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Showing toxin card for Dibromochloropropane (T3D0060)

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Version 1.0
Creation Date 2009-03-06 18:58:00
Update Date 2010-03-18 21:52:19
Accession Number T3D0060
Name Dibromochloropropane
Compound Type
  • Organic Compound
  • Organobromide
  • Organochloride
  • Pesticide
Description Dibromochloropropane is a manufactured chemical and the active ingredient in the nematicide Nemagon, also known as Fumazone. Nemagon is a soil fumigant formerly used in agriculture but banned to most areas today. (R237)
Synonyms
  1. 1,2-Dibromo-3-chloropropane
  2. 1,2-Dibrom-3-chlor-propan [German]
  3. 1,2-Dibromo-3-cloro-propano [Italian]
  4. 1,2-Dibromochloropropane
  5. 1,2-Dibroom-3-chloorpropaan [Dutch]
  6. 1,3-Dibromo-3-chloropropane
  7. 1-Chloro-2,3-dibromopropane
  8. 2,3-Dibromo-1-chloropropane
  9. 3-Chloro-1,2-dibromopropane
  10. Dibromchlorpropan [german]
  11. 1,2-Dibromo-3-chloropropane (DBCP)
  12. Dibromochloropropane
  13. Gro-tone nematode granular
  14. Nemabrom
  15. Nemafume
  16. Nemagon soil fumigant
  17. Nemagone
  18. Nemanax
  19. Nemanex
  20. Nemapaz
  21. Nemaset
  22. Nematocide
  23. Nematox
  24. Nemazon
Chemical IUPAC Name 1,2-dibromo-3-chloropropane
Chemical Formula C3H5Br2Cl
Chemical Structure Structure
CAS Registry Number 67708-83-2
InChI Identifier InChI=1S/C3H5Br2Cl/c4-1-3(5)2-6/h3H,1-2H2
InChI Key InChIKey=WBEJYOJJBDISQU-UHFFFAOYSA-N
PubChem Compound ID 7280 Link Image
KEGG ID Not Available
UniProt ID Not Available
OMIM ID Not Available
ChEBI ID Not Available
BioCyc ID Not Available
SuperToxic ID Not Available
CTD ID Not Available
Stitch ID Dibromochloropropane Link Image
DrugBank ID Not Available
PDB ID Not Available
ACToR ID Not Available
Wikipedia Link Not Available
Monoisotopic Mass 233.844653
MOL File Show
PDB File Show
SDF File Show
SMILES ClCC(Br)CBr
Appearance Colorless liquid.
Melting Point Not Available
Solubility Not Available
Predicted LogP 2.5958
Route of Exposure Oral (R236) ; inhalation (R236) ; dermal (R236)
Mechanism of Action The initial metabolism of dibromochloropropane to reactive epoxide metabolites that bind to DNA and other macromolecules may be responsible for its hepatotoxicity and nephrotoxicity. The mechanism of dibromochloropropane's testicular toxicity is believed to be due to either the inhibition of sperm carbohydrate metabolism, probably at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain, or direct DNA damage caused by its metabolites. (R236, R043)
Metabolism Dibromochloropropane is absorbed via oral, inhalation, and dermal routes. It accumulates mainly in the kidney, liver, and adipose tissues. Dibromochloropropane is initially converted to epoxy derivatives, which are further hydrolyzed and debrominated. Glutathione (GSH) conjugation of epoxide intermediates in the liver is believed to produce precursors to toxic intermediates. The metabolites are excreted mainly in the urine. (R236)
Toxicity Values LD50: 100 mg/kg (Oral, Rabbit) (R292) LC50: 1480 mg/m3 over 1 hour (Inhalation, Rat) (R292)
Lethal Dose Not Available
Carcinogenicity (IARC Classification) 2B, possibly carcinogenic to humans. (R264)
Uses/Sources Dibromochloropropane is the active ingredient in the nematicide Nemagon, also known as Fumazone. Nemagon is a soil fumigant formerly used in agriculture. (R236)
Minimum Risk Level Intermediate Inhalation: 0.0002 ppm (R260) Intermediate Oral: 0.002 mg/kg/day (R260)
Health Effects Breathing high levels of dibromochloropropane causes reproductive damage, including reduced sperm counts, birth defects, and infertility. It may also damage the stomach, liver, kidneys, brain, spleen, blood, and lungs, and cause skin and eye damage from direct contact. (R236)
Symptoms Symptoms of dibromochloropropane exposure include headaches, nausea, lightheadedness, and weakness. (R236)
Treatment Not Available
General References
  • R236 - ATSDR - Agency for Toxic Substances and Disease Registry (1992). Toxicological profile for 1,2-dibromo-3-chloropropane. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
  • R264 - International Agency for Research on Cancer (2009). IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.
  • R292 - USEPA (1985). Drinking Water Criteria Document (Draft) 1,2-Dibromo-3-chloropropane.
  • R260 - ATSDR - Agency for Toxic Substances and Disease Registry (2001). Minimal Risk Levels (MRLs) for Hazardous Substances. U.S. Public Health Service in collaboration with U.S. Environmental Protection Agency (EPA).
  • R237 - Wikipedia. 1,2-Dibromo-3-chloropropane. Last Updated 25 April 2009.
Targets
  1. NADH-ubiquinone oxidoreductase chain 1
  2. NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
  3. NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
  4. NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
  5. NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
  6. NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
  7. NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
  8. NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
  9. NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
  10. NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
  11. NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
  12. NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
  13. NADH-ubiquinone oxidoreductase chain 2
  14. NADH-ubiquinone oxidoreductase chain 3
  15. NADH-ubiquinone oxidoreductase chain 4
  16. NADH-ubiquinone oxidoreductase chain 4L
  17. NADH-ubiquinone oxidoreductase chain 5
  18. NADH-ubiquinone oxidoreductase chain 6
  19. Estrogen receptor
  20. Estrogen receptor beta
Target 1 [top]
Target 1 ID 211
Target 1 Name NADH-ubiquinone oxidoreductase chain 1
Target 1 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 1 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 1 Synonyms
  1. NADH dehydrogenase subunit 1
Target 1 Gene Name MT-ND1
Target 1 Protein Sequence >NADH-ubiquinone oxidoreductase chain 1 
MPMANLLLLIVPILIAMAFLMLTERKILGYMQLRKGPNVVGPYGLLQPFADAMKLFTKEP
LKPATSTITLYITAPTLALTIALLLWTPLPMPNPLVNLNLGLLFILATSSLAVYSILWSG
WASNSNYALIGALRAVAQTISYEVTLAIILLSTLLMSGSFNLSTLITTQEHLWLLLPSWP
LAMMWFISTLAETNRTPFDLAEGESELVSGFNIEYAAGPFALFFMAEYTNIIMMNTLTTT
IFLGTTYDALSPELYTTYFVTKTLLLTSLFLWIRTAYPRFRYDQLMHLLWKNFLPLTLAL
LMWYVSMPITISSIPPQT
Target 1 Number of Residues 318
Target 1 Molecular Weight 35660.1
Target 1 Theoretical pI 6.53
Target 1 GO Classification
Function
Not Available
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
Component
cell
membrane
Target 1 General Function Energy production and conversion
Target 1 Pathways Not Available
Target 1 Reactions Not Available
Target 1 Signals
  • None
Target 1 Transmembrane Regions
  • 2-22
  • 68-88
  • 100-120
  • 146-166
  • 171-191
  • 231-251
  • 253-273
  • 294-314
Target 1 Essentiality Non Essential
Target 1 Domain Function PF00146:NADHdh
Target 1 GenBank ID Protein Not Available
Target 1 UniProtKB ID P03886 Link Image
Target 1 Cellular Location Mitochondrion inner membrane
Target 1 Gene Sequence >957 bp 
ATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCATTCCTA
ATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTGGTA
GGCCCCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCC
CTAAAACCCGCCACATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACC
ATCGCTCTTCTACTATGAACCCCCCTCCCCATACCCAACCCCCTGGTCAACCTCAACCTA
GGCCTCCTATTTATTCTAGCCACCTCTAGCCTAGCCGTTTACTCAATCCTCTGATCAGGG
TGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGCAGTAGCCCAAACAATC
TCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGCTCCTTT
AACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCC
TTGGCCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTT
GCCGAAGGGGAGTCCGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTC
GCCCTATTCTTCATAGCCGAATACACAAACATTATTATAATAAACACCCTCACCACTACA
ATCTTCCTAGGAACAACATATGACGCACTCTCCCCTGAACTCTACACAACATATTTTGTC
ACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAACAGCATACCCCCGATTC
CGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTAGCATTA
CTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTAA
Target 1 GenBank Gene ID Not Available
Target 1 GeneCard ID MT-ND1 Link Image
Target 1 GenAtlas ID MT-ND1 Link Image
Target 1 HGNC ID HGNC:7455 Link Image
Target 1 Chromosome Location Chromosome:MT   
HGNC chromosome: mitochondria
Target 1 Locus Not Available
Target 1 SNPs SNPJam Report Link Image
Target 1 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 1 General References 7219534; 7530363; 12949126; 11130070; 12840039; 14760490; 6260957; 3921850; 1928099; 1674640
Target 2 [top]
Target 2 ID 350
Target 2 Name NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Target 2 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 2 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 2 Synonyms
  1. NADH-ubiquinone oxidoreductase 51 kDa subunit; Complex I-51kD; CI-51kD; NADH dehydrogenase flavoprotein 1
Target 2 Gene Name NDUFV1
Target 2 Protein Sequence >NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 
MLATRRLLGWSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGSLSRG
DWYKTKEILLKGPDWILGEIKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEG
EPGTCKDREILRHDPHKLLEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAG
LIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPT
TVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELI
EKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRS
TDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIE
GHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQHQARQAAS
Target 2 Number of Residues 464
Target 2 Molecular Weight 50816.7
Target 2 Theoretical pI 8.29
Target 2 GO Classification
Function
cofactor binding
coenzyme binding
NAD binding
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on NADH or NADPH
nucleotide binding
FMN binding
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
binding
ion binding
cation binding
transition metal ion binding
iron ion binding
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
ATP synthesis coupled electron transport
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
Component
Not Available
Target 2 General Function Energy production and conversion
Target 2 Pathways Not Available
Target 2 Reactions Not Available
Target 2 Signals
  • None
Target 2 Transmembrane Regions
  • None
Target 2 Essentiality Non Essential
Target 2 Domain Function PF01512:Complex1_51K PF10589:NADH_4Fe-4S PF10531:SLBB
Target 2 GenBank ID Protein Not Available
Target 2 UniProtKB ID P49821 Link Image
Target 2 Cellular Location Mitochondrion inner membrane
Target 2 Gene Sequence >1395 bp 
ATGCTGGCAACACGGCGGCTGCTCGGCTGGTCGCTTCCCGCGCGGGTATCTGTGCGTTTC
AGCGGCGACACGACAGCACCCAAGAAAACCTCATTTGGCTCGCTGAAGGATGAAGACCGG
ATTTTCACCAACCTGTACGGCCGCCATGACTGGAGGCTGAAAGGTTCCCTGAGTCGAGGT
GACTGGTACAAGACAAAGGAGATCCTGCTGAAGGGGCCCGACTGGATCCTGGGCGAGATC
AAGACATCGGGTTTGAGGGGCCGTGGAGGCGCTGGCTTCCCCACTGGCCTCAAGTGGAGC
TTCATGAATAAGCCCTCAGATGGCAGGCCCAAGTATCTGGTGGTGAACGCAGACGAGGGG
GAGCCGGGCACCTGCAAGGACCGGGAGATCTTACGCCATGATCCTCACAAGCTGCTGGAA
GGCTGCCTGGTGGGGGGCCGGGCCATGGGCGCCCGCGCTGCCTATATCTACATCCGAGGG
GAATTCTACAATGAGGCCTCCAATCTGCAGGTGGCCATCCGAGAGGCCTATGAGGCAGGT
CTGATTGGCAAGAATGCTTGTGGCTCTGGCTATGATTTTGACGTGTTTGTGGTGCGCGGG
GCTGGGGCCTACATCTGTGGAGAGGAGACAGCGCTCATCGAGTCCATTGAGGGCAAGCAG
GGCAAGCCCCGCCTGAAGCCCCCCTTCCCCGCAGACGTGGGAGTGTTTGGCTGCCCCACA
ACTGTGGCCAACGTGGAGACAGTGGCAGTGTCCCCCACAATCTGCCGCCGTGGAGGTACC
TGGTTTGCTGGCTTTGGCAGAGAACGCAACTCAGGCACCAAACTATTCAACATCTCTGGC
CATGTCAACCACCCTTGCACTGTGGAGGAGGAGATGTCTGTGCCCTTGAAAGAACTGATT
GAGAAGCATGCTGGGGGTGTCACGGGCGGCTGGGACAACCTCCTTGCTGTGATCCCTGGC
GGCTCGTCTACCCCACTGATCCCCAAGTCTGTGTGTGAGACGGTGCTGATGGACTTCGAT
GCGCTGGTGCAGGCACAGACAGGCCTGGGCACAGCTGCGGTGATCGTCATGGACCGCTCG
ACGGACATCGTGAAAGCCATCGCCCGCCTCATTGAGTTCTATAAGCACGAGAGCTGTGGC
CAGTGTACCCCATGCCGTGAGGGTGTGGACTGGATGAACAAGGTGATGGCACGTTTCGTG
AGGGGGGATGCCCGGCCGGCCGAGATCGACTCCCTGTGGGAGATCAGCAAGCAGATAGAA
GGCCATACGATTTGTGCTCTGGGTGACGGGGCCGCCTGGCCTGTGCAGGGTCTGATCCGC
CACTTTCGGCCGGAGCTCGAGGAGCGGATGCAGCGGTTTGCCCAGCAGCATCAGGCCCGG
CAGGCTGCCTCTTAG
Target 2 GenBank Gene ID Not Available
Target 2 GeneCard ID NDUFV1 Link Image
Target 2 GenAtlas ID NDUFV1 Link Image
Target 2 HGNC ID HGNC:7716 Link Image
Target 2 Chromosome Location Chromosome:11
Target 2 Locus 11q13
Target 2 SNPs SNPJam Report Link Image
Target 2 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 2 General References 9892733; 9571201; 10931946; 15489334; 1478657; 8288251; 10080174; 11349233
Target 3 [top]
Target 3 ID 355
Target 3 Name NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial
Target 3 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 3 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 3 Synonyms
  1. NADH-ubiquinone oxidoreductase 24 kDa subunit
Target 3 Gene Name NDUFV2
Target 3 Protein Sequence >NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial 
MFFSAALRARAAGLTAHWGRHVRNLHKTVMQNGAGGALFVHRDTPENNPDTPFDFTPENY
KRIEAIVKNYPEGHKAAAVLPVLDLAQRQNGWLPISAMNKVAEVLQVPPMRVYEVATFYT
MYNRKPVGKYHIQVCTTTPCMLRNSDSILEAIQKKLGIKVGETTPDKLFTLIEVECLGAC
VNAPMVQINDNYYEDLTAKDIEEIIDELKAGKIPKPGPRSGRFSCEPAGGLTSLTEPPKG
PGFGVQAGL
Target 3 Number of Residues 249
Target 3 Molecular Weight 27391.4
Target 3 Theoretical pI 8.21
Target 3 GO Classification
Function
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
ATP synthesis coupled electron transport
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
Component
Not Available
Target 3 General Function Energy production and conversion
Target 3 Pathways Not Available
Target 3 Reactions Not Available
Target 3 Signals
  • None
Target 3 Transmembrane Regions
  • None
Target 3 Essentiality Non Essential
Target 3 Domain Function PF01257:Complex1_24kDa
Target 3 GenBank ID Protein Not Available
Target 3 UniProtKB ID P19404 Link Image
Target 3 Cellular Location Mitochondrion inner membrane
Target 3 Gene Sequence >750 bp 
ATGTTCTTCTCCGCGGCGCTCCGGGCCCGGGCGGCTGGCCTCACCGCCCACTGGGGAAGA
CATGTAAGGAATTTGCATAAGACAGCTATGCAAAATGGAGCTGGAGGAGCTTTATTTGTG
CACAGAGATACTCCTGAGAATAACCCTGATACTCCATTTGATTTCACACCAGAAAACTAT
AAGAGGATAGAGGCAATTGTAAAAAACTATCCAGAAGGCCATAAAGCAGCAGCTGTTCTT
CCAGTCCTGGATTTAGCCCAAAGGCAGAATGGGTGGTTGCCCATCTCTGCTATGAACAAG
GTTGCAGAAGTTTTACAAGTACCTCCAATGAGAGTATATGAAGTAGCAACTTTTTATACA
ATGTATAATCGAAAGCCAGTTGGAAAGTATCACATTCAGGTCTGCACTACTACACCCTGC
ATGCTTCGAAACTCTGACAGCATACTGGAGGCCATTCAGAAAAAGCTTGGAATAAAGGTT
GGGGAGACTACACCTGACAAACTTTTCACTCTTATAGAAGTGGAATGTTTAGGGGCCTGT
GTGAACGCACCAATGGTTCAAATAAATGACAATTACTATGAGGATTTGACAGCTAAGGAT
ATTGAAGAAATTATTGATGAGCTCAAGGCTGGCAAAATCCCAAAACCAGGGCCAAGGAGT
GGACGCTTCTCTTGTGAGCCAGCTGGAGGTCTTACCTCTTTGACTGAACCACCCAAGGGA
CCTGGATTTGGTGTACAAGCAGGCCTTTAA
Target 3 GenBank Gene ID Not Available
Target 3 GeneCard ID NDUFV2 Link Image
Target 3 GenAtlas ID NDUFV2 Link Image
Target 3 HGNC ID HGNC:7717 Link Image
Target 3 Chromosome Location Chromosome:18
Target 3 Locus 18p11.31-p11.2
Target 3 SNPs SNPJam Report Link Image
Target 3 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 3 General References 2500970; 15489334
Target 4 [top]
Target 4 ID 359
Target 4 Name NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial
Target 4 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 4 Description Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Target 4 Synonyms
  1. NADH-ubiquinone oxidoreductase 9 kDa subunit; Complex I-9kD; CI-9kD; Renal carcinoma antigen NY-REN-4
Target 4 Gene Name NDUFV3
Target 4 Protein Sequence >NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial 
MAAPCLLRQGRAGALKTMLQEAQVFRGLASTVSLSAESGKSEKGQPQNSKKQSPPKKPAP
VPAEPFDNTTYKNLQHHDYSTYTFLDLNLELSKFRMPQPSSGRESPRH
Target 4 Number of Residues 108
Target 4 Molecular Weight 11940.4
Target 4 Theoretical pI 10.30
Target 4 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 4 General Function Involved in NADH dehydrogenase (ubiquinone) activity
Target 4 Pathways Not Available
Target 4 Reactions Not Available
Target 4 Signals
  • None
Target 4 Transmembrane Regions
  • None
Target 4 Essentiality Non Essential
