGGCCTTTCCGTCCGAGAAATTCTCGCAG
AGCTTACAGGACGAAAAGGAGGTTGTGCTAAAGGGAAAGGAGGATCGATGCACATGTATG
CCAAGAACTTCTACGGGGGCAATGGCATCGTGGGAGCGCAGGTGCCCCTGGGCGCTGGGA
TTGCTCTAGCCTGTAAGTATAATGGAAAAGATGAGGTCTGCCTGACTTTATATGGCGATG
GTGCTGCTAACCAGGGCCAGATATTCGAAGCTTACAACATGGCAGCTTTGTGGAAATTAC
CTTGTATTTTCATCTGTGAGAATAATCGCTATGGAATGGGAACGTCTGTTGAGAGAGCGG
CAGCCAGCACTGATTACTACAAGAGAGGCGATTTCATTCCTGGGCTGAGAGTGGATGGAA
TGGATATCCTGTGCGTCCGAGAGGCAACAAGGTTTGCTGCTGCCTATTGTAGATCTGGGA
AGGGGCCCATCCTGATGGAGCTGCAGACTTACCGTTACCACGGACACAGTATGAGTGACC
CTGGAGTCAGTTACCGTACACGAGAAGAAATTCAGGAAGTAAGAAGTAAGAGTGACCCTA
TTATGCTTCTCAAGGACAGGATGGTGAACAGCAATCTTGCCAGTGTGGAAGAACTAAAGG
AAATTGATGTGGAAGTGAGGAAGGAGATTGAGGATGCTGCCCAGTTTGCCACGGCCGATC
CTGAGCCACCTTTGGAAGAGCTGGGCTACCACATCTACTCCAGCGACCCACCTTTTGAAG
TTCGTGGTGCCAATCAGTGGATCAAGTTTAAGT

Target 22 GenBank Gene ID

Not Available

Target 22 GeneCard ID

PDHA1

Target 22 GenAtlas ID

PDHA1

Target 22 HGNC ID

HGNC:8806

Target 22 Chromosome Location

Not Available

Target 22 Locus

Xp22.2-p22.1

Target 22 SNPs

SNPJam Report Link Image

Target 22 Toxin References

R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.

Target 22 General References

2227443; 2748588; 3034892; 2745444; 2828359; 3422424; 15489334; 10077682

Target 23 [top]

Target 23 ID

Target 23 Name

Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

Target 23 Mechanism of Action

Target 23 Description

Target 23 Synonyms

PDHE1-A type II

Target 23 Gene Name

PDHA2

Target 23 Protein Sequence

>Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

MLAAFISRVLRRVAQKSARRVLVASRNSSNDATFEIKKCDLYLLEEGPPVTTVLTRAEGL
KYYRMMLTVRRMELKADQLYKQKFIRGFCHLCDGQEACCVGLEAGINPSDHVITSYRAHG
VCYTRGLSVRSILAELTGRRGGCAKGKGGSMHMYTKNFYGGNGIVGAQGPLGAGIALACK
YKGNDEICLTLYGDGAANQGQIAEAFNMAALWKLPCVFICENNLYGMGTSTERAAASPDY
YKRGNFIPGLKVDGMDVLCVREATKFAANYCRSGKGPILMELQTYRYHGHSMSDPGVSYR
TREEIQEVRSKRDPIIILQDRMVNSKLATVEELKEIGAEVRKEIDDAAQFATTDPEPHLE
ELGHHIYSSDSSFEVRGANPWIKFKSVS

Target 23 Number of Residues

388

Target 23 Molecular Weight

42932.9

Target 23 Theoretical pI

8.56

Target 23 GO Classification

Function
catalytic activity oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Process
physiological process metabolism
Component
Not Available

Target 23 General Function

Energy production and conversion

Target 23 Pathways

Not Available

Target 23 Reactions

Not Available

Target 23 Signals

None

Target 23 Transmembrane Regions

None

Target 23 Essentiality

Non Essential

Target 23 Domain Function

PF00676:E1_dh

Target 23 GenBank ID Protein

Not Available

Target 23 UniProtKB ID

P29803

Target 23 Cellular Location

Mitochondrion matrix

Target 23 Gene Sequence

Not Available

Target 23 GenBank Gene ID

Not Available

Target 23 GeneCard ID

PDHA2

Target 23 GenAtlas ID

PDHA2

Target 23 HGNC ID

HGNC:8807

Target 23 Chromosome Location

Not Available

Target 23 Locus

4q22-q23

Target 23 SNPs

SNPJam Report Link Image

Target 23 Toxin References

R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.

Target 23 General References

2249846; 14702039; 15489334; 17081983; 18083107; 18088087; 18669648

Target 24 [top]

Target 24 ID

275

Target 24 Name

Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Target 24 Mechanism of Action

Target 24 Description

Target 24 Synonyms

PDHE1-B

Target 24 Gene Name

PDHB

Target 24 Protein Sequence

>Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

MAAVSGLVRRPLREVSGLLKRRFHWTAPAALQVTVRDAINQGMDEELERDEKVFLLGEEV
AQYDGAYKVSRGLWKKYGDKRIIDTPISEMGFAGIAVGAAMAGLRPICEFMTFNFSMQAI
DQVINSAAKTYYMSGGLQPVPIVFRGPNGASAGVAAQHSQCFAAWYGHCPGLKVVSPWNS
EDAKGLIKSAIRDNNPVVVLENELMYGVPFEFPPEAQSKDFLIPIGKAKIERQGTHITVV
SHSRPVGHCLEAAAVLSKEGVECEVINMRTIRPMDMETIEASVMKTNHLVTVEGGWPQFG
VGAEICARIMEGPAFNFLDAPAVRVTGADVPMPYAKILEDNSIPQVKDIIFAIKKTLNI

Target 24 Number of Residues

359

Target 24 Molecular Weight

39233.1

Target 24 Theoretical pI

6.63

Target 24 GO Classification

Function
Not Available
Process
Not Available
Component
Not Available

Target 24 General Function

Energy production and conversion

Target 24 Pathways

Not Available

Target 24 Reactions

Not Available

Target 24 Signals

None

Target 24 Transmembrane Regions

None

Target 24 Essentiality

Non Essential

Target 24 Domain Function

PF02779:Transket_pyr PF02780:Transketolase_C

Target 24 GenBank ID Protein

Not Available

Target 24 UniProtKB ID

P11177

Target 24 Cellular Location

Mitochondrion matrix

Target 24 Gene Sequence

>1080 bp

ATGGCGGCGGTGTCTGGCTTGGTGCGGAGACCCCTTCGGGAGGTCTCCGGGCTGCTGAAG
AGGCGCTTTCACTGGACCGCGCCGGCTGCGCTGCAGGTGACAGTTCGTGATGCTATAAAT
CAGGGTATGGATGAGGAGCTGGAAAGAGATGAGAAGGTATTTCTGCTTGGAGAAGAAGTT
GCCCAGTATGATGGGGCATACAAGGTTAGTCGAGGGCTGTGGAAGAAATATGGAGACAAG
AGGATTATTGACACTCCCATATCAGAGATGGGCTTTGCTGGAATTGCTGTAGGTGCAGCT
ATGGCTGGGTTGCGGCCCATTTGTGAATTTATGACCTTCAATTTCTCCATGCAAGCCATT
GACCAGGTTATAAACTCAGCTGCCAAGACCTACTACATGTCTGGTGGCCTTCAGCCTGTG
CCTATAGTCTTCAGGGGACCCAATGGTGCCTCAGCAGGTGTAGCTGCCCAGCACTCACAG
TGCTTTGCTGCCTGGTATGGGCACTGCCCAGGCTTAAAGGTGGTCAGTCCCTGGAATTCA
GAGGATGCTAAAGGACTTATTAAATCAGCCATTCGGGATAACAATCCAGTGGTGGTGCTA
GAGAATGAATTGATGTATGGGGTTCCTTTTGAATTTCCTCCGGAAGCTCAGTCAAAAGAT
TTTCTGATTCCTATTGGAAAAGCCAAAATAGAAAGGCAAGGAACACATATAACTGTGGTT
TCCCATTCAAGACCTGTGGGCCACTGCTTAGAAGCTGCAGCAGTGCTATCTAAAGAAGGA
GTTGAATGTGAGGTGATAAATATGCGTACCATTAGACCAATGGACATGGAAACCATAGAA
GCCAGTGTCATGAAGACAAATCATCTTGTAACTGTGGAAGGAGGCTGGCCACAGTTTGGA
GTAGGAGCTGAAATCTGTGCCAGGATCATGGAAGGTCCTGCGTTCAATTTCCTGGATGCT
CCTGCTGTTCGTGTCACTGGTGCTGATGTCCCTATGCCTTATGCAAAGATTCTAGAGGAC
AACTCTATACCTCAGGTCAAAGACATCATATTTGCAATAAAGAAAACATTAAATATTTAG

Target 24 GenBank Gene ID

Not Available

Target 24 GeneCard ID

PDHB

Target 24 GenAtlas ID

PDHB

Target 24 HGNC ID

HGNC:8808

Target 24 Chromosome Location

Not Available

Target 24 Locus

3p21.1-p14.2

Target 24 SNPs

SNPJam Report Link Image

Target 24 Toxin References

R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.

Target 24 General References

2323578; 1702713; 2376596; 2377599; 3422424; 11230166; 15489334; 2829898; 7895732

Target 25 [top]

Target 25 ID

274

Target 25 Name

Pyruvate dehydrogenase protein X component, mitochondrial

Target 25 Mechanism of Action

Target 25 Description

Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex

Target 25 Synonyms

Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex; Lipoyl-containing pyruvate dehydrogenase complex component X; E3-binding protein; E3BP; proX

Target 25 Gene Name

PDHX

Target 25 Protein Sequence

>Pyruvate dehydrogenase protein X component, mitochondrial

MAASWRLGCDPRLLRYLVGFPGRRSVGLVKGALGWSVSRGANWRWFHSTQWLRGDPIKIL
MPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVEEGSK
NIRLGSLIGLIVEEGEDWKHVEIPKDVGPPPPVSKPSEPRPSPEPQISIPVKKEHIPGTL
RFRLSPAARNILEKHSLDASQGTATGPRGIFTKEDALKLVQLKQTGKITESRPTPAPTAT
PTAPSPLQATAGPSYPRPVIPPVSTPGQPNAVGTFTEIPASNIRRVIAKRLTESKSTVPH
AYATADCDLGAVLKVRQDLVKDDIKVSVNDFIIKAAAVTLKQMPDVNVSWDGEGPKQLPF
IDISVAVATDKGLLTPIIKDAAAKGIQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL
GMFGIDEFTAVINPPQACILAVGRFRPVLKLTEDEEGNAKLQQRQLITVTMSSDSRVVDD
ELATRFLKSFKANLENPIRLA

Target 25 Number of Residues

501

Target 25 Molecular Weight

54121.8

Target 25 Theoretical pI

9.09

Target 25 GO Classification

Function
binding protein binding catalytic activity transferase activity transferase activity, transferring acyl groups transferase activity, transferring groups other than amino-acyl groups acyltransferase activity
Process
physiological process metabolism
Component
Not Available

