Showing toxin card for Barium (T3D0109)

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Version	1.0
Creation Date	2009-03-06 18:58:05
Update Date	2010-03-18 21:52:23
Accession Number	T3D0109
Name	Barium
Compound Type	Barium Compound Inorganic Compound Metal
Description	Barium is a metallic alkaline earth metal with the symbol Ba, and atomic number 56. It never occurs in nature in its pure form due to its reactivity with air, but combines with other chemicals such as sulfur or carbon and oxygen to form barium compounds found as minerals such as barium sulfate and barium carbonate. Barium compounds are used by the oil and gas industries to make drilling muds, and can also be used in the production of paint, bricks, ceramics, glass, and rubber. They are also often used in pyrotechnics, as they emit a green light when burned. (R407, 408)
Synonyms	Bario [spanish] Baryta carbonica Baryum [french] Baryum carbonicum Cheetah Enhancer Entroease Esobar Polibar plus Recto-barium
Chemical IUPAC Name	barium(2+) ion
Chemical Formula	Ba
Chemical Structure
CAS Registry Number	7440-39-3
InChI Identifier	InChI=1S/Ba/q+2
InChI Key	InChIKey=XDFCIPNJCBUZJN-UHFFFAOYSA-N
PubChem Compound ID	5355457
KEGG ID	C13881
UniProt ID	Not Available
OMIM ID	Not Available
ChEBI ID	32595
BioCyc ID	CPD0-1592
SuperToxic ID	Not Available
CTD ID	D001464
Stitch ID	Barium
DrugBank ID	Not Available
PDB ID	Not Available
ACToR ID	6373
Wikipedia Link	http://en.wikipedia.org/wiki/Barium
Monoisotopic Mass	137.905241
MOL File	Show
PDB File	Show
SDF File	Show
SMILES	[Ba++]
Appearance	Silvery white metal.
Melting Point	710 °C
Solubility	Not Available
Predicted LogP	-0.2
Route of Exposure	Oral (R407) ; inhalation (R407)
Mechanism of Action	Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. (R407)
Metabolism	Barium compounds are absorbed via ingestion and inhalation. Barium is principally found in the bone, while small amounts exists in the muscle, adipose tissue, skin, and connective tissue. Barium is not metabolized, but may be transported and incorporated into complexes or tissues. Barium is excreted in the urine and faeces. (R407)
Toxicity Values	Not Available
Lethal Dose	1 to 15 grams for an adult human (barium salts). (R521)
Carcinogenicity (IARC Classification)	Not Available
Uses/Sources	Barium compounds are used by the oil and gas industries to make drilling muds, and can also be used in the production of paint, bricks, ceramics, glass, and rubber. They are also often used in pyrotechnics, as they emit a green light when burned. (R407, R408)
Minimum Risk Level	Intermediate Oral: 0.2 mg/kg/day (Barium salts) (R260) Chronic Oral: 0.2 mg/kg/day (Barium salts) (R260)
Health Effects	The health effects of the different barium compounds depend on how well the compound dissolves in water or the stomach contents. At low doses, barium acts as a muscle stimulant, while higher doses affect the nervous system, causing cardiac irregularities, tremors, weakness, anxiety, dyspnea, paralysisand possibly death. Barium may also cause gastrointestinal disturbances, damage the kidneys and cause decreases in body weight. (R407)
Symptoms	Ingesting excess barium may cause vomiting, abdominal cramps, diarrhea, difficulties in breathing, increased or decreased blood pressure, numbness around the face, and muscle weakness. High levels may result in changes in heart rhythm or paralysis and possibly death. (R407)
Treatment	Intravenous infusion of potassium often relieves many of the symptoms of barium toxicity. (R407)
General References	R407 - ATSDR - Agency for Toxic Substances and Disease Registry (2007). Toxicological profile for barium. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA). R521 - Gosselin RE, Smith RP, and Hodge HC (1984). Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins. R408 - Wikipedia. Barium. Last Updated 21 May 2009.
Targets	Calmodulin Inward rectifier potassium channel 13 Inward rectifier potassium channel 16 Inward rectifier potassium channel 2 Inward rectifier potassium channel 4 G protein-activated inward rectifier potassium channel 1 G protein-activated inward rectifier potassium channel 2 G protein-activated inward rectifier potassium channel 3 G protein-activated inward rectifier potassium channel 4 ATP-sensitive inward rectifier potassium channel 1 ATP-sensitive inward rectifier potassium channel 10 ATP-sensitive inward rectifier potassium channel 11 ATP-sensitive inward rectifier potassium channel 12 ATP-sensitive inward rectifier potassium channel 14 ATP-sensitive inward rectifier potassium channel 15 ATP-sensitive inward rectifier potassium channel 8 Potassium voltage-gated channel subfamily KQT member 1 Potassium voltage-gated channel subfamily KQT member 2 Potassium voltage-gated channel subfamily KQT member 3 Potassium voltage-gated channel subfamily KQT member 4 Potassium voltage-gated channel subfamily KQT member 5

Target 1 [top]

Target 1 ID

Target 1 Name

Calmodulin

Target 1 Mechanism of Action

Barium is believed to bind and activate calmodulin, causing certain neurotoxic effects. (R413)

Target 1 Description

Calmodulin mediates the control of a large number of enzymes and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Together with CEP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis

Target 1 Synonyms

Target 1 Gene Name

CALM1

Target 1 Protein Sequence

>Calmodulin

MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADG
NGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDE
EVDEMIREADIDGDGQVNYEEFVQMMTAK

Target 1 Number of Residues

149

Target 1 Molecular Weight

16837.5

Target 1 Theoretical pI

3.84

Target 1 GO Classification

Function
binding ion binding cation binding calcium ion binding
Process
Not Available
Component
Not Available

Target 1 General Function

Involved in calcium ion binding

Target 1 Pathways

Not Available

Target 1 Reactions

Not Available

Target 1 Signals

None

Target 1 Transmembrane Regions

None

Target 1 Essentiality

Non Essential

Target 1 Domain Function

PF00036:efhand

Target 1 GenBank ID Protein

Not Available

Target 1 UniProtKB ID

P62158

Target 1 Cellular Location

Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole

Target 1 Gene Sequence

>450 bp

ATGGCTGACCAGCTGACTGAGGAGCAGATTGCAGAGTTCAAGGAGGCCTTCTCCCTCTTT
GACAAGGATGGAGATGGCACTATCACCACCAAGGAGTTGGGGACAGTGATGAGATCCCTG
GGACAGAACCCCACTGAAGCAGAGCTGCAGGATATGATCAATGAGGTGGATGCAGATGGG
AACGGGACCATTGACTTCCCGGAGTTCCTGACCATGATGGCCAGAAAGATGAAGGACACA
GACAGTGAGGAGGAGATCCGAGAGGCGTTCCGTGTCTTTGACAAGGATGGGAATGGCTAC
ATCAGCGCCGCAGAGCTGCGTCACGTAATGACGAACCTGGGGGAGAAGCTGACCGATGAG
GAGGTGGATGAGATGATCAGGGAGGCTGACATCGATGGAGATGGCCAGGTCAATTATGAA
GAGTTTGTACAGATGATGACTGCAAAGTGA

Target 1 GenBank Gene ID

Not Available

Target 1 GeneCard ID

CALM1

Target 1 GenAtlas ID

CALM1

Target 1 HGNC ID

HGNC:1442

Target 1 Chromosome Location

Chromosome:14

Target 1 Locus

14q24-q31

Target 1 SNPs

SNPJam Report Link Image

Target 1 Toxin References

R413 - Kursula P, Majava V: A structural insight into lead neurotoxicity and calmodulin activation by heavy metals. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Aug 1;63(Pt 8):653-6. Epub 2007 Jul 28. [PubMed ]

Target 1 General References

6385987; 2445749; 3182832; 2223880; 7925473; 9681195; 12508121

Target 2 [top]

Target 2 ID

581

Target 2 Name

Inward rectifier potassium channel 13

Target 2 Mechanism of Action

Barium is a competitive antagonist at inward rectifier potassium channels and blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. (R418)

Target 2 Description

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium

Target 2 Synonyms

Potassium channel, inwardly rectifying subfamily J member 13; Inward rectifier K(+) channel Kir7.1

Target 2 Gene Name

KCNJ13

Target 2 Protein Sequence

>Inward rectifier potassium channel 13

MDSSNCKVIAPLLSQRYRRMVTKDGHSTLQMDGAQRGLAYLRDAWGILMDMRWRWMMLVF
SASFVVHWLVFAVLWYVLAEMNGDLELDHDAPPENHTICVKYITSFTAAFSFSLETQLTI
GYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDTAVVAH
MDGKPNLIFQVANTRPSPLTSVRVSAVLYQERENGKLYQTSVDFHLDGISSDECPFFIFP
LTYYHSITPSSPLATLLQHENPSHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHCFA
SLLTRGSKGEYQIKMENFDKTVPEFPTPLVSKSPNRTDLDIHINGQSIDNFQISETGLTE

Target 2 Number of Residues

360

Target 2 Molecular Weight

40529.2

Target 2 Theoretical pI

6.23

Target 2 GO Classification

Function
transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 2 General Function

Involved in inward rectifier potassium channel activity

Target 2 Pathways

Not Available

Target 2 Reactions

Not Available

Target 2 Signals

None

Target 2 Transmembrane Regions

54-78
134-155

Target 2 Essentiality

Non Essential

Target 2 Domain Function

PF01007:IRK

Target 2 GenBank ID Protein

Not Available

Target 2 UniProtKB ID

O60928

Target 2 Cellular Location

Membrane

Target 2 Gene Sequence

>1083 bp

ATGGACAGCAGTAATTGCAAAGTTATTGCTCCTCTCCTAAGTCAAAGATACCGGAGGATG
GTCACCAAGGATGGCCACAGCACACTTCAAATGGATGGCGCTCAAAGAGGTCTTGCATAT
CTTCGAGATGCTTGGGGAATCCTAATGGACATGCGCTGGCGTTGGATGATGTTGGTCTTT
TCTGCTTCTTTTGTTGTCCACTGGCTTGTCTTTGCAGTGCTCTGGTATGTTCTGGCTGAG
ATGAATGGTGATCTGGAACTAGATCATGATGCCCCACCTGAAAACCACACTATCTGTGTC
AAGTATATCACCAGTTTCACAGCTGCATTCTCCTTCTCCCTGGAGACACAACTCACAATT
GGTTATGGTACCATGTTCCCCAGTGGTGACTGTCCAAGTGCAATCGCCTTACTTGCCATA
CAAATGCTCCTAGGCCTCATGCTAGAGGCTTTTATCACAGGTGCTTTTGTGGCGAAGATT
GCCCGGCCAAAAAATCGAGCTTTTTCAATTCGCTTTACTGACATAGCAGTAGTAGCTCAC
ATGGATGGCAAACCTAATCTTATCTTCCAAGTGGCCAACACCCGACCTAGCCCTCTAACC
AGTGTCCGGGTCTCAGCTGTACTCTATCAGGAAAGAGAAAATGGCAAACTCTACCAGACC
AGTGTGGATTTCCACCTTGATGGCATCAGTTCTGACGAATGTCCATTCTTCATCTTTCCA
CTAACGTACTATCACTCCATTACACCATCAAGTCCTCTGGCTACTCTGCTCCAGCATGAA
AATCCTTCTCACTTTGAATTAGTTGTATTCCTTTCAGCAATGCAGGAGGGCACTGGAGAA
ATATGCCAAAGGAGGACATCCTACCTACCGTCTGAAATCATGTTACATCACTGTTTTGCA
TCTCTGTTGACCCGAGGTTCCAAAGGTGAATATCAAATCAAGATGGAGAATTTTGACAAG
ACTGTCCCTGAATTTCCAACTCCTCTGGTTTCTAAAAGCCCAAACAGGACTGACCTGGAT
ATCCACATCAATGGACAAAGCATTGACAATTTTCAGATCTCTGAAACAGGACTGACAGAA
TAA

Target 2 GenBank Gene ID

Not Available

Target 2 GeneCard ID

KCNJ13

Target 2 GenAtlas ID

KCNJ13

Target 2 HGNC ID

HGNC:6259

Target 2 Chromosome Location

Not Available

Target 2 Locus

Not Available

Target 2 SNPs

SNPJam Report Link Image

Target 2 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 2 General References

9738472; 9620703; 15489334; 9878260; 18179896

Target 3 [top]

Target 3 ID

586

Target 3 Name

Inward rectifier potassium channel 16

Target 3 Mechanism of Action

Target 3 Description

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance

Target 3 Synonyms

Potassium channel, inwardly rectifying subfamily J member 16; Inward rectifier K(+) channel Kir5.1

Target 3 Gene Name

KCNJ16

Target 3 Protein Sequence

>Inward rectifier potassium channel 16

MSYYGSSYHIINADAKYPGYPPEHIIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVD
IFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLLNDPDITPCVDNVHSFTG
AFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMATARKRAQ
TIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGRMTMAFKDLKL
VNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYV
PREILWGHRFNDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLHIEKAPPVR
ESCTSDTKARRRSFSAVAIVSSCENPEETTTSATHEYRETPYQKALLTLNRISVESQM

Target 3 Number of Residues

418

Target 3 Molecular Weight

47948.6

Target 3 Theoretical pI

7.94

Target 3 GO Classification

Function
transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 3 General Function

Involved in inward rectifier potassium channel activity

Target 3 Pathways

Not Available

Target 3 Reactions

Not Available

Target 3 Signals

None

Target 3 Transmembrane Regions

71-95
146-167

Target 3 Essentiality

Non Essential

Target 3 Domain Function

PF01007:IRK

Target 3 GenBank ID Protein

Not Available

Target 3 UniProtKB ID

Q9NPI9

Target 3 Cellular Location

Membrane

Target 3 Gene Sequence

Not Available

Target 3 GenBank Gene ID

Not Available

Target 3 GeneCard ID

KCNJ16

Target 3 GenAtlas ID

KCNJ16

Target 3 HGNC ID

HGNC:6262

Target 3 Chromosome Location

Chromosome:17

Target 3 Locus

17q23.1-q24.2

Target 3 SNPs

SNPJam Report Link Image

Target 3 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 3 General References