Target 4 Domain Function Not Available
Target 4 GenBank ID Protein Not Available
Target 4 UniProtKB ID P56181 Link Image
Target 4 Cellular Location Mitochondrion inner membrane
Target 4 Gene Sequence Not Available
Target 4 GenBank Gene ID Not Available
Target 4 GeneCard ID NDUFV3 Link Image
Target 4 GenAtlas ID NDUFV3 Link Image
Target 4 HGNC ID HGNC:7719 Link Image
Target 4 Chromosome Location Chromosome:21
Target 4 Locus 21q22.3
Target 4 SNPs SNPJam Report Link Image
Target 4 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 4 General References 9344673; 10950923; 15489334; 10508479
Target 5 [top]
Target 5 ID 351
Target 5 Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial
Target 5 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 5 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 5 Synonyms
  1. NADH-ubiquinone oxidoreductase 49 kDa subunit; Complex I-49kD; CI-49kD
Target 5 Gene Name NDUFS2
Target 5 Protein Sequence >NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 
MAALRALCGFRGVAAQVLRPGAGVRLPIQPSRGVRQWQPDVEWAQQFGGAVMYPSKETAH
WKPPPWNDVDPPKDTIVKNITLNFGPQHPAAHGVLRLVMELSGEMVRKCDPHIGLLHRGT
EKLIEYKTYLQALPYFDRLDYVSMMCNEQAYSLAVEKLLNIRPPPRAQWIRVLFGEITRL
LNHIMAVTTHALDLGAMTPFFWLFEEREKMFEFYERVSGARMHAAYIRPGGVHQDLPLGL
MDDIYQFSKNFSLRLDELEELLTNNRIWRNRTIDIGVVTAEEALNYGFSGVMLRGSGIQW
DLRKTQPYDVYDQVEFDVPVGSRGDCYDRYLCRVEEMRQSLRIIAQCLNKMPPGEIKVDD
AKVSPPKRAEMKTSMESLIHHFKLYTEGYQVPPGATYTAIEAPKGEFGVYLVSDGSSRPY
RCKIKAPGFAHLAGLDKMSKGHMLADVVAIIGTQDIVFGEVDR
Target 5 Number of Residues 463
Target 5 Molecular Weight 52545.3
Target 5 Theoretical pI 7.61
Target 5 GO Classification
Function
transporter activity
electron transporter activity
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on NADH or NADPH
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
Component
Not Available
Target 5 General Function Energy production and conversion
Target 5 Pathways Not Available
Target 5 Reactions Not Available
Target 5 Signals
  • None
Target 5 Transmembrane Regions
  • None
Target 5 Essentiality Non Essential
Target 5 Domain Function PF00346:Complex1_49kDa
Target 5 GenBank ID Protein Not Available
Target 5 UniProtKB ID O75306 Link Image
Target 5 Cellular Location Mitochondrion inner membrane
Target 5 Gene Sequence >1392 bp 
ATGGCGGCGCTGAGGGCTTTGTGCGGCTTCCGGGGCGTCGCGGCCCAGGTGCTGCGGCCT
GGGGCTGGAGTCCGATTGCCGATTCAGCCCAGCAGAGGTGTTCGGCAGTGGCAGCCAGAT
GTGGAATGGGCACAGCAGTTTGGGGGAGCTGTTATGTACCCAAGCAAAGAAACAGCCCAC
TGGAAGCCTCCACCTTGGAATGATGTGGACCCTCCAAAGGACACAATTGTGAAGAACATT
ACCCTGAACTTTGGGCCCCAACACCCAGCAGCGCATGGTGTCCTGCGACTAGTGATGGAA
TTGAGTGGGGAGATGGTGCGGAAGTGTGATCCTCACATCGGGCTCCTGCACCGAGGCACT
GAGAAGCTCATTGAATACAAGACCTATCTTCAGGCCCTTCCATACTTTGACCGGCTAGAC
TATGTGTCCATGATGTGTAACGAACAGGCCTATTCTCTAGCTGTGGAGAAGTTGCTAAAC
ATCCGGCCTCCTCCTCGGGCACAGTGGATCCGAGTGCTGTTTGGAGAAATCACACGTTTG
TTGAACCACATCATGGCTGTGACCACACATGCCCTGGACCTTGGGGCCATGACCCCTTTC
TTCTGGCTGTTTGAAGAAAGGGAGAAGATGTTTGAGTTCTACGAGCGAGTGTCTGGAGCC
CGAATGCATGCTGCTTATATCCGGCCAGGAGGAGTGCACCAGGACCTACCCCTTGGGCTT
ATGGATGACATTTATCAGTTTTCTAAGAACTTCTCTCTTCGGCTTGATGAGTTGGAGGAG
TTGCTGACCAACAATAGGATCTGGCGAAATCGGACAATTGACATTGGGGTTGTAACAGCA
GAAGAAGCACTTAACTATGGTTTTAGTGGAGTGATGCTTCGGGGCTCAGGCATCCAGTGG
GACCTGCGGAAGACCCAGCCCTATGATGTTTACGACCAGGTTGAGTTTGATGTTCCTGTT
GGTTCTCGAGGGGACTGCTATGATAGGTACCTGTGCCGGGTGGAGGAGATGCGCCAGTCC
CTGAGAATTATCGCACAGTGTCTAAACAAGATGCCTCCTGGGGAGATCAAGGTTGATGAT
GCCAAAGTGTCTCCACCTAAGCGAGCAGAGATGAAGACTTCCATGGAGTCACTGATTCAT
CACTTTAAGTTGTATACTGAGGGCTACCAAGTTCCTCCAGGAGCCACATATACTGCCATT
GAGGCTCCCAAGGGAGAGTTTGGGGTGTACCTGGTGTCTGATGGCAGCAGCCGCCCTTAT
CGATGCAAGATCAAGGCTCCTGGTTTTGCCCATCTGGCTGGTTTGGACAAGATGTCTAAG
GGACACATGTTGGCAGATGTCGTTGCCATCATAGGTACCCAAGATATTGTATTTGGAGAA
GTAGATCGGTGA
Target 5 GenBank Gene ID Not Available
Target 5 GeneCard ID NDUFS2 Link Image
Target 5 GenAtlas ID NDUFS2 Link Image
Target 5 HGNC ID HGNC:7708 Link Image
Target 5 Chromosome Location Not Available
Target 5 Locus 1q23
Target 5 SNPs SNPJam Report Link Image
Target 5 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 5 General References 9647766; 9585441; 16710414; 15489334; 19463981; 11220739
Target 6 [top]
Target 6 ID 354
Target 6 Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial
Target 6 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 6 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 6 Synonyms
  1. NADH-ubiquinone oxidoreductase 30 kDa subunit; Complex I-30kD; CI-30kD
Target 6 Gene Name NDUFS3
Target 6 Protein Sequence >NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 
MAAAAVARLWWRGILGASALTRGTGRPSVLLLPVRRESAGADTRPTVRPRNDVAHKQLSA
FGEYVAEILPKYVQQVQVSCFNELEVCIHPDGVIPVLTFLRDHTNAQFKSLVDLTAVDVP
TRQNRFEIVYNLLSLRFNSRIRVKTYTDELTPIESAVSVFKAANWYEREIWDMFGVFFAN
HPDLRRILTDYGFEGHPFRKDFPLSGYVELRYDDEVKRVVAEPVELAQEFRKFDLNSPWE
AFPVYRQPPESLKLEAGDKKPDAK
Target 6 Number of Residues 264
Target 6 Molecular Weight 30241.2
Target 6 Theoretical pI 7.62
Target 6 GO Classification
Function
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on NADH or NADPH
Process
ATP synthesis coupled electron transport
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
Component
Not Available
Target 6 General Function Energy production and conversion
Target 6 Pathways Not Available
Target 6 Reactions Not Available
Target 6 Signals
  • None
Target 6 Transmembrane Regions
  • None
Target 6 Essentiality Non Essential
Target 6 Domain Function PF00329:Complex1_30kDa
Target 6 GenBank ID Protein Not Available
Target 6 UniProtKB ID O75489 Link Image
Target 6 Cellular Location Mitochondrion inner membrane
Target 6 Gene Sequence >795 bp 
ATGGCGGCGGCGGCGGTAGCCAGGCTGTGGTGGCGCGGGATCTTGGGGGCCTCGGCGCTG
ACCAGGGGGACTGGGCGACCCTCCGTTCTGTTGCTGCCGGTGAGGCGGGAGAGCGCCGGG
GCCGACACGCGCCCCACTGTCAGACCACGGAATGATGTGGCCCACAAGCAGCTCTCAGCT
TTTGGAGAGTATGTGGCTGAAATCTTGCCCAAGTATGTCCAACAAGTTCAGGTGTCCTGC
TTCAATGAGTTAGAGGTCTGTATCCATCCTGATGGCGTCATCCCAGTGCTGACTTTCCTC
AGGGATCACACCAATGCACAGTTCAAATCTCTGGTTGACTTGACAGCAGTGGACGTCCCA
ACTCGGCAAAACCGTTTTGAGATTGTCTACAACCTGTTGTCTCTGCGCTTCAACTCACGG
ATCCGTGTGAAGACCTACACAGATGAGCTGACGCCCATTGAGTCTGCTGTCTCTGTGTTC
AAGGCAGCCAACTGGTATGAAAGGGAGATCTGGGACATGTTTGGAGTCTTCTTTGCTAAC
CACCCTGATCTAAGAAGGATCCTGACAGATTATGGCTTCGAGGGACATCCTTTCCGGAAA
GACTTTCCTCTATCTGGCTATGTTGAGTTACGTTATGATGATGAAGTGAAGCGGGTGGTG
GCAGAGCCGGTGGAGTTGGCCCAAGAGTTCCGCAAATTTGACCTGAACAGCCCCTGGGAG
GCTTTCCCAGTCTATCGCCAACCCCCGGAGAGTCTCAAGCTTGAAGCCGGAGACAAGAAG
CCTGATGCCAAGTAG
Target 6 GenBank Gene ID Not Available
Target 6 GeneCard ID NDUFS3 Link Image
Target 6 GenAtlas ID NDUFS3 Link Image
Target 6 HGNC ID HGNC:7710 Link Image
Target 6 Chromosome Location Chromosome:11
Target 6 Locus 11p11.11
Target 6 SNPs SNPJam Report Link Image
Target 6 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 6 General References 9647766; 10967146; 10931946; 15489334; 19463981
Target 7 [top]
Target 7 ID 356
Target 7 Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Target 7 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 7 Description Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Target 7 Synonyms
  1. NADH-ubiquinone oxidoreductase 18 kDa subunit; Complex I-18 kDa; CI-18 kDa; Complex I-AQDQ; CI-AQDQ
Target 7 Gene Name NDUFS4
Target 7 Protein Sequence >NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 
MAAVSMSVVLRQTLWRRRAVAVAALSVSRVPTRSLRTSTWRLAQDQTQDTQLITVDEKLD
ITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADP
LSNMVLTFSTKEDAVSFAEKNGWSYDIEERKVPKPKSKSYGANFSWNKRTRVSTK
Target 7 Number of Residues 175
Target 7 Molecular Weight 20107.8
Target 7 Theoretical pI 11.02
Target 7 GO Classification
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on NADH or NADPH
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
Component
Not Available
Target 7 General Function Involved in NADH dehydrogenase (ubiquinone) activity
Target 7 Pathways Not Available
Target 7 Reactions Not Available
Target 7 Signals
  • None
Target 7 Transmembrane Regions
  • None
Target 7 Essentiality Non Essential
Target 7 Domain Function PF04800:ETC_C1_NDUFA4
Target 7 GenBank ID Protein Not Available
Target 7 UniProtKB ID O43181 Link Image