Target 25 General Function

Energy production and conversion

Target 25 Pathways

Not Available

Target 25 Reactions

Not Available

Target 25 Signals

None

Target 25 Transmembrane Regions

None

Target 25 Essentiality

Non Essential

Target 25 Domain Function

PF00198:2-oxoacid_dh PF00364:Biotin_lipoyl PF02817:E3_binding

Target 25 GenBank ID Protein

Not Available

Target 25 UniProtKB ID

O00330

Target 25 Cellular Location

Mitochondrion matrix

Target 25 Gene Sequence

>1506 bp

ATGGCGGCCTCCTGGAGGCTGGGCTGTGATCCGCGGCTGCTGCGTTATCTTGTGGGCTTC
CCTGGCTGCCGAAGCGTAGGGCTGGTGAAGGGGGCTCTTGGGTGGTCCGTAAGCCGCGGA
GCTAATTGGAGATGGTTTCACAGCACGCAGTGGCTTCGGGGTGATCCCATTAAGATACTA
ATGCCATCACTGTCTCCTACAATGGAAGAAGGAAACATTGTGAAATGGCTGAAAAAGGAA
GGTGAAGCGGTGAGTGCTGGAGATGCATTATGTGAAATTGAGACTGACAAAGCTGTGGTT
ACCTTAGATGCAAGTGATGATGGAATCTTGGCCAAAATCGTGGTTGAAGAAGGAAGTAAA
AATATACGGCTAGGTTCACTAATTGGTTTGATAGTAGAAGAAGGAGAAGATTGGAAACAT
GTTGAAATTCCCAAAGACGTAGGTCCTCCACCACCAGTTTCAAAACCTTCAGAGCCTCGC
CCCTCACCAGAACCACAGATTTCCATCCCTGTCAAGAAGGAACACATACCCGGGACACTA
CGGTTCCGTTTAAGTCCAGCTGCCCGCAATATTCTGGAAAAACACTCACTGGATGCTAGC
CAGGGCACAGCCACTGGCCCTCGGGGGATATTCACTAAAGAGGATGCTCTCAAACTTGTC
CAGTTGAAACAAACGGGCAAGATTACCGAGTCCAGACCAACTCCAGCCCCCACAGCCACT
CCCACAGCACCTTCGCCCCTACAGGCCACATCTGGACCATCTTATCCCCGGCCTGTGATC
CCACCAGTATCAACTCCCGGACAACCCAATGCAGTGGGCACATTCACTGAAATCCCCGCC
AGCAATATTCGAAGAGTTATTGCCAAGAGATTAACTGAATCTAAAAGTACTGTACCTCAT
GCATATGCTACTGCTGACTGTGACCTTGGAGCTGTTTTAAAAGTTAGGCAAGATCTGGTC
AAAGATGACATTAAAGTATCAGTAAATGATTTTATCATCAAGGCAGCAGCTGTTACCCTT
AAACAAATGCCAGATGTTAATGTAAGCTGGGATGGAGAGGGCCCAAAGCAACTGCCATTT
ATTGACATTTCAGTGGCTGTGGCAACAGATAAAGGCTTACTTACTCCAATCATAAAAGAT
GCTGCTGCTAAAGGTATCCAGGAAATTGCTGACTCTGTAAAGGCTCTATCAAAGAAAGCA
AGAGATGGAAAATTGTTGCCTGAAGAATACCAAGGAGGATCTTTTAGTATTTCCAACTTG
GGGATGTTTGGCATCGACGAATTTACTGCAGTGATTAACCCTCCTCAGGCCTGCATTTTG
GCGGTTGGGAGGTTCCGACCTGTGCTGAAGCTCACTGAGGATGAAGAGGGAAATGCCAAA
CTGCAGCAGCGCCAGCTCATAACAGTCACAATGTCAAGTGACAGTCGAGTGGTTGATGAC
GAACTGGCAACCAGGTTTCTTAAAAGTTTTAAAGCAAACCTAGAGAATCCTATCCGACTT
GCCTAG

Target 25 GenBank Gene ID

Not Available

Target 25 GeneCard ID

PDHX

Target 25 GenAtlas ID

PDHX

Target 25 HGNC ID

HGNC:21350 Link Image

Target 25 Chromosome Location

Chromosome:11

Target 25 Locus

11p13

Target 25 SNPs

SNPJam Report Link Image

Target 25 Toxin References

R001 - Klaassen C and Watkins J (2003). Casarett and Doull's Essentials of Toxicology. New York, NY: McGraw-Hill.

Target 25 General References

9242632; 9399911; 9467010; 15489334; 9110174; 16263718; 16442803

Target 26 [top]

Target 26 ID

171

Target 26 Name

Thioredoxin reductase 1, cytoplasmic

Target 26 Mechanism of Action

Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)

Target 26 Description

Isoform 1 may possess glutaredoxin activity as well as thioredoxin reductase activity and induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4 enhances the transcriptional activity of estrogen receptors alpha and beta while isoform 5 enhances the transcriptional activity of the beta receptor only. Isoform 5 also mediates cell death induced by a combination of interferon-beta and retinoic acid

Target 26 Synonyms

TR; Thioredoxin reductase TR1; KM-102-derived reductase-like factor; Gene associated with retinoid-IFN-induced mortality 12 protein; GRIM-12

Target 26 Gene Name

TXNRD1

Target 26 Protein Sequence

>Thioredoxin reductase 1, cytoplasmic

MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQ
AYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDL
PVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKE
AAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKV
EETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEK
IYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLA
GIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVV
AQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIY
AIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKA
VEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQ
GFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG

Target 26 Number of Residues

649

Target 26 Molecular Weight

70905.6

Target 26 Theoretical pI

7.42

Target 26 GO Classification

Function
oxidoreductase activity, acting on NADH or NADPH oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor disulfide oxidoreductase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding FAD binding catalytic activity oxidoreductase activity transporter activity electron transporter activity
Process
homeostasis cell homeostasis cell redox homeostasis physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell intracellular cytoplasm

Target 26 General Function

Energy production and conversion

Target 26 Pathways

Not Available

Target 26 Reactions

Not Available

Target 26 Signals

None

Target 26 Transmembrane Regions

None

Target 26 Essentiality

Non Essential

Target 26 Domain Function

PF00462:Glutaredoxin PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim

Target 26 GenBank ID Protein

Not Available

Target 26 UniProtKB ID

Q16881

Target 26 Cellular Location

Isoform 5:Cytoplasm

Target 26 Gene Sequence

Not Available

Target 26 GenBank Gene ID

Not Available

Target 26 GeneCard ID

TXNRD1

Target 26 GenAtlas ID

TXNRD1

Target 26 HGNC ID

HGNC:12437 Link Image

Target 26 Chromosome Location

Chromosome:12

Target 26 Locus

12q23-q24.1

Target 26 SNPs

SNPJam Report Link Image

Target 26 Toxin References

R009 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 26 General References

7589432; 8999974; 9774665; 14980707; 15489334

Target 27 [top]

Target 27 ID

229

Target 27 Name

Thioredoxin reductase 2, mitochondrial

Target 27 Mechanism of Action

Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)

Target 27 Description

Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling

Target 27 Synonyms

Thioredoxin reductase TR3; TR-beta; Selenoprotein Z; SelZ

Target 27 Gene Name

TXNRD2

Target 27 Protein Sequence

>Thioredoxin reductase 2, mitochondrial

MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAAGQRDYDLLVVGGGSGGLACAKEAAQ
LGRKVAVVDYVEPSPQGTRWGLGGTCVNVGCIPKKLMHQAALLGGLIQDAPNYGWEVAQP
VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKASFVDEHTVCGVAKGGKEILLS
ADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPGKTLVVGASYVALECAGFLTGI
GLDTTIMMRSIPLRGFDQQMSSMVIEHMASHGTRFLRGCAPSRVRRLPDGQLQVTWEDST
TGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSPDTQKILVDSREATSVPHIYAIGDV
VEGRPELTPIAIMAGRLLVQRLFGGSSDLMDYDNVPTTVFTPLEYGCVGLSEEEAVARHG
QEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCLREPPQLVLGLHFLGPNAGEVTQGFALG
IKCGASYAQVMRTVGIHPTCSEEVVKLRISKRSGLDPTVTGCUG

Target 27 Number of Residues

524

Target 27 Molecular Weight

56506.3

Target 27 Theoretical pI

7.55

Target 27 GO Classification

Function
oxidoreductase activity, acting on NADH or NADPH oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor disulfide oxidoreductase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding FAD binding catalytic activity oxidoreductase activity
Process
physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell intracellular cytoplasm

Target 27 General Function

Energy production and conversion

Target 27 Pathways

Not Available

Target 27 Reactions

Not Available

Target 27 Signals

None

Target 27 Transmembrane Regions

None

Target 27 Essentiality

Non Essential

Target 27 Domain Function

PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim

Target 27 GenBank ID Protein

Not Available

Target 27 UniProtKB ID

Q9NNW7

Target 27 Cellular Location

Mitochondrion

Target 27 Gene Sequence

>1575 bp

ATGGCGGCAATGGCGGTGGCGCTGCGGGGATTAGGAGGGCGCTTCCGGTGGCGGACGCAG
GCCGTGGCGGGCGGGGTGCGGGGCGCGGCGCGGGGCGCAGCAGCAGGTCAGCGGGACTAT
GATCTCCTGGTGGTCGGCGGGGGATCTGGTGGCCTGGCTTGTGCCAAGGAGGCCGCCCAG
CTGGGAAGGAAGGTGGCCGTGGTGGACTACGTGGAACCTTCTCCCCAAGGCACCCGGTGG
GGCCTCGGCGGCACCTGCGTCAACGTGGGCTGCATCCCCAAGAAGCTGATGCACCAGGCG
GCACTGCTGGGAGGCCTGATCCAAGATGCCCCCAACTATGGCTGGGAGGTGGCCCAGCCC
GTGCCGCATGACTGGAGGAAGATGGCAGAAGCTGTTCAAAATCACGTGAAATCCTTGAAC
TGGGGCCACCGTGTCCAGCTTCAGGACAGAAAAGTCAAGTACTTTAACATCAAAGCCAGC
TTTGTTGACGAGCACACGGTTTGCGGCGTTGCCAAAGGTGGGAAAGAGATTCTGCTGTCA
GCCGATCACATCATCATTGCTACTGGAGGGCGGCCGAGATACCCCACGCACATCGAAGGT
GCCTTGGAATATGGAATCACAAGTGATGACATCTTCTGGCTGAAGGAATCCCCTGGAAAA
ACGTTGGTGGTCGGGGCCAGCTATGTGGCCCTGGAGTGTGCTGGCTTCCTCACCGGGATT
GGGCTGGACACCACCATCATGATGCGCAGCATCCCCCTCCGCGGCTTCGACCAGCAAATG
TCCTCCATGGTCATAGAGCACATGGCATCTCATGGCACCCGGTTCCTGAGGGGCTGTGCC
CCCTCGCGGGTCAGGAGGCTCCCTGATGGCCAGCTGCAGGTCACCTGGGAGGACAGCACC
ACCGGCAAGGAGGACACGGGCACCTTTGACACCGTCCTGTGGGCCATAGGTCGAGTCCCA
GACACCAGAAGTCTGAATTTGGAGAAGGCTGGGGTAGATACTAGCCCCGACACTCAGAAG
ATCCTGGTGGACTCCCGGGAAGCCACCTCTGTGCCCCACATCTACGCCATTGGTGACGTG
GTGGAGGGGCGGCCTGAGCTGACACCCATAGCGATCATGGCCGGGAGGCTCCTGGTGCAG
CGGCTCTTCGGCGGGTCCTCAGATCTGATGGACTACGACAATGTTCCCACGACCGTCTTC
ACCCCGCTGGAGTATGGCTGTGTGGGGCTGTCCGAGGAGGAGGCAGTGGCTCGCCACGGG
CAGGAGCATGTTGAGGTCTATCACGCCCATTATAAACCACTGGAGTTCACGGTGGCTGGA
CGAGATGCATCCCAGTGTTATGTAAAGATGGTGTGCCTGAGGGAGCCCCCACAGCTGGTG
CTGGGCCTGCATTTCCTTGGCCCCAACGCAGGCGAAGTTACTCAAGGATTTGCTCTGGGG
ATCAAGTGTGGGGCTTCCTATGCGCAGGTGATGCGGACCGTGGGTATCCATCCCACATGC
TCTGAGGAGGTAGTCAAGCTGCGCATCTCCAAGCGCTCAGGCCTGGACCCCACGGTGACA
GGCTGCTGAGGGTAA

