| Version |
1.0 |
| Creation Date |
2009-06-02 22:22:59 |
| Update Date |
2010-05-18 20:51:11 |
| Accession Number |
T3D0804 |
| Name |
2-Methyl-4-chlorophenoxyacetic acid |
| Compound Type |
- Aromatic Hydrocarbon
- Organic Compound
- Organochloride
- Pesticide
|
| Description |
Not Available |
| Synonyms |
- ((4-Chloro-o-tolyl)oxy)acetic Acid
- (2-Methyl-4-chlorophenoxy)acetic Acid
- (4-Chloro-2-methylphenoxy)acetic Acid
- (4-Chloro-o-cresoxy)acetic Acid
- (4-Chloro-o-toloxy)acetic Acid
- 2,4-MCPA
- 2-(4-Chloro-2-methylphenoxy)acetic Acid
- 2-Methyl-4-chlorophenoxyacetic Acid
- 2-Methyl-4-chlorophenoxymethylacetic Acid
- 2-Methyl-4-chlorphenoxyessigsaeure
- 2-Methyl-4-chlorphenoxyessigsaeure [German]
- 4-Chloro-2-methylphenoxyacetic Acid
- 4-Chloro-o-cresoxyacetic Acid
- 4-Chloro-o-toloxyacetic Acid
- 4-Chloro-o-tolyloxyacetic Acid
- Acetic Acid, ((4-chloro-o-tolyl)oxy)-
- Acetic Acid, (4-chloro-2-methylphenoxy)-
- Acetic Acid, [(4-chloro-o-tolyl)oxy]-
- Acetic Acid, {[(4-chloro-o-tolyl)oxy]-}
- Acme mcpa amine 4
- Agrichem MCPA-25, 50
- Agricorn 500
- Agritox
- Agritox 50
- Agroxon
- Agroxone
- Agroxone 50
- Albar-m
- Anicon kombi
- Anicon m
- Atlas mcpa
- B-selektonon m
- BH MCPA 75
- BH mcpa
- Banvel m
- Bordermaster
- Brominal m and plus
- CMP acetate
- Campbell's MCPA 25, 50
- Caswell No. 557C
- Cekherbex
- Chafer MCPA 675
- Chiptox
- Chloro-(o-cresoxy)acetic Acid
- Chloro-(o-tolyloxy)acetic Acid
- Chwastox
- Chwastox 30
- Chwastox extra
- Chwastox f
- Cornox-m
- Ded-weed
- Dicopur-m
- Dicotex
- Dikotes
- Dikotex
- Dow MCP amine weed killer
- Emcepan
- Empal
- FBC mcpa
- FLUID 4
- Farmon MCPA 50
- Hedapur M 52
- Hedarex m
- Hedonal
- Hedonal m
- Herbicide m
- Hormotuho
- Hornotuho
- Kilsem
- Kilsem4k-2m
- Krezone
- Kwas 4-chloro-2-metylofenoksyoctowy [Polish]
- Kyselina 4-chlor-2-methylfenoxyoctova [Czech]
- Legumex DB
- Leuna m
- Leyspray
- Linormone
- MCP
- MCP (van)
- MCP ester
- MCPA
- MSS MCPA 50
- Mcpa [bsi:iso]
- Mcpa [chlorophenoxy herbicides]
- Mcpa ester
- Mcpa solution
- Mecpa
- Mephanac
- Metaxon
- Methoxone
- Methyl chlorophenoxy acetic Acid
- Methylchlorophenoxyacetic Acid
- Netazol
- Okultin m
- Phenoxylene 50
- Phenoxylene plus
- Phenoxylene super
- Power mcpa
- Raphone
- Razol dock killer
- Rhomenc
- Rhomene
- Rhonox
- Selektonon m
- Seppic MMD
- Shamrox
- Soviet technical herbicide 2M-4C
- Star mcpa
- Trasan
- U 46 M-FLUID
- Ustinex
- Vacate
- Verdone
- Vesakontuho mcpa
- WLN: QV1OR DG B1
- Weed-rhap
- Weedar
- Weedar mcpa
- Weedar mcpa concentrate
- Weedone
- Weedone mcpa ester
- Zelan
- {[(4-Chloro-o-tolyl)oxy]acetic} Acid
|
| Chemical IUPAC Name |
2-(4-chloro-2-methylphenoxy)acetic acid |
| Chemical Formula |
C9H9ClO3 |
| Chemical Structure |
 |
| CAS Registry Number |
94-74-6 |
| InChI Identifier |
InChI=1S/C9H9ClO3/c1-6-4-7(10)2-3-8(6)13-5-9(11)12/h2-4H,5H2,1H3,(H,11,12) |
| InChI Key |
InChIKey=WHKUVVPPKQRRBV-UHFFFAOYSA-N |
| PubChem Compound ID |
7204  |
| KEGG ID |
Not Available |
| UniProt ID |
Not Available |
| OMIM ID |
Not Available |
| ChEBI ID |
50099 |
| BioCyc ID |
Not Available |
| SuperToxic ID |
Not Available |
| CTD ID |
D008456 |
| Stitch ID |
2-Methyl-4-chlorophenoxyacetic acid |
| DrugBank ID |
Not Available |
| PDB ID |
Not Available |
| ACToR ID |
852 |
| Wikipedia Link |
Not Available |
| Monoisotopic Mass |
200.024022 |
| MOL File |
Show |
| PDB File |
Show |
| SDF File |