Target 7 Cellular Location Mitochondrion inner membrane
Target 7 Gene Sequence >528 bp 
ATGGCGGCGGTCTCAATGTCAGTGGTACTGAGGCAGACGTTGTGGCGGAGAAGGGCAGTG
GCTGTAGCTGCCCTTTCCGTTTCCAGGGTTCCGACCAGGTCGTTGAGGACTTCCACATGG
AGATTGGCACAGGACCAGACTCAAGACACACAACTCATAACAGTTGATGAAAAATTGGAT
ATCACTACTTTAACTGGCGTTCCAGAAGAGCATATAAAAACTAGAAAAGTCAGGATCTTT
GTTCCTGCTCGCAATAACATGCAGTCTGGAGTAAACAACACAAAGAAATGGAAGATGGAG
TTTGATACCAGGGAGCGATGGGAAAATCCTTTGATGGGTTGGGCATCAACGGCTGATCCC
TTATCCAACATGGTTCTAACCTTCAGTACTAAAGAAGATGCAGTTTCCTTTGCAGAAAAA
AATGGATGGAGCTATGACATTGAAGAGAGGAAGGTTCCAAAACCCAAGTCCAAGTCTTAT
GGTGCAAACTTTTCTTGGAACAAAAGAACAAGAGTATCCACAAAATAG
Target 7 GenBank Gene ID Not Available
Target 7 GeneCard ID NDUFS4 Link Image
Target 7 GenAtlas ID NDUFS4 Link Image
Target 7 HGNC ID HGNC:7711 Link Image
Target 7 Chromosome Location Not Available
Target 7 Locus 5q11.1
Target 7 SNPs SNPJam Report Link Image
Target 7 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 7 General References 9463323; 15489334; 16094384
Target 8 [top]
Target 8 ID 358
Target 8 Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 5
Target 8 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 8 Description Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Target 8 Synonyms
  1. NADH-ubiquinone oxidoreductase 15 kDa subunit; Complex I-15 kDa; CI-15 kDa
Target 8 Gene Name NDUFS5
Target 8 Protein Sequence >NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 
MPFLDIQKRFGLNIDRWLTIQSGEQPYKMAGRCHAFEKEWIECAHGIGYTRAEKECKIEY
DDFVECLLRQKTMRRAGTIRKQRDKLIKEGKYTPPPHHIGKGEPRP
Target 8 Number of Residues 106
Target 8 Molecular Weight 12517.4
Target 8 Theoretical pI 9.54
Target 8 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 8 General Function Involved in NADH dehydrogenase (ubiquinone) activity
Target 8 Pathways Not Available
Target 8 Reactions Not Available
Target 8 Signals
  • None
Target 8 Transmembrane Regions
  • None
Target 8 Essentiality Non Essential
Target 8 Domain Function PF10200:Ndufs5
Target 8 GenBank ID Protein Not Available
Target 8 UniProtKB ID O43920 Link Image
Target 8 Cellular Location Mitochondrion inner membrane
Target 8 Gene Sequence >321 bp 
ATGCCTTTCTTGGACATCCAGAAAAGGTTCGGCCTTAACATAGATCGATGGTTGACAATC
CAGAGTGGTGAACAGCCCTACAAGATGGCTGGTCGATGCCATGCTTTTGAAAAAGAATGG
ATAGAATGTGCACATGGAATCGGTTATACTCGGGCAGAGAAAGAGTGCAAGATAGAATAT
GATGATTTCGTAGAGTGTTTGCTTCGGCAGAAAACGATGAGACGTGCAGGTACCATCAGG
AAGCAGCGGGATAAGCTGATAAAGGAAGGAAAGTACACCCCTCCACCTCACCACATTGGC
AAGGGGGAGCCTCGGCCCTGA
Target 8 GenBank Gene ID Not Available
Target 8 GeneCard ID NDUFS5 Link Image
Target 8 GenAtlas ID NDUFS5 Link Image
Target 8 HGNC ID HGNC:7712 Link Image
Target 8 Chromosome Location Not Available
Target 8 Locus 1p34.2-p33
Target 8 SNPs SNPJam Report Link Image
Target 8 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 8 General References 9653160; 10070614; 15489334
Target 9 [top]
Target 9 ID 357
Target 9 Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
Target 9 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 9 Description Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Target 9 Synonyms
  1. NADH-ubiquinone oxidoreductase 13 kDa-A subunit; Complex I-13kD-A; CI-13kD-A
Target 9 Gene Name NDUFS6
Target 9 Protein Sequence >NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial 
MAAAMTFCRLLNRCGEAARSLPLGARCFGVRVSPTGEKVTHTGQVYDDKDYRRIRFVGRQ
KEVNENFAIDLIAEQPVSEVETRVIACDGGGGALGHPKVYINLDKETKTGTCGYCGLQFR
QHHH
Target 9 Number of Residues 124
Target 9 Molecular Weight 13711.5
Target 9 Theoretical pI 8.38
Target 9 GO Classification
Function
Not Available
Process
Not Available
Component
Not Available
Target 9 General Function Involved in electron carrier activity
Target 9 Pathways Not Available
Target 9 Reactions Not Available
Target 9 Signals
  • None
Target 9 Transmembrane Regions
  • None
Target 9 Essentiality Non Essential
Target 9 Domain Function PF10276:zf-CHCC
Target 9 GenBank ID Protein Not Available
Target 9 UniProtKB ID O75380 Link Image
Target 9 Cellular Location Mitochondrion inner membrane
Target 9 Gene Sequence >375 bp 
ATGGCGGCGGCGATGACCTTCTGCCGGCTGCTGAACCGGTGTGGCGAGGCGGCGCGGAGC
CTGCCCCTGGGCGCCAGGTGTTTCGGGGTGCGGGTCTCGCCGACCGGGGAGAAGGTCACG
CACACTGGCCAGGTTTATGATGATAAAGACTACAGGAGAATTCGGTTTGTAGGTCGTCAG
AAAGAGGTGAATGAAAACTTTGCCATTGATTTGATAGCAGAGCAGCCCGTGAGCGAGGTG
GAGACTCGGGTGATAGCGTGCGATGGCGGCGGGGGAGCTCTTGGCCACCCAAAAGTGTAT
ATAAACTTGGACAAAGAAACAAAAACCGGCACATGCGGTTACTGTGGGCTCCAGTTCAGA
CAGCACCACCACTAG
Target 9 GenBank Gene ID Not Available
Target 9 GeneCard ID NDUFS6 Link Image
Target 9 GenAtlas ID NDUFS6 Link Image
Target 9 HGNC ID HGNC:7713 Link Image
Target 9 Chromosome Location Not Available
Target 9 Locus 5p15.33
Target 9 SNPs SNPJam Report Link Image
Target 9 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 9 General References 9647766; 15489334
Target 10 [top]
Target 10 ID 352
Target 10 Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial
Target 10 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 10 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 10 Synonyms
  1. NADH-ubiquinone oxidoreductase 20 kDa subunit; Complex I-20kD; CI-20kD; PSST subunit
Target 10 Gene Name NDUFS7
Target 10 Protein Sequence >NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 
MAVLSAPGLRGFRILGLRSSVGPAVQARGVHQSVATDGPSSTQPALPKARAVAPKPSSRG
EYVVAKLDDLVNWARRSSLWPMTFGLACCAVEMMHMAAPRYDMDRFGVVFRASPRQSDVM
IVAGTLTNKMAPALRKVYDQMPEPRYVVSMGSCANGGGYYHYSYSVVRGCDRIVPVDIYI
PGCPPTAEALLYGILQLQRKIKRERRLQIWYRR
Target 10 Number of Residues 213
Target 10 Molecular Weight 23563.3
Target 10 Theoretical pI 10.36
Target 10 GO Classification
Function
NADH dehydrogenase (ubiquinone) activity
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
Process
ATP synthesis coupled electron transport (sensu Eukaryota)
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
ATP synthesis coupled electron transport
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
Component
Not Available
Target 10 General Function Energy production and conversion
Target 10 Pathways Not Available
Target 10 Reactions Not Available
Target 10 Signals
  • None
Target 10 Transmembrane Regions
  • None
Target 10 Essentiality Non Essential
Target 10 Domain Function PF01058:Oxidored_q6
Target 10 GenBank ID Protein Not Available
Target 10 UniProtKB ID O75251 Link Image
Target 10 Cellular Location Mitochondrion
Target 10 Gene Sequence Not Available
Target 10 GenBank Gene ID Not Available
Target 10 GeneCard ID NDUFS7 Link Image
Target 10 GenAtlas ID NDUFS7 Link Image
Target 10 HGNC ID HGNC:7714 Link Image
Target 10 Chromosome Location Chromosome:19
Target 10 Locus 19p13.3
Target 10 SNPs SNPJam Report Link Image
Target 10 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 10 General References 8938450; 15057824; 15489334; 10360771; 10330338
Target 11 [top]
Target 11 ID 353
Target 11 Name NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial
Target 11 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 11 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). May donate electrons to ubiquinone
Target 11 Synonyms
  1. NADH-ubiquinone oxidoreductase 23 kDa subunit; Complex I-23kD; CI-23kD; TYKY subunit
Target 11 Gene Name NDUFS8
Target 11 Protein Sequence >NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial 
MRCLTTPMLLRALAQAARAGPPGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLL
WTELFRGLGMTLSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAI
CPAQAITIEAEPRADGSRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEE
LLYNKEKLLNNGDKWEAEIAANIQADYLYR
Target 11 Number of Residues 210
Target 11 Molecular Weight 23704.8
Target 11 Theoretical pI 6.27
Target 11 GO Classification
Function
catalytic activity
oxidoreductase activity
oxidoreductase activity, acting on NADH or NADPH
binding
ion binding
cation binding
transition metal ion binding
iron ion binding
transporter activity
electron transporter activity
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
Component
Not Available
Target 11 General Function Energy production and conversion
Target 11 Pathways Not Available