Target 27 GenBank Gene ID

Not Available

Target 27 GeneCard ID

TXNRD2

Target 27 GenAtlas ID

TXNRD2

Target 27 HGNC ID

HGNC:18155 Link Image

Target 27 Chromosome Location

Chromosome:22

Target 27 Locus

22q11.21

Target 27 SNPs

SNPJam Report Link Image

Target 27 Toxin References

R009 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 27 General References

10455115; 9923614; 10215850; 10608886; 10591208; 15489334; 11060283

Target 28 [top]

Target 28 ID

Target 28 Name

Thioredoxin reductase 3

Target 28 Mechanism of Action

Arsenic binds thioredoxin reductase, which results in the inhibition of essential biochemical reactions, alteration of cellular redox status, and eventual cytotoxicity. (R009)

Target 28 Description

Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity)

Target 28 Synonyms

Thioredoxin reductase TR2; Thioredoxin and glutathione reductase

Target 28 Gene Name

TXNRD3

Target 28 Protein Sequence

>Thioredoxin reductase 3

MGHVHRLVSGKRRMHLTSRPVASTHSPLILDMCPHLNNGPMTGCGRAGDPISHARGGAGG
RGERLPRGFARVVRVASEGSVRRPSGPVPAPQPPAFRFVSRPGRARSESETLERSPPQSP
GPGKAGDAPNRRSGHVRGARVLSPPGRRARLSSPGPSRSSEAREELRRHLVGLIERSRVV
IFSKSYCPHSTRVKELFSSLGVECNVLELDQVDDGARVQEVLSEITNQKTVPNIFVNKVH
VGGCDQTFQAYQSGLLQKLLQEDLAYDYDLIIIGGGSGGLSCAKEAAILGKKVMVLDFVV
PSPQGTSWGLGGTCVNVGCIPKKLMHQAALLGQALCDSRKFGWEYNQQVRHNWETMTKAI
QNHISSLNWGYRLSLREKAVAYVNSYGEFVEHHKIKATNKKGQETYYTAAQFVIATGERP
RYLGIQGDKEYCITSDDLFSLPYCPGKTLVVGASYVALECAGFLAGFGLDVTVMVRSILL
RGFDQEMAEKVGSYMEQHGVKFLRKFIPVMVQQLEKGSPGKLKVLAKSTEGTETIEGVYN
TVLLAIGRDSCTRKIGLEKIGVKINEKSGKIPVNDVEQTNVPYVYAVGDILEDKPELTPV
AIQSGKLLAQRLFGASLEKCDYINVPTTVFTPLEYGCCGLSEEKAIEVYKKENLEIYHTL
FWPLEWTVAGRENNTCYAKIICNKFDHDRVIGFHILGPNAGEVTQGFAAAMKCGLTKQLL
DDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG

Target 28 Number of Residues

754

Target 28 Molecular Weight

82463.9

Target 28 Theoretical pI

8.80

Target 28 GO Classification

Function
oxidoreductase activity, acting on NADH or NADPH oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor disulfide oxidoreductase activity binding nucleotide binding purine nucleotide binding adenyl nucleotide binding FAD binding catalytic activity oxidoreductase activity transporter activity electron transporter activity
Process
homeostasis cell homeostasis cell redox homeostasis physiological process metabolism cellular metabolism generation of precursor metabolites and energy electron transport
Component
cell intracellular cytoplasm

Target 28 General Function

Energy production and conversion

Target 28 Pathways

Not Available

Target 28 Reactions

Not Available

Target 28 Signals

None

Target 28 Transmembrane Regions

None

Target 28 Essentiality

Non Essential

Target 28 Domain Function

PF00462:Glutaredoxin PF00070:Pyr_redox PF07992:Pyr_redox_2 PF02852:Pyr_redox_dim

Target 28 GenBank ID Protein

Not Available

Target 28 UniProtKB ID

Q86VQ6

Target 28 Cellular Location

Cytoplasm (By similarity). Nucleus (By similarity). Microsome (By similarity). Endoplasmic reticulum (By similarity)

Target 28 Gene Sequence

Not Available

Target 28 GenBank Gene ID

Not Available

Target 28 GeneCard ID

TXNRD3

Target 28 GenAtlas ID

TXNRD3

Target 28 HGNC ID

HGNC:20667 Link Image

Target 28 Chromosome Location

Not Available

Target 28 Locus

3q21.3

Target 28 SNPs

SNPJam Report Link Image

Target 28 Toxin References

R009 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for arsenic. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).

Target 28 General References

16641997; 15489334; 10455115; 18669648

Target 29 [top]

Target 29 ID

399

Target 29 Name

Tubulin alpha chain-like 3

Target 29 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 29 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 29 Synonyms

Not Available

Target 29 Gene Name

TUBAL3

Target 29 Protein Sequence

>Tubulin alpha chain-like 3

MRECLSIHIGQAGIQIGDACWELYCLEHGIQPNGVVLDTQQDQLENAKMEHTNASFDTFF
CETRAGKHVPRALFVDLEPTVIDGIRTGQHRSLFHPEQLLSGKEDAANNYARGRYSVGSE
VIDLVLERTRKLAEQCGGLQGFLIFRSFGGGTGSGFTSLLMERLTGEYSRKTKLEFSVYP
APRISTAVVEPYNSVLTTHSTTEHTDCTFMVDNEAVYDICHRKLGVECPSHASINRLVVQ
VVSSITASLRFEGPLNVDLIEFQTNLVPYPRIHFPMTAFAPIVSADKAYHEQFSVSDITT
ACFESSNQLVKCDPRLGKYMACCLLYRGDVVPKEVNAAIAATKSRHSVQFVDWCPTGFKV
GINNRPPTVMPGGDLAKVHRSICMLSNTTAIVEAWARLDHKFDLMYAKRAFLHWYLREGM
EEAEFLEAREDLAALERDYEEVAQSF

Target 29 Number of Residues

446

Target 29 Molecular Weight

49908.3

Target 29 Theoretical pI

5.96

Target 29 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 29 General Function

Involved in GTP binding

Target 29 Pathways

Not Available

Target 29 Reactions

Not Available

Target 29 Signals

None

Target 29 Transmembrane Regions

None

Target 29 Essentiality

Non Essential

Target 29 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 29 GenBank ID Protein

Not Available

Target 29 UniProtKB ID

A6NHL2

Target 29 Cellular Location

Cytoplasmic

Target 29 Gene Sequence

>1341 bp

ATGAGGGAGTGCCTTTCCATCCACATCGGTCAAGCTGGCATCCAGATTGGGGACGCCTGC
TGGGAACTCTATTGCCTGGAACATGGAATCCAGCCAAATGGCGTTGTTCTTGACACTCAA
CAGGATCAGCTGGAAAATGCAAAAATGGAGCACACAAATGCATCTTTCGATACCTTCTTC
TGTGAGACAAGAGCTGGGAAGCATGTGCCTAGAGCACTCTTCGTGGACTTGGAGCCAACT
GTTATAGATGGGATCCGGACGGGCCAGCACCGTTCACTCTTCCACCCCGAGCAGCTCCTT
AGCGGAAAGGAGGATGCTGCCAACAATTACGCGCGAGGCCGTTACTCTGTGGGGTCGGAG
GTCATCGACCTTGTGCTGGAGAGGACCCGGAAGCTGGCAGAACAGTGTGGTGGACTTCAG
GGATTTTTGATTTTCCGAAGCTTTGGAGGAGGCACTGGTTCAGGGTTTACGTCTCTCTTA
ATGGAGAGGCTCACAGGAGAATATAGCAGAAAGACTAAGCTGGAGTTCTCGGTCTACCCA
GCCCCCAGGATCTCCACTGCCGTGGTAGAGCCTTATAACTCTGTCCTCACCACCCACTCC
ACCACAGAGCACACGGACTGTACCTTCATGGTGGACAACGAGGCCGTCTATGATATATGC
CATCGTAAACTCGGTGTTGAATGCCCCTCTCATGCCAGCATCAATAGATTGGTGGTTCAG
GTGGTATCTTCCATCACTGCCTCCCTCCGGTTTGAAGGGCCCTTGAATGTAGACCTAATT
GAATTCCAGACCAACCTGGTACCTTATCCGAGAATACATTTCCCCATGACAGCCTTCGCC
CCCATCGTCTCTGCTGACAAAGCCTACCATGAGCAGTTCTCTGTGTCAGACATCACCACT
GCTTGCTTTGAGTCCTCCAACCAGCTGGTCAAGTGTGATCCTCGGCTTGGGAAGTACATG
GCCTGCTGCCTACTCTATAGAGGGGATGTGGTCCCCAAGGAAGTGAATGCAGCAATCGCA
GCCACGAAGTCGAGGCACTCTGTTCAGTTTGTAGATTGGTGTCCAACTGGTTTCAAGGTG
GGCATCAACAATCGGCCGCCCACGGTGATGCCGGGTGGGGACCTGGCCAAAGTCCACCGG
TCCATCTGCATGCTGAGCAACACCACGGCGATTGTGGAGGCCTGGGCCCGCCTGGACCAC
AAGTTTGACCTCATGTACGCCAAGAGAGCATTTCTGCACTGGTACCTCAGAGAAGGCATG
GAAGAAGCAGAGTTCTTGGAGGCCAGGGAAGATCTGGCAGCCCTGGAGAGGGACTATGAG
GAAGTGGCGCAAAGTTTCTGA

Target 29 GenBank Gene ID

Not Available

Target 29 GeneCard ID

TUBAL3

Target 29 GenAtlas ID

TUBAL3

Target 29 HGNC ID

HGNC:23534 Link Image

Target 29 Chromosome Location

Chromosome:10

Target 29 Locus

10p15.1

Target 29 SNPs

SNPJam Report Link Image

Target 29 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 29 General References

14702039; 15164054; 15489334; 17924679

Target 30 [top]

Target 30 ID

Target 30 Name

Tubulin alpha-1A chain

Target 30 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 30 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 30 Synonyms

Tubulin B-alpha-1; Tubulin alpha-3 chain; Alpha-tubulin 3

Target 30 Gene Name

TUBA1A

Target 30 Protein Sequence

>Tubulin alpha-1A chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Target 30 Number of Residues

451

Target 30 Molecular Weight

50135.2

Target 30 Theoretical pI

4.70

Target 30 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 30 General Function

Involved in GTP binding

Target 30 Pathways

Not Available

Target 30 Reactions

Not Available

Target 30 Signals

None

Target 30 Transmembrane Regions

None

Target 30 Essentiality

Non Essential

Target 30 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 30 GenBank ID Protein