Show |
| SMILES |
CC1=CC(Cl)=CC=C1OCC(O)=O |
| Appearance |
Not Available |
| Melting Point |
120 oC |
| Solubility |
0.63 mg/mL at 25 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)] |
| Predicted LogP |
2.411 |
| Route of Exposure |
Not Available |
| Mechanism of Action |
CDDs cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the trascription of certain genes. The affinity for the Ah receptor depends on the structure of the specific CDD. The change in gene expression may result from the direct interaction of the Ah receptor and its heterodimer-forming partner, the aryl hydrocarbon receptor nuclear translocator, with gene regulatory elements or the initiation of a phosphorylation/dephosphorylation cascade that subsequently activates other transcription factors. The affected genes include several oncogenes, growth factors, receptors, hormones, and drug-metabolizing enzymes. The change in transcription/translation of these genes is believed to be the cause of most of the toxic effects of CDDs. This includes 2,3,7,8-tetrachlorodibenzo-p-dioxin's carcinogenicity is thought to be the result of its ability to alter the capacity of both exogenous and endogenous substances to damage the DNA by inducing CYP1A1- and CYP1A2-dependent drug-metabolizing enzymes. (R346) |
| Metabolism |
CDDs are absorbed through oral, inhalation, and dermal routes of exposure. CDDs are carried in the plasma by serum lipids and lipoproteins, distributing mainly to the liver and adipose tissue. CDDs are very slowly metabolized by the microsomal monooxygenase system to polar metabolites that can undergo conjugation with glucuronic acid and glutathione. They may increase the rate of their own metabolism by inducing CDDs induce both phase I and phase II enzymes. The major routes of excretion of CDDs are the bile and the feces, though smaller amounts are excreted in the urine and via lactation. (R346) |
| Toxicity Values |
Not Available |
| Lethal Dose |
Not Available |
| Carcinogenicity (IARC Classification) |
Not Available |
| Uses/Sources |
Dioxins occur as by-products from the manufacture of organochlorides, the bleaching of paper, chlorination by waste and drinking water treatment plants, municipal solid waste and industrial incinerators, and natural sources such as volcanoes and forest fires. (R346, R347) |
| Minimum Risk Level |
Not Available |
| Health Effects |
Exposure to large amounts of CDDs causes chloracne, a severe skin disease with acne-like lesions that occur mainly on the face and upper body. CDDs may also cause liver damage and induce long-term alterations in glucose metabolism and subtle changes in hormonal levels. In addition, studies have shown that CDDs may disrupt the endocrine system and weaken the immune system, as well as cause reproductive damage and birth defects, central and peripheral nervous system pathology, thyroid disorders, endometriosis, and diabetes. 2,3,7,8-Tetrachlorodibenzo-p-dioxin is also a known human carcinogen. (R346, R347) |
| Symptoms |
In addition to chloracne, CDD exposure causes skin rashes, discoloration, and excessive body hair. (R346) |
| Treatment |
Treatment may include washing any areas of contact, GI decontamination if swallowed, administering an IV and forced alkaline diuresis. (R622) |
| General References |
- R347 - Wikipedia. Polychlorinated dibenzodioxins. Last Updated 19 May 2009.