Target 11 Reactions Not Available
Target 11 Signals
  • None
Target 11 Transmembrane Regions
  • None
Target 11 Essentiality Non Essential
Target 11 Domain Function PF00037:Fer4
Target 11 GenBank ID Protein Not Available
Target 11 UniProtKB ID O00217 Link Image
Target 11 Cellular Location Mitochondrion (Probable)
Target 11 Gene Sequence >633 bp 
ATGCGCTGCCTGACCACGCCTATGCTGCTGCGGGCCCTGGCCCAGGCTGCACGTGCAGGA
CCTCCTGGTGGCCGGAGCCTCCACAGCAGTGCAGTGGCAGCCACCTACAAGTATGTGAAC
ATGCAGGATCCCGAGATGGACATGAAGTCAGTGACTGACCGGGCAGCCCGCACCCTGCTG
TGGACTGAGCTCTTCCGAGGCCTGGGCATGACCCTGAGCTACCTGTTCCGGGAACCGGCC
ACCATCAACTACCCGTTCGAGAAGGGCCCGCTGAGCCCTCGCTTCCGTGGGGAGCATGCG
CTGCGCCGGTACCCATCCGGGGAGGAGCGTTGCATTGCCTGCAAGCTCTGCGAGGCCATC
TGCCCCGCCCAGGCCATCACCATCGAGGCTGAGCCAAGAGCTGATGGCAGCCGCCGGACC
ACCCGCTATGACATCGACATGACCAAGTGCATCTACTGCGGCTTCTGCCAGGAGGCCTGT
CCCGTGGATGCCATCGTCGAGGGCCCCAACTTTGAGTTCTCCACGGAGACCCATGAGGAG
CTGCTGTACAACAAGGAGAAGTTGCTCAACAACGGGGACAAGTGGGAGGCCGAGATCGCC
GCCAACATCCAGGCTGACTACTTGTATCGGTGA
Target 11 GenBank Gene ID Not Available
Target 11 GeneCard ID NDUFS8 Link Image
Target 11 GenAtlas ID NDUFS8 Link Image
Target 11 HGNC ID HGNC:7715 Link Image
Target 11 Chromosome Location Chromosome:11
Target 11 Locus 11q13
Target 11 SNPs SNPJam Report Link Image
Target 11 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 11 General References 9116042; 9666055; 14702039; 15489334; 9837812
Target 12 [top]
Target 12 ID 360
Target 12 Name NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial
Target 12 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 12 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). This is the largest subunit of complex I and it is a component of the iron-sulfur (IP) fragment of the enzyme. It may form part of the active site crevice where NADH is oxidized
Target 12 Synonyms
  1. Complex I-75kD; CI-75kD
Target 12 Gene Name NDUFS1
Target 12 Protein Sequence >NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 
MLRIPVRKALVGLSKSPKGCVRTTATAASNLIEVFVDGQSVMVEPGTTVLQACEKVGMQI
PRFCYHERLSVAGNCRMCLVEIEKAPKVVAACAMPVMKGWNILTNSEKSKKAREGVMEFL
LANHPLDCPICDQGGECDLQDQSMMFGNDRSRFLEGKRAVEDKNIGPLVKTIMTRCIQCT
RCIRFASEIAGVDDLGTTGRGNDMQVGTYIEKMFMSELSGNIIDICPVGALTSKPYAFTA
RPWETRKTESIDVMDAVGSNIVVSTRTGEVMRILPRMHEDINEEWISDKTRFAYDGLKRQ
RLTEPMVRNEKGLLTYTSWEDALSRVAGMLQSFQGKDVAAIAGGLVDAEALVALKDLLNR
VDSDTLCTEEVFPTAGAGTDLRSNYLLNTTIAGVEEADVVLLVGTNPRFEAPLFNARIRK
SWLHNDLKVALIGSPVDLTYTYDHLGDSPKILQDIASGSHPFSQVLKEAKKPMVVLGSSA
LQRNDGAAILAAVSSIAQKIRMTSGVTGDWKVMNILHRIASQVAALDLGYKPGVEAIRKN
PPKVLFLLGADGGCITRQDLPKDCFIIYQGHHGDVGAPIADVILPGAAYTEKSATYVNTE
GRAQQTKVAVTPPGLAREDWKIIRALSEIAGMTLPYDTLDQVRNRLEEVSPNLVRYDDIE
GANYFQQANELSKLVNQQLLADPLVPPQLTIKDFYMTDSISRASQTMAKCVKAVTEGAQA
VEEPSIC
Target 12 Number of Residues 727
Target 12 Molecular Weight 79466.8
Target 12 Theoretical pI 6.11
Target 12 GO Classification
Function
oxidoreductase activity, acting on NADH or NADPH
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
catalytic activity
oxidoreductase activity
binding
ion binding
cation binding
transition metal ion binding
iron ion binding
transporter activity
electron transporter activity
Process
ATP synthesis coupled electron transport
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
Component
Not Available
Target 12 General Function Energy production and conversion
Target 12 Pathways Not Available
Target 12 Reactions Not Available
Target 12 Signals
  • None
Target 12 Transmembrane Regions
  • None
Target 12 Essentiality Non Essential
Target 12 Domain Function PF09326:DUF1982 PF00111:Fer2 PF00384:Molybdopterin PF10588:NADH-G_4Fe-4S_3
Target 12 GenBank ID Protein Not Available
Target 12 UniProtKB ID P28331 Link Image
Target 12 Cellular Location Mitochondrion inner membrane
Target 12 Gene Sequence >2184 bp 
ATGTTAAGGATACCTGTAAGAAGGGCCTTAGTAGGCCTTTCTAAGTCTCCTAAAGGATGT
GTTCGAACAACTGCCACAGCAGCAAGCAACTTGATTGAAGTATTTGTTGATGGTCAGTCT
GTCATGGTGGAACCGGGAACGACCGTCCTCCAAGCTTGTGAGAAGGTTGGCATGCAGATC
CCTCGATTCTGTTATCATGAAAGGTTGTCTGTTGCTGGAAACTGCAGGATGTGCCTTGTT
GAAATTGAGAAAGCCCCTAAGGTTGTAGCTGCTTGTGCCATGCCAGTAATGAAGGGTTGG
AATATCCTAACAAACTCAGAAAAATCCAAAAAGGCCAGGGAAGGTGTGATGGAGTTCTTA
TTAGCAAATCACCCATTGGACTGTCCTATTTGTGACCAGGGAGGTGAATGTGATCTGCAG
GACCAGTCCATGATGTTTGGAAATGATAGGAGCCGATTTTTAGAGGGGAAGCGTGCTGTG
GAAGACAAGAACATTGGGCCATTGGTAAAGACCATCATGACAAGATGTATACAGTGTACT
CGCTGCATCAGGTTTGCAAGTGAGATTGCAGGAGTAGATGATTTGGGAACAACAGGCAGA
GGAAATGATATGCAAGTTGGCACATACATTGAAAAGATGTTCATGTCTGAACTGTCTGGG
AATATCATTGATATCTGCCCTGTAGGTGCCCTAACCTCTAAGCCCTATGCCTTTACTGCC
CGGCCTTGGGAAACAAGAAAGACAGAATCCATTGATGTAATGGATGCGGTTGGAAGTAAT
ATTGTGGTTAGCACAAGAACTGGAGAAGTGATGAGGATTTTGCCACGTATGCATGAGGAC
ATCAATGAAGAGTGGATCTCTGATAAAACCAGATTTGCCTATGATGGGCTAAAACGTCAA
AGACTTACCGAGCCAATGGTCAGAAATGAAAAAGGGCTTTTAACCTATACTTCTTGGGAG
GATGCTCTCTCTCGCGTAGCTGGAATGTTGCAGAGTTTTCAAGGCAAAGATGTGGCAGCA
ATTGCAGGTGGCTTGGTGGATGCTGAAGCCCTGGTAGCTCTCAAAGATTTGCTTAATAGA
GTGGACTCTGACACCTTATGCACTGAAGAGGTCTTCCCCACTGCAGGAGCTGGCACAGAT
TTGCGTTCCAATTATCTTCTTAATACTACAATTGCTGGTGTGGAAGAGGCAGATGTTGTT
CTTCTGGTTGGTACAAACCCACGTTTTGAGGCACCACTGTTTAATGCATGGATTCGAAAG
AGCTGGCTGCATAATGACTTAAAAGTGGCCCTTATAGGCAGTCCAGTGGACCTCACTTAC
ACATATGACCACCTGGGAGACTCCCCCAAAATTCTTCAAGACATTGCTTCGGGAAGCCAT
CCATTTAGCCAGGTCCTAAAGGAAGCTAAAAAACCAATGGTGGTTTTAGGCAGTTCTGCA
CTCCAAAGAAATGATGGAGCAGCAATTCTTGCAGCTGTTTCTAGCATTGCACAAAAGATT
CGGATGACTAGTGGTGTTACTGGTGATTGGAAAGTTATGAATATCCTTCATAGGATTGCA
AGTCAAGTAGCTGCTTTGGACCTTGGCTATAAGCCTGGGGTGGAAGCAATTCGGAAGAAC
CCTCCCAAGGTGCTGTTTCTCCTGGGAGCAGATGGAGGTTGTATCACACGACAGGATTTG
CCAAAGGATTGTTTCATTATTTATCAAGGACATCATGGTGATGTTGGGGCTCCCATAGCT
GATGTTATTCTCCCAGGAGCTGCTTACACAGAGAAGTCTGCTACATATGTCAACACTGAG
GGTAGAGCTCAGCAGACTAAGGTAGCAGTGACACCTCCTGGCTTGGCAAGAGAAGACTGG
AAAATTATAAGAGCACTCTCTGAGATTGCTGGAATGACTCTTCCATATGATACTCTGGAT
CAAGTAAGGAACAGATTGGAAGAATTCTCTCCTAATCTTGTTCGATATGATGATATTGAA
GGGGCTAATTACTTCCAGCAAGCAAATGAGCTCTCAAAGCTAGTGAACCAGCAGCTTCTT
GCTGACCCACTTGTTCCACCTCAGCTAACTCTAAAAGACTTCTACATGACAGATTCGATT
AGCAGAGCCTCACAGACAATGGCCAAATGTGTCAAAGCTGTCACAGAGGGTGCCCAGGCA
GTAGAGGAACCATCCATATGCTGA
Target 12 GenBank Gene ID Not Available
Target 12 GeneCard ID NDUFS1 Link Image
Target 12 GenAtlas ID NDUFS1 Link Image
Target 12 HGNC ID HGNC:7707 Link Image
Target 12 Chromosome Location Not Available
Target 12 Locus 2q33-q34
Target 12 SNPs SNPJam Report Link Image
Target 12 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 12 General References 1935949; 15815621; 15489334; 11349233
Target 13 [top]
Target 13 ID 344
Target 13 Name NADH-ubiquinone oxidoreductase chain 2
Target 13 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 13 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 13 Synonyms
  1. NADH dehydrogenase subunit 2
Target 13 Gene Name MT-ND2
Target 13 Protein Sequence >NADH-ubiquinone oxidoreductase chain 2 
MNPLAQPVIYSTIFAGTLITALSSHWFFTWVGLEMNMLAFIPVLTKKMNPRSTEAAIKYF
LTQATASMILLMAILFNNMLSGQWTMTNTTNQYSSLMIMMAMAMKLGMAPFHFWVPEVTQ
GTPLTSGLLLLTWQKLAPISIMYQISPSLNVSLLLTLSILSIMAGSWGGLNQTQLRKILA
YSSITHMGWMMAVLPYNPNMTILNLTIYIILTTTAFLLLNLNSSTTTLLLSRTWNKLTWL
TPLIPSTLLSLGGLPPLTGFLPKWAIIEEFTKNNSLIIPTIMATITLLNLYFYLRLIYST
SITLLPMSNNVKMKWQFEHTKPTPFLPTLIALTTLLLPISPFMLMIL
Target 13 Number of Residues 347
Target 13 Molecular Weight 38960.5
Target 13 Theoretical pI 10.30
Target 13 GO Classification
Function
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase (ubiquinone) activity
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
Process
ATP synthesis coupled electron transport (sensu Eukaryota)
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
ATP synthesis coupled electron transport
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
Component
Not Available
Target 13 General Function Energy production and conversion
Target 13 Pathways Not Available
Target 13 Reactions Not Available
Target 13 Signals
  • None
Target 13 Transmembrane Regions
  • 13-33
  • 56-76
  • 96-116
  • 123-143
  • 149-169
  • 178-198
  • 201-221
  • 247-267
  • 274-294
  • 326-346
Target 13 Essentiality Non Essential
Target 13 Domain Function PF06444:NADH_dehy_S2_C PF00361:Oxidored_q1