Not Available

Target 30 UniProtKB ID

Q71U36

Target 30 Cellular Location

Cytoplasmic

Target 30 Gene Sequence

>1356 bp

ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAGACGGGGGCTGGCAAG
CATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAACTTATCACAGGCAAAGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTCGTGTTGGAC
CGAATTCGCAAGCTGGCCGACCAGTGCACGGGTCTCCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCGCTGCTCATGGAACGTCTCTCAGTTGAT
TATGGCAAGAAGTCCAAGCTGGAGTTCTCTATTTACCCGGCGCCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATTGAG
CGTCCAACCTATACTAACCTGAATAGGTTAATAGGTCAAATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTG
CCCTATCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTTCTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAGACCAAGCGTACC
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCC
ACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAC
ACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAACGTGCCTTTGTTCACTGGTACGTTGGGGAGGGGATGGAGGAAGGTGAGTTTTCAGAG
GCCCGTGAGGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTT
GAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAA

Target 30 GenBank Gene ID

Not Available

Target 30 GeneCard ID

TUBA1A

Target 30 GenAtlas ID

TUBA1A

Target 30 HGNC ID

HGNC:20766 Link Image

Target 30 Chromosome Location

Chromosome:12

Target 30 Locus

12q12-q14.3

Target 30 SNPs

SNPJam Report Link Image

Target 30 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 30 General References

3839072; 11504633; 15489334; 6646120; 17081983; 17584854; 18669648; 19524510

Target 31 [top]

Target 31 ID

223

Target 31 Name

Tubulin alpha-1B chain

Target 31 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 31 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 31 Synonyms

Tubulin alpha-ubiquitous chain; Alpha-tubulin ubiquitous; Tubulin K-alpha-1

Target 31 Gene Name

TUBA1B

Target 31 Protein Sequence

>Tubulin alpha-1B chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGVDSVEGEGEEEGEEY

Target 31 Number of Residues

451

Target 31 Molecular Weight

50151.2

Target 31 Theoretical pI

4.70

Target 31 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 31 General Function

Involved in GTP binding

Target 31 Pathways

Not Available

Target 31 Reactions

Not Available

Target 31 Signals

None

Target 31 Transmembrane Regions

None

Target 31 Essentiality

Non Essential

Target 31 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 31 GenBank ID Protein

Not Available

Target 31 UniProtKB ID

P68363

Target 31 Cellular Location

Cytoplasmic

Target 31 Gene Sequence

>1356 bp

ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGACTCCTTCAACACCTTCTTCAGTGAGACGGGCGCTGGCAAG
CACGTGCCCCGGGCTGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTTGTGTTGGAC
CGAATTCGCAAGCTGGCTGACCAGTGCACCCGTCTTCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCCCTGCTCATGGAACGCCTGTCAGTTGAT
TATGGCAAGAAATCCAAGCTGGAGTTCTCCATTTACCCGGCACCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAG
CGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTC
CCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTTCTGTAGCAGACATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTGGCCATGGTAAATACATGGCTTGCTGCCTGTTGTACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGCACG
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATCAACTACCAGCCTCCC
ACTGTGGTGCCTGGTGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAC
ACCACAGCCATTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAG
GCCCGTGAAGATATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGTGTGGATTCTGTT
GAAGGAGAGGGTGAGGAAGAAGGAGAGGAATACTAA

Target 31 GenBank Gene ID

Not Available

Target 31 GeneCard ID

TUBA1B

Target 31 GenAtlas ID

TUBA1B

Target 31 HGNC ID

HGNC:18809 Link Image

Target 31 Chromosome Location

Chromosome:12

Target 31 Locus

12q13.12

Target 31 SNPs

SNPJam Report Link Image

Target 31 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 31 General References

6646120; 15489334; 8619814; 15592455; 19007248; 18781797

Target 32 [top]

Target 32 ID

145

Target 32 Name

Tubulin alpha-1C chain

Target 32 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 32 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 32 Synonyms

Tubulin alpha-6 chain; Alpha-tubulin 6

Target 32 Gene Name

TUBA1C

Target 32 Protein Sequence

>Tubulin alpha-1C chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLD
RIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLTVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAVAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGADSADGEDEGEEY

Target 32 Number of Residues

449

Target 32 Molecular Weight

49894.9

Target 32 Theoretical pI

4.73

Target 32 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 32 General Function

Involved in GTP binding

Target 32 Pathways

Not Available

Target 32 Reactions

Not Available

Target 32 Signals

None

Target 32 Transmembrane Regions

None

Target 32 Essentiality

Non Essential

Target 32 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 32 GenBank ID Protein

Not Available

Target 32 UniProtKB ID

Q9BQE3

Target 32 Cellular Location

Cytoplasmic

Target 32 Gene Sequence

>1350 bp

ATGCGTGAGTGCATCTCCATCCACGTTGGCCAGGCTGGTGTCCAGATTGGCAATGCCTGC
TGGGAGCTCTACTGCCTGGAACACGGCATCCAGCCCGATGGCCAGATGCCAAGTGACAAG
ACCATTGGGGGAGGAGATGATTCCTTCAACACCTTCTTCAGTGAAACGGGTGCTGGCAAG
CATGTGCCCCGGGCAGTGTTTGTAGACTTGGAACCCACAGTCATTGATGAAGTTCGCACT
GGCACCTACCGCCAGCTCTTCCACCCTGAGCAGCTCATCACAGGCAAGGAAGATGCTGCC
AATAACTATGCCCGAGGGCACTACACCATTGGCAAGGAGATCATTGACCTCGTGTTGGAC
CGAATTCGCAAGCTGGCTGACCAGTGCACCGGTCTTCAGGGCTTCTTGGTTTTCCACAGC
TTTGGTGGGGGAACTGGTTCTGGGTTCACCTCGCTGCTCATGGAACGTCTCTCAGTTGAT
TATGGCAAGAAGTCCAAGCTGGAGTTCTCTATTTACCCGGCGCCCCAGGTTTCCACAGCT
GTAGTTGAGCCCTACAACTCCATCCTCACCACCCACACCACCCTGGAGCACTCTGATTGT
GCCTTCATGGTAGACAATGAGGCCATCTATGACATCTGTCGTAGAAACCTCGATATCGAG
CGCCCAACCTACACTAACCTTAACCGCCTTATTAGCCAGATTGTGTCCTCCATCACTGCT
TCCCTGAGATTTGATGGAGCCCTGAATGTTGACCTGACAGAATTCCAGACCAACCTGGTG
CCCTACCCCCGCATCCACTTCCCTCTGGCCACATATGCCCCTGTCATCTCTGCTGAGAAA
GCCTACCATGAACAGCTTACTGTAGCAGAGATCACCAATGCTTGCTTTGAGCCAGCCAAC
CAGATGGTGAAATGTGACCCTCGCCATGGTAAATACATGGCTTGCTGCCTGTTATACCGT
GGTGACGTGGTTCCCAAAGATGTCAATGCTGCCATTGCCACCATCAAAACCAAGCGTACC
ATCCAGTTTGTGGATTGGTGCCCCACTGGCTTCAAGGTTGGCATTAATTACCAGCCTCCC
ACTGTGGTGCCTGGCGGAGACCTGGCCAAGGTACAGAGAGCTGTGTGCATGCTGAGCAAT
ACCACAGCTGTTGCTGAGGCCTGGGCTCGCCTGGACCACAAGTTTGACCTGATGTATGCC
AAGCGTGCCTTTGTTCACTGGTACGTGGGTGAGGGGATGGAGGAAGGCGAGTTTTCAGAG
GCCCGTGAGGACATGGCTGCCCTTGAGAAGGATTATGAGGAGGTTGGAGCAGATAGTGCT
GACGGAGAGGATGAGGGTGAAGAGTATTAA

Target 32 GenBank Gene ID

Not Available

Target 32 GeneCard ID

TUBA1C

Target 32 GenAtlas ID

TUBA1C

Target 32 HGNC ID

HGNC:20768 Link Image

Target 32 Chromosome Location

Chromosome:12

Target 32 Locus

12q12-q14

Target 32 SNPs

SNPJam Report Link Image

Target 32 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 32 General References

15489334; 15592455; 17081983; 19007248; 18691976; 18669648; 19524510

Target 33 [top]

Target 33 ID

147

Target 33 Name

Tubulin alpha-3C/D chain

Target 33 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 33 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 33 Synonyms

Alpha-tubulin 3C/D; Tubulin alpha-2 chain; Alpha-tubulin 2

Target 33 Gene Name

TUBA3C

Target 33 Protein Sequence

>Tubulin alpha-3C/D chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGVDSVEAEAEEGEEY

Target 33 Number of Residues

450

Target 33 Molecular Weight

49959.1

Target 33 Theoretical pI

4.74

Target 33 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 33 General Function

Involved in GTP binding

Target 33 Pathways

Not Available

Target 33 Reactions

Not Available

Target 33 Signals

None

Target 33 Transmembrane Regions

None

Target 33 Essentiality

Non Essential

Target 33 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 33 GenBank ID Protein

Not Available

Target 33 UniProtKB ID

Q13748

Target 33 Cellular Location

Cytoplasmic

Target 33 Gene Sequence

>1257 bp

ATGCGTGAGTGTATCTCTATCCACGTGGGGCAGGCAGGAGTCCAGATCGGCAATGCCTGC
TGGGAACTGTACTGCCTGGAACATGGAATTCAGCCCGATGGTCAGATGCCAAGTGATAAA
ACCATTGGTGGTGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAG
CACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACA
GGAACCTATAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCGGCC
AATAATTACGCCAGAGGCCATTACACCATCGGCAAGGAGATCGTCGACCTGGTCCTGGAC
CGGATCCGCAAACTGGCGGATCTGTGCACGGGACTGCAGGGCTTCCTCATCTTCCACAGT
TTTGGGGGTGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGAT
TACGGCAAGAAGTCCAAGCTAGAATTTGCCATTTACCCAGCCCCCCAGGTCTCCACGGCC
GTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACGACCCTGGAACATTCTGACTGT
GCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATCGAG
CGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCC
TCCCTGCGATTTGACGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTAGTG
CCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCGGTCATCTCAGCCGAGAAG
GCCTACCACGAGCAGCTGTCCGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAAT
CAGATGGTCAAGTGTGACCCTCGCCACGGCAAGTACATGGCCTGCTGCATGTTGTACAGG
GGGGATGTGGTCCCGAAAGATGTCAACGCGGCCATCGCCACCATCAAGACCAAGCGCACC
ATCCAGTTTGTAGATTGGTGCCCAACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCC
ACGGTGGTCCCTGGGGGAGACCTGGCCAAGGTGCAGCGGGCTGTGTGCATGCTGAGCAAC
ACCACGGCCATCGCGGAGGCCTGGGCTCGCCTGGACCTGGCAGCTCTGGAGAAGGATTAT
GAAGAGGTGGGCGTGGATTCCGTGGAAGCCGAGGCTGAAGAAGGTGAAGAATACTGA

Target 33 GenBank Gene ID

Not Available

Target 33 GeneCard ID

TUBA3C

Target 33 GenAtlas ID

TUBA3C

Target 33 HGNC ID

HGNC:12408 Link Image

Target 33 Chromosome Location

Chromosome:13

Target 33 Locus

13q11

Target 33 SNPs

SNPJam Report Link Image

Target 33 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 33 General References

9465305; 15057823; 15489334; 17924679; 19524510

Target 34 [top]

Target 34 ID

Target 34 Name

Tubulin alpha-3E chain

Target 34 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 34 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 34 Synonyms