11060447; 11240146

Target 4 [top]

Target 4 ID

577

Target 4 Name

Inward rectifier potassium channel 2

Target 4 Mechanism of Action

Target 4 Description

Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium or cesium

Target 4 Synonyms

Potassium channel, inwardly rectifying subfamily J member 2; Inward rectifier K(+) channel Kir2.1; Cardiac inward rectifier potassium channel; IRK1

Target 4 Gene Name

KCNJ2

Target 4 Protein Sequence

>Inward rectifier potassium channel 2

MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFIN
VGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKEGK
ACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVM
AKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEG
EYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEG
MVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARD
LAEKKYILSNANSFCYENEVALTSKEEDDSENGVPESTSTDTPPDIDLHNQASVPLEPRP
LRRESEI

Target 4 Number of Residues

427

Target 4 Molecular Weight

48287.8

Target 4 Theoretical pI

5.47

Target 4 GO Classification

Function
transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 4 General Function

Involved in potassium ion binding

Target 4 Pathways

Not Available

Target 4 Reactions

Not Available

Target 4 Signals

None

Target 4 Transmembrane Regions

82-106
157-178

Target 4 Essentiality

Non Essential

Target 4 Domain Function

PF01007:IRK PF08466:IRK_N

Target 4 GenBank ID Protein

Not Available

Target 4 UniProtKB ID

P63252

Target 4 Cellular Location

Membrane

Target 4 Gene Sequence

>1284 bp

ATGGGCAGTGTGCGAACCAACCGCTACAGCATCGTTTCTTCAGAAGAAGACGGTATGAAG
TTGGCCACCATGGCAGTTGCAAATGGCTTTGGGAACGGGAAGAGTAAAGTCCACACCCGA
CAACAGTGCAGGAGCCGCTTTGTGAAGAAAGATGGCCACTGTAATGTTCAGTTCATCAAT
GTGGGTGAGAAGGGGCAACGGTACCTCGCAGACATCTTCACCACGTGTGTGGACATTCGC
TGGCGGTGGATGCTGGTTATTTTCTGCCTGGCTTTCGTCCTGTCATGGCTGTTTTTTGGC
TGTGTGTTTTGGTTGATAGCTCTGCTCCATGGGGACCTGGATGCATCCAAAGAGGGCAAA
GCTTGTGTGTCCGAGGTCAACAGCTTCACGGCTGCCTTCCTCTTCTCCATTGAGACCCAG
ACAACCATAGGCTATGGTTTCAGATGTGTCACGGATGAATGCCCAATTGCTGTTTTCATG
GTGGTGTTCCAGTCAATCGTGGGCTGCATCATCGATGCTTTCATCATTGGCGCAGTCATG
GCCAAGATGGCAAAGCCAAAGAAGAGAAACGAGACTCTTGTCTTCAGTCACAATGCCGTG
ATTGCCATGAGAGACGGCAAGCTGTGTTTGATGTGGCGAGTGGGCAATCTTCGGAAAAGC
CACTTGGTGGAAGCTCATGTTCGAGCACAGCTCCTCAAATCCAGAATTACTTCTGAAGGG
GAGTATATCCCTCTGGATCAAATAGACATCAATGTTGGGTTTGACAGTGGAATCGATCGT
ATATTTCTGGTGTCCCCAATCACTATAGTCCATGAAATAGATGAAGACAGTCCTTTATAT
GATTTGAGTAAACAGGACATTGACAACGCAGACTTTGAAATCGTGGTCATACTGGAAGGC
ATGGTGGAAGCCACTGCCATGACGACACAGTGCCGTAGCTCTTATCTAGCAAATGAAATC
CTGTGGGGCCACCGCTATGAGCCTGTGCTCTTTGAAGAGAAGCACTACTACAAAGTGGAC
TATTCCAGGTTCCACAAAACTTACGAAGTCCCCAACACTCCCCTTTGTAGTGCCAGAGAC
TTAGCAGAAAAGAAATATATCCTCTCAAATGCAAATTCATTTTGCTATGAAAATGAAGTT
GCCCTCACAAGCAAAGAGGAAGACGACAGTGAAAATGGAGTTCCAGAAAGCACTAGTACG
GACACGCCCCCTGACATAGACCTTCACAACCAGGCAAGTGTACCTCTAGAGCCCAGGCCC
TTACGGCGAGAGTCGGAGATATGA

Target 4 GenBank Gene ID

Not Available

Target 4 GeneCard ID

KCNJ2

Target 4 GenAtlas ID

KCNJ2

Target 4 HGNC ID

HGNC:6263

Target 4 Chromosome Location

Chromosome:17

Target 4 Locus

17q23.1-q24.2

Target 4 SNPs

SNPJam Report Link Image

Target 4 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 4 General References

7696590; 7590287; 9490857; 11240146; 7840300; 18083107; 11371347; 12148092; 12163457

Target 5 [top]

Target 5 ID

578

Target 5 Name

Inward rectifier potassium channel 4

Target 5 Mechanism of Action

Target 5 Description

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity)

Target 5 Synonyms

Potassium channel, inwardly rectifying subfamily J member 4; Inward rectifier K(+) channel Kir2.3; Hippocampal inward rectifier; HIRK2; HRK1; HIR

Target 5 Gene Name

KCNJ4

Target 5 Protein Sequence

>Inward rectifier potassium channel 4

MHGHSRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLM
IFSAAFLVSWLFFGLLFWCIAFFHGDLEASPGVPAAGGPAAGGGGAAPVAPKPCIMHVNG
FLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKK
RAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQR
DLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMT
TQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITV
LPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFG
SHLDLERMQASLPLDNISYRRESAI

Target 5 Number of Residues

445

Target 5 Molecular Weight

49499.6

Target 5 Theoretical pI

6.15

Target 5 GO Classification

Function
transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 5 General Function

Involved in inward rectifier potassium channel activity

Target 5 Pathways

Not Available

Target 5 Reactions

Not Available

Target 5 Signals

None

Target 5 Transmembrane Regions

56-80
149-170

Target 5 Essentiality

Non Essential

Target 5 Domain Function

PF01007:IRK

Target 5 GenBank ID Protein

Not Available

Target 5 UniProtKB ID

P48050

Target 5 Cellular Location

Membrane

Target 5 Gene Sequence

>1338 bp

ATGCACGGACACAGCCGCAACGGCCAGGCCCACGTGCCCCGGCGGAAGCGCCGCAACCGC
TTCGTCAAGAAGAACGGCCAATGCAACGTGTACTTCGCCAACCTGAGCAACAAGTCGCAG
CGCTACATGGCGGACATCTTCACCACCTGCGTGGACACGCGCTGGCGCTACATGCTCATG
ATCTTCTCCGCGGCCTTCCTTGTCTCCTGGCTCTTTTTCGGCCTCCTCTTCTGGTGTATC
GCCTTCTTCCACGGTGACCTGGAGGCCAGCCCAGGGGTGCCTGCGGCGGGGGGCCCGGCG
GCGGGTGGTGGCGGAGCAGCCCCGGTGGCCCCCAAGCCCTGCATCATGCACGTGAACGGC
TTCCTGGGTGCCTTCCTGTTCTCGGTGGAGACGCAGACGACCATCGGCTATGGGTTCCGG
TGCGTGACAGAGGAGTGCCCGCTGGCAGTCATCGCTGTGGTGGTCCAGTCCATCGTGGGC
TGCGTCATCGACTCCTTCATGATTGGCACCATCATGGCCAAGATGGCGCGGCCCAAGAAG
CGGGCGCAGACGTTGCTGTTCAGCCACCACGCGGTCATTTCGGTGCGCGACGGCAAGCTC
TGCCTCATGTGGCGCGTGGGCAACCTGCGCAAGAGCCACATTGTGGAGGCCCACGTGCGG
GCCCAGCTCATCAAGCCCTACATGACCCAGGAGGGCGAGTACCTGCCCCTGGACCAGCGG
GACCTCAACGTGGGCTATGACATCGGCCTGGACCGCATCTTCCTGGTGTCGCCCATCATC
ATTGTCCACGAGATCGACGAGGACAGCCCGCTTTATGGCATGGGCAAGGAGGAGCTGGAG
TCGGAGGACTTTGAGATCGTGGTCATCCTGGAGGGCATGGTGGAGGCCACGGCCATGACC
ACCCAGGCCCGCAGCTCCTACCTGGCCAGCGAGATCCTGTGGGGCCACCGCTTTGAGCCT
GTGGTCTTCGAGGAGAAGAGCCACTACAAGGTGGACTACTCACGTTTTCACAAGACCTAC
GAGGTGGCCGGCACGCCCTGCTGCTCGGCCCGGGAGCTGCAGGAGAGTAAGATCACCGTG
CTGCCCGCCCCACCGCCCCCTCCCAGTGCCTTCTGCTACGAGAACGAGCTGGCCCTTATG
AGCCAGGAGGAAGAGGAGATGGAGGAGGAGGCAGCTGCGGCGGCCGCGGTGGCCGCAGGC
CTGGGCCTGGAGGCGGGTTCCAAGGAGGAGGCGGGCATCATCCGGATGCTGGAGTTCGGC
AGCCACCTGGACCTGGAGCGCATGCAGGCTTCCCTCCCGCTGGACAACATCTCCTACCGC
AGGGAGTCTGCCATCTGA

Target 5 GenBank Gene ID

Not Available

Target 5 GeneCard ID

KCNJ4

Target 5 GenAtlas ID

KCNJ4

Target 5 HGNC ID

HGNC:6265

Target 5 Chromosome Location

Chromosome:22

Target 5 Locus

22q13.1

Target 5 SNPs

SNPJam Report Link Image

Target 5 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 5 General References

8016146; 8034048; 8051145; 15461802; 10591208; 15489334

Target 6 [top]

Target 6 ID

587

Target 6 Name

G protein-activated inward rectifier potassium channel 1

Target 6 Mechanism of Action

Target 6 Description

This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat

Target 6 Synonyms

GIRK1; Potassium channel, inwardly rectifying subfamily J member 3; Inward rectifier K(+) channel Kir3.1

Target 6 Gene Name

KCNJ3

Target 6 Protein Sequence

>G protein-activated inward rectifier potassium channel 1

MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNL
GSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNY
TPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCM
FIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPE
GEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILE
GIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKE
QEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMS
STTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGG
AARMEGNLPAKLRKMNSDRFT

Target 6 Number of Residues

501

Target 6 Molecular Weight

56602.8

Target 6 Theoretical pI

8.36

Target 6 GO Classification

Function
G-protein activated inward rectifier potassium channel activity transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 6 General Function

Involved in G-protein activated inward rectifier potass

Target 6 Pathways

Not Available

Target 6 Reactions

Not Available

Target 6 Signals

None

Target 6 Transmembrane Regions

81-105
158-179

Target 6 Essentiality

Non Essential

Target 6 Domain Function

PF01007:IRK

Target 6 GenBank ID Protein

Not Available

Target 6 UniProtKB ID

P48549

Target 6 Cellular Location

Membrane

Target 6 Gene Sequence

>1506 bp

ATGTCTGCACTCCGAAGGAAATTTGGGGACGATTATCAGGTAGTGACCACATCGTCCAGC
GGCTCGGGCTTGCAGCCCCAGGGGCCAGGCCAGGACCCTCAGCAGCAGCTTGTGCCCAAG
AAGAAGCGGCAGCGGTTCGTGGACAAGAACGGCCGGTGCAATGTACAGCACGGCAACCTG
GGCAGCGAGACAAGCCGCTACCTCTCGGACCTCTTCACCACGCTGGTGGACCTCAAGTGG
CGCTGGAACCTCTTCATCTTCATTCTCACCTACACCGTGGCCTGGCTTTTCATGGCGTCC
ATGTGGTGGGTGATCGCCTACACTCGGGGCGACCTGAACAAAGCCCACGTCGGTAACTAC
ACGCCTTGCGTGGCCAATGTCTATAACTTCCCTTCTGCCTTCCTCTTCTTCATCGAGACG
GAGGCCACCATCGGCTATGGCTACCGATACATCACAGACAAGTGCCCCGAGGGCATCATC
CTCTTCCTCTTCCAGTCCATCCTGGGCTCCATCGTGGACGCCTTCCTCATCGGCTGCATG
TTCATCAAGATGTCCCAGCCCAAGAAGCGCGCCGAGACCCTCATGTTCAGCGAGCACGCG
GTGATCTCCATGAGGGACGGAAAACTCACGCTTATGTTCCGGGTGGGCAACCTGCGCAAC
AGCCACATGGTCTCCGCGCAGATTCGCTGCAAGCTGCTCAAATCTCGGCAGACACCTGAG
GGTGAGTTCCTTCCCCTTGACCAACTTGAACTGGATGTAGGTTTTAGTACAGGGGCAGAT
CAACTTTTTCTTGTGTCCCCCCTCACAATTTGCCACGTGATCGATGCCAAAAGCCCCTTT
TATGACCTATCCCAGCGAAGCATGCAAACTGAACAGTTCGAGATTGTCGTCATCCTAGAA
GGCATTGTGGAAACAACTGGGATGACTTGTCAAGCTCGAACATCATATACTGAAGATGAA
GTTCTTTGGGGTCATCGTTTTTTTCCTGTAATTTCCTTAGAAGAGGGATTCTTTAAAGTT
GATTATTCCCAGTTCCATGCAACATTTGAAGTCCCCACCCCACCTTACAGTGTGAAAGAG
CAGGAGGAAATGCTTCTCATGTCGTCCCCCTTAATAGCACCAGCCATAACTAACAGCAAA
GAAAGACATAATTCTGTGGAATGCTTAGATGGACTAGATGATATTACTACAAAACTACCA
TCTAAGCTGCAGAAAATTACTGGAAGAGAAGACTTTCCCAAAAAACTCTTGAGGATGAGT
TCTACAACTTCAGAAAAAGCCTACAGCTTGGGAGACTTGCCCATGAAACTTCAACGAATA
AGTTCAGTTCCGGGCAACTCAGAAGAAAAACTGGTATCTAAAACCACCAAGATGTTATCT
GATCCCATGAGCCAGTCTGTGGCTGATTTGCCACCAAAGCTTCAAAAGATGGCTGGAGGA
GCAGCTAGGATGGAAGGGAACCTTCCAGCCAAATTAAGAAAAATGAACTCTGATCGCTTC
ACATAA