Target 13 GenBank ID Protein Not Available
Target 13 UniProtKB ID P03891 Link Image
Target 13 Cellular Location Mitochondrion inner membrane
Target 13 Gene Sequence >956 bp 
ATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCATTCCTA
ATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTTGTA
GGCCCCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCC
CTAAAACCCGCCACATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACC
ATCGCTCTTCTACTATGAACCCCCCTCCCCATACCCAACCCCCTGGTCAACCTCAACCTA
GGCCTCCTATTTATTCTAGCCACCTCTAGCCTAGCCGTTTACTCAATCCTCTGATCAGGG
TGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGCAGTAGCCCAAACAATC
TCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGCTCCTTT
AACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCC
TTGGCCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTT
GCCGAAGGGGAGTCCGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTC
GCCCTATTCTTCATAGCCGAATACACAAACATTATTATAATAAACACCCTCACCACTACA
ATCTTCCTAGGAACAACATATGACGCACTCTCCCCTGAACTCTACACAACATATTTTGTC
ACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAACAGCATACCCCCGATTC
CGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTAGCATTA
CTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTA
Target 13 GenBank Gene ID Not Available
Target 13 GeneCard ID MT-ND2 Link Image
Target 13 GenAtlas ID MT-ND2 Link Image
Target 13 HGNC ID HGNC:7456 Link Image
Target 13 Chromosome Location Chromosome:MT   
HGNC chromosome: mitochondria
Target 13 Locus Not Available
Target 13 SNPs SNPJam Report Link Image
Target 13 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 13 General References 7219534; 6260957; 9475751; 7530363; 12949126; 11130070; 12840039; 14760490; 3921850; 1900003
Target 14 [top]
Target 14 ID 349
Target 14 Name NADH-ubiquinone oxidoreductase chain 3
Target 14 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 14 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 14 Synonyms
  1. NADH dehydrogenase subunit 3
Target 14 Gene Name MT-ND3
Target 14 Protein Sequence >NADH-ubiquinone oxidoreductase chain 3 
MNFALILMINTLLALLLMIITFWLPQLNGYMEKSTPYECGFDPMSPARVPFSMKFFLVAI
TFLLFDLEIALLLPLPWALQTTNLPLMVMSSLLLIIILALSLAYEWLQKGLDWTE
Target 14 Number of Residues 115
Target 14 Molecular Weight 13185.9
Target 14 Theoretical pI 4.08
Target 14 GO Classification
Function
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
ATP synthesis coupled electron transport
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
Component
Not Available
Target 14 General Function Energy production and conversion
Target 14 Pathways Not Available
Target 14 Reactions Not Available
Target 14 Signals
  • None
Target 14 Transmembrane Regions
  • 3-23
  • 55-75
  • 84-104
Target 14 Essentiality Non Essential
Target 14 Domain Function PF00507:Oxidored_q4
Target 14 GenBank ID Protein Not Available
Target 14 UniProtKB ID P03897 Link Image
Target 14 Cellular Location Mitochondrion membrane
Target 14 Gene Sequence >956 bp 
ATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCATTCCTA
ATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTTGTA
GGCCCCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCC
CTAAAACCCGCCACATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACC
ATCGCTCTTCTACTATGAACCCCCCTCCCCATACCCAACCCCCTGGTCAACCTCAACCTA
GGCCTCCTATTTATTCTAGCCACCTCTAGCCTAGCCGTTTACTCAATCCTCTGATCAGGG
TGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGCAGTAGCCCAAACAATC
TCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGCTCCTTT
AACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCC
TTGGCCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTT
GCCGAAGGGGAGTCCGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTC
GCCCTATTCTTCATAGCCGAATACACAAACATTATTATAATAAACACCCTCACCACTACA
ATCTTCCTAGGAACAACATATGACGCACTCTCCCCTGAACTCTACACAACATATTTTGTC
ACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAACAGCATACCCCCGATTC
CGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTAGCATTA
CTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTA
Target 14 GenBank Gene ID Not Available
Target 14 GeneCard ID MT-ND3 Link Image
Target 14 GenAtlas ID MT-ND3 Link Image
Target 14 HGNC ID HGNC:7458 Link Image
Target 14 Chromosome Location Chromosome:MT   
HGNC chromosome: mitochondria
Target 14 Locus Not Available
Target 14 SNPs SNPJam Report Link Image
Target 14 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 14 General References 7219534; 12949126; 11130070; 12840039; 14760490; 3921850; 6343397; 1757091; 11456298; 17152068
Target 15 [top]
Target 15 ID 347
Target 15 Name NADH-ubiquinone oxidoreductase chain 4
Target 15 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 15 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 15 Synonyms
  1. NADH dehydrogenase subunit 4
Target 15 Gene Name MT-ND4
Target 15 Protein Sequence >NADH-ubiquinone oxidoreductase chain 4 
MLKLIVPTIMLLPLTWLSKKHMIWINTTTHSLIISIIPLLFFNQINNNLFSCSPTFSSDP
LTTPLLMLTTWLLPLTIMASQRHLSSEPLSRKKLYLSMLISLQISLIMTFTATELIMFYI
FFETTLIPTLAIITRWGNQPERLNAGTYFLFYTLVGSLPLLIALIYTHNTLGSLNILLLT
LTAQELSNSWANNLMWLAYTMAFMVKMPLYGLHLWLPKAHVEAPIAGSMVLAAVLLKLGG
YGMMRLTLILNPLTKHMAYPFLVLSLWGMIMTSSICLRQTDLKSLIAYSSISHMALVVTA
ILIQTPWSFTGAVILMIAHGLTSSLLFCLANSNYERTHSRIMILSQGLQTLLPLMAFWWL
LASLANLALPPTINLLGELSVLVTTFSWSNITLLLTGLNMLVTALYSLYMFTTTQWGSLT
HHINNMKPSFTRENTLMFMHLSPILLLSLNPDIITGFSS
Target 15 Number of Residues 459
Target 15 Molecular Weight 51580.3
Target 15 Theoretical pI 9.67
Target 15 GO Classification
Function
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase (ubiquinone) activity
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
Process
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
ATP synthesis coupled electron transport
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
mitochondrion
Target 15 General Function Energy production and conversion
Target 15 Pathways Not Available
Target 15 Reactions Not Available
Target 15 Signals
  • None
Target 15 Transmembrane Regions
  • 22-42
  • 60-80
  • 102-122
  • 145-165
  • 196-216
  • 224-244
  • 257-277
  • 284-303
  • 308-330
  • 351-371
  • 391-411
Target 15 Essentiality Non Essential
Target 15 Domain Function PF00361:Oxidored_q1 PF01059:Oxidored_q5_N
Target 15 GenBank ID Protein Not Available
Target 15 UniProtKB ID P03905 Link Image
Target 15 Cellular Location Mitochondrion membrane
Target 15 Gene Sequence >956 bp 
ATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCATTCCTA
ATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTTGTA
GGCCCCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCC
CTAAAACCCGCCACATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACC
ATCGCTCTTCTACTATGAACCCCCCTCCCCATACCCAACCCCCTGGTCAACCTCAACCTA
GGCCTCCTATTTATTCTAGCCACCTCTAGCCTAGCCGTTTACTCAATCCTCTGATCAGGG
TGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGCAGTAGCCCAAACAATC
TCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGCTCCTTT
AACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCC
TTGGCCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTT
GCCGAAGGGGAGTCCGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTC
GCCCTATTCTTCATAGCCGAATACACAAACATTATTATAATAAACACCCTCACCACTACA
ATCTTCCTAGGAACAACATATGACGCACTCTCCCCTGAACTCTACACAACATATTTTGTC
ACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAACAGCATACCCCCGATTC
CGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTAGCATTA
CTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTA
Target 15 GenBank Gene ID Not Available
Target 15 GeneCard ID MT-ND4 Link Image
Target 15 GenAtlas ID MT-ND4 Link Image
Target 15 HGNC ID HGNC:7459 Link Image
Target 15 Chromosome Location Chromosome:MT   
HGNC chromosome: mitochondria
Target 15 Locus Not Available
Target 15 SNPs SNPJam Report Link Image
Target 15 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 15 General References 7219534; 1377597; 12022039; 12949126; 11130070; 12840039; 14760490; 6284948; 3921850; 3201231
Target 16 [top]
Target 16 ID 348
Target 16 Name NADH-ubiquinone oxidoreductase chain 4L
Target 16 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 16 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 16 Synonyms