Alpha-tubulin 3E

Target 34 Gene Name

TUBA3E

Target 34 Protein Sequence

>Tubulin alpha-3E chain

MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAASNYARGHYTIGKEIVDLVLD
RIRKLADLCTGLQGFLIFHSFGGGTGSGFASLLMERLSVDYSKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLIGQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLVHKFDLMYAKWAFVHWYVGEGMEEGEFSE
AREDLAALEKDCEEVGVDSVEAEAEEGEAY

Target 34 Number of Residues

450

Target 34 Molecular Weight

49858.1

Target 34 Theoretical pI

4.77

Target 34 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 34 General Function

Involved in GTP binding

Target 34 Pathways

Not Available

Target 34 Reactions

Not Available

Target 34 Signals

None

Target 34 Transmembrane Regions

None

Target 34 Essentiality

Non Essential

Target 34 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 34 GenBank ID Protein

Not Available

Target 34 UniProtKB ID

Q6PEY2

Target 34 Cellular Location

Cytoplasmic

Target 34 Gene Sequence

>1353 bp

ATGCGCGAGTGTATCTCTATCCACGTGGGGCAGGCGGGTGTCCAGATCGGCAATGCCTGC
TGGGAACTGTACTGCCTTGAACATGGAATTCAGCCCGATGGTCAAATGCCAAGTGATAAA
ACCATTGGTGGCGGGGACGACTCCTTCAACACGTTCTTCAGTGAGACTGGAGCTGGCAAG
CACGTGCCCAGAGCAGTGTTTGTGGACCTGGAGCCCACTGTGGTCGATGAAGTGCGCACA
GGGACCTACAGGCAGCTCTTCCACCCAGAGCAGCTGATCACCGGGAAGGAAGATGCAGCC
AGTAATTACGCCAGGGGCCATTACACCATCGGCAAGGAGATTGTTGACCTAGTCCTGGAC
CGGATCCGCAAACTGGCGGATCTGTGCACAGGACTGCAGGGCTTCCTCATCTTCCACAGC
TTTGGGGGCGGCACTGGCTCTGGGTTCGCATCTCTGCTCATGGAGCGGCTCTCAGTGGAT
TACAGCAAGAAGTCCAAGCTAGAGTTTGCCATTTACCCAGCCCCCCAGGTCTCCACAGCC
GTGGTGGAGCCCTACAACTCCATCCTAACCACCCACACGACCCTGGAACATTCTGACTGT
GCCTTCATGGTCGACAATGAAGCCATCTATGACATATGTCGGCGCAACCTGGACATTGAA
CGTCCCACGTACACCAACCTCAATCGCCTGATTGGGCAGATCGTGTCCTCCATCACGGCC
TCCCTGCGATTTGATGGGGCCCTGAATGTGGACTTGACGGAATTCCAGACCAACCTCGTG
CCGTACCCCCGCATCCACTTCCCCCTGGCCACCTACGCCCCAGTCATCTCAGCTGAGAAG
GCCTACCATGAGCAGCTGTCTGTGGCTGAGATCACCAATGCCTGCTTCGAGCCAGCCAAT
CAGATGGTCAAGTGTGACCCTCGCCATGGCAAGTACATGGCCTGCTGCATGTTGTACAGG
GGGGACGTGGTCCCCAAAGACGTCAATGCGGCCATCGCCACCATCAAGACCAAGCGCACT
ATCCAGTTTGTGGATTGGTGCCCGACTGGATTTAAGGTGGGCATTAACTACCAGCCCCCC
ACAGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTGTGCATGCTGAGCAAC
ACCACGGCCATTGCGGAGGCCTGGGCCCGCCTGGTCCATAAGTTCGATCTCATGTATGCC
AAGTGGGCCTTTGTGCACTGGTACGTGGGCGAAGGCATGGAAGAGGGAGAGTTCTCTGAG
GCCCGCGAGGACCTGGCAGCTCTAGAGAAGGATTGTGAAGAGGTGGGCGTGGATTCCGTG
GAAGCTGAGGCTGAAGAAGGCGAAGAATACTGA

Target 34 GenBank Gene ID

Not Available

Target 34 GeneCard ID

TUBA3E

Target 34 GenAtlas ID

TUBA3E

Target 34 HGNC ID

HGNC:20765 Link Image

Target 34 Chromosome Location

Not Available

Target 34 Locus

2q21.1

Target 34 SNPs

SNPJam Report Link Image

Target 34 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 34 General References

15815621; 15489334; 16565220; 19524510

Target 35 [top]

Target 35 ID

Target 35 Name

Tubulin alpha-4A chain

Target 35 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 35 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 35 Synonyms

Tubulin alpha-1 chain; Alpha-tubulin 1; Testis-specific alpha-tubulin; Tubulin H2-alpha

Target 35 Gene Name

TUBA4A

Target 35 Protein Sequence

>Tubulin alpha-4A chain

MRECISVHVGQAGVQMGNACWELYCLEHGIQPDGQMPSDKTIGGGDDSFTTFFCETGAGK
HVPRAVFVDLEPTVIDEIRNGPYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDPVLD
RIRKLSDQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPAN
QMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIAAIKTKRSIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDMAALEKDYEEVGIDSYEDEDEGEE

Target 35 Number of Residues

448

Target 35 Molecular Weight

49924.0

Target 35 Theoretical pI

4.69

Target 35 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 35 General Function

Involved in GTP binding

Target 35 Pathways

Not Available

Target 35 Reactions

Not Available

Target 35 Signals

None

Target 35 Transmembrane Regions

None

Target 35 Essentiality

Non Essential

Target 35 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 35 GenBank ID Protein

Not Available

Target 35 UniProtKB ID

P68366

Target 35 Cellular Location

Cytoplasmic

Target 35 Gene Sequence

Not Available

Target 35 GenBank Gene ID

Not Available

Target 35 GeneCard ID

TUBA4A

Target 35 GenAtlas ID

TUBA4A

Target 35 HGNC ID

HGNC:12407 Link Image

Target 35 Chromosome Location

Not Available

Target 35 Locus

2q35

Target 35 SNPs

SNPJam Report Link Image

Target 35 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 35 General References

3029670; 15489334; 15592455; 17924679; 18088087; 18691976; 18669648

Target 36 [top]

Target 36 ID

134

Target 36 Name

Tubulin alpha-8 chain

Target 36 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 36 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 36 Synonyms

Alpha-tubulin 8; Tubulin alpha chain-like 2

Target 36 Gene Name

TUBA8

Target 36 Protein Sequence

>Tubulin alpha-8 chain

MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGK
HVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLD
RIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTA
VVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITA
SLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNS
QMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGTDSFEEENEGEEF

Target 36 Number of Residues

449

Target 36 Molecular Weight

50093.1

Target 36 Theoretical pI

4.70

Target 36 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 36 General Function

Involved in GTP binding

Target 36 Pathways

Not Available

Target 36 Reactions

Not Available

Target 36 Signals

None

Target 36 Transmembrane Regions

None

Target 36 Essentiality

Non Essential

Target 36 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 36 GenBank ID Protein

Not Available

Target 36 UniProtKB ID

Q9NY65

Target 36 Cellular Location

Cytoplasmic

Target 36 Gene Sequence

>1350 bp

ATGCGGGAATGCATATCAGTCCACGTGGGCCAAGCGGGAGTTCAGATTGGCAATGCCTGC
TGGGAGCTCTTCTGCCTGGAACACGGCATCCAGGCAGACGGCACTTTTGATGCTCAAGCT
AGCAAGATCAACGATGATGACTCCTTCACCACCTTTTTCAGCGAGACTGGCAATGGGAAG
CATGTGCCCCGGGCCGTCATGATAGATCTGGAGCCTACTGTAGTGGATGAGGTTCGGGCA
GGAACCTACCGCCAGCTCTTCCATCCAGAGCAGCTGATCACAGGAAAGGAGGATGCAGCC
AACAACTATGCCCGGGGCCACTACACGGTGGGCAAGGAGAGCATTGACCTGGTGCTGGAC
CGCATACGGAAGCTGACAGATGCTTGCTCTGGCCTGCAGGGCTTCCTGATTTTCCACAGT
TTTGGTGGGGGCACTGGCTCCGGCTTCACTTCTCTGCTGATGGAACGCCTCTCCCTGGAT
TATGGCAAGAAATCCAAGCTGGAGTTTGCCATCTACCCAGCCCCCCAGGTCTCTACTGCA
GTGGTGGAGCCCTACAACTCCATCCTGACCACCCACACCACACTGGAACATTCAGATTGT
GCTTTCATGGTGGACAACGAAGCCATCTATGACATCTGCCGCAGGAACCTTGACATTGAG
CGCCCTACCTATACCAACCTCAACCGCCTCATCAGTCAGATTGTGTCCTCAATCACTGCT
TCTCTCCGCTTTGACGGGGCCCTCAATGTGGACCTCACTGAGTTCCAGACCAACCTGGTG
CCCTACCCCCGCATCCACTTCCCGCTGGTCACCTACGCGCCCATCATCTCTGCCGAGAAA
GCCTATCACGAACAGCTCTCTGTGGCCGAGATAACCAGCTCCTGCTTTGAGCCCAACAGC
CAGATGGTGAAGTGCGACCCGAGACATGGCAAGTACATGGCCTGCTGCATGCTCTACCGG
GGCGACGTGGTGCCCAAGGATGTGAATGTCGCTATTGCTGCCATCAAGACCAAGAGGACC
ATCCAGTTTGTAGACTGGTGTCCCACAGGCTTCAAGGTGGGCATCAACTACCAGCCCCCG
ACCGTGGTCCCCGGGGGAGACCTGGCCAAGGTGCAGCGGGCCGTCTGCATGCTCAGCAAC
ACCACGGCCATTGCGGAGGCCTGGGCCCGCCTCGACCACAAGTTCGACCTCATGTACGCC
AAGCGGGCCTTTGTGCATTGGTATGTGGGAGAGGGGATGGAAGAAGGAGAATTTTCTGAG
GCCAGGGAAGACTTAGCTGCCCTGGAGAAGGATTATGAAGAAGTGGGGACTGATTCGTTT
GAAGAAGAAAATGAAGGGGAGGAATTTTAA

Target 36 GenBank Gene ID

Not Available

Target 36 GeneCard ID

TUBA8

Target 36 GenAtlas ID

TUBA8

Target 36 HGNC ID

HGNC:12410 Link Image

Target 36 Chromosome Location

Chromosome:22

Target 36 Locus

22q11.1

Target 36 SNPs

SNPJam Report Link Image

Target 36 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 36 General References

10772959; 15461802; 15489334; 19524510

Target 37 [top]

Target 37 ID

Target 37 Name

Tubulin beta chain

Target 37 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 37 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 37 Synonyms

Tubulin beta-5 chain

Target 37 Gene Name

TUBB

Target 37 Protein Sequence

>Tubulin beta chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDRISVYYNEATGGKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQVFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAVTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDFGEEAEEEA

Target 37 Number of Residues

444

Target 37 Molecular Weight

49670.5

Target 37 Theoretical pI

4.52

Target 37 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 37 General Function

Cell cycle control, cell division, chromosome partitioning

Target 37 Pathways

Not Available

Target 37 Reactions

Not Available

Target 37 Signals

None

Target 37 Transmembrane Regions

None

Target 37 Essentiality

Non Essential

Target 37 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 37 GenBank ID Protein