Target 6 GenBank Gene ID

Not Available

Target 6 GeneCard ID

KCNJ3

Target 6 GenAtlas ID

KCNJ3

Target 6 HGNC ID

HGNC:6264

Target 6 Chromosome Location

Not Available

Target 6 Locus

2q24.1

Target 6 SNPs

SNPJam Report Link Image

Target 6 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 6 General References

8868049; 8804710; 15489334; 17924679

Target 7 [top]

Target 7 ID

588

Target 7 Name

G protein-activated inward rectifier potassium channel 2

Target 7 Mechanism of Action

Target 7 Description

This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium

Target 7 Synonyms

GIRK2; Potassium channel, inwardly rectifying subfamily J member 6; Inward rectifier K(+) channel Kir3.2; KATP-2; BIR1

Target 7 Gene Name

KCNJ6

Target 7 Protein Sequence

>G protein-activated inward rectifier potassium channel 2

MAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKD
GKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGD
MDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSI
VNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAK
LIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKE
ELEIVVILEGMVEATGMTCQARSSYITSEILWGYRFTPVLTLEDGFYEVDYNSFHETYET
STPSLSAKELAELASRAELPLSWSVSSKLNQHAELETEEEEKNLEEQTERNGDVANLENE
SKV

Target 7 Number of Residues

423

Target 7 Molecular Weight

48451.0

Target 7 Theoretical pI

5.04

Target 7 GO Classification

Function
G-protein activated inward rectifier potassium channel activity transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 7 General Function

Involved in G-protein activated inward rectifier potass

Target 7 Pathways

Not Available

Target 7 Reactions

Not Available

Target 7 Signals

None

Target 7 Transmembrane Regions

90-114
167-188

Target 7 Essentiality

Non Essential

Target 7 Domain Function

PF01007:IRK

Target 7 GenBank ID Protein

Not Available

Target 7 UniProtKB ID

P48051

Target 7 Cellular Location

Membrane

Target 7 Gene Sequence

>1272 bp

ATGGCCAAGCTGACAGAATCCATGACTAACGTCCTGGAGGGCGACTCCATGGATCAGGAC
GTCGAAAGCCCAGTGGCCATTCACCAGCCAAAGTTGCCTAAGCAGGCCAGGGATGACCTG
CCAAGACACATCAGCCGAGATCGGACCAAAAGGAAAATCCAGAGGTACGTGAGGAAAGAC
GGAAAGTGCAATGTTCATCACGGCAACGTGAGGGAGACCTATCGCTACCTGACCGATATC
TTCACCACATTAGTGGACCTGAAGTGGAGATTCAACCTATTGATTTTTGTCATGGTTTAC
ACAGTGACCTGGCTCTTTTTTGGAATGATCTGGTGGTTGATCGCATACATACGGGGAGAC
ATGGACCACATAGAGGACCCCTCCTGGACTCCTTGTGTTACCAACCTCAACGGGTTCGTC
TCTGCTTTTTTATTCTCAATAGAGACAGAAACCACCATTGGTTATGGCTACCGGGTCATC
ACAGATAAATGCCCGGAGGGAATTATTCTTCTCTTAATCCAATCTGTGTTGGGGTCCATT
GTCAATGCATTCATGGTGGGATGCATGTTTGTAAAAATCTCTCAACCCAAGAAGAGGGCA
GAGACCCTGGTCTTTTCCACCCATGCAGTGATCTCCATGCGGGATGGGAAACTGTGCCTG
ATGTTCCGGGTAGGGGACCTTAGGAATTCCCACATTGTGGAGGCTTCCATCAGAGCCAAG
TTGATCAAATCCAAACAGACCTCGGAGGGGGAGTTCATCCCGTTGAACCAGACGGATATC
AACGTAGGGTATTACACGGGGGATGACCGTCTGTTTCTGGTGTCACCGCTGATCATTAGC
CATGAAATTAACCAACAGAGTCCTTTCTGGGAGATCTCCAAAGCCCAGCTGCCCAAAGAG
GAACTGGAAATTGTGGTCATCCTAGAAGGAATGGTGGAAGCCACAGGGATGACATGCCAA
GCTCGAAGCTCCTACATCACCAGTGAGATCCTGTGGGGTTACCGGTTCACACCTGTCCTG
ACCCTGGAGGATGGGTTCTACGAAGTTGACTACAACAGCTTCCATGAGACCTATGAGACC
AGCACCCCATCCCTTAGTGCCAAAGAGCTGGCCGAGTTAGCCAGCAGGGCAGAGCTGCCC
CTGAGTTGGTCTGTATCCAGCAAACTCAACCAACATGCAGAACTGGAGACTGAAGAGGAA
GAAAAGAACCTCGAAGAGCAAACAGAAAGAAATGGTGATGTGGCAAACCTGGAGAATGAA
TCCAAAGTTTAG

Target 7 GenBank Gene ID

Not Available

Target 7 GeneCard ID

KCNJ6

Target 7 GenAtlas ID

KCNJ6

Target 7 HGNC ID

HGNC:6267

Target 7 Chromosome Location

Chromosome:21

Target 7 Locus

21q22.1|21q22.13-q22.2

Target 7 SNPs

SNPJam Report Link Image

Target 7 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 7 General References

7592809; 10659995; 15489334; 7796919; 7729621

Target 8 [top]

Target 8 ID

590

Target 8 Name

G protein-activated inward rectifier potassium channel 3

Target 8 Mechanism of Action

Target 8 Description

Target 8 Synonyms

GIRK3; Potassium channel, inwardly rectifying subfamily J member 9; Inwardly rectifier K(+) channel Kir3.3

Target 8 Gene Name

KCNJ9

Target 8 Protein Sequence

>G protein-activated inward rectifier potassium channel 3

MAQENAAFSPGQEEPPRRRGRQRYVEKDGRCNVQQGNVRETYRYLTDLFTTLVDLQWRLS
LLFFVLAYALTWLFFGAIWWLIAYGRGDLEHLEDTAWTPCVNNLNGFVAAFLFSIETETT
IGYGHRVITDQCPEGIVLLLLQAILGSMVNAFMVGCMFVKISQPNKRAATLVFSSHAVVS
LRDGRLCLMFRVGDLRSSHIVEASIRAKLIRSRQTLEGEFIPLHQTDLSVGFDTGDDRLF
LVSPLVISHEIDAASPFWEASRRALERDDFEIVVILEGMVEATGMTCQARSSYLVDEVLW
GHRFTSVLTLEDGFYEVDYASFHETFEVPTPSCSARELAEAAARLDAHLYWSIPSRLDEK
VEEEGAGEGAGGEAGADKEQNGCLPPPESESKV

Target 8 Number of Residues

393

Target 8 Molecular Weight

44019.4

Target 8 Theoretical pI

4.59

Target 8 GO Classification

Function
G-protein activated inward rectifier potassium channel activity transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 8 General Function

Involved in G-protein activated inward rectifier potass

Target 8 Pathways

Not Available

Target 8 Reactions

Not Available

Target 8 Signals

None

Target 8 Transmembrane Regions

58-82
135-156

Target 8 Essentiality

Non Essential

Target 8 Domain Function

PF01007:IRK

Target 8 GenBank ID Protein

Not Available

Target 8 UniProtKB ID

Q92806

Target 8 Cellular Location

Membrane

Target 8 Gene Sequence

>1182 bp

ATGGCGCAGGAGAACGCGGCCTTCTCGCCCGGGCAGGAGGAGCCGCCGCGGCGCCGCGGC
CGCCAGCGCTACGTGGAGAAGGATGGCCGGTGCAACGTGCAGCAGGGCAACGTGCGCGAG
ACATACCGCTACCTGACGGACCTGTTCACCACGCTGGTGGACCTGCAGTGGCGCCTCAGC
CTGTTGTTCTTCGTCCTGGCCTACGCGCTCACCTGGCTCTTCTTCGGCGCCATCTGGTGG
CTGATCGCCTACGGCCGCGGCGACCTGGAGCACCTGGAGGACACCGCGTGGACGCCGTGC
GTCAACAACCTCAACGGCTTCGTGGCCGCCTTCCTCTTCTCCATCGAGACCGAGACCACC
ATCGGCTACGGGCACCGCGTCATCACCGACCAGTGCCCCGAGGGCATCGTGCTGCTGCTG
CTGCAGGCCATCCTGGGCTCCATGGTGAACGCCTTCATGGTGGGCTGCATGTTCGTCAAG
ATCTCGCAGCCCAACAAGCGCGCAGCCACGCTCGTCTTCTCCTCGCACGCCGTGGTGTCG
CTGCGCGACGGGCGCCTCTGCCTCATGTTCCGCGTGGGCGACTTGCGCTCCTCACACATA
GTGGAGGCCTCCATCCGCGCCAAGCTCATCCGCTCGCGCCAGACGCTGGAGGGCGAGTTC
ATCCCGCTGCACCAGACCGACCTCAGCGTGGGCTTCGACACGGGAGACGACCGCCTCTTC
CTCGTCTCGCCGCTGGTTATCAGCCACGAGATCGACGCCGCCAGCCCCTTCTGGGAGGCG
TCGCGCCGTGCCCTCGAGAGGGACGACTTCGAGATCGTCGTTATCCTCGAGGGCATGGTG
GAAGCCACGGGAATGACATGCCAAGCTCGGAGCTCCTACCTGGTAGACGAGGTGCTGTGG
GGCCACCGCTTCACGTCAGTGCTGACTCTGGAGGACGGCTTCTACGAAGTGGACTATGCC
AGCTTTCACGAGACTTTTGAGGTGCCCACACCTTCGTGCAGTGCTCGAGAGCTGGCAGAG
GCTGCCGCCCGCCTTGATGCCCATCTCTACTGGTCCATCCCCAGCCGGCTGGATGAGAAG
GTGGAGGAGGAGGGGGTGGGGGAGGGGGCGGGTGGGGAAGCTGGGGCTGACAAGGAGCAG
AATGGCTGCCTGCCACCCCCAGAGAGTGAGTCCAAGGTGTGA

Target 8 GenBank Gene ID

Not Available

Target 8 GeneCard ID

KCNJ9

Target 8 GenAtlas ID

KCNJ9

Target 8 HGNC ID

HGNC:6270

Target 8 Chromosome Location

Not Available

Target 8 Locus

1q21-q23

Target 8 SNPs

SNPJam Report Link Image

Target 8 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 8 General References

10659995; 10913335; 16710414

Target 9 [top]

Target 9 ID

583

Target 9 Name

G protein-activated inward rectifier potassium channel 4

Target 9 Mechanism of Action

Target 9 Description

Target 9 Synonyms

GIRK4; Potassium channel, inwardly rectifying subfamily J member 5; Inward rectifier K(+) channel Kir3.4; Heart KATP channel; KATP-1; Cardiac inward rectifier; CIR

Target 9 Gene Name

KCNJ5

Target 9 Protein Sequence

>G protein-activated inward rectifier potassium channel 4

MAGDSRNAMNQDMEIGVTPWDPKKIPKQARDYVPIATDRTRLLAEGKKPRQRYMEKSGKC
NVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTVTWLFFGFIWWLIAYIRGDLDH
VGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNA
FMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIK
SRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINEKSPFWEMSQAQLHQEEFE
VVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTP
SCCAKELAEMKREGRLLQYLPSPPLLGGCAEAGLDAEAEQNEEDEPKGLGGSREARGSV

Target 9 Number of Residues

419

Target 9 Molecular Weight

47668.3

Target 9 Theoretical pI

4.96

Target 9 GO Classification

Function
G-protein activated inward rectifier potassium channel activity transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 9 General Function

Involved in G-protein activated inward rectifier potass

Target 9 Pathways

Not Available

Target 9 Reactions

Not Available

Target 9 Signals

None

Target 9 Transmembrane Regions

87-111
164-185

Target 9 Essentiality

Non Essential

Target 9 Domain Function

PF01007:IRK

Target 9 GenBank ID Protein

Not Available

Target 9 UniProtKB ID

P48544

Target 9 Cellular Location

Membrane

Target 9 Gene Sequence

>1260 bp

ATGGCTGGCGATTCTAGGAATGCCATGAACCAGGACATGGAGATTGGAGTCACTCCCTGG
GACCCCAAGAAGATTCCAAAACAGGCCCGCGATTATGTCCCCATTGCCACAGACCGTACG
CGCCTGCTGGCCGAGGGCAAGAAGCCACGCCAGCGCTACATGGAGAAGAGCGGCAAGTGC
AACGTGCACCACGGCAACGTCCAGGAGACCTACCGGTACCTGAGTGACCTCTTCACCACC
CTGGTGGACCTCAAGTGGCGCTTCAACTTGCTCGTCTTCACCATGGTTTACACTGTCACC
TGGCTGTTCTTCGGCTTCATTTGGTGGCTCATTGCTTATATCCGGGGTGACCTGGACCAT
GTTGGCGACCAAGAGTGGATTCCTTGTGTTGAAAACCTCAGTGGCTTCGTGTCCGCTTTC
CTGTTCTCCATTGAGACCGAAACAACCATTGGGTATGGCTTCCGAGTCATCACAGAGAAG
TGTCCAGAGGGGATTATACTCCTCTTGGTCCAGGCCATCCTGGGCTCCATCGTCAATGCC
TTCATGGTGGGGTGCATGTTTGTCAAGATCAGCCAGCCCAAGAAGAGAGCGGAGACCCTC
ATGTTTTCCAACAACGCAGTCATCTCCATGCGGGACGAGAAGCTGTGCCTCATGTTCCGG
GTGGGCGACCTCCGCAACTCCCACATCGTGGAGGCCTCCATCCGGGCCAAGCTCATCAAG
TCCCGGCAGACCAAAGAGGGGGAGTTCATCCCCCTGAACCAGACAGACATCAACGTGGGC
TTTGACACGGGCGACGACCGCCTCTTCCTGGTGTCTCCTCTGATCATCTCCCACGAGATC
AACGAGAAGAGCCCTTTCTGGGAGATGTCTCAGGCTCAGCTGCATCAGGAAGAGTTTGAA
GTTGTGGTCATTCTAGAAGGGATGGTGGAAGCCACAGGCATGACCTGCCAAGCCCGGAGC
TCCTACATGGATACAGAGGTGCTCTGGGGCCACCGATTCACACCAGTCCTCACCTTGGAA
AAGGGCTTCTATGAGGTGGACTACAACACCTTCCATGATACCTATGAGACCAACACACCC
AGCTGCTGTGCCAAGGAGCTGGCAGAAATGAAGAGGGAAGGCCGGCTCCTCCAGTACCTC
CCCAGCCCCCCACTGCTGGGGGGCTGTGCTGAGGCAGGGCTGGATGCAGAGGCTGAGCAG
AATGAAGAAGATGAGCCCAAGGGGCTGGGTGGGTCCAGGGAGGCCAGGGGCTCGGTGTGA