  1. NADH dehydrogenase subunit 4L
Target 16 Gene Name MT-ND4L
Target 16 Protein Sequence >NADH-ubiquinone oxidoreductase chain 4L 
MPLIYMNIMLAFTISLLGMLVYRSHLMSSLLCLEGMMLSLFIMATLMTLNTHSLLANIVP
IAMLVFAACEAAVGLALLVSISNTYGLDYVHNLNLLQC
Target 16 Number of Residues 98
Target 16 Molecular Weight 10741.0
Target 16 Theoretical pI 6.20
Target 16 GO Classification
Function
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
ATP synthesis coupled electron transport
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
Component
Not Available
Target 16 General Function Involved in NADH dehydrogenase (ubiquinone) activity
Target 16 Pathways Not Available
Target 16 Reactions Not Available
Target 16 Signals
  • None
Target 16 Transmembrane Regions
  • 1-21
  • 29-49
  • 58-78
Target 16 Essentiality Non Essential
Target 16 Domain Function PF00420:Oxidored_q2
Target 16 GenBank ID Protein Not Available
Target 16 UniProtKB ID P03901 Link Image
Target 16 Cellular Location Mitochondrion membrane
Target 16 Gene Sequence >956 bp 
ATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCATTCCTA
ATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTTGTA
GGCCCCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCC
CTAAAACCCGCCACATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACC
ATCGCTCTTCTACTATGAACCCCCCTCCCCATACCCAACCCCCTGGTCAACCTCAACCTA
GGCCTCCTATTTATTCTAGCCACCTCTAGCCTAGCCGTTTACTCAATCCTCTGATCAGGG
TGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGCAGTAGCCCAAACAATC
TCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGCTCCTTT
AACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCC
TTGGCCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTT
GCCGAAGGGGAGTCCGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTC
GCCCTATTCTTCATAGCCGAATACACAAACATTATTATAATAAACACCCTCACCACTACA
ATCTTCCTAGGAACAACATATGACGCACTCTCCCCTGAACTCTACACAACATATTTTGTC
ACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAACAGCATACCCCCGATTC
CGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTAGCATTA
CTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTA
Target 16 GenBank Gene ID Not Available
Target 16 GeneCard ID MT-ND4L Link Image
Target 16 GenAtlas ID MT-ND4L Link Image
Target 16 HGNC ID HGNC:7460 Link Image
Target 16 Chromosome Location Chromosome:MT   
HGNC chromosome: mitochondria
Target 16 Locus Not Available
Target 16 SNPs SNPJam Report Link Image
Target 16 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 16 General References 7219534; 7530363; 8919866; 12949126; 11130070; 12840039; 14760490; 3921850; 1757091; 8680405
Target 17 [top]
Target 17 ID 345
Target 17 Name NADH-ubiquinone oxidoreductase chain 5
Target 17 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 17 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 17 Synonyms
  1. NADH dehydrogenase subunit 5
Target 17 Gene Name MT-ND5
Target 17 Protein Sequence >NADH-ubiquinone oxidoreductase chain 5 
MTMHTTMTTLTLTSLIPPILTTLVNPNKKNSYPHYVKSIVASTFIISLFPTTMFMCLDQE
VIISNWHWATTQTTQLSLSFKLDYFSMMFIPVALFVTWSIMEFSLWYMNSDPNINQFFKY
LLIFLITMLILVTANNLFQLFIGWEGVGIMSFLLISWWYARADANTAAIQAILYNRIGDI
GFILALAWFILHSNSWDPQQMALLNANPSLTPLLGLLLAAAGKSAQLGLHPWLPSAMEGP
TPVSALLHSSTMVVAGIFLLIRFHPLAENSPLIQTLTLCLGAITTLFAAVCALTQNDIKK
IVAFSTSSQLGLMMVTIGINQPHLAFLHICTHAFFKAMLFMCSGSIIHNLNNEQDIRKMG
GLLKTMPLTSTSLTIGSLALAGMPFLTGFYSKDHIIETANMSYTNAWALSITLIATSLTS
AYSTRMILLTLTGQPRFPTLTNINENNPTLLNPIKRLAAGSLFAGFLITNNISPASPFQT
TIPLYLKLTALAVTFLGLLTALDLNYLTNKLKMKSPLCTFYFSNMLGFYPSITHRTIPYL
GLLTSQNLPLLLLDLTWLEKLLPKTISQHQISTSIITSTQKGMIKLYFLSFFFPLILTLL
LIT
Target 17 Number of Residues 603
Target 17 Molecular Weight 67025.7
Target 17 Theoretical pI 9.32
Target 17 GO Classification
Function
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase (ubiquinone) activity
NADH dehydrogenase (ubiquinone) activity
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
ATP synthesis coupled electron transport
Component
Not Available
Target 17 General Function Energy production and conversion
Target 17 Pathways Not Available
Target 17 Reactions Not Available
Target 17 Signals
  • None
Target 17 Transmembrane Regions
  • 38-58
  • 87-107
  • 122-142
  • 144-160
  • 171-191
  • 211-233
  • 241-261
  • 272-292
  • 301-320
  • 325-347
  • 370-390
  • 407-429
  • 458-478
  • 482-502
  • 582-602
Target 17 Essentiality Non Essential
Target 17 Domain Function PF06455:NADH5_C PF00361:Oxidored_q1 PF00662:Oxidored_q1_N
Target 17 GenBank ID Protein Not Available
Target 17 UniProtKB ID P03915 Link Image
Target 17 Cellular Location Mitochondrion inner membrane
Target 17 Gene Sequence >956 bp 
ATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCATTCCTA
ATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTTGTA
GGCCCCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCC
CTAAAACCCGCCACATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACC
ATCGCTCTTCTACTATGAACCCCCCTCCCCATACCCAACCCCCTGGTCAACCTCAACCTA
GGCCTCCTATTTATTCTAGCCACCTCTAGCCTAGCCGTTTACTCAATCCTCTGATCAGGG
TGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGCAGTAGCCCAAACAATC
TCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGCTCCTTT
AACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCC
TTGGCCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTT
GCCGAAGGGGAGTCCGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTC
GCCCTATTCTTCATAGCCGAATACACAAACATTATTATAATAAACACCCTCACCACTACA
ATCTTCCTAGGAACAACATATGACGCACTCTCCCCTGAACTCTACACAACATATTTTGTC
ACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAACAGCATACCCCCGATTC
CGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTAGCATTA
CTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTA
Target 17 GenBank Gene ID Not Available
Target 17 GeneCard ID MT-ND5 Link Image
Target 17 GenAtlas ID MT-ND5 Link Image
Target 17 HGNC ID HGNC:7461 Link Image
Target 17 Chromosome Location Chromosome:MT   
HGNC chromosome: mitochondria
Target 17 Locus Not Available
Target 17 SNPs SNPJam Report Link Image
Target 17 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 17 General References 7219534; 7530363; 11553319; 12949126; 11130070; 12840039; 14760490; 6284948; 3921850
Target 18 [top]
Target 18 ID 346
Target 18 Name NADH-ubiquinone oxidoreductase chain 6
Target 18 Mechanism of Action Inhibition of sperm carbohydrate metabolism at the step of nicotinamide adenine dinucleotide (NADH) dehydrogenase activity in the mitochondrial electron transport chain is a factor of 1,2-dibromo-3-chloropropane's testicular toxicity. (R238)
Target 18 Description Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)
Target 18 Synonyms
  1. NADH dehydrogenase subunit 6
Target 18 Gene Name MT-ND6
Target 18 Protein Sequence >NADH-ubiquinone oxidoreductase chain 6 
MMYALFLLSVGLVMGFVGFSSKPSPIYGGLVLIVSGVVGCVIILNFGGGYMGLMVFLIYL
GGMMVVFGYTTAMAIEEYPEAWGSGVEVLVSVLVGLAMEVGLVLWVKEYDGVVVVVNFNS
VGSWMIYEGEGSGLIREDPIGAGALYDYGRWLVVVTGWTLFVGVYIVIEIARGN
Target 18 Number of Residues 174
Target 18 Molecular Weight 18622.0
Target 18 Theoretical pI 3.90
Target 18 GO Classification
Function
transporter activity
ion transporter activity
cation transporter activity
monovalent inorganic cation transporter activity
hydrogen ion transporter activity
NADH dehydrogenase (ubiquinone) activity
Process
physiological process
metabolism
cellular metabolism
generation of precursor metabolites and energy
electron transport
ATP synthesis coupled electron transport
ATP synthesis coupled electron transport (sensu Eukaryota)
mitochondrial electron transport, NADH to ubiquinone
Component
Not Available
Target 18 General Function Involved in NADH dehydrogenase (ubiquinone) activity
Target 18 Pathways Not Available
Target 18 Reactions Not Available
Target 18 Signals
  • None
Target 18 Transmembrane Regions
  • 1-21
  • 26-46
  • 47-67
  • 86-106
  • 111-131
  • 151-171
Target 18 Essentiality Non Essential
Target 18 Domain Function PF00499:Oxidored_q3
Target 18 GenBank ID Protein Not Available
Target 18 UniProtKB ID P03923 Link Image
Target 18 Cellular Location Mitochondrion membrane
Target 18 Gene Sequence >956 bp 