- R622 - US Environmental Protection Agency (2009). Recognition and Management of Pesticide Poisonings.
- R346 - ATSDR - Agency for Toxic Substances and Disease Registry (1998). Toxicological profile for chlorinated dibenzo-p-dioxins (CDDs). U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
|
| Targets |
- Aryl hydrocarbon receptor
- Estrogen receptor
- Estrogen receptor beta
|
|
Target 1
[top]
|
| Target 1 ID |
201 |
| Target 1 Name |
Aryl hydrocarbon receptor |
| Target 1 Mechanism of Action |
Chlorinated dibenzo-p-dioxins cause their toxic effects by binding to the aryl hydrocarbon receptor and subsequently altering the trascription of certain genes. The affinity for the Ah receptor depends on the structure of the specific CDD. The change in gene expression may result from the direct interaction of the Ah receptor and its heterodimer-forming partner, the aryl hydrocarbon receptor nuclear translocator, with gene regulatory elements or the initiation of a phosphorylation/dephosphorylation cascade that subsequently activates other transcription factors. The affected genes include several oncogenes, growth factors, receptors, hormones, and drug-metabolizing enzymes. The change in transcription/translation of these genes is believed to be the cause of most of the toxic effects of CDDs. This includes 2,3,7,8-tetrachlorodibenzo-p-dioxin's carcinogenicity is thought to be the result of its ability to alter the capacity of both exogenous and endogenous substances to damage the DNA by inducing CYP1A1- and CYP1A2-dependent drug-metabolizing enzymes. (R346) |
| Target 1 Description |
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues |
| Target 1 Synonyms |
- Ah receptor; AhR; Class E basic helix-loop-helix protein 76; bHLHe76
|
| Target 1 Gene Name |
AHR |
| Target 1 Protein Sequence |
>Aryl hydrocarbon receptor
MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDV
INKLDKLSVLRLSVSYLRAKSFFDVALKSSPTERNGGQDNCRAANFREGLNLQEGEFLLQ
ALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNP
SQCTESGQGIEEATGLPQTVVCYNPDQIPPENSPLMERCFICRLRCLLDNSSGFLAMNFQ
GKLKYLHGQKKKGKDGSILPPQLALFAIATPLQPPSILEIRTKNFIFRTKHKLDFTPIGC
DAKGRIVLGYTEAELCTRGSGYQFIHAADMLYCAESHIRMIKTGESGMIVFRLLTKNNRW
TWVQSNARLLYKNGRPDYIIVTQRPLTDEEGTEHLRKRNTKLPFMFTTGEAVLYEATNPF
PAIMDPLPLRTKNGTSGKDSATTSTLSKDSLNPSSLLAAMMQQDESIYLYPASSTSSTAP
FENNFFNESMNECRNWQDNTAPMGNDTILKHEQIDQPQDVNSFAGGHPGLFQDSKNSDLY
SIMKNLGIDFEDIRHMQNEKFFRNDFSGEVDFRDIDLTDEILTYVQDSLSKSPFIPSDYQ
QQQSLALNSSCMVQEHLHLEQQQQHHQKQVVVEPQQQLCQKMKHMQVNGMFENWNSNQFV
PFNCPQQDPQQYNVFTDLHGISQEFPYKSEMDSMPYTQNFISCNQPVLPQHSKCTELDYP
MGSFEPSPYPTTSSLEDFVTCLQLPENQKHGLNPQSAIITPQTCYAGAVSMYQCQPEPQH
THVGQMQYNPVLPGQQAFLNKFQNGVLNETYPAELNNINNTQTTTHLQPLHHPSEARPFP
DLTSSGFL
|