Not Available

Target 37 UniProtKB ID

P07437

Target 37 Cellular Location

Cytoplasmic

Target 37 Gene Sequence

>1335 bp

ATGAGGGAAATCGTGCACATCCAGGCTGGTCAGTGTGGCAACCAGATCGGTGCCAAGTTC
TGGGAGGTGATCAGTGATGAACATGGCATCGACCCCACCGGCACCTACCACGGGGACAGC
GACCTGCAGCTGGACCGCATCTCTGTGTACTACAATGAAGCCACAGGTGGCAAATATGTT
CCTCGTGCCATCCTGGTGGATCTAGAACCTGGGACCATGGACTCTGTTCGCTCAGGTCCT
TTTGGCCAGATCTTTAGACCAGACAACTTTGTATTTGGTCAGTCTGGGGCAGGTAACAAC
TGGGCCAAAGGCCACTACACAGAGGGCGCCGAGCTGGTTGATTCTGTCCTGGATGTGGTA
CGGAAGGAGGCAGAGAGCTGTGACTGCCTGCAGGGCTTCCAGCTGACCCACTCACTGGGC
GGGGGCACAGGCTCTGGAATGGGCACTCTCCTTATCAGCAAGATCCGAGAAGAATACCCT
GATCGCATCATGAATACCTTCAGTGTGGTGCCTTCACCCAAAGTGTCTGACACCGTGGTC
GAGCCCTACAATGCCACCCTCTCCGTCCATCAGTTGGTAGAGAATACTGATGAGACCTAT
TGCATTGACAACGAGGCCCTCTATGATATCTGCTTCCGCACTCTGAAGCTGACCACACCA
ACCTACGGGGATCTGAACCACCTTGTCTCAGCCACCATGAGTGGTGTCACCACCTGCCTC
CGTTTCCCTGGCCAGCTCAATGCTGACCTCCGCAAGTTGGCAGTCAACATGGTCCCCTTC
CCACGTCTCCATTTCTTTATGCCTGGCTTTGCCCCTCTCACCAGCCGTGGAAGCCAGCAG
TATCGAGCTCTCACAGTGCCGGAACTCACCCAGCAGGTCTTCGATGCCAAGAACATGATG
GCTGCCTGTGACCCCCGCCACGGCCGATACCTCACCGTGGCTGCTGTCTTCCGTGGTCGG
ATGTCCATGAAGGAGGTCGATGAGCAGATGCTTAACGTGCAGAACAAGAACAGCAGCTAC
TTTGTGGAATGGATCCCCAACAATGTCAAGACAGCCGTCTGTGACATCCCACCTCGTGGC
CTCAAGATGGCAGTCACCTTCATTGGCAATAGCACAGCCATCCAGGAGCTCTTCAAGCGC
ATCTCGGAGCAGTTCACTGCCATGTTCCGCCGGAAGGCCTTCCTCCACTGGTACACAGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCTGAGAGCAACATGAACGACCTCGTCTCT
GAGTATCAGCAGTACCAGGATGCCACCGCAGAAGAGGAGGAGGATTTCGGTGAGGAGGCC
GAAGAGGAGGCCTAA

Target 37 GenBank Gene ID

Not Available

Target 37 GeneCard ID

TUBB

Target 37 GenAtlas ID

TUBB

Target 37 HGNC ID

HGNC:20778 Link Image

Target 37 Chromosome Location

Chromosome:6
Entrez Gene cytogenetic band: 6p21.33 HGNC cytogenetic band: 6p21.33

Target 37 Locus

6p21.33

Target 37 SNPs

SNPJam Report Link Image

Target 37 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 37 General References

6688039; 6865944; 11504633; 15489334

Target 38 [top]

Target 38 ID

Target 38 Name

Tubulin beta-1 chain

Target 38 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 38 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 38 Synonyms

Not Available

Target 38 Gene Name

TUBB1

Target 38 Protein Sequence

>Tubulin beta-1 chain

MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYV
PRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVV
RHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVV
EPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTM
AACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRG
LSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVS
EYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH

Target 38 Number of Residues

451

Target 38 Molecular Weight

50326.6

Target 38 Theoretical pI

4.82

Target 38 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 38 General Function

Cell cycle control, cell division, chromosome partitioning

Target 38 Pathways

Not Available

Target 38 Reactions

Not Available

Target 38 Signals

None

Target 38 Transmembrane Regions

None

Target 38 Essentiality

Non Essential

Target 38 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 38 GenBank ID Protein

Not Available

Target 38 UniProtKB ID

Q9H4B7

Target 38 Cellular Location

Cytoplasmic

Target 38 Gene Sequence

>1356 bp

ATGCGTGAAATTGTCCATATTCAGATTGGCCAGTGTGGCAACCAGATCGGAGCCAAGTTC
TGGGAGATGATTGGTGAGGAACACGGGATCGACTTGGCTGGGAGCGACCGCGGGGCCTCG
GCCTTGCAGCTGGAGAGAATCAGCGTGTACTACAACGAAGCCTACGGTAGGAAATATGTG
CCCCGAGCAGTCTTGGTGGACCTAGAACCTGGGACGATGGACAGCATTCGATCTAGCAAA
TTAGGAGCTCTCTTTCAACCCGACAGTTTTGTCCATGGTAACTCTGGGGCTGGCAACAAC
TGGGCCAAAGGCCACTACACGGAGGGAGCCGAGCTGATCGAGAATGTCCTAGAGGTGGTG
AGGCACGAGAGTGAGAGCTGTGACTGCCTGCAGGGCTTCCAGATCGTCCACTCCCTGGGC
GGGGGCACAGGCTCCGGGATGGGCACTCTGCTCATGAACAAGATTAGAGAGGAGTACCCG
GACCGGATCATGAATTCCTTCAGCGTCATGCCTTCTCCCAAGGTGTCGGACACGGTGGTG
GAGCCCTACAACGCGGTTCTGTCTATCCACCAGCTGATTGAGAATGCAGATGCCTGTTTC
TGCATTGACAATGAGGCCCTCTATGACATCTGCTTCCGTACCCTGAAGCTGACGACACCC
ACCTATGGGGATCTCAACCACCTAGTGTCCTTGACCATGAGCGGCATAACCACCTCCCTC
CGGTTCCCGGGTCAGCTCAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTCCCCTTC
CCCCGCCTGCACTTCTTTATGCCCGGCTTTGCCCCACTCACGGCCCAGGGCAGCCAGCAG
TACCGAGCCCTCTCCGTGGCCGAGCTCACCCAGCAGATGTTCGATGCCCGCAATACCATG
GCTGCCTGTGACCTCCGCCGTGGCCGCTACCTCACAGTGGCCTGCATTTTCCGGGGCAAG
ATGTCCACCAAGGAAGTGGACCAGCAACTGCTCTCCGTGCAGACCAGGAACAGCAGCTGC
TTTGTGGAGTGGATTCCCAACAACGTCAAGGTGGCTGTCTGCGACATCCCGCCCCGGGGG
CTGAGCATGGCCGCCACCTTCATTGGCAACAACACGGCCATCCAAGAGATCTTTAATAGG
GTCTCTGAGCATTTCTCAGCCATGTTCAAAAGGAAAGCTTTTGTGCACTGGTACACCAGC
GAAGGGATGGACATAAACGAATTTGGGGAAGCTGAAAATAACATCCATGATTTGGTATCC
GAGTACCAACAATTTCAAGATGCCAAAGCAGTTCTAGAGGAAGATGAAGAGGTCACGGAG
GAGGCAGAAATGGAGCCAGAAGATAAGGGACATTAA

Target 38 GenBank Gene ID

Not Available

Target 38 GeneCard ID

TUBB1

Target 38 GenAtlas ID

TUBB1

Target 38 HGNC ID

HGNC:16257 Link Image

Target 38 Chromosome Location

Chromosome:20

Target 38 Locus

20q13.32

Target 38 SNPs

SNPJam Report Link Image

Target 38 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 38 General References

11780052; 15489334; 12665801; 19524510

Target 39 [top]

Target 39 ID

219

Target 39 Name

Tubulin beta-2A chain

Target 39 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 39 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 39 Synonyms

Not Available

Target 39 Gene Name

TUBB2A

Target 39 Protein Sequence

>Tubulin beta-2A chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA

Target 39 Number of Residues

445

Target 39 Molecular Weight

49906.7

Target 39 Theoretical pI

4.52

Target 39 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 39 General Function

Cell cycle control, cell division, chromosome partitioning

Target 39 Pathways

Not Available

Target 39 Reactions

Not Available

Target 39 Signals

None

Target 39 Transmembrane Regions

None

Target 39 Essentiality

Non Essential

Target 39 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 39 GenBank ID Protein

Not Available

Target 39 UniProtKB ID

Q13885

Target 39 Cellular Location

Cytoplasmic

Target 39 Gene Sequence

>1338 bp

ATGCGCGAGATCGTGCACATCCAGGCGGGCCAGTGCGGCAACCAGATCGGCGCCAAGTTT
TGGGAGGTCATCAGCGATGAGCATGGGATCGACCCCACAGGCAGTTACCATGGAGACAGT
GACTTGCAGCTGGAGAGAATCAACGTGTACTACAATGAGGCTGCTGGTAACAAATATGTA
CCTCGGGCCATCCTGGTGGATCTGGAGCCTGGCACCATGGACTCTGTCAGGTCTGGACCC
TTCGGCCAGATCTTCAGACCAGACAACTTCGTGTTCGGCCAGAGTGGAGCCGGGAATAAC
TGGGCCAAGGGCCACTACACAGAGGGAGCCGAGCTGGTCGACTCGGTCCTGGATGTGGTG
AGGAAGGAGTCAGAGAGCTGTGACTGTCTCCAGGGCTTCCAGCTGACCCACTCTCTGGGG
GGCGGCACGGGGTCCGGGATGGGCACCCTGCTCATCAGCAAGATCCGGGAAGAGTACCCA
GACCGCATCATGAACACCTTCAGCGTCATGCCCTCACCCAAGGTGTCAGACACGGTGGTG
GAGCCCTACAACGCCACCCTCTCGGTCCACCAGCTGGTGGAAAACACAGATGAAACCTAC
TCCATTGATAACGAGGCCCTGTATGACATCTGCTTCCGCACCCTGAAGCTGACCACCCCC
ACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTG
CGCTTCCCGGGCCAGCTGAACGCAGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTC
CCTCGCCTGCACTTCTTCATGCCCGGCTTCGCGCCCCTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCGCTCACGGTGCCCGAGCTCACCCAGCAGATGTTCGACTCCAAGAACATGATG
GCCGCCTGCGACCCGCGCCACGGCCGCTACCTGACGGTGGCTGCCATCTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTCAACGTGCAGAACAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGTCGGCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCC
GAGTACCAGCAGTACCAGGACGCCACGGCCGACGAACAAGGGGAGTTCGAGGAGGAGGAG
GGCGAGGACGAGGCTTAA

Target 39 GenBank Gene ID

Not Available

Target 39 GeneCard ID

TUBB2A

Target 39 GenAtlas ID

TUBB2A

Target 39 HGNC ID

HGNC:12412 Link Image

Target 39 Chromosome Location

Not Available

Target 39 Locus

6p25

Target 39 SNPs

SNPJam Report Link Image

Target 39 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 39 General References

14574404; 15489334; 19524510; 16959974

Target 40 [top]

Target 40 ID

247

Target 40 Name

Tubulin beta-2B chain

Target 40 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 40 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 40 Synonyms