ATACCCATGGCCAACCTCCTACTCCTCATTGTACCCATTCTAATCGCAATGGCATTCCTA
ATGCTTACCGAACGAAAAATTCTAGGCTATATACAACTACGCAAAGGCCCCAACGTTGTA
GGCCCCTACGGGCTACTACAACCCTTCGCTGACGCCATAAAACTCTTCACCAAAGAGCCC
CTAAAACCCGCCACATCTACCATCACCCTCTACATCACCGCCCCGACCTTAGCTCTCACC
ATCGCTCTTCTACTATGAACCCCCCTCCCCATACCCAACCCCCTGGTCAACCTCAACCTA
GGCCTCCTATTTATTCTAGCCACCTCTAGCCTAGCCGTTTACTCAATCCTCTGATCAGGG
TGAGCATCAAACTCAAACTACGCCCTGATCGGCGCACTGCGAGCAGTAGCCCAAACAATC
TCATATGAAGTCACCCTAGCCATCATTCTACTATCAACATTACTAATAAGTGGCTCCTTT
AACCTCTCCACCCTTATCACAACACAAGAACACCTCTGATTACTCCTGCCATCATGACCC
TTGGCCATAATATGATTTATCTCCACACTAGCAGAGACCAACCGAACCCCCTTCGACCTT
GCCGAAGGGGAGTCCGAACTAGTCTCAGGCTTCAACATCGAATACGCCGCAGGCCCCTTC
GCCCTATTCTTCATAGCCGAATACACAAACATTATTATAATAAACACCCTCACCACTACA
ATCTTCCTAGGAACAACATATGACGCACTCTCCCCTGAACTCTACACAACATATTTTGTC
ACCAAGACCCTACTTCTAACCTCCCTGTTCTTATGAATTCGAACAGCATACCCCCGATTC
CGCTACGACCAACTCATACACCTCCTATGAAAAAACTTCCTACCACTCACCCTAGCATTA
CTTATATGATATGTCTCCATACCCATTACAATCTCCAGCATTCCCCCTCAAACCTA
Target 18 GenBank Gene ID Not Available
Target 18 GeneCard ID MT-ND6 Link Image
Target 18 GenAtlas ID MT-ND6 Link Image
Target 18 HGNC ID HGNC:7462 Link Image
Target 18 Chromosome Location Chromosome:MT   
HGNC chromosome: mitochondria
Target 18 Locus Not Available
Target 18 SNPs SNPJam Report Link Image
Target 18 Toxin References
  • R043 - Greenwell A, Tomaszewski KE, Melnick RL: A biochemical basis for 1,2-dibromo-3-chloropropane-induced male infertility: inhibition of sperm mitochondrial electron transport activity. Toxicol Appl Pharmacol. 1987 Nov;91(2):274-80. [PubMed Link Image]
Target 18 General References 7219534; 7530363; 9452107; 12949126; 11130070; 12840039; 14760490; 2043137; 1757091
Target 19 [top]
Target 19 ID 5
Target 19 Name Estrogen receptor
Target 19 Mechanism of Action Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
Target 19 Description Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues
Target 19 Synonyms
  1. ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1
Target 19 Gene Name ESR1
Target 19 Protein Sequence >Estrogen receptor 
MTMTLHTKASGMALLHQIQGNELEPLNRPQLKIPLERPLGEVYLDSSKPAVYNYPEGAAY
EFNAAAAANAQVYGQTGLPYGPGSEAAAFGSNGLGGFPPLNSVSPSPLMLLHPPPQLSPF
LQPHGQQVPYYLENEPSGYTVREAGPPAFYRPNSDNRRQGGRERLASTNDKGSMAMESAK
ETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQAC
RLRKCYEVGMMKGGIRKDRRGGRMLKHKRQRDDGEGRGEVGSAGDMRAANLWPSPLMIKR
SKKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADRELVHMINW
AKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNLLLDRNQGKCVEG
MVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGVYTFLSSTLKSLEEKDHIHRVLD
KITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHLYSMKCKNVVPLYDLL
LEMLDAHRLHAPTSRGGASVEETDQSHLATAGSTSSHSLQKYYITGEAEGFPATV
Target 19 Number of Residues 595
Target 19 Molecular Weight 66215.4
Target 19 Theoretical pI 8.14
Target 19 GO Classification
Function
steroid binding
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 19 General Function Involved in estrogen receptor activity
Target 19 Pathways Not Available
Target 19 Reactions Not Available
Target 19 Signals
  • None
Target 19 Transmembrane Regions
  • None
Target 19 Essentiality Non Essential
Target 19 Domain Function PF00104:Hormone_recep PF02159:Oest_recep PF00105:zf-C4
Target 19 GenBank ID Protein Not Available
Target 19 UniProtKB ID P03372 Link Image
Target 19 Cellular Location Nucleus
Target 19 Gene Sequence >63 bp 
ATGCGCTGCGTCGCCTCTAACCTCGGGCTGTGCTCTTTTTCCAGGTGGCCCGCCGGTTTC
TGA
Target 19 GenBank Gene ID Not Available
Target 19 GeneCard ID ESR1 Link Image
Target 19 GenAtlas ID ESR1 Link Image
Target 19 HGNC ID HGNC:3467 Link Image
Target 19 Chromosome Location Not Available
Target 19 Locus 6q25.1
Target 19 SNPs SNPJam Report Link Image
Target 19 Toxin References
  • S301 - Luft S, Milki E, Glustrom E, Ampiah-Bonney R, O'Hara P. Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors ? and ?: A Fluorescence Polarization Assay. Biophysical Journal 2009;96(3):444a.
Target 19 General References 3754034; 3753802; 8600466; 14574404; 7476978; 10619354; 7916651; 7539106
Target 20 [top]
Target 20 ID 208
Target 20 Name Estrogen receptor beta
Target 20 Mechanism of Action Causes endocrine disruption in humans by binding to and inhibiting the estrogen receptor. (S301)
Target 20 Description Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA- binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual
Target 20 Synonyms
  1. ER-beta; Nuclear receptor subfamily 3 group A member 2
Target 20 Gene Name ESR2
Target 20 Protein Sequence >Estrogen receptor beta 
MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
Target 20 Number of Residues 530
Target 20 Molecular Weight 59215.8
Target 20 Theoretical pI 8.55
Target 20 GO Classification
Function
signal transducer activity
receptor activity
ligand-dependent nuclear receptor activity
steroid hormone receptor activity
binding
nucleic acid binding
DNA binding
transcription factor activity
Process
regulation of biological process
regulation of physiological process
regulation of metabolism
regulation of cellular metabolism
regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism
regulation of transcription
regulation of transcription, DNA-dependent
Component
organelle
membrane-bound organelle
intracellular membrane-bound organelle
nucleus
Target 20 General Function Involved in estrogen receptor activity
Target 20 Pathways Not Available
Target 20 Reactions Not Available
Target 20 Signals
  • None
Target 20 Transmembrane Regions
  • None
Target 20 Essentiality Non Essential
Target 20 Domain Function PF00104:Hormone_recep PF00105:zf-C4
Target 20 GenBank ID Protein Not Available
Target 20 UniProtKB ID Q92731 Link Image
Target 20 Cellular Location Nucleus
Target 20 Gene Sequence >1593 bp 
ATGGATATAAAAAACTCACCATCTAGCCTTAATTCTCCTTCCTCCTACAACTGCAGTCAA
TCCATCTTACCCCTGGAGCACGGCTCCATATACATACCTTCCTCCTATGTAGACAGCCAC
CATGAATATCCAGCCATGACATTCTATAGCCCTGCTGTGATGAATTACAGCATTCCCAGC
AATGTCACTAACTTGGAAGGTGGGCCTGGTCGGCAGACCACAAGCCCAAATGTGTTGTGG
CCAACACCTGGGCACCTTTCTCCTTTAGTGGTCCATCGCCAGTTATCACATCTGTATGCG
GAACCTCAAAAGAGTCCCTGGTGTGAAGCAAGATCGCTAGAACACACCTTACCTGTAAAC
AGAGAGACACTGAAAAGGAAGGTTAGTGGGAACCGTTGCGCCAGCCCTGTTACTGGTCCA
GGTTCAAAGAGGGATGCTCACTTCTGCGCTGTCTGCAGCGATTACGCATCGGGATATCAC
TATGGAGTCTGGTCGTGTGAAGGATGTAAGGCCTTTTTTAAAAGAAGCATTCAAGGACAT
AATGATTATATTTGTCCAGCTACAAATCAGTGTACAATCGATAAAAACCGGCGCAAGAGC
TGCCAGGCCTGCCGACTTCGGAAGTGTTACGAAGTGGGAATGGTGAAGTGTGGCTCCCGG
AGAGAGAGATGTGGGTACCGCCTTGTGCGGAGACAGAGAAGTGCCGACGAGCAGCTGCAC
TGTGCCGGCAAGGCCAAGAGAAGTGGCGGCCACGCGCCCCGAGTGCGGGAGCTGCTGCTG
GACGCCCTGAGCCCCGAGCAGCTAGTGCTCACCCTCCTGGAGGCTGAGCCGCCCCATGTG
CTGATCAGCCGCCCCAGTGCGCCCTTCACCGAGGCCTCCATGATGATGTCCCTGACCAAG
TTGGCCGACAAGGAGTTGGTACACATGATCAGCTGGGCCAAGAAGATTCCCGGCTTTGTG
GAGCTCAGCCTGTTCGACCAAGTGCGGCTCTTGGAGAGCTGTTGGATGGAGGTGTTAATG
ATGGGGCTGATGTGGCGCTCAATTGACCACCCCGGCAAGCTCATCTTTGCTCCAGATCTT
GTTCTGGACAGGGATGAGGGGAAATGCGTAGAAGGAATTCTGGAAATCTTTGACATGCTC
CTGGCAACTACTTCAAGGTTTCGAGAGTTAAAACTCCAACACAAAGAATATCTCTGTGTC
AAGGCCATGATCCTGCTCAATTCCAGTATGTACCCTCTGGTCACAGCGACCCAGGATGCT
GACAGCAGCCGGAAGCTGGCTCACTTGCTGAACGCCGTGACCGATGCTTTGGTTTGGGTG
ATTGCCAAGAGCGGCATCTCCTCCCAGCAGCAATCCATGCGCCTGGCTAACCTCCTGATG
CTCCTGTCCCACGTCAGGCATGCGAGTAACAAGGGCATGGAACATCTGCTCAACATGAAG
TGCAAAAATGTGGTCCCAGTGTATGACCTGCTGCTGGAGATGCTGAATGCCCACGTGCTT
CGCGGGTGCAAGTCCTCCATCACGGGGTCCGAGTGCAGCCCGGCAGAGGACAGTAAAAGC
AAAGAGGGCTCCCAGAACCCACAGTCTCAGTGA
Target 20 GenBank Gene ID Not Available
Target 20 GeneCard ID ESR2 Link Image
Target 20 GenAtlas ID ESR2 Link Image
Target 20 HGNC ID HGNC:3468 Link Image
Target 20 Chromosome Location Chromosome:14
Target 20 Locus 14q23.2
Target 20 SNPs SNPJam Report Link Image
Target 20 Toxin References
  • S301 - Luft S, Milki E, Glustrom E, Ampiah-Bonney R, O'Hara P. Binding of Organochloride and Pyrethroid Pesticides To Estrogen Receptors ? and ?: A Fluorescence Polarization Assay. Biophysical Journal 2009;96(3):444a.
Target 20 General References 9473491; 9636657; 9685228; 9671811; 16938840; 15489334; 10964723; 8769313

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