Target 9 GenBank Gene ID

Not Available

Target 9 GeneCard ID

KCNJ5

Target 9 GenAtlas ID

KCNJ5

Target 9 HGNC ID

HGNC:6266

Target 9 Chromosome Location

Chromosome:11

Target 9 Locus

11q24

Target 9 SNPs

SNPJam Report Link Image

Target 9 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 9 General References

8047164; 8524415; 10659995; 8834003; 15489334

Target 10 [top]

Target 10 ID

576

Target 10 Name

ATP-sensitive inward rectifier potassium channel 1

Target 10 Mechanism of Action

Target 10 Description

In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium

Target 10 Synonyms

Potassium channel, inwardly rectifying subfamily J member 1; ATP-regulated potassium channel ROM-K; Kir1.1

Target 10 Gene Name

KCNJ1

Target 10 Protein Sequence

>ATP-sensitive inward rectifier potassium channel 1

MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQS
RFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTP
CVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGE
TIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLY
NEKDVRARMKRGYDNPNFILSEVNETDDTKM

Target 10 Number of Residues

391

Target 10 Molecular Weight

44794.6

Target 10 Theoretical pI

9.04

Target 10 GO Classification

Function
transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 10 General Function

Involved in ATP binding

Target 10 Pathways

Not Available

Target 10 Reactions

Not Available

Target 10 Signals

None

Target 10 Transmembrane Regions

78-102
156-177

Target 10 Essentiality

Non Essential

Target 10 Domain Function

PF01007:IRK

Target 10 GenBank ID Protein

Not Available

Target 10 UniProtKB ID

P48048

Target 10 Cellular Location

Membrane

Target 10 Gene Sequence

>1176 bp

ATGAATGCTTCCAGTCGGAATGTGTTTGACACGTTGATCAGGGTGTTGACAGAAAGTATG
TTCAAACATCTTCGGAAATGGGTCGTCACTCGCTTTTTTGGGCATTCTCGGCAAAGAGCA
AGGCTAGTCTCCAAAGATGGAAGGTGCAACATAGAATTTGGCAATGTGGAGGCACAGTCA
AGGTTTATATTCTTTGTGGACATCTGGACAACGGTACTTGACCTCAAGTGGAGATACAAA
ATGACCATTTTCATCACAGCCTTCTTGGGGAGTTGGTTTTTCTTTGGTCTCCTGTGGTAT
GCAGTAGCGTACATTCACAAAGACCTCCCGGAATTCCATCCTTCTGCCAATCACACTCCC
TGTGTGGAGAATATTAATGGCTTGACCTCAGCTTTTCTGTTTTCTCTGGAGACTCAAGTG
ACCATTGGATATGGATTCAGGTGTGTGACAGAACAGTGTGCCACTGCCATTTTTCTGCTT
ATCTTTCAGTCTATACTTGGAGTTATAATCAATTCTTTCATGTGTGGGGCCATCTTAGCC
AAGATCTCCAGGCCCAAAAAACGTGCCAAGACCATTACGTTCAGCAAGAACGCAGTGATC
AGCAAACGGGGAGGGAAGCTTTGCCTCCTAATCCGAGTGGCTAATCTCAGGAAGAGCCTT
CTTATTGGCAGTCACATTTATGGAAAGCTTCTGAAGACCACAGTCACTCCTGAAGGAGAG
ACCATTATTTTGGACCAGATCAATATCAACTTTGTAGTTGACGCTGGGAATGAAAATTTA
TTCTTCATCTCCCCATTGACAATTTACCATGTCATTGATCACAACAGCCCTTTCTTCCAC
ATGGCAGCGGAGACCCTTCTCCAGCAGGACTTTGAATTAGTGGTGTTTTTAGATGGCACA
GTGGAGTCCACCAGTGCTACCTGCCAAGTCCGGACATCCTATGTCCCAGAGGAGGTGCTT
TGGGGCTACCGTTTTGCTCCCATAGTATCCAAGACAAAGGAAGGGAAATACCGAGTGGAT
TTCCATAACTTTAGCAAGACAGTGGAAGTGGAGACCCCTCACTGTGCCATGTGCCTTTAT
AATGAGAAAGATGTTAGAGCCAGGATGAAGAGAGGCTATGACAACCCCAACTTCATCTTG
TCAGAAGTCAATGAAACAGATGACACCAAAATGTAA

Target 10 GenBank Gene ID

Not Available

Target 10 GeneCard ID

KCNJ1

Target 10 GenAtlas ID

KCNJ1

Target 10 HGNC ID

HGNC:6255

Target 10 Chromosome Location

Chromosome:11

Target 10 Locus

11q24

Target 10 SNPs

SNPJam Report Link Image

Target 10 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 10 General References

7929082; 8190102; 9099852; 15489334; 7635463; 8841184; 9002665; 9727001; 16959974

Target 11 [top]

Target 11 ID

584

Target 11 Name

ATP-sensitive inward rectifier potassium channel 10

Target 11 Mechanism of Action

Target 11 Description

May be responsible for potassium buffering action of glial cells in the brain. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity)

Target 11 Synonyms

Potassium channel, inwardly rectifying subfamily J member 10; Inward rectifier K(+) channel Kir1.2; ATP-dependent inwardly rectifying potassium channel Kir4.1

Target 11 Gene Name

KCNJ10

Target 11 Protein Sequence

>ATP-sensitive inward rectifier potassium channel 10

MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFI
DMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFL
FSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIR
FSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQV
DTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSY
LPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEES
LREQAEKEGSALSVRISNV

Target 11 Number of Residues

379

Target 11 Molecular Weight

42507.7

Target 11 Theoretical pI

8.20

Target 11 GO Classification

Function
transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 11 General Function

Involved in ATP binding

Target 11 Pathways

Not Available

Target 11 Reactions

Not Available

Target 11 Signals

None

Target 11 Transmembrane Regions

65-89
143-164

Target 11 Essentiality

Non Essential

Target 11 Domain Function

PF01007:IRK

Target 11 GenBank ID Protein

Not Available

Target 11 UniProtKB ID

P78508

Target 11 Cellular Location

Membrane

Target 11 Gene Sequence

Not Available

Target 11 GenBank Gene ID

Not Available

Target 11 GeneCard ID

KCNJ10

Target 11 GenAtlas ID

KCNJ10

Target 11 HGNC ID

HGNC:6256

Target 11 Chromosome Location

Not Available

Target 11 Locus

1q22-q23

Target 11 SNPs

SNPJam Report Link Image

Target 11 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 11 General References

8995301; 10659995; 16710414; 15489334

Target 12 [top]

Target 12 ID

579

Target 12 Name

ATP-sensitive inward rectifier potassium channel 11

Target 12 Mechanism of Action

Target 12 Description

Target 12 Synonyms

Potassium channel, inwardly rectifying subfamily J member 11; Inward rectifier K(+) channel Kir6.2; IKATP

Target 12 Gene Name

KCNJ11

Target 12 Protein Sequence

>ATP-sensitive inward rectifier potassium channel 11

MLSRKGIIPEEYVLTRLAEDPAEPRYRARQRRARFVSKKGNCNVAHKNIREQGRFLQDVF
TTLVDLKWPHTLLIFTMSFLCSWLLFAMAWWLIAFAHGDLAPSEGTAEPCVTSIHSFSSA
FLFSIEVQVTIGFGGRMVTEECPLAILILIVQNIVGLMINAIMLGCIFMKTAQAHRRAET
LIFSKHAVIALRHGRLCFMLRVGDLRKSMIISATIHMQVVRKTTSPEGEVVPLHQVDIPM
ENGVGGNSIFLVAPLIIYHVIDANSPLYDLAPSDLHHHQDLEIIVILEGVVETTGITTQA
RTSYLADEILWGQRFVPIVAEEDGRYSVDYSKFGNTIKVPTPLCTARQLDEDHSLLEALT
LASARGPLRKRSVPMAKAKPKFSISPDSLS

Target 12 Number of Residues

390

Target 12 Molecular Weight

43540.4

Target 12 Theoretical pI

8.10

Target 12 GO Classification

Function
ATP-activated inward rectifier potassium channel activity transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 12 General Function

Involved in ATP binding

Target 12 Pathways

Not Available

Target 12 Reactions

Not Available

Target 12 Signals

None

Target 12 Transmembrane Regions

69-93
145-166

Target 12 Essentiality

Non Essential

Target 12 Domain Function

PF01007:IRK

Target 12 GenBank ID Protein

Not Available

Target 12 UniProtKB ID

Q14654

Target 12 Cellular Location

Membrane

Target 12 Gene Sequence

>1173 bp

ATGCTGTCCCGCAAGGGCATCATCCCCGAGGAATACGTGCTGACACGCCTGGCAGAGGAC
CCTGCCGAGCCCAGGTACCGTGCCCGCCAGCGGAGGGCCCGCTTTGTGTCCAAGAAAGGC
AACTGCAACGTGGCCCACAAGAACATCCGGGAGCAGGGCCGCTTCCTGCAGGACGTGTTC
ACCACGCTGGTGGACCTCAAGTGGCCACACACATTGCTCATCTTCACCATGTCCTTCCTG
TGCAGCTGGCTGCTCTTCGCCATGGCCTGGTGGCTCATCGCCTTCGCCCACGGTGACCTG
GCCCCCAGCGAGGGCACTGCTGAGCCCTGTGTCACCAGCATCCACTCCTTCTCGTCTGCC
TTCCTTTTCTCCATTGAGGTCCAAGTGACTATTGGCTTTGGGGGGCGCATGGTGACTGAG
GAGTGCCCACTGGCCATCCTGATCCTCATCGTGCAGAACATCGTGGGGCTCATGATCAAC
GCCATCATGCTTGGCTGCATCTTCATGAAGACTGCCCAAGCCCACCGCAGGGCTGAGACC
CTCATCTTCAGCAAGCATGCGGTGATCGCCCTGCGCCACGGCCGCCTCTGCTTCATGCTA
CGTGTGGGTGACCTCCGCAAGAGCATGATCATCAGCGCCACCATCCACATGCAGGTGGTA
CGCAAGACCACCAGCCCCGAGGGCGAGGTGGTGCCCCTCCACCAGGTGGACATCCCCATG
GAGAACGGCGTGGGTGGCAACAGCATCTTCCTGGTGGCCCCGCTGATCATCTACCATGTC
ATTGATGCCAACAGCCCACTCTACGACCTGGCACCCAGCGACCTGCACCACCACCAGGAC
CTCGAGATCATCGTCATCCTGGAAGGCGTGGTGGAAACCACGGGCATCACCACCCAGGCC
CGCACCTCCTACCTGGCCGATGAGATCCTGTGGGGCCAGCGCTTTGTGCCCATTGTAGCT
GAGGAGGACGGACGTTACTCTGTGGACTACTCCAAGTTTGGCAACACCATCAAAGTGCCC
ACACCACTCTGCACGGCCCGCCAGCTTGATGAGGACCACAGCCTACTGGAAGCTCTGACC
CTCGCCTCAGCCCGCGGGCCCCTGCGCAAGCGCAGCGTGCCCATGGCCAAGGCCAAGCCC
AAGTTCAGCATCTCTCCAGATTCCCTGTCCTGA

Target 12 GenBank Gene ID

Not Available

Target 12 GeneCard ID

KCNJ11

Target 12 GenAtlas ID

KCNJ11

Target 12 HGNC ID

HGNC:6257

Target 12 Chromosome Location

Chromosome:11

Target 12 Locus

11p15.1

Target 12 SNPs

SNPJam Report Link Image

Target 12 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 12 General References

7502040; 15489334; 12524280; 10338089; 7847376; 8923010; 8897013; 9032109; 10204114; 10391210

Target 13 [top]

Target 13 ID

580

Target 13 Name

ATP-sensitive inward rectifier potassium channel 12

Target 13 Mechanism of Action

Target 13 Description

Target 13 Synonyms

Potassium channel, inwardly rectifying subfamily J member 12; Inward rectifier K(+) channel Kir2.2; Kir2.2v; IRK2

Target 13 Gene Name

KCNJ12

Target 13 Protein Sequence

>ATP-sensitive inward rectifier potassium channel 12

MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANM
DEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGR
TPCVMQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAI
MAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEE
GEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILE
GMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAK
DLVENKFLLPSANSFCYENELAFLSRDEEDEADGDQDGRSRDGLSPQARHDFDRLQAGGG
VLEQRPYRRESEI

Target 13 Number of Residues

433

Target 13 Molecular Weight

49000.6

Target 13 Theoretical pI

5.79

Target 13 GO Classification

Function
transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 13 General Function