| Target 1 Number of Residues |
848 |
| Target 1 Molecular Weight |
96146.7 |
| Target 1 Theoretical pI |
6.34 |
| Target 1 GO Classification |
|
Function
|
signal transducer activity
transcription regulator activity |
|
Process
|
cellular process
cell communication
signal transduction
regulation of transcription, DNA-dependent
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription |
|
Component
|
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus |
|
| Target 1 General Function |
Involved in Hsp90 protein binding |
| Target 1 Pathways |
Not Available |
| Target 1 Reactions |
Not Available |
| Target 1 Signals |
|
| Target 1 Transmembrane Regions |
|
| Target 1 Essentiality |
Non Essential |
| Target 1 Domain Function |
PF00010:HLH
PF00989:PAS
PF08447:PAS_3 |
| Target 1 GenBank ID Protein |
Not Available |
| Target 1 UniProtKB ID |
P35869 |
| Target 1 Cellular Location |
Cytoplasm. Nucleus |
| Target 1 Gene Sequence |
>2427 bp
ATGAACAGCAGCAGCGCCAACATCACCTACGCCAGTCGCAAGCGGCGGAAGCCGGTGCAG
AAAACAGTAAAGCCAATCCCAGCTGAAGGAATCAAGTCAAATCCTTCCAAGCGGCATAGA
GACCGACTTAATACAGAGTTGGACCGTTTGGCTAGCCTGCTGCCTTTCCCACAAGATGTT
ATTAATAAGTTGGACAAACTTTCAGTTCTTAGGCTCAGCGTCAGTTACCTGAGAGCCAAG
AGCTTCTTTGATGTTGCATTAAAATCCTCCCCTACTGAAAGAAACGGAGGCCAGGATAAC
TGTAGAGCAGCAAATTTCAGAGAAGGCCTGAACTTACAAGAAGGAGAATTCTTATTACAG
GCTCTGAATGGCTTTGTATTAGTTGTCACTACAGATGCTTTGGTCTTTTATGCTTCTTCT
ACTATACAAGATTATCTAGGGTTTCAGCAGTCTGATGTCATACATCAGAGTGTATATGAA
CTTATCCATACCGAAGACCGAGCTGAATTTCAGCGTCAGCTACACTGGGCATTAAATCCT
TCTCAGTGTACAGAGTCTGGACAAGGAATTGAAGAAGCCACTGGTCTCCCCCAGACAGTA
GTCTGTTATAACCCAGACCAGATTCCTCCAGAAAACTCTCCTTTAATGGAGAGGTGCTTC
ATATGTCGTCTAAGGTGTCTGCTGGATAATTCATCTGGTTTTCTGGCAATGAATTTCCAA
GGGAAGTTAAAGTATCTTCATGGACAGAAAAAGAAAGGGAAAGATGGATCAATACTTCCA
CCTCAGTTGGCTTTGTTTGCGATAGCTACTCCACTTCAGCCACCATCCATACTTGAAATC
CGGACCAAAAATTTTATCTTTAGAACCAAACACAAACTAGACTTCACACCTATTGGTTGT
GATGCCAAAGGAAGAATTGTTTTAGGATATACTGAAGCAGAGCTGTGCACGAGAGGCTCA
GGTTATCAGTTTATTCATGCAGCTGATATGCTTTATTGTGCCGAGTCCCATATCCGAATG
ATTAAGACTGGAGAAAGTGGCATGATAGTTTTCCGGCTTCTTACAAAAAACAACCGATGG
ACTTGGGTCCAGTCTAATGCACGCCTGCTTTATAAAAATGGAAGACCAGATTATATCATT
GTAACTCAGAGACCACTAACAGATGAGGAAGGAACAGAGCATTTACGAAAACGAAATACG
AAGTTGCCTTTTATGTTTACCACTGGAGAAGCTGTGTTGTATGAGGCAACCAACCCTTTT
CCTGCCATAATGGATCCCTTACCACTAAGGACTAAAAATGGCACTAGTGGAAAAGACTCT
GCTACCACATCCACTCTAAGCAAGGACTCTCTCAATCCTAGTTCCCTCCTGGCTGCCATG
ATGCAACAAGATGAGTCTATTTATCTCTATCCTGCTTCAAGTACTTCAAGTACTGCACCT
TTTGAAAACAACTTTTTCAACGAATCTATGAATGAATGCAGAAATTGGCAAGATAATACT
GCACCGATGGGAAATGATACTATCCTGAAACATGAGCAAATTGACCAGCCTCAGGATGTG
AACTCATTTGCTGGAGGTCACCCAGGGCTCTTTCAAGATAGTAAAAACAGTGACTTGTAC
AGCATAATGAAAAACCTAGGCATTGATTTTGAAGACATCAGACACATGCAGAATGAAAAA
TTTTTCAGAAATGATTTTTCTGGTGAGGTTGACTTCAGAGACATTGACTTAACGGATGAA