Not Available

Target 40 Gene Name

TUBB2B

Target 40 Protein Sequence

>Tubulin beta-2B chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEATGNKYV
PRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMM
AACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATADEQGEFEEEEGEDEA

Target 40 Number of Residues

445

Target 40 Molecular Weight

49952.8

Target 40 Theoretical pI

4.52

Target 40 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 40 General Function

Cell cycle control, cell division, chromosome partitioning

Target 40 Pathways

Not Available

Target 40 Reactions

Not Available

Target 40 Signals

None

Target 40 Transmembrane Regions

None

Target 40 Essentiality

Non Essential

Target 40 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 40 GenBank ID Protein

Not Available

Target 40 UniProtKB ID

Q9BVA1

Target 40 Cellular Location

Cytoplasmic

Target 40 Gene Sequence

Not Available

Target 40 GenBank Gene ID

Not Available

Target 40 GeneCard ID

TUBB2B

Target 40 GenAtlas ID

TUBB2B

Target 40 HGNC ID

HGNC:30829 Link Image

Target 40 Chromosome Location

Not Available

Target 40 Locus

6p25

Target 40 SNPs

SNPJam Report Link Image

Target 40 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 40 General References

14574404; 15489334; 19524510

Target 41 [top]

Target 41 ID

Target 41 Name

Tubulin beta-2C chain

Target 41 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 41 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 41 Synonyms

Tubulin beta-2 chain

Target 41 Gene Name

TUBB2C

Target 41 Protein Sequence

>Tubulin beta-2C chain

MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEFEEEAEEEVA

Target 41 Number of Residues

445

Target 41 Molecular Weight

49830.7

Target 41 Theoretical pI

4.52

Target 41 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 41 General Function

Cell cycle control, cell division, chromosome partitioning

Target 41 Pathways

Not Available

Target 41 Reactions

Not Available

Target 41 Signals

None

Target 41 Transmembrane Regions

None

Target 41 Essentiality

Non Essential

Target 41 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 41 GenBank ID Protein

Not Available

Target 41 UniProtKB ID

P68371

Target 41 Cellular Location

Cytoplasmic

Target 41 Gene Sequence

>1338 bp

ATGAGGGAAATCGTGCACTTGCAGGCCGGGCAGTGCGGCAACCAAATCGGCGCCAAGTTT
TGGGAGGTGATCAGCGATGAGCACGGCATCGACCCCACGGGCACCTACCACGGGGACAGC
GACCTGCAGCTGGAACGCATCAACGTGTACTACAATGAGGCCACCGGCGGCAAGTACGTG
CCCCGCGCCGTGCTCGTGGATCTGGAGCCCGGCACCATGGACTCCGTGCGCTCGGGGCCC
TTCGGGCAGATCTTCCGGCCGGACAACTTCGTTTTCGGTCAGAGTGGTGCTGGGAACAAC
TGGGCCAAGGGGCACTACACAGAAGGCGCGGAGCTGGTGGACTCGGTGCTGGATGTTGTG
AGAAAGGAGGCTGAGAGCTGTGACTGCCTGCAGGGTTTCCAGCTGACCCACTCCCTGGGT
GGGGGGACTGGGTCTGGGATGGGTACCCTCCTCATCAGCAAGATCCGGGAGGAGTACCCA
GACAGGATCATGAACACGTTTAGTGTGGTGCCTTCGCCCAAAGTGTCAGACACAGTGGTG
GAGCCCTACAACGCCACCCTCTCAGTCCACCAGCTCGTAGAAAACACAGACGAGACCTAC
TGCATTGATAACGAAGCTCTCTACGACATTTGCTTCAGAACCCTAAAGCTGACCACGCCC
ACCTATGGTGACCTGAACCACCTGGTGTCTGCTACCATGAGTGGGGTCACCACCTGCCTG
CGCTTCCCAGGCCAGCTCAATGCTGACCTGCGGAAGCTGGCTGTGAACATGGTCCCGTTT
CCCCGGCTGCACTTCTTCATGCCCGGCTTTGCCCCACTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCGCTGACCGTGCCCGAGCTCACCCAGCAGATGTTTGATGCCAAGAACATGATG
GCTGCCTGCGACCCCCGCCATGGCCGCTACCTGACGGTTGCCGCCGTGTTCAGGGGCCGC
ATGTCCATGAAGGAGGTGGATGAGCAAATGCTTAATGTCCAAAACAAAAACAGCAGCTAT
TTTGTTGAGTGGATCCCCAACAATGTGAAAACGGCTGTCTGTGACATCCCACCTCGGGGG
CTAAAAATGTCCGCCACCTTCATTGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTGTCC
GAGTACCAGCAGTACCAGGATGCCACAGCCGAGGAGGAGGGCGAGTTCGAGGAGGAGGCT
GAGGAGGAGGTGGCCTAG

Target 41 GenBank Gene ID

Not Available

Target 41 GeneCard ID

TUBB2C

Target 41 GenAtlas ID

TUBB2C

Target 41 HGNC ID

HGNC:20771 Link Image

Target 41 Chromosome Location

Not Available

Target 41 Locus

9q34

Target 41 SNPs

SNPJam Report Link Image

Target 41 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 41 General References

3999141; 15164053; 15489334; 17081983; 19007248; 18691976; 18669648; 19524510

Target 42 [top]

Target 42 ID

242

Target 42 Name

Tubulin beta-3 chain

Target 42 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 42 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 42 Synonyms

Tubulin beta-III; Tubulin beta-4

Target 42 Gene Name

TUBB3

Target 42 Protein Sequence

>Tubulin beta-3 chain

MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPSGNYVGDSDLQLERISVYYNEASSHKYV
PRAILVDLEPGTMDSVRSGAFGHLFRPDNFIFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKECENCDCLQGFQLTHSLGGGTGSGMGTLLISKVREEYPDRIMNTFSVVPSPKVSDTVV
EPYNATLSIHQLVENTDETYCIDNEALYDICFRTLKLATPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTARGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVATVFRGRMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMSSTFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEGEMYEDDEEESEAQGPK

Target 42 Number of Residues

450

Target 42 Molecular Weight

50432.4

Target 42 Theoretical pI

4.57

Target 42 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 42 General Function

Cell cycle control, cell division, chromosome partitioning

Target 42 Pathways

Not Available

Target 42 Reactions

Not Available

Target 42 Signals

None

Target 42 Transmembrane Regions

None

Target 42 Essentiality

Non Essential

Target 42 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 42 GenBank ID Protein

Not Available

Target 42 UniProtKB ID

Q13509

Target 42 Cellular Location

Cytoplasmic

Target 42 Gene Sequence

>1353 bp

ATGCGGGAGATCGTGCACATCCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTC
TGGGAAGTCATCAGTGATGAGCATGGCATCGACCCCAGCGGCAACTACGTGGGCGACTCG
GACTTGCAGCTGGAGCGGATCAGCGTCTACTACAACGAGGCCTCTTCTCACAAGTACGTG
CCTCGAGCCATTCTGGTGGACCTGGAACCCGGAACCATGGACAGTGTCCGCTCAGGGGCC
TTTGGACATCTCTTCAGGCCTGACAATTTCATCTTTGGTCAGAGTGGGGCCGGCAACAAC
TGGGCCAAGGGTCACTACACGGAGGGGGCGGAGCTGGTGGATTCGGTCCTGGATGTGGTG
CGGAAGGAGTGTGAAAACTGCGACTGCCTGCAGGGCTTCCAGCTGACCCACTCGCTGGGG
GGGGGGACGGGCTCCGGCATGGGCACGTTGCTCATCAGCAAGGTGCGTGAGGAGTATCCC
GACCGCATCATGAACACCTTCAGCGTCGTGCCCTCACCCAAGGTGTCAGACACGGTGGTG
GAACCCTACAACGCCACGCTGTCCATCCACCAGCTGGTGGAAAACACGGATGAAACCTAC
TGCATCGACAACGAGGCGCTCTACGACATCTGCTTCCGCACCCTCAAGCTGGCCACGCCC
ACCTACGGGGACCTCAACCACCTGGTATCGGCCACCATGAGCGGAGTCACCACCTCCTTG
CGCTTCCCGGGCCAGCTCAACGCTGACCTGCGCAAGCTGGCCGTCAACATGGTGCCCTTC
CCGCGCCTGCACTTCTTCATGCCCGGCTTCGCCCCCCTCACCAGGCGGGGCAGCCAGCAG
TACCGGGCCCTGACCGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATG
GCCGCCTGCGACCCGCGCCACGGCCGCTACCTGACGGTGGCCACCGTGTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGGCCATCCAGAGCAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGGTGGCCGTGTGTGACATCCCGCCCCGCGGC
CTCAAGATGTCCTCCACCTTCATCGGGAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAACGACCTGGTGTCC
GAGTACCAGCAGTACCAGGACGCCACGGCCGAGGAAGAGGGCGAGATGTACGAAGACGAC
GAGGAGGAGTCGGAGGCCCAGGGCCCCAAGTGA

Target 42 GenBank Gene ID

Not Available

Target 42 GeneCard ID

TUBB3

Target 42 GenAtlas ID

TUBB3

Target 42 HGNC ID

HGNC:20772 Link Image

Target 42 Chromosome Location

Chromosome:16

Target 42 Locus

16q24.3

Target 42 SNPs

SNPJam Report Link Image

Target 42 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 42 General References

9473684; 15489334; 19524510

Target 43 [top]

Target 43 ID

136

Target 43 Name

Tubulin beta-4 chain

Target 43 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 43 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain

Target 43 Synonyms

Tubulin 5 beta

Target 43 Gene Name

TUBB4

Target 43 Protein Sequence

>Tubulin beta-4 chain

MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGNYV
PRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDAVLDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVVPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMM
AACDPRHGRYLTVAAVFRGRMSMKEVDEQMLSVQSKNSSYFVEWIPNNVKTAVCDIPPRG
LKMAATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEGEFEEEAEEEVA

Target 43 Number of Residues

444

Target 43 Molecular Weight

49585.5

Target 43 Theoretical pI

4.51

Target 43 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 43 General Function

Cell cycle control, cell division, chromosome partitioning

Target 43 Pathways

Not Available

Target 43 Reactions

Not Available

Target 43 Signals

None

Target 43 Transmembrane Regions

None

Target 43 Essentiality

Non Essential

Target 43 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 43 GenBank ID Protein