Involved in inward rectifier potassium channel activity

Target 13 Pathways

Not Available

Target 13 Reactions

Not Available

Target 13 Signals

None

Target 13 Transmembrane Regions

81-105
158-179

Target 13 Essentiality

Non Essential

Target 13 Domain Function

PF01007:IRK PF08466:IRK_N

Target 13 GenBank ID Protein

Not Available

Target 13 UniProtKB ID

Q14500

Target 13 Cellular Location

Membrane

Target 13 Gene Sequence

>1299 bp

ATGACCGCGGCCAGCCGGGCCAACCCCTACAGCATCGTGTCATCGGAGGAGGACGGGCTG
CACCTGGTCACCATGTCGGGCGCCAACGGCTTCGGCAACGGCAAGGTGCACACGCGGCGC
AGGTGCCGCAACCGCTTCGTCAAGAAGAATGGCCAGTGCAACATTGAGTTCGCCAACATG
GACGAGAAGTCACAGCGCTACCTGGCTGACATGTTCACCACCTGTGTGGACATCCGCTGG
CGGTACATGCTGCTCATCTTCTCGCTGGCCTTCCTTGCCTCCTGGCTGCTGTTCGGCATC
ATCTTCTGGGTCATCGCGGTGGCACACGGTGACCTGGAGCCGGCTGAGGGCCGGGGCCGC
ACACCCTGTGTGATGCAGGTGCACGGCTTCATGGCGGCCTTCCTCTTCTCCATCGAGACG
CAGACCACCATCGGCTACGGGCTGCGCTGTGTGACGGAGGAGTGCCCGGTGGCCGTCTTC
ATGGTGGTGGCCCAGTCCATCGTGGGCTGCATCATCGACTCCTTCATGATTGGTGCCATC
ATGGCCAAGATGGCAAGGCCCAAGAAGCGGGCACAGACGCTGCTGTTCAGCCACAACGCC
GTGGTGGCCCTGCGTGACGGCAAGCTCTGCCTCATGTGGCGTGTGGGTAACCTGCGCAAG
AGCCACATTGTGGAGGCCCATGTGCGCGCGCAGCTCATCAAGCCGCGGGTCACCGAGGAG
GGCGAGTACATCCCGCTGGACCAGATCGACATCGATGTGGGCTTCGACAAGGGCCTGGAC
CGCATCTTTCTGGTGTCGCCCATCACCATCTTGCATGAGATTGACGAGGCCAGCCCGCTC
TTCGGCATCAGCCAGGACCTGGAGACGGACGACTTTGAGATCGTGGTCATCCTGGAAGGC
ATGGTGGAGGCCACAGCCATGACCACCCAGGCCCGCAGCTCCTACCTGGCCAATGAGATC
CTGTGGGGTCACCGCTTTGAGCCCGTGCTCTTCGAGGAGAAGAACCAGTACAAGATTGAC
TACTCGCACTTCCACAAGACCTATGAGGTGCCCTCTACGCCCCGCTGCAGTGCGAAGGAT
CTGGTAGAGAACAAGTTCCTGCTGCCCAGCGCCAACTCCTTCTGCTACGAGAACGAGCTG
GCCTTCCTGAGCCGTGACGAGGAGGATGAGGCGGACGGAGACCAGGACGGCCGAAGCCGG
GACGGCCTCAGCCCCCAGGCCAGGCATGACTTTGACAGACTCCAGGCTGGCGGCGGGGTC
CTGGAGCAGCGGCCCTACAGACGGGAGTCAGAGATCTGA

Target 13 GenBank Gene ID

Not Available

Target 13 GeneCard ID

KCNJ12

Target 13 GenAtlas ID

KCNJ12

Target 13 HGNC ID

HGNC:6258

Target 13 Chromosome Location

Chromosome:17

Target 13 Locus

17p11.2

Target 13 SNPs

SNPJam Report Link Image

Target 13 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 13 General References

7859381; 8647284; 12417321; 15489334; 9430667; 18669648

Target 14 [top]

Target 14 ID

585

Target 14 Name

ATP-sensitive inward rectifier potassium channel 14

Target 14 Mechanism of Action

Target 14 Description

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ14 gives rise to low-conductance channels with a low affinity to the channel blockers Barium and Cesium (By similarity)

Target 14 Synonyms

Potassium channel, inwardly rectifying subfamily J member 14; Inward rectifier K(+) channel Kir2.4; IRK4

Target 14 Gene Name

KCNJ14

Target 14 Protein Sequence

>ATP-sensitive inward rectifier potassium channel 14

MGLARALRRLSGALDSGDSRAGDEEEAGPGLCRNGWAPAPVQSPVGRRRGRFVKKDGHCN
VRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLAFWLIASLHGDLAA
PPPPAPCFSHVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFV
VGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWRVGNLRRSHLVEAHVRAQLLQPR
VTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELARADFELV
VILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFHRTYEVPGTPV
CSAKELDERAEQASHSLKSSFPGSLTAFCYENELALSCCQEEDEDDETEEGNGVETEDGA
ASPRVLTPTLALTLPP

Target 14 Number of Residues

436

Target 14 Molecular Weight

47845.0

Target 14 Theoretical pI

5.10

Target 14 GO Classification

Function
transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 14 General Function

Involved in inward rectifier potassium channel activity

Target 14 Pathways

Not Available

Target 14 Reactions

Not Available

Target 14 Signals

None

Target 14 Transmembrane Regions

87-111
162-183

Target 14 Essentiality

Non Essential

Target 14 Domain Function

PF01007:IRK

Target 14 GenBank ID Protein

Not Available

Target 14 UniProtKB ID

Q9UNX9

Target 14 Cellular Location

Membrane

Target 14 Gene Sequence

>1311 bp

ATGGGCCTGGCCAGGGCCCTACGCCGCCTCAGCGGCGCCCTGGATTCGGGAGACAGCCGG
GCGGGCGATGAAGAGGAGGCCGGGCCCGGGTTGTGCCGCAACGGGTGGGCGCCGGCACCG
GTGCAGTCACCCGTGGGCCGGCGCCGCGGTCGCTTCGTCAAGAAAGACGGGCACTGCAAC
GTGCGTTTCGTAAACCTGGGTGGCCAGGGCGCGCGCTACCTGAGCGACCTGTTCACCACA
TGCGTGGACGTGCGCTGGCGCTGGATGTGCCTGCTCTTCTCCTGCTCCTTCCTCGCCTCC
TGGCTGCTCTTCGGCCTGGCCTTCTGGCTCATTGCCTCGCTGCACGGCGACCTGGCCGCC
CCGCCACCGCCCGCGCCCTGCTTCTCACACGTGGCCAGCTTCCTGGCCGCCTTCCTCTTC
GCGCTGGAGACGCAGACGTCCATCGGCTACGGCGTGCGCAGCGTCACCGAGGAGTGCCCG
GCCGCTGTGGCCGCCGTGGTGCTGCAGTGCATTGCCGGCTGCGTGCTCGACGCCTTCGTC
GTGGGTGCTGTCATGGCCAAGATGGCCAAACCCAAGAAGCGCAACGAGACGCTGGTCTTC
AGCGAGAACGCCGTCGTGGCGCTGCGCGACCACCGCCTCTGCCTCATGTGGCGCGTCGGC
AACCTGCGCCGCAGCCACCTGGTCGAGGCCCACGTGCGTGCCCAGCTGCTGCAGCCCCGT
GTGACCCCAGAGGGTGAGTACATCCCGCTGGACCACCAGGATGTGGATGTGGGCTTTGAT
GGAGGCACCGATCGTATCTTCCTCGTGTCCCCCATCACCATCGTCCATGAGATCGACTCT
GCCAGTCCTCTGTATGAGCTAGGACGTGCCGAGCTGGCCAGGGCTGACTTTGAGCTGGTG
GTCATTCTCGAGGGGATGGTTGAGGCCACAGCCATGACCACACAGTGTCGCTCGTCCTAC
CTCCCTGGTGAACTGCTCTGGGGCCATCGTTTTGAGCCAGTTCTCTTCCAGCGTGGCTCC
CAGTATGAGGTCGACTATCGCCACTTCCATCGCACTTATGAGGTCCCAGGGACACCGGTC
TGCAGTGCTAAGGAGCTGGATGAACGGGCAGAGCAGGCTTCCCACAGCCTCAAGTCTAGT
TTCCCCGGCTCTCTGACTGCATTTTGTTATGAGAATGAACTTGCTCTGAGCTGCTGCCAG
GAGGAAGATGAGGACGATGAGACTGAGGAAGGGAATGGGGTGGAAACAGAAGATGGGGCT
GCTAGCCCCCGAGTTCTCACACCAACCCTGGCGCTGACCCTGCCTCCATGA

Target 14 GenBank Gene ID

Not Available

Target 14 GeneCard ID

KCNJ14

Target 14 GenAtlas ID

KCNJ14

Target 14 HGNC ID

HGNC:6260

Target 14 Chromosome Location

Chromosome:19

Target 14 Locus

19q13

Target 14 SNPs

SNPJam Report Link Image

Target 14 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 14 General References

10942728; 10723734; 15489334

Target 15 [top]

Target 15 ID

582

Target 15 Name

ATP-sensitive inward rectifier potassium channel 15

Target 15 Mechanism of Action

Target 15 Description

Target 15 Synonyms

Potassium channel, inwardly rectifying subfamily J member 15; Inward rectifier K(+) channel Kir4.2; Kir1.3

Target 15 Gene Name

KCNJ15

Target 15 Protein Sequence

>ATP-sensitive inward rectifier potassium channel 15

MDAIHIGMSSTPLVKHTAGAGLKANRPRVMSKSGHSNVRIDKVDGIYLLYLQDLWTTVID
MKWRYKLTLFAATFVMTWFLFGVIYYAIAFIHGDLEPGEPISNHTPCIMKVDSLTGAFLF
SLESQTTIGYGVRSITEECPHAIFLLVAQLVITTLIEIFITGTFLAKIARPKKRAETIKF
SHCAVITKQNGKLCLVIQVANMRKSLLIQCQLSGKLLQTHVTKEGERILLNQATVKFHVD
SSSESPFLILPMTFYHVLDETSPLRDLTPQNLKEKEFELVVLLNATVESTSAVCQSRTSY
IPEEIYWGFEFVPVVSLSKNGKYVADFSQFEQIRKSPDCTFYCADSEKQQLEEKYRQEDQ
RERELRTLLLQQSNV

Target 15 Number of Residues

375

Target 15 Molecular Weight

42577.0

Target 15 Theoretical pI

7.78

Target 15 GO Classification

Function
transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 15 General Function

Involved in inward rectifier potassium channel activity

Target 15 Pathways

Not Available

Target 15 Reactions

Not Available

Target 15 Signals

None

Target 15 Transmembrane Regions

64-88
142-163

Target 15 Essentiality

Non Essential

Target 15 Domain Function

PF01007:IRK

Target 15 GenBank ID Protein

Not Available

Target 15 UniProtKB ID

Q99712

Target 15 Cellular Location

Membrane

Target 15 Gene Sequence

>1128 bp

ATGGATGCCATTCACATCGGCATGTCCAGCACCCCCCTGGTGAAGCACACTGCTGGGGCT
GGGCTCAAGGCCAACAGACCCCGCGTCATGTCCAAGAGTGGGCACAGCAACGTGAGAATT
GACAAAGTGGATGGCATATACCTACTCTACCTGCAAGACCTGTGGACCACAGTTATCGAC
ATGAAGTGGAGATACAAACTCACCCTGTTCGCTGCCACTTTTGTGATGACCTGGTTCCTT
TTTGGAGTCATCTACTATGCCATCGCGTTTATTCATGGGGACTTAGAACCCGATGAGCCC
ATTTCAAATCATACCCCCTGCATCATGAAAGTGGACTCTCTCACTGGGGCGTTTCTCTTT
TCCCTGGAATCCCAGACAACCATTGGCTATGGAGTCCGTTCCATCACAGAGGAATGTCCT
CATGCCATCTTCCTGTTGGTTGCTCAGTTGGTCATCACGACCTTGATTGAGATCTTCATC
ACCGGAACCTTCCTGGCCAAAATCGCCAGACCCAAAAAGCGGGCTGAGACCATCAAGTTC
AGCCACTGTGCAGTCATCACCAAGCAGAATGGGAAGCTGTGCTTGGTGATTCAGGTAGCC
AATATGAGGAAGAGCCTCTTGATTCAGTGCCAGCTCTCTGGCAAGCTCCTGCAGACCCAC
GTCACCAAGGAGGGGGAGCGGATTCTCCTCAACCAAGCCACTGTCAAATTCCACGTGGAC
TCCTCCTCTGAGAGCCCCTTCCTCATTCTGCCCATGACATTCTACCATGTGCTGGATGAG
ACGAGCCCCCTGAGAGACCTCACACCCCAAAACCTAAAGGAGAAGGAGTTTGAGCTTGTG
GTCCTCCTCAATGCCACTGTGGAATCCACCAGCGCTGTCTGCCAGAGCCGAACATCTTAT
ATCCCAGAGGAAATCTACTGGGGTTTTGAGTTTGTGCCTGTGGTATCTCTCTCCAAAAAT
GGAAAATATGTGGCTGATTTCAGTCAGTTTGAACAGATTCGGAAAAGCCCAGATTGCACA
TTTTACTGTGCAGATTCTGAGAAACAGCAACTCGAGGAGAAGTACAGGCAGGAGGATCAG
AGGGAAAGAGAACTGAGGACACTTTTATTACAACAGAGCAATGTCTGA

Target 15 GenBank Gene ID

Not Available

Target 15 GeneCard ID

KCNJ15

Target 15 GenAtlas ID

KCNJ15

Target 15 HGNC ID

HGNC:6261

Target 15 Chromosome Location

Chromosome:21

Target 15 Locus

21q22.2

Target 15 SNPs

SNPJam Report Link Image

Target 15 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 15 General References

8995301; 9299242; 15489334; 9647694; 16959974

Target 16 [top]