ATCCTGACGTATGTCCAAGATTCTTTAAGTAAGTCTCCCTTCATACCTTCAGATTATCAA
CAGCAACAGTCCTTGGCTCTGAACTCAAGCTGTATGGTACAGGAACACCTACATCTAGAA
CAGCAACAGCAACATCACCAAAAGCAAGTAGTAGTGGAGCCACAGCAACAGCTGTGTCAG
AAGATGAAGCACATGCAAGTTAATGGCATGTTTGAAAATTGGAACTCTAACCAATTCGTG
CCTTTCAATTGTCCACAGCAAGACCCACAACAATATAATGTCTTTACAGACTTACATGGG
ATCAGTCAAGAGTTCCCCTACAAATCTGAAATGGATTCTATGCCTTATACACAGAACTTT
ATTTCCTGTAATCAGCCTGTATTACCACAACATTCCAAATGTACAGAGCTGGACTACCCT
ATGGGGAGTTTTGAACCATCCCCATACCCCACTACTTCTAGTTTAGAAGATTTTGTCACT
TGTTTACAACTTCCTGAAAACCAAAAGCATGGATTAAATCCACAGTCAGCCATAATAACT
CCTCAGACATGTTATGCTGGGGCCGTGTCGATGTATCAGTGCCAGCCAGAACCTCAGCAC
ACCCACGTGGGTCAGATGCAGTACAATCCAGTACTGCCAGGCCAACAGGCATTTTTAAAC
AAGTTTCAGAATGGAGTTTTTAAATGA
|
| Target 1 GenBank Gene ID |
Not Available |
| Target 1 GeneCard ID |
AHR |
| Target 1 GenAtlas ID |
AHR |
| Target 1 HGNC ID |
HGNC:348 |
| Target 1 Chromosome Location |
Not Available |
| Target 1 Locus |
7p15 |
| Target 1 SNPs |
SNPJam Report |
| Target 1 Toxin References |
- R346 - ATSDR - Agency for Toxic Substances and Disease Registry (1998). Toxicological profile for chlorinated dibenzo-p-dioxins (CDDs). U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
|
| Target 1 General References |
8393992; 8246913; 7883760; 12853948; 15489334; 16696038; 7515333; 7961644; 10395741; 11259615 |
|
Target 2
[top]
|
| Target 2 ID |
5 |
| Target 2 Name |
Estrogen receptor |
| Target 2 Mechanism of Action |
Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301) |
| Target 2 Description |
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues |
| Target 2 Synonyms |
- ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1
|
| Target 2 Gene Name |
ESR1 |
| Target 2 Protein Sequence |
>Estrogen receptor
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
|
| Target 2 Number of Residues |
595 |
| Target 2 Molecular Weight |
66215.4 |
| Target 2 Theoretical pI |
8.14 |
| Target 2 GO Classification |
|
Function
|
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity |
|
Process
|
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent |
|
Component
|
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus |
|
| Target 2 General Function |
Involved in estrogen receptor activity |
| Target 2 Pathways |
Not Available |
| Target 2 Reactions |
Not Available |
| Target 2 Signals |
|
| Target 2 Transmembrane Regions |
|
| Target 2 Essentiality |
Non Essential |
| Target 2 Domain Function |
PF00104:Hormone_recep
PF02159:Oest_recep
PF00105:zf-C4 |
| Target 2 GenBank ID Protein |
Not Available |
| Target 2 UniProtKB ID |
P03372 |
| Target 2 Cellular Location |
Nucleus |
| Target 2 Gene Sequence |
>63 bp
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA
|
| Target 2 GenBank Gene ID |
Not Available |