Not Available

Target 43 UniProtKB ID

P04350

Target 43 Cellular Location

Cytoplasmic

Target 43 Gene Sequence

>1335 bp

ATGCGGGAGATCGTGCACCTGCAGGCCGGCCAGTGCGGCAACCAGATCGGGGCCAAGTTT
TGGGAGGTTATCAGTGACGAACATGGCATCGACCCCACAGGCACATACCATGGGGACAGT
GACCTGCAACTGGAGAGGATCAACGTGTACTACAACGAGGCCACAGGAGGAAATTATGTC
CCCAGAGCGGTGCTGGTGGACCTGGAACCCGGCACCATGGACTCTGTCCGTTCTGGCCCC
TTCGGTCAGATCTTTCGGCCGGACAACTTCGTGTTTGGCCAATCCGGAGCCGGCAACAAC
TGGGCAAAGGGGCACTACACGGAGGGCGCAGAGCTGGTGGACGCTGTCCTGGACGTAGTC
CGGAAGGAGGCCGAGAGCTGCGACTGCCTTCAGGGCTTCCAGCTGACCCACTCGCTGGGG
GGTGGCACGGGGTCCGGAATGGGCACGCTGCTCATCAGTAAGATCCGCGAGGAGTTCCCA
GACCGCATCATGAACACCTTCAGCGTGGTGCCCTCGCCCAAAGTGTCAGACACGGTGGTG
GAGCCCTACAACGCCACGCTGTCTGTGCACCAGCTGGTGGAGAATACGGATGAGACCTAC
TGCATCGACAACGAGGCACTCTACGACATCTGTTTCCGCACCCTCAAGCTGACCACCCCC
ACCTACGGGGACCTCAACCACCTGGTGTCGGCCACCATGAGCGGGGTCACCACCTGCCTG
CGCTTCCCGGGCCAGCTGAACGCCGACCTGCGCAAGCTGGCCGTCAACATGGTCCCCTTT
CCTCGCCTGCACTTCTTCATGCCCGGCTTCGCACCCCTGACCAGCCGGGGCAGCCAGCAG
TACCGGGCCCTGACGGTGCCCGAGCTCACCCAGCAGATGTTCGATGCCAAGAACATGATG
GCGGCGTGCGACCCGCGCCACGGCCGCTACCTGACCGTGGCCGCCGTGTTCCGGGGCCGC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGAGCGTGCAGAGCAAGAACAGCAGCTAC
TTCGTGGAGTGGATCCCCAACAACGTGAAGACGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGGCCGCGACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCACGGCCATGTTCCGGCGCAAGGCCTTCTTGCACTGGTACACGGGC
GAGGGCATGGACGAGATGGAGTTCACCGAGGCCGAGAGCAACATGAATGACCTGGTATCT
GAGTACCAGCAGTACCAGGACGCCACGGCCGAGGAGGGCGAGTTCGAGGAGGAGGCGGAG
GAGGAGGTGGCCTAG

Target 43 GenBank Gene ID

Not Available

Target 43 GeneCard ID

TUBB4

Target 43 GenAtlas ID

TUBB4

Target 43 HGNC ID

HGNC:20774 Link Image

Target 43 Chromosome Location

Chromosome:19

Target 43 Locus

19p13.3

Target 43 SNPs

SNPJam Report Link Image

Target 43 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 43 General References

6462917; 15489334; 8619814; 16565220; 19524510

Target 44 [top]

Target 44 ID

Target 44 Name

Tubulin beta-6 chain

Target 44 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 44 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 44 Synonyms

Not Available

Target 44 Gene Name

TUBB6

Target 44 Protein Sequence

>Tubulin beta-6 chain

MREIVHIQAGQCGNQIGTKFWEVISDEHGIDPAGGYVGDSALQLERINVYYNESSSQKYV
PRAALVDLEPGTMDSVRSGPFGQLFRPDNFIFGQTGAGNNWAKGHYTEGAELVDAVLDVV
RKECEHCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEFPDRIMNTFSVMPSPKVSDTVV
EPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTSL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDARNMM
AACDPRHGRYLTVATVFRGPMSMKEVDEQMLAIQSKNSSYFVEWIPNNVKVAVCDIPPRG
LKMASTFIGNSTAIQELFKRISEQFSAMFRRKAFLHWFTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATANDGEEAFEDEEEEIDG

Target 44 Number of Residues

446

Target 44 Molecular Weight

49856.8

Target 44 Theoretical pI

4.51

Target 44 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 44 General Function

Involved in GTP binding

Target 44 Pathways

Not Available

Target 44 Reactions

Not Available

Target 44 Signals

None

Target 44 Transmembrane Regions

None

Target 44 Essentiality

Non Essential

Target 44 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 44 GenBank ID Protein

Not Available

Target 44 UniProtKB ID

Q9BUF5

Target 44 Cellular Location

Cytoplasmic

Target 44 Gene Sequence

>1341 bp

ATGAGGGAGATCGTGCACATCCAGGCGGGCCAGTGCGGGAACCAGATCGGCACCAAGTTT
TGGGAAGTGATCAGCGATGAGCACGGCATCGACCCGGCCGGAGGCTACGTGGGAGACTCG
GCGCTGCAGCTGGAGAGAATCAACGTCTACTACAATGAGTCATCGTCTCAGAAATATGTG
CCCAGGGCCGCCCTGGTGGACTTAGAGCCAGGCACCATGGACAGCGTGCGGTCTGGGCCT
TTTGGGCAGCTTTTCCGGCCTGACAACTTCATCTTTGGCCAGACGGGTGCAGGGAACAAC
TGGGCGAAAGGGCACTACACGGAGGGCGCGGAGCTGGTGGACGCAGTGCTGGACGTGGTG
CGGAAGGAGTGCGAGCACTGCGACTGCCTGCAGGGCTTCCAGCTCACGCACTCGCTGGGC
GGCGGCACGGGCTCAGGCATGGGCACGCTGCTCATCAGCAAGATCCGTGAGGAGTTCCCG
GACCGCATCATGAACACCTTCAGCGTCATGCCCTCGCCCAAGGTGTCGGACACGGTGGTG
GAGCCCTACAATGCCACACTGTCGGTGCACCAGCTGGTGGAGAATACAGACGAGACCTAC
TGCATCGACAACGAGGCGCTCTATGACATCTGCTTCCGCACTCTGAAGCTGACAACGCCC
ACCTACGGGGACCTCAACCACCTGGTGTCCGCCACCATGAGTGGGGTCACCACCTCGCTG
CGCTTCCCGGGCCAGCTCAATGCTGACCTGCGCAAGCTGGCGGTGAACATGGTGCCCTTC
CCGCGCCTGCACTTCTTCATGCCTGGCTTCGCGCCGCTCACCAGCCGCGGCAGCCAGCAG
TACCGGGCCCTGACCGTGCCCGAGCTCACCCAGCAGATGTTCGACGCCAGGAACATGATG
GCCGCCTGCGATCCGCGCCATGGCCGCTACCTGACCGTGGCCACCGTGTTCCGCGGGCCC
ATGTCCATGAAGGAGGTGGACGAGCAGATGCTGGCCATCCAGAGTAAGAACAGCAGCTAC
TTCGTGGAGTGGATTCCCAACAACGTGAAGGTGGCCGTGTGCGACATCCCGCCCCGCGGC
CTGAAGATGGCCTCCACCTTCATCGGCAACAGCACGGCCATCCAGGAGCTGTTCAAGCGC
ATCTCCGAGCAGTTCTCAGCCATGTTCCGGCGCAAGGCCTTCCTGCACTGGTTCACGGGT
GAGGGCATGGATGAAATGGAGTTCACCGAGGCGGAGAGCAACATGAACGACCTGGTATCC
GAGTACCAGCAGTACCAGGATGCCACCGCCAATGACGGGGAGGAAGCTTTTGAGGATGAG
GAAGAGGAGATCGATGGATAG

Target 44 GenBank Gene ID

Not Available

Target 44 GeneCard ID

TUBB6

Target 44 GenAtlas ID

TUBB6

Target 44 HGNC ID

HGNC:20776 Link Image

Target 44 Chromosome Location

Chromosome:18

Target 44 Locus

18p11.21

Target 44 SNPs

SNPJam Report Link Image

Target 44 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 44 General References

14702039; 15489334; 17525332; 19524510

Target 45 [top]

Target 45 ID

228

Target 45 Name

Tubulin beta-8 chain

Target 45 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 45 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 45 Synonyms

Not Available

Target 45 Gene Name

TUBB8

Target 45 Protein Sequence

>Tubulin beta-8 chain

MREIVLTQIGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVYYNEASGGRYV
PRAVLVDLEPGTMDSVRSGPFGQVFRPDNFIFGQCGAGNNWAKGHYTEGAELMESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSKTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGRYLTAAAIFRGRMPMREVDEQMFNIQDKNSSYFADWLPNNVKTAVCDIPPRG
LKMSATFIGNNTAIQELFKRVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA

Target 45 Number of Residues

444

Target 45 Molecular Weight

49775.7

Target 45 Theoretical pI

4.52

Target 45 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 45 General Function

Cell cycle control, cell division, chromosome partitioning

Target 45 Pathways

Not Available

Target 45 Reactions

Not Available

Target 45 Signals

None

Target 45 Transmembrane Regions

None

Target 45 Essentiality

Non Essential

Target 45 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 45 GenBank ID Protein

Not Available

Target 45 UniProtKB ID

Q3ZCM7

Target 45 Cellular Location

Cytoplasmic

Target 45 Gene Sequence

Not Available

Target 45 GenBank Gene ID

Not Available

Target 45 GeneCard ID

TUBB8

Target 45 GenAtlas ID

Not Available

Target 45 HGNC ID

Not Available

Target 45 Chromosome Location

Not Available

Target 45 Locus

Not Available

Target 45 SNPs

SNPJam Report Link Image

Target 45 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 45 General References

11731935; 15164054; 15489334; 19524510

Target 46 [top]

Target 46 ID

400

Target 46 Name

Tubulin beta-8 chain B

Target 46 Mechanism of Action

Arsenic's carginogenicity is believed to be caused by the arsenical binding of tubulin, which results in aneuploidy, polyploidy and mitotic arrests. (R054)

Target 46 Description

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity)

Target 46 Synonyms

Not Available

Target 46 Gene Name

Not Available

Target 46 Protein Sequence

>Tubulin beta-8 chain B

MREIVLTQTGQCGNQIGAKFWEVISDEHAIDSAGTYHGDSHLQLERINVHHHEASGGRYV
PRAVLVDLEPGTMDSVHSGPFGQVFRPDNFISGQCGAGNNWAKGRYTEGAELTESVMDVV
RKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIINTFSILPSPKVSDTVV
EPYNATLSVHQLIENADETFCIDNEALYDICSRTLKLPTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVAELTQQMFDAKNMM
AACDPRHGCYLTVAAIFRGRMPMREVDEQMFNIQDKNSSYFADWFPDNVKTAVCDIPPRG
LKMSATFIGNNAAIQELFTCVSEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS
EYQQYQDATAEEEEDEEYAEEEVA

Target 46 Number of Residues

444

Target 46 Molecular Weight

49572.3

Target 46 Theoretical pI

4.49

Target 46 GO Classification

Function
structural molecule activity
Process
physiological process cellular physiological process cell organization and biogenesis organelle organization and biogenesis cytoskeleton organization and biogenesis microtubule-based process microtubule-based movement
Component
organelle non-membrane-bound organelle intracellular non-membrane-bound organelle cytoskeleton microtubule cytoskeleton microtubule

Target 46 General Function

Cell cycle control, cell division, chromosome partitioning

Target 46 Pathways

Not Available

Target 46 Reactions

Not Available

Target 46 Signals

None

Target 46 Transmembrane Regions

None

Target 46 Essentiality

Non Essential

Target 46 Domain Function

PF00091:Tubulin PF03953:Tubulin_C

Target 46 GenBank ID Protein

Not Available

Target 46 UniProtKB ID

A6NNZ2

Target 46 Cellular Location

Cytoplasmic

Target 46 Gene Sequence

Not Available

Target 46 GenBank Gene ID

Not Available

Target 46 GeneCard ID

Not Available

Target 46 GenAtlas ID

Not Available

Target 46 HGNC ID

Not Available

Target 46 Chromosome Location

Not Available

Target 46 Locus

Not Available

Target 46 SNPs

Not Available

Target 46 Toxin References

R054 - Kitchin KT, Wallace K: The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J Inorg Biochem. 2008 Mar;102(3):532-9. Epub 2007 Nov 22. [PubMed ]

Target 46 General References

16177791; 19524510

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.