Target 16 ID

589

Target 16 Name

ATP-sensitive inward rectifier potassium channel 8

Target 16 Mechanism of Action

Target 16 Description

Target 16 Synonyms

Potassium channel, inwardly rectifying subfamily J member 8; Inwardly rectifier K(+) channel Kir6.1; uKATP-1

Target 16 Gene Name

KCNJ8

Target 16 Protein Sequence

>ATP-sensitive inward rectifier potassium channel 8

MLARKSIIPEEYVLARIAAENLRKPRIRDRLPKARFIAKSGACNLAHKNIREQGRFLQDI
FTTLVDLKWRHTLVIFTMSFLCSWLLFAIMWWLVAFAHGDIYAYMEKSGMEKSGLESTVC
VTNVRSFTSAFLFSIEVQVTIGFGGRMMTEECPLAITVLILQNIVGLIINAVMLGCIFMK
TAQAHRRAETLIFSRHAVIAVRNGKLCFMFRVGDLRKSMIISASVRIQVVKKTTTPEGEV
VPIHQLDIPVDNPIESNNIFLVAPLIICHVIDKRSPLYDISATDLANQDLEVIVILEGVV
ETTGITTQARTSYIAEEIQWGHRFVSIVTEEEGVYSVDYSKFGNTVKVAAPRCSARELDE
KPSILIQTLQKSELSHQNSLRKRNSMRRNNSMRRNNSIRRNNSSLMVPKVQFMTPEGNQN
TSES

Target 16 Number of Residues

424

Target 16 Molecular Weight

47967.5

Target 16 Theoretical pI

9.70

Target 16 GO Classification

Function
ATP-activated inward rectifier potassium channel activity transporter activity ion transporter activity ion channel activity voltage-gated ion channel activity voltage-gated potassium channel activity inward rectifier potassium channel activity
Process
physiological process cellular physiological process transport ion transport cation transport monovalent inorganic cation transport potassium ion transport
Component
cell membrane

Target 16 General Function

Involved in ATP-activated inward rectifier potassium ch

Target 16 Pathways

Not Available

Target 16 Reactions

Not Available

Target 16 Signals

None

Target 16 Transmembrane Regions

70-94
155-176

Target 16 Essentiality

Non Essential

Target 16 Domain Function

PF01007:IRK

Target 16 GenBank ID Protein

Not Available

Target 16 UniProtKB ID

Q15842

Target 16 Cellular Location

Membrane

Target 16 Gene Sequence

>1275 bp

ATGTTGGCCAGAAAGAGTATCATCCCGGAGGAGTATGTGCTGGCGCGCATCGCCGCAGAG
AACCTGCGCAAGCCGCGCATCCGAGACCGCCTCCCCAAAGCCCGCTTCATCGCCAAGAGC
GGGGCCTGCAACCTGGCGCATAAGAACATCCGTGAGCAAGGACGCTTTCTACAGGACATC
TTCACCACCTTGGTGGACCTGAAATGGCGCCACACGCTGGTCATCTTTACCATGTCCTTC
CTCTGCAGCTGGCTGCTCTTCGCTATCATGTGGTGGCTGGTGGCCTTTGCCCATGGGGAC
ATCTATGCTTACATGGAGAAAAGTGGAATGGAGAAAAGTGGTTTGGAGTCCACTGTGTGT
GTGACTAATGTCAGGTCTTTCACTTCTGCTTTTCTCTTCTCCATTGAAGTTCAAGTTACC
ATTGGGTTTGGAGGGAGGATGATGACAGAGGAATGCCCTTTGGCCATCACGGTTTTGATT
CTCCAGAATATTGTGGGTTTGATCATCAATGCAGTCATGTTAGGCTGCATTTTCATGAAA
ACAGCTCAGGCTCACAGAAGGGCAGAAACTTTGATTTTCAGCCGCCATGCTGTGATTGCC
GTCCGAAATGGCAAGCTGTGCTTCATGTTCCGAGTGGGTGACCTGAGGAAAAGCATGATC
ATTAGTGCCTCTGTGCGCATCCAGGTGGTCAAGAAAACAACTACACCTGAAGGGGAGGTG
GTTCCTATTCACCAACTGGACATTCCTGTTGATAACCCAATCGAGAGCAATAACATTTTT
CTGGTGGCCCCTTTGATCATCTGCCACGTGATTGACAAGCGCAGTCCCCTGTATGACATC
TCAGCAACTGACCTGGCCAACCAAGACTTGGAGGTCATAGTTATTCTGGAAGGAGTGGTT
GAAACTACTGGCATCACCACACAAGCACGAACCTCCTACATTGCTGAGGAGATCCAATGG
GGCCACCGCTTTGTGTCCATTGTGACTGAGGAAGAAGGAGTGTATTCTGTGGATTACTCC
AAATTTGGCAACACTGTTAAAGTAGCTGCTCCACGGTGCAGTGCCCGAGAGCTGGATGAG
AAACCTTCCATCCTTATTCAGACCCTCCAAAAGAGTGAACTGTCTCATCAAAATTCTCTG
AGGAAGCGCAACTCCATGAGAAGAAACAATTCCATGAGGAGGAACAATTCTATCCGAAGG
AACAATTCTTCCCTCATGGTACCAAAGGTGCAATTTATGACTCCAGAAGGAAATCAAAAC
ACATCGGAATCATGA

Target 16 GenBank Gene ID

Not Available

Target 16 GeneCard ID

KCNJ8

Target 16 GenAtlas ID

KCNJ8

Target 16 HGNC ID

HGNC:6269

Target 16 Chromosome Location

Chromosome:12

Target 16 Locus

12p11.23

Target 16 SNPs

SNPJam Report Link Image

Target 16 Toxin References

R418 - Alagem N, Dvir M, Reuveny E: Mechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residues. J Physiol. 2001 Jul 15;534(Pt. 2):381-93. [PubMed ]

Target 16 General References

8595887; 15489334; 17081983; 18187866

Target 17 [top]

Target 17 ID

591

Target 17 Name

Potassium voltage-gated channel subfamily KQT member 1

Target 17 Mechanism of Action

Barium is a competitive potassium channel antagonist that blocks the passive efflux of intracellular potassium, resulting in a shift of potassium from extracellular to intracellular compartments. The intracellular translocation of potassium results in a decreased resting membrane potential, making the muscle fibers electrically unexcitable and causing paralysis. (R419)

Target 17 Description

Probably important in cardiac repolarization. Associates with KCNE1 (MinK) to form the I(Ks) cardiac potassium current. Elicits a rapidly activating, potassium-selective outward current. Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current in CHO cells in which cloned KCNQ1/KCNE1 channels were coexpressed with M1 muscarinic receptors. May associate also with KCNE3 (MiRP2) to form the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions, which is reduced in cystic fibrosis and pathologically stimulated in cholera and other forms of secretory diarrhea

Target 17 Synonyms

Voltage-gated potassium channel subunit Kv7.1; IKs producing slow voltage-gated potassium channel subunit alpha KvLQT1; KQT-like 1

Target 17 Gene Name

KCNQ1

Target 17 Protein Sequence

>Potassium voltage-gated channel subfamily KQT member 1

MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS

Target 17 Number of Residues

676

Target 17 Molecular Weight

74697.9

Target 17 Theoretical pI

10.39

Target 17 GO Classification

Function
voltage-gated ion channel activity voltage-gated potassium channel activity transporter activity ion transporter activity ion channel activity
Process
cation transport monovalent inorganic cation transport potassium ion transport physiological process cellular physiological process transport ion transport
Component
protein complex voltage-gated potassium channel complex cell membrane

Target 17 General Function

Inorganic ion transport and metabolism

Target 17 Pathways

Not Available

Target 17 Reactions

Not Available

Target 17 Signals

None

Target 17 Transmembrane Regions

122-142
148-168
197-217
226-248
262-282
328-348

Target 17 Essentiality

Non Essential

Target 17 Domain Function

PF00520:Ion_trans PF03520:KCNQ_channel

Target 17 GenBank ID Protein

Not Available

Target 17 UniProtKB ID

P51787

Target 17 Cellular Location

Cell membrane

Target 17 Gene Sequence

>2031 bp

ATGGCCGCGGCCTCCTCCCCGCCCAGGGCCGAGAGGAAGCGCTGGGGTTGGGGCCGCCTG
CCAGGCGCCCGGCGGGGCAGCGCGGGCCTGGCCAAGAAGTGCCCCTTCTCGCTGGAGCTG
GCGGAGGGCGGCCCGGCGGGCGGCGCGCTCTACGCGCCCATCGCGCCCGGCGCCCCAGGT
CCCGCGCCCCCTGCGTCCCCGGCCGCGCCCGCCGCGCCCCCAGTTGCCTCCGACCTTGGC
CCGCGGCCGCCGGTGAGCCTAGACCCGCGCGTCTCCATTTACAGCACGCGCCGCCCGGTG
TTGGCGCGCACCCACGTCCAGGGCCGCGTCTACAACTTCCTCGAGCGTCCCACCGGCTGG
AAATGCTTCGTTTACCACTTCGCCGTCTTCCTCATCGTCCTGGTCTGCCTCATCTTCAGC
GTGCTGTCCACCATCGAGCAGTATGCCGCCCTGGCCACGGGGACTCTCTTCTGGATGGAG
ATCGTGCTGGTGGTGTTCTTCGGGACGGAGTACGTGGTCCGCCTCTGGTCCGCCGGCTGC
CGCAGCAAGTACGTGGGCCTCTGGGGGCGGCTGCGCTTTGCCCGGAAGCCCATTTCCATC
ATCGACCTCATCGTGGTCGTGGCCTCCATGGTGGTCCTCTGCGTGGGCTCCAAGGGGCAG
GTGTTTGCCACGTCGGCCATCAGGGGCATCCGCTTCCTGCAGATCCTGAGGATGCTACAC
GTCGACCGCCAGGGAGGCACCTGGAGGCTCCTGGGCTCCGTGGTCTTCATCCACCGCCAG
GAGCTGATAACCACCCTGTACATCGGCTTCCTGGGCCTCATCTTCTCCTCGTACTTTGTG
TACCTGGCTGAGAAGGACGCGGTGAACGAGTCAGGCCGCGTGGAGTTCGGCAGCTACGCA
GATGCGCTGTGGTGGGGGGTGGTCACAGTCACCACCATCGGCTATGGGGACAAGGTGCCC
CAGACGTGGGTCGGGAAGACCATCGCCTCCTGCTTCTCTGTCTTTGCCATCTCCTTCTTT
GCGCTCCCAGCGGGGATTCTTGGCTCGGGGTTTGCCCTGAAGGTGCAGCAGAAGCAGAGG
CAGAAGCACTTCAACCGGCAGATCCCGGCGGCAGCCTCACTCATTCAGACCGCATGGAGG
TGCTATGCTGCCGAGAACCCCGACTCCTCCACCTGGAAGATCTACATCCGGAAGGCCCCC
CGGAGCCACACTCTGCTGTCACCCAGCCCCAAACCCAAGAAGTCTGTGGTGGTAAAGAAA
AAAAAGTTCAAGCTGGACAAAGACAATGGGGTGACTCCTGGAGAGAAGATGCTCACAGTC
CCCCATATCACGTGCGACCCCCCAGAAGAGCGGCGGCTGGACCACTTCTCTGTCGACGGC
TATGACAGTTCTGTAAGGAAGAGCCCAACACTGCTGGAAGTGAGCATGCCCCATTTCATG
AGAACCAACAGCTTCGCCGAGGACCTGGACCTGGAAGGGGAGACTCTGCTGACACCCATC
ACCCACATCTCACAGCTGCGGGAACACCATCGGGCCACCATTAAGGTCATTCGACGCATG
CAGTACTTTGTGGCCAAGAAGAAATTCCAGCAAGCGCGGAAGCCTTACGATGTGCGGGAC
GTCATTGAGCAGTACTCGCAGGGCCACCTCAACCTCATGGTGCGCATCAAGGAGCTGCAG
AGGAGGCTGGACCAGTCCATTGGGAAGCCCTCACTGTTCATCTCCGTCTCAGAAAAGAGC
AAGGATCGCGGCAGCAACACGATCGGCGCCCGCCTGAACCGAGTAGAAGACAAGGTGACG
CAGCTGGACCAGAGGCTGGCACTCATCACCGACATGCTTCACCAGCTGCTCTCCTTGCAC
GGTGGCAGCACCCCCGGCAGCGGCGGCCCCCCCAGAGAGGGCGGGGCCCACATCACCCAG
CCCTGCGGCAGTGGCGGCTCCGTCGACCCTGAGCTCTTCCTGCCCAGCAACACCCTGCCC
ACCTACGAGCAGCTGACCGTGCCCAGGAGGGGCCCCGATGAGGGGTCCTGA

Target 17 GenBank Gene ID

Not Available

Target 17 GeneCard ID

KCNQ1

Target 17 GenAtlas ID

KCNQ1

Target 17 HGNC ID

HGNC:6294

Target 17 Chromosome Location

Chromosome:11

Target 17 Locus

11p15.5

Target 17 SNPs

SNPJam Report Link Image

Target 17 Toxin References

R419 - Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [PubMed ]

Target 17 General References

9312006; 9799083; 10024302; 9108097; 8900283; 8528244; 9305853; 9323054; 10713961

Target 18 [top]

Target 18 ID

592

Target 18 Name

Potassium voltage-gated channel subfamily KQT member 2

Target 18 Mechanism of Action

Target 18 Description

Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine. Muscarinic agonist oxotremorine-M strongly suppress KCNQ2/KCNQ3 current in cells in which cloned KCNQ2/KCNQ3 channels were coexpressed with M1 muscarinic receptors

Target 18 Synonyms

Voltage-gated potassium channel subunit Kv7.2; Neuroblastoma-specific potassium channel subunit alpha KvLQT2; KQT-like 2