| Target 2 GeneCard ID |
ESR1 |
| Target 2 GenAtlas ID |
ESR1 |
| Target 2 HGNC ID |
HGNC:3467 |
| Target 2 Chromosome Location |
Not Available |
| Target 2 Locus |
6q25.1 |
| Target 2 SNPs |
SNPJam Report |
| Target 2 Toxin References |
- S301 - Luft S, Milki E, Glustrom E, Ampiah-Bonney R, O'Hara P. Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors ? and ?: A Fluorescence Polarization Assay. Biophysical Journal 2009;96(3):444a.
|
| Target 2 General References |
3754034; 3753802; 8600466; 14574404; 7476978; 10619354; 7916651; 7539106 |
|
Target 3
[top]
|
| Target 3 ID |
208 |
| Target 3 Name |
Estrogen receptor beta |
| Target 3 Mechanism of Action |
Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301) |
| Target 3 Description |
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual |
| Target 3 Synonyms |
- ER-beta; Nuclear receptor subfamily 3 group A member 2
|
| Target 3 Gene Name |
ESR2 |
| Target 3 Protein Sequence |
>Estrogen receptor beta
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
|
| Target 3 Number of Residues |
530 |
| Target 3 Molecular Weight |
59215.8 |
| Target 3 Theoretical pI |
8.55 |
| Target 3 GO Classification |
|
Function
|
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity |
|
Process
|
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent |
|
Component
|
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus |
|
| Target 3 General Function |
Involved in estrogen receptor activity |
| Target 3 Pathways |
Not Available |
| Target 3 Reactions |
Not Available |
| Target 3 Signals |
|
| Target 3 Transmembrane Regions |
|
| Target 3 Essentiality |
Non Essential |
| Target 3 Domain Function |
PF00104:Hormone_recep
PF00105:zf-C4 |
| Target 3 GenBank ID Protein |
Not Available |
| Target 3 UniProtKB ID |
Q92731 |
| Target 3 Cellular Location |
Nucleus |
| Target 3 Gene Sequence |
>1593 bp
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGTAACAAGGGCATGGAACATCTGCTCAACATGAAG
TGCAAAAATGTGGTCCCAGTGTATGACCTGCTGCTGGAGATGCTGAATGCCCACGTGCTT
CGCGGGTGCAAGTCCTCCATCACGGGGTCCGAGTGCAGCCCGGCAGAGGACAGTAAAAGC
AAAGAGGGCTCCCAGAACCCACAGTCTCAGTGA
|
| Target 3 GenBank Gene ID |
Not Available |
| Target 3 GeneCard ID |
ESR2 |
| Target 3 GenAtlas ID |
ESR2 |
| Target 3 HGNC ID |
HGNC:3468 |
| Target 3 Chromosome Location |
Chromosome:14 |
| Target 3 Locus |
14q23.2 |
| Target 3 SNPs |
SNPJam Report |
| Target 3 Toxin References |
- S301 - Luft S, Milki E, Glustrom E, Ampiah-Bonney R, O'Hara P. Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors ? and ?: A Fluorescence Polarization Assay. Biophysical Journal 2009;96(3):444a.
|
| Target 3 General References |
9473491; 9636657; 9685228; 9671811; 16938840; 15489334; 10964723; 8769313 |