Target 18 Gene Name

KCNQ2

Target 18 Protein Sequence

>Potassium voltage-gated channel subfamily KQT member 2

MVQKSRNGGVYPGPSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSILSKPRAG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRQKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYSSQTQTYGASRLIPPLNQLELLRNLKSKSGLAFRKDPPPEPSPSKGSP
CRGPLCGCCPGRSSQKVSLKDRVFSSPRGVAAKGKGSPQAQTVRRSPSADQSLEDSPSKV
PKSWSFGDRSRARQAFRIKGAASRQNSEEASLPGEDIVDDKSCPCEFVTEDLTPGLKVSI
RAVCVMRFLVSKRKFKESLRPYDVMDVIEQYSAGHLDMLSRIKSLQSRVDQIVGRGPAIT
DKDRTKGPAEAELPEDPSMMGRLGKVEKQVLSMEKKLDFLVNIYMQRMGIPPTETEAYFG
AKEPEPAPPYHSPEDSREHVDRHGCIVKIVRSSSSTGQKNFSAPPAAPPVQCPPSTSWQP
QSHPRQGHGTSPVGDHGSLVRIPPPPAHERSLSAYGGGNRASMEFLRQEDTPGCRPPEGN
LRDSDTSISIPSVDHEELERSFSGFSISQSKENLDALNSCYAAVAPCAKVRPYIAEGESD
TDSDLCTPCGPPPRSATGEGPFGDVGWAGPRK

Target 18 Number of Residues

872

Target 18 Molecular Weight

95846.6

Target 18 Theoretical pI

9.59

Target 18 GO Classification

Function
voltage-gated ion channel activity voltage-gated potassium channel activity transporter activity ion transporter activity ion channel activity
Process
cation transport monovalent inorganic cation transport potassium ion transport physiological process cellular physiological process transport ion transport
Component
protein complex voltage-gated potassium channel complex cell membrane

Target 18 General Function

Inorganic ion transport and metabolism

Target 18 Pathways

Not Available

Target 18 Reactions

Not Available

Target 18 Signals

None

Target 18 Transmembrane Regions

92-112
123-143
167-187
196-218
232-252
292-312

Target 18 Essentiality

Non Essential

Target 18 Domain Function

PF00520:Ion_trans PF03520:KCNQ_channel

Target 18 GenBank ID Protein

Not Available

Target 18 UniProtKB ID

O43526

Target 18 Cellular Location

Membrane

Target 18 Gene Sequence

>1182 bp

ATGGTGCAGAAGTCGCGCAACGGCGGCGTATACCCCGGCCCGAGCGGGGAGAAGAAGCTG
AAGGTGGGCTTCGTGGGGCTGGACCCCGGCGCGCCCGACTCCACCCGGGACGGGGCGCTG
CTGATCGCCGGCTCCGAGGCCCCCAAGCGCGGCAGCATCCTCAGCAAACCTCGCGCGGGC
GGCGCGGGCGCCGGGAAGCCCCCCAAGCGCAACGCCTTCTACCGCAAGCTGCAGAATTTC
CTCTACAACGTGCTGGAGCGGCCGCGCGGCTGGGCGTTCATCTACCACGCCTACGTGTTC
CTCCTGGTTTTCTCCTGCCTCGTGCTGTCTGTGTTTTCCACCATCAAGGAGTATGAGAAG
AGCTCGGAGGGGGCCCTCTACATCCTGGAAATCGTGACTATCGTGGTGTTTGGCGTGGAG
TACTTCGTGCGGATCTGGGCCGCAGGCTGCTGCTGCCGGTACCGTGGCTGGAGGGGGCGG
CTCAAGTTTGCCCGGAAACCGTTCTGTGTGATTGACATCATGGTGCTCATCGCCTCCATT
GCGGTGCTGGCCGCCGGCTCCCAGGGCAACGTCTTTGCCACATCTGCGCTCCGGAGCCTG
CGCTTCCTGCAGATTCTGCGGATGATCCGCATGGACCGGCGGGGAGGCACCTGGAAGCTG
CTGGGCTCTGTGGTCTATGCCCACAGCAAGGAGCTGGTCACTGCCTGGTACATCGGCTTC
CTTTGTCTCATCCTGGCCTCGTTCCTGGTGTACTTGGCAGAGAAGGGGGAGAACGACCAC
TTTGACACCTACGCGGATGCACTCTGGTGGGGCCTGATCACGCTGACCACCATTGGCTAC
GGGGACAAGTACCCCCAGACCTGGAACGGCAGGCTCCTTGCGGCAACCTTCACCCTCATC
GGTGTCTCCTTCTTCGCGCTGCCTGCAGGCATCTTGGGGTCTGGGTTTGCCCTGAAGGTT
CAGGAGCAGCACAGGCAGAAGCACTTTGAGAAGAGGCGGAACCCGGCAGCAGGCCTGATC
CAGTCGGCCTGGAGATTCTACGCCACCAACCTCTCGCGCACAGACCTGCACTCCACGTGG
CAGTACTACGAGCGAACGGTCACCGTGCCCATGTACAGGTACCGCCGCCGGGCACCTGCC
ACCAAGCAACTGTTTCATTTTTTATTTTCCATTTGTTCTTAA

Target 18 GenBank Gene ID

Not Available

Target 18 GeneCard ID

KCNQ2

Target 18 GenAtlas ID

KCNQ2

Target 18 HGNC ID

HGNC:6296

Target 18 Chromosome Location

Chromosome:20

Target 18 Locus

20q13.3

Target 18 SNPs

SNPJam Report Link Image

Target 18 Toxin References

R419 - Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [PubMed ]

Target 18 General References

9039501; 9425895; 9430594; 9836639; 9827540; 9677360; 11160379; 11780052; 15489334; 9872318

Target 19 [top]

Target 19 ID

593

Target 19 Name

Potassium voltage-gated channel subfamily KQT member 3

Target 19 Mechanism of Action

Target 19 Description

Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs

Target 19 Synonyms

Voltage-gated potassium channel subunit Kv7.3; Potassium channel subunit alpha KvLQT3; KQT-like 3

Target 19 Gene Name

KCNQ3

Target 19 Protein Sequence

>Potassium voltage-gated channel subfamily KQT member 3

MGLKARRAAGAAGGGGDGGGGGGGAANPAGGDAAAAGDEERKVGLAPGDVEQVTLALGAG
ADKDGTLLLEGGGRDEGQRRTPQGIGLLAKTPLSRPVKRNNAKYRRIQTLIYDALERPRG
WALLYHALVFLIVLGCLILAVLTTFKEYETVSGDWLLLLETFAIFIFGAEFALRIWAAGC
CCRYKGWRGRLKFARKPLCMLDIFVLIASVPVVAVGNQGNVLATSLRSLRFLQILRMLRM
DRRGGTWKLLGSAICAHSKELITAWYIGFLTLILSSFLVYLVEKDVPEVDAQGEEMKEEF
ETYADALWWGLITLATIGYGDKTPKTWEGRLIAATFSLIGVSFFALPAGILGSGLALKVQ
EQHRQKHFEKRRKPAAELIQAAWRYYATNPNRIDLVATWRFYESVVSFPFFRKEQLEAAS
SQKLGLLDRVRLSNPRGSNTKGKLFTPLNVDAIEESPSKEPKPVGLNNKERFRTAFRMKA
YAFWQSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAVRILQFRLYKKKFKETLRP
YDVKDVIEQYSAGHLDMLSRIKYLQTRIDMIFTPGPPSTPKHKKSQKGSAFTFPSQQSPR
NEPYVARPSTSEIEDQSMMGKFVKVERQVQDMGKKLDFLVDMHMQHMERLQVQVTEYYPT
KGTSSPAEAEKKEDNRYSDLKTIICNYSETGPPEPPYSFHQVTIDKVSPYGFFAHDPVNL
PRGGPSSGKVQATPPSSATTYVERPTVLPILTLLDSRVSCHSQADLQGPYSDRISPRQRR
SITRDSDTPLSLMSVNHEELERSPSGFSISQDRDDYVFGPNGGSSWMREKRYLAEGETDT
DTDPFTPSGSMPLSSTGDGISDSVWTPSNKPI

Target 19 Number of Residues

872

Target 19 Molecular Weight

96741.5

Target 19 Theoretical pI

9.20

Target 19 GO Classification

Function
voltage-gated ion channel activity voltage-gated potassium channel activity transporter activity ion transporter activity ion channel activity
Process
cation transport monovalent inorganic cation transport potassium ion transport physiological process cellular physiological process transport ion transport
Component
protein complex voltage-gated potassium channel complex cell membrane

Target 19 General Function

Inorganic ion transport and metabolism

Target 19 Pathways

Not Available

Target 19 Reactions

Not Available

Target 19 Signals

None

Target 19 Transmembrane Regions

122-142
153-173
197-217
226-247
262-282
331-351

Target 19 Essentiality

Non Essential

Target 19 Domain Function

PF00520:Ion_trans PF03520:KCNQ_channel

Target 19 GenBank ID Protein

Not Available

Target 19 UniProtKB ID

O43525

Target 19 Cellular Location

Membrane

Target 19 Gene Sequence

Not Available

Target 19 GenBank Gene ID

Not Available

Target 19 GeneCard ID

KCNQ3

Target 19 GenAtlas ID

KCNQ3

Target 19 HGNC ID

HGNC:6297

Target 19 Chromosome Location

Not Available

Target 19 Locus

8q24

Target 19 SNPs

SNPJam Report Link Image

Target 19 Toxin References

R419 - Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [PubMed ]

Target 19 General References

9872318; 9425900; 9677360; 10479678; 11034315; 10788442; 10684873; 10713961; 10908292; 10953053

Target 20 [top]

Target 20 ID

594

Target 20 Name

Potassium voltage-gated channel subfamily KQT member 4

Target 20 Mechanism of Action

Target 20 Description

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinnic receptors

Target 20 Synonyms

Voltage-gated potassium channel subunit Kv7.4; Potassium channel subunit alpha KvLQT4; KQT-like 4

Target 20 Gene Name

KCNQ4

Target 20 Protein Sequence

>Potassium voltage-gated channel subfamily KQT member 4

MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPG
PGSGSGSACGQRSSAAHKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLST
IQEHQELANECLLILEFVMIVVFGLEYIVRVWSAGCCCRYRGWQGRFRFARKPFCVIDFI
VFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELIT
AWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLA
AGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDMSRA
YLTATWYYYDSILPSFRELALLFEHVQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHR
PGSTSFCPGESSRMGIKDRIRMGSSQRRTGPSKQHLAPPTMPTSPSSEQVGEATSPTKVQ
KSWSFNDRTRFRASLRLKPRTSAEDAPSEEVAEEKSYQCELTVDDIMPAVKTVIRSIRIL
KFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQTRVDQIVGRGPGDRKAREKG
DKGPSDAEVVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGAVQVPLF
DPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD

Target 20 Number of Residues

695

Target 20 Molecular Weight

77100.0

Target 20 Theoretical pI

9.95

Target 20 GO Classification

Function
voltage-gated ion channel activity voltage-gated potassium channel activity transporter activity ion transporter activity ion channel activity
Process
cation transport monovalent inorganic cation transport potassium ion transport physiological process cellular physiological process transport ion transport
Component
protein complex voltage-gated potassium channel complex cell membrane

Target 20 General Function

Inorganic ion transport and metabolism

Target 20 Pathways

Not Available

Target 20 Reactions

Not Available

Target 20 Signals

None

Target 20 Transmembrane Regions

98-118
132-152
173-193
202-224
238-258
297-317

Target 20 Essentiality

Non Essential

Target 20 Domain Function

PF00520:Ion_trans PF03520:KCNQ_channel

Target 20 GenBank ID Protein

Not Available

Target 20 UniProtKB ID

P56696

Target 20 Cellular Location

Basal cell membrane

Target 20 Gene Sequence

>2088 bp

ATGGCCGAGGCCCCCCCGCGCCGCCTCGGCCTGGGTCCCCCGCCCGGGGACGCCCCCCGC
GCGGAGCTAGTGGCGCTCACGGCCGTGCAGAGCGAACAGGGCGAGGCGGGCGGGGGCGGC
TCCCCGCGCCGCCTCGGCCTCCTGGGCAGCCCCCTGCCGCCGGGCGCGCCCCTCCCTGGG
CCGGGCTCCGGCTCGGGCTCCGCCTGCGGCCAGCGCTCCTCGGCCGCGCACAAGCGCTAC
CGCCGCCTGCAGAACTGGGTCTACAACGTGCTGGAGCGGCCCCGCGGCTGGGCCTTCGTC
TACCACGTCTTCATATTTTTGCTGGTCTTCAGCTGCCTGGTGCTGTCTGTGCTGTCCACT
ATCCAGGAGCACCAGGAACTTGCCAACGAGTGTCTCCTCATCTTGGAATTCGTGATGATC
GTGGTTTTCGGCTTGGAGTACATCGTCCGGGTCTGGTCCGCCGGATGCTGCTGCCGCTAC
CGAGGATGGCAGGGTCGCTTCCGCTTTGCCAGAAAGCCCTTCTGTGTCATCGACTTCATC
GTGTTCGTGGCCTCGGTGGCCGTCATCGCCGCGGGTACCCAGGGCAACATCTTCGCCACG
TCCGCGCTGCGCAGCATGCGCTTCCTGCAGATCCTGCGCATGGTGCGCATGGACCGCCGC
GGCGGCACCTGGAAGCTGCTGGGCTCAGTGGTCTACGCGCATAGCAAGGAGCTGATCACC
GCCTGGTACATCGGGTTCCTGGTGCTCATCTTCGCCTCCTTCCTGGTCTACCTGGCCGAG
AAGGACGCCAACTCCGACTTCTCCTCCTACGCCGACTCGCTCTGGTGGGGGACGATTACA
TTGACAACCATCGGCTATGGTGACAAGACACCGCACACATGGCTGGGCAGGGTCCTGGCT
GCTGGCTTCGCCTTACTGGGCATCTCTTTCTTTGCCCTGCCTGCCGGCATCCTAGGCTCC
GGCTTTGCCCTGAAGGTCCAGGAGCAGCACCGGCAGAAGCACTTCGAGAAGCGGAGGATG
CCGGCAGCCAACCTCATCCAGGCTGCCTGGCGCCTGTACTCCACCGATATGAGCCGGGCC
TACCTGACAGCCACCTGGTACTACTATGACAGTATCCTCCCATCCTTCAGAGAGCTGGCC
CTCTTGTTTGAGCACGTGCAACGGGCCCGCAATGGGGGCCTACGGCCCCTGGAGGTGCGG
CGGGCGCCGGTACCCGACGGAGCACCCTCCCGTTACCCGCCCGTTGCCACCTGCCACCGG
CCGGGCAGCACCTCCTTCTGCCCTGGGGAAAGCAGCCGGATGGGCATCAAAGACCGCATC
CGCATGGGCAGCTCCCAGCGGCGGACGGGTCCTTCCAAGCAGCAGCTGGCACCTCCAACA
ATGCCCACCTCCCCAAGCAGCGAGCAGGTGGGTGAGGCCACCAGCCCCACCAAGGTGCAA
AAGAGCTGGAGCTTCAATGACCGCACCCGCTTCCGGGCATCTCTGAGACTCAAACCCCGC
ACCTCTGCTGAGGATGCCCCCTCAGAGGAAGTAGCAGAGGAGAAGAGCTACCAGTGTGAG
CTCACGGTGGACGACATCATGCCTGCTGTGAAGACAGTCATCCGCTCCATCAGGATTCTC
AAGTTCCTGGTGGCCAAAAGGAAATTCAAGGAGACACTGCGACCGTACGACGTGAAGGAC
GTCATTGAGCAGTACTCAGCAGGCCACCTGGACATGCTGGGCCGGATCAAGAGCCTGCAA
ACTCGGGTGGACCAAATTGTGGGTCGGGGGCCCGGGGACAGGAAGGCCCGGGAGAAGGGC
GACAAGGGGCCCTCCGACGCGGAGGTGGTGGATGAAATCAGCATGATGGGACGCGTGGTC
AAGGTGGAGAAGCAGGTGCAGTCCATCGAGCACAAGCTGGACCTGCTGTTGGGCTTCTAT
TCGCGCTGCCTGCGCTCTGGCACCTCGGCCAGCCTGGGCGCCGTGCAAGTGCCGCTGTTC
GACCCCGACATCACCTCCGACTACCACAGCCCTGTGGACCACGAGGACATCTCCGTCTCC
GCACAGACGCTCAGCATCTCCCGCTCGGTCAGCACCAACATGGACTGA

Target 20 GenBank Gene ID

Not Available

Target 20 GeneCard ID

KCNQ4

Target 20 GenAtlas ID

KCNQ4

Target 20 HGNC ID

HGNC:6298

Target 20 Chromosome Location

Not Available

Target 20 Locus

1p34

Target 20 SNPs

SNPJam Report Link Image

Target 20 Toxin References

R419 - Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [PubMed ]

Target 20 General References

10025409; 16710414; 10713961; 11245603; 10369879; 10571947; 10925378

Target 21 [top]

Target 21 ID

595

Target 21 Name

Potassium voltage-gated channel subfamily KQT member 5

Target 21 Mechanism of Action

Target 21 Description

Probably important in the regulation of neuronal excitability. Associates with KCNQ3 to form a potassium channel which contributes to M-type current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons. May contribute, with other potassium channels, to the molecular diversity of an heterogeneous population of M-channels, varying in kinetic and pharmacological properties, which underlie this physiologically important current. Insensitive to tetraethylammonium, but inhibited by barium, linopirdine and XE991. Activated by niflumic acid and the anticonvulsant retigabine. Muscarine suppresses KCNQ5 current in Xenopus oocytes in which cloned KCNQ5 channels were coexpressed with M(1) muscarinic receptors

Target 21 Synonyms

Voltage-gated potassium channel subunit Kv7.5; Potassium channel subunit alpha KvLQT5; KQT-like 5

Target 21 Gene Name

KCNQ5

Target 21 Protein Sequence

>Potassium voltage-gated channel subfamily KQT member 5

MPRHHAGGEEGGAAGLWVKSGAAAAAAGGGRLGSGMKDVESGRGRVLLNSAAARGDGLLL
LGTRAATLGGGGGGLRESRRGKQGARMSLLGKPLSYTSSQSCRRNVKYRRVQNYLYNVLE
RPRGWAFIYHAFVFLLVFGCLILSVFSTIPEHTKLASSCLLILEFVMIVVFGLEFIIRIW
SAGCCCRYRGWQGRLRFARKPFCVIDTIVLIASIAVVSAKTQGNIFATSALRSLRFLQIL
RMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFSSFLVYLVEKDANKEFSTYAD
ALWWGTITLTTIGYGDKTPLTWLGRLLSAGFALLGISFFALPAGILGSGFALKVQEQHRQ
KHFEKRRNPAANLIQCVWRSYAADEKSVSIATWKPHLKALHTCSPTKKEQGEASSSQKLS
FKERVRMASPRGQSIKSRQASVGDRRSPSTDITAEGSPTKVQKSWSFNDRTRFRPSLRLK
SSQPKPVIDADTALGTDDVYDEKGCQCDVSVEDLTPPLKTVIRAIRIMKFHVAKRKFKET
LRPYDVKDVIEQYSAGHLDMLCRIKSLQTRVDQILGKGQITSDKKSREKITAEHETTDDL
SMLGRVVKVEKQVQSIESKLDCLLDIYQQVLRKGSASALALASFQIPPFECEQTSDYQSP
VDSKDLSGSAQNSGCLSRSTSANISRGLQFILTPNEFSAQTFYALSPTMHSQATQVPISQ
SDGSAVAATNTIANQINTAPKPAAPTTLQIPPPLPAIKHLPRPETLHPNPAGLQESISDV
TTCLVASKENVQVAQSNLTKDRSMRKSFDMGGETLLSVCPMVPKDLGKSLSVQNLIRSTE
ELNIQLSGSESSGSRGSQDFYPKWRESKLFITDEEVGPEETETDTFDAAPQPAREAAFAS
DSLRTGRSRSSQSICKAGESTDALSLPHVKLK

Target 21 Number of Residues

932

Target 21 Molecular Weight

102178.0

Target 21 Theoretical pI

10.01

Target 21 GO Classification

Function
voltage-gated ion channel activity voltage-gated potassium channel activity transporter activity ion transporter activity ion channel activity
Process
cation transport monovalent inorganic cation transport potassium ion transport physiological process cellular physiological process transport ion transport
Component
protein complex voltage-gated potassium channel complex cell membrane

Target 21 General Function

Inorganic ion transport and metabolism

Target 21 Pathways

Not Available

Target 21 Reactions

Not Available

Target 21 Signals

None

Target 21 Transmembrane Regions

126-146
157-177
201-221
230-252
267-287
326-346

Target 21 Essentiality

Non Essential

Target 21 Domain Function

PF00520:Ion_trans PF03520:KCNQ_channel

Target 21 GenBank ID Protein

Not Available

Target 21 UniProtKB ID

Q9NR82

Target 21 Cellular Location

Membrane

Target 21 Gene Sequence

>2799 bp

ATGCCCCGCCACCACGCGGGAGGAGAGGAGGGCGGCGCCGCCGGGCTCTGGGTGAAGAGC
GGCGCAGCGGCGGCGGCGGCGGGCGGGGGGCGCTTGGGCAGCGGCATGAAGGATGTGGAG
TCGGGCCGGGGCAGGGTGCTGCTGAACTCGGCAGCCGCCAGGGGCGACGGCCTGCTACTG
CTGGGCACCCGCGCGGCCACGCTTGGTGGCGGCGGCGGTGGCCTGAGGGAGAGCCGCCGG
GGCAAGCAGGGGGCCCGGATGAGCCTGCTGGGAAGCCGCCTCTCTTACACGAGTAGCCAG
AGCTGCCGGCGCAACGTCAAGTACCGGCGGGTGCAGAACTACCTGTACAACGTGCTGGAG
AGACCCCGCGGCTGGGCGTTCATCTACCACGCTTTCGTTTTCCTCCTTGTCTTTGGTTGC
TTGATTTTGTCAGTGTTTTCTACCATCCCTGAGCACACAAAATTGGCCTCAAGTTGCCTC
TTGATCCTGGAGTTCGTGATGATTGTCGTCTTTGGTTTGGAGTTCATCATTCGAATCTGG
TCTGCGGGTTGCTGTTGTCGATATAGAGGATGGCAAGGAAGACTGAGGTTTGCTCGAAAG
CCCTTCTGTGTTATAGATACCATTGTTCTTATCGCTTCAATAGCAGTTGTTTCTGCAAAA
ACTCAGGGTAATATTTTTGCCACGTCTGCACTCAGAAGTCTCCGTTTCCTACAGATCCTC
CGCATGGTGCGCATGGACCGAAGGGGAGGCACTTGGAAATTACTGGGTTCAGTGGTTTAT
GCTCACAGCAAGGAATTAATCACAGCTTGGTACATAGGATTTTTGGTTCTTATTTTTTCG
TCTTTCCTTGTCTATCTGGTGGAAAAGGATGCCAATAAAGAGTTTTCTACATATGCAGAT
GCTCTCTGGTGGGGCACAATTACATTGACAACTATTGGCTATGGAGACAAAACTCCCCTA
ACTTGGCTGGGAAGATTGCTTTCTGCAGGCTTTGCACTCCTTGGCATTTCTTTCTTTGCA
CTTCCTGCCGGCATTCTTGGCTCAGGTTTTGCATTAAAAGTACAAGAACAACACCGCCAG
AAACACTTTGAGAAAAGAAGGAACCCAGCTGCCAACCTCATTCAGTGTGTTTGGCGTAGT
TACGCAGCTGATGAGAAATCTGTTTCCATTGCAACCTGGAAGCCACACTTGAAGGCCTTG
CACACCTGCAGCCCTACCAAGAAAGAACAAGGGGAAGCATCAAGCAGTCAGAAGCTAAGT
TTTAAGGAGCGAGTGCGCATGGCTAGCCCCAGGGGCCAGAGTATTAAGAGCCGACAAGCC
TCAGTAGGTGACAGGAGGTCCCCAAGCACCGACATCACAGCCGAGGGCAGTCCCACCAAA
GTGCAGAAGAGCTGGAGCTTCAACGACCGAACCCGCTTCCGGCCCTCGCTGCGCCTCAAA
AGTTCTCAGCCAAAACCAGTGATAGATGCTGACACAGCCCTTGGCACTGATGATGTATAT
GATGAAAAAGGATGCCAGTGTGATGTATCAGTGGAAGACCTCACCCCACCACTTAAAACT
GTCATTCGAGCTATCAGAATTATGAAATTTCATGTTGCAAAACGGAAGTTTAAGGAAACA
TTACGTCCATATGATGTAAAAGATGTCATTGAACAATATTCTGCTGGTCATCTGGACATG
TTGTGTAGAATTAAAAGCCTTCAAACACGTGTTGATCAAATTCTTGGAAAAGGGCAAATC
ACATCAGATAAGAAGAGCCGAGAGAAAATAACAGCAGAACATGAGACCACAGACGATCTC
AGTATGCTCGGTCGGGTGGTCAAGGTTGAAAAACAGGTACAGTCCATAGAATCCAAGCTG
GACTGCCTACTAGACATCTATCAACAGGTCCTTCGGAAAGGCTCTGCCTCAGCCCTCGCT
TTGGCTTCATTCCAGATCCCACCTTTTGAATGTGAACAGACATCTGACTATCAAAGCCCT
GTGGATAGCAAAGATCTTTCGGGTTCCGCACAAAACAGTGGCTGCTTATCCAGATCAACT
AGTGCCAACATCTCGAGAGGCCTGCAGTTCATTCTGACGCCAAATGAGTTCAGTGCCCAG
ACTTTCTACGCGCTTAGCCCTACTATGCACAGTCAAGCAACACAGGTGCCAATTAGTCAA
AGCGATGGCTCAGCAGTGGCAGCCACCAACACCATTGCAAACCAAATAAATACGGCACCC
AAGCCAGCAGCCCCAACAACTTTACAGATCCCACCTCCTCTCCCAGCCATCAAGCATCTG
CCCAGGCCAGAAACTCTGCACCCTAACCCTGCAGGCTTACAGGAAAGCATTTCTGACGTC
ACCACCTGCCTTGTTGCCTCCAAGGAAAATGTTCAGGTTGCACAGTCAAATCTCACCAAG
GACCGTTCTATGAGGAAAAGCTTTGACATGGGAGGAGAAACTCTGTTGTCTGTCTGTCCC
ATGGTGCCGAAGGACTTGGGCAAATCTTTGTCTGTGCAAAACCTGATCAGGTCGACCGAG
GAACTGAATATACAACTTTCAGGGAGTGAGTCAAGTGGCTCCAGAGGCAGCCAAGATTTT
TACCCCAAATGGAGGGAATCCAAATTGTTTATAACTGATGAAGAGGTGGGTCCCGAAGAG
ACAGAGACAGACACTTTTGATGCCGCACCGCAGCCTGCCAGGGAAGCTGCCTTTGCATCA
GACTCTCTAAGGACTGGAAGGTCACGATCATCTCAGAGCATTTGTAAGGCAGGAGAAAGT
ACAGATGCCCTCAGCTTGCCTCATGTCAAACTGAAATAA

Target 21 GenBank Gene ID

Not Available

Target 21 GeneCard ID

KCNQ5

Target 21 GenAtlas ID

KCNQ5

Target 21 HGNC ID

HGNC:6299

Target 21 Chromosome Location

Not Available

Target 21 Locus

6q14

Target 21 SNPs

SNPJam Report Link Image

Target 21 Toxin References

R419 - Gibor G, Yakubovich D, Peretz A, Attali B: External barium affects the gating of KCNQ1 potassium channels and produces a pore block via two discrete sites. J Gen Physiol. 2004 Jul;124(1):83-102. [PubMed ]

Target 21 General References

10787416; 14574404; 15489334; 10816588; 11159685; 16959974

This project is supported by Genome Alberta & Genome Canada, a not-for-profit organization that is leading Canada's national genomics strategy with $600 million in funding from the federal